NB-ARC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AUF2_LEIMU

TriTrypDb:

LmxM.20.0120

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

E9AUF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.554
CLV_C14_Caspase3-7	280	284	PF00656	0.369
CLV_C14_Caspase3-7	546	550	PF00656	0.377
CLV_NRD_NRD_1	124	126	PF00675	0.479
CLV_NRD_NRD_1	165	167	PF00675	0.316
CLV_NRD_NRD_1	2	4	PF00675	0.662
CLV_NRD_NRD_1	237	239	PF00675	0.563
CLV_NRD_NRD_1	348	350	PF00675	0.421
CLV_PCSK_FUR_1	235	239	PF00082	0.335
CLV_PCSK_KEX2_1	165	167	PF00082	0.316
CLV_PCSK_KEX2_1	2	4	PF00082	0.651
CLV_PCSK_KEX2_1	234	236	PF00082	0.469
CLV_PCSK_KEX2_1	237	239	PF00082	0.509
CLV_PCSK_KEX2_1	348	350	PF00082	0.420
CLV_PCSK_KEX2_1	553	555	PF00082	0.376
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.463
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.376
CLV_PCSK_SKI1_1	128	132	PF00082	0.378
CLV_PCSK_SKI1_1	267	271	PF00082	0.425
CLV_PCSK_SKI1_1	389	393	PF00082	0.357
CLV_PCSK_SKI1_1	6	10	PF00082	0.671
DEG_APCC_DBOX_1	266	274	PF00400	0.449
DEG_Kelch_Keap1_1	15	20	PF01344	0.683
DEG_Nend_UBRbox_1	1	4	PF02207	0.695
DEG_ODPH_VHL_1	475	488	PF01847	0.336
DOC_CDC14_PxL_1	203	211	PF14671	0.386
DOC_CDC14_PxL_1	41	49	PF14671	0.487
DOC_CYCLIN_RxL_1	432	443	PF00134	0.344
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.406
DOC_MAPK_gen_1	123	133	PF00069	0.373
DOC_MAPK_gen_1	234	244	PF00069	0.515
DOC_MAPK_gen_1	452	460	PF00069	0.297
DOC_MAPK_MEF2A_6	125	134	PF00069	0.355
DOC_MAPK_MEF2A_6	499	507	PF00069	0.521
DOC_PP1_RVXF_1	434	441	PF00149	0.337
DOC_PP2B_LxvP_1	330	333	PF13499	0.247
DOC_PP2B_LxvP_1	535	538	PF13499	0.516
DOC_USP7_MATH_1	110	114	PF00917	0.501
DOC_USP7_MATH_1	12	16	PF00917	0.681
DOC_USP7_MATH_1	180	184	PF00917	0.487
DOC_USP7_MATH_1	480	484	PF00917	0.361
DOC_WW_Pin1_4	171	176	PF00397	0.434
DOC_WW_Pin1_4	305	310	PF00397	0.426
DOC_WW_Pin1_4	377	382	PF00397	0.453
LIG_14-3-3_CanoR_1	14	22	PF00244	0.660
LIG_14-3-3_CanoR_1	165	173	PF00244	0.288
LIG_14-3-3_CanoR_1	223	231	PF00244	0.322
LIG_14-3-3_CanoR_1	32	40	PF00244	0.669
LIG_14-3-3_CanoR_1	389	394	PF00244	0.369
LIG_14-3-3_CanoR_1	499	504	PF00244	0.389
LIG_14-3-3_CanoR_1	98	105	PF00244	0.346
LIG_Actin_WH2_2	37	52	PF00022	0.328
LIG_BRCT_BRCA1_1	22	26	PF00533	0.693
LIG_BRCT_BRCA1_1	389	393	PF00533	0.379
LIG_BRCT_BRCA1_1	95	99	PF00533	0.425
LIG_Clathr_ClatBox_1	131	135	PF01394	0.326
LIG_Clathr_ClatBox_1	500	504	PF01394	0.328
LIG_FHA_1	239	245	PF00498	0.381
LIG_FHA_1	276	282	PF00498	0.396
LIG_FHA_1	363	369	PF00498	0.292
LIG_FHA_1	378	384	PF00498	0.337
LIG_FHA_1	516	522	PF00498	0.338
LIG_FHA_2	260	266	PF00498	0.483
LIG_FHA_2	383	389	PF00498	0.454
LIG_LIR_Gen_1	152	162	PF02991	0.387
LIG_LIR_Gen_1	518	524	PF02991	0.342
LIG_LIR_Gen_1	60	66	PF02991	0.410
LIG_LIR_Gen_1	96	105	PF02991	0.347
LIG_LIR_LC3C_4	129	134	PF02991	0.405
LIG_LIR_Nem_3	197	203	PF02991	0.398
LIG_LIR_Nem_3	518	523	PF02991	0.335
LIG_LIR_Nem_3	60	65	PF02991	0.402
LIG_LIR_Nem_3	96	102	PF02991	0.379
LIG_NRP_CendR_1	553	556	PF00754	0.619
LIG_Pex14_1	409	413	PF04695	0.366
LIG_Pex14_1	516	520	PF04695	0.454
LIG_Pex14_2	307	311	PF04695	0.437
LIG_PTB_Apo_2	199	206	PF02174	0.442
LIG_PTB_Phospho_1	199	205	PF10480	0.443
LIG_SH2_CRK	42	46	PF00017	0.504
LIG_SH2_CRK	71	75	PF00017	0.369
LIG_SH2_NCK_1	366	370	PF00017	0.311
LIG_SH2_PTP2	205	208	PF00017	0.357
LIG_SH2_SRC	478	481	PF00017	0.360
LIG_SH2_STAP1	413	417	PF00017	0.410
LIG_SH2_STAT5	154	157	PF00017	0.404
LIG_SH2_STAT5	205	208	PF00017	0.357
LIG_SH2_STAT5	366	369	PF00017	0.303
LIG_SH2_STAT5	478	481	PF00017	0.375
LIG_SH3_3	134	140	PF00018	0.359
LIG_SH3_3	474	480	PF00018	0.321
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.346
LIG_SUMO_SIM_anti_2	141	149	PF11976	0.375
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.216
LIG_SUMO_SIM_anti_2	483	491	PF11976	0.472
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.506
LIG_SUMO_SIM_par_1	129	136	PF11976	0.333
LIG_SUMO_SIM_par_1	239	245	PF11976	0.395
LIG_SUMO_SIM_par_1	255	260	PF11976	0.270
LIG_SUMO_SIM_par_1	45	51	PF11976	0.320
LIG_SUMO_SIM_par_1	499	504	PF11976	0.319
LIG_TRAF2_1	139	142	PF00917	0.350
LIG_TRAF2_1	33	36	PF00917	0.656
LIG_TRAF2_1	418	421	PF00917	0.536
LIG_TRAF2_1	508	511	PF00917	0.523
LIG_TYR_ITIM	203	208	PF00017	0.355
LIG_UBA3_1	437	442	PF00899	0.487
LIG_UBA3_1	519	526	PF00899	0.396
MOD_CDK_SPK_2	305	310	PF00069	0.396
MOD_CK1_1	15	21	PF00069	0.684
MOD_CK1_1	176	182	PF00069	0.484
MOD_CK1_1	249	255	PF00069	0.298
MOD_CK1_1	25	31	PF00069	0.720
MOD_CK1_1	424	430	PF00069	0.489
MOD_CK1_1	465	471	PF00069	0.519
MOD_CK2_1	14	20	PF00069	0.703
MOD_CK2_1	25	31	PF00069	0.696
MOD_CK2_1	461	467	PF00069	0.474
MOD_CK2_1	484	490	PF00069	0.508
MOD_Cter_Amidation	123	126	PF01082	0.405
MOD_GlcNHglycan	14	17	PF01048	0.771
MOD_GlcNHglycan	159	162	PF01048	0.434
MOD_GlcNHglycan	175	178	PF01048	0.314
MOD_GlcNHglycan	244	247	PF01048	0.474
MOD_GlcNHglycan	388	392	PF01048	0.352
MOD_GlcNHglycan	421	426	PF01048	0.433
MOD_GlcNHglycan	464	467	PF01048	0.385
MOD_GSK3_1	176	183	PF00069	0.470
MOD_GSK3_1	238	245	PF00069	0.375
MOD_GSK3_1	27	34	PF00069	0.663
MOD_GSK3_1	271	278	PF00069	0.333
MOD_GSK3_1	295	302	PF00069	0.493
MOD_GSK3_1	461	468	PF00069	0.387
MOD_GSK3_1	480	487	PF00069	0.350
MOD_GSK3_1	89	96	PF00069	0.382
MOD_N-GLC_1	484	489	PF02516	0.390
MOD_NEK2_1	118	123	PF00069	0.448
MOD_NEK2_1	156	161	PF00069	0.340
MOD_NEK2_1	242	247	PF00069	0.392
MOD_NEK2_1	259	264	PF00069	0.211
MOD_NEK2_1	387	392	PF00069	0.347
MOD_NEK2_1	515	520	PF00069	0.321
MOD_NEK2_1	89	94	PF00069	0.488
MOD_NEK2_2	295	300	PF00069	0.347
MOD_PIKK_1	110	116	PF00454	0.504
MOD_PIKK_1	180	186	PF00454	0.489
MOD_PIKK_1	190	196	PF00454	0.523
MOD_PIKK_1	222	228	PF00454	0.254
MOD_PIKK_1	299	305	PF00454	0.388
MOD_PK_1	499	505	PF00069	0.469
MOD_PKA_1	165	171	PF00069	0.298
MOD_PKA_2	164	170	PF00069	0.300
MOD_PKA_2	222	228	PF00069	0.228
MOD_PKA_2	31	37	PF00069	0.739
MOD_PKA_2	97	103	PF00069	0.361
MOD_Plk_1	188	194	PF00069	0.525
MOD_Plk_1	238	244	PF00069	0.513
MOD_Plk_1	259	265	PF00069	0.556
MOD_Plk_1	295	301	PF00069	0.485
MOD_Plk_1	484	490	PF00069	0.477
MOD_Plk_2-3	31	37	PF00069	0.614
MOD_Plk_2-3	484	490	PF00069	0.350
MOD_Plk_4	149	155	PF00069	0.407
MOD_Plk_4	211	217	PF00069	0.414
MOD_Plk_4	246	252	PF00069	0.452
MOD_Plk_4	341	347	PF00069	0.397
MOD_Plk_4	389	395	PF00069	0.357
MOD_Plk_4	484	490	PF00069	0.510
MOD_Plk_4	515	521	PF00069	0.365
MOD_ProDKin_1	171	177	PF00069	0.435
MOD_ProDKin_1	305	311	PF00069	0.443
MOD_ProDKin_1	377	383	PF00069	0.447
MOD_SUMO_for_1	309	312	PF00179	0.573
MOD_SUMO_rev_2	546	555	PF00179	0.451
TRG_DiLeu_BaEn_1	127	132	PF01217	0.349
TRG_DiLeu_BaEn_1	142	147	PF01217	0.437
TRG_DiLeu_BaEn_1	433	438	PF01217	0.336
TRG_DiLeu_BaEn_4	510	516	PF01217	0.314
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.330
TRG_DiLeu_LyEn_5	36	41	PF01217	0.629
TRG_DiLeu_LyEn_5	433	438	PF01217	0.336
TRG_ENDOCYTIC_2	154	157	PF00928	0.376
TRG_ENDOCYTIC_2	205	208	PF00928	0.338
TRG_ENDOCYTIC_2	359	362	PF00928	0.460
TRG_ENDOCYTIC_2	71	74	PF00928	0.472
TRG_ER_diArg_1	1	3	PF00400	0.696
TRG_ER_diArg_1	164	166	PF00400	0.294
TRG_ER_diArg_1	235	238	PF00400	0.510
TRG_ER_diArg_1	347	349	PF00400	0.410
TRG_NES_CRM1_1	484	497	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P560	Leptomonas seymouri	72%	100%
A0A0S4JGE1	Bodo saltans	36%	94%
A0A1X0NY36	Trypanosomatidae	43%	98%
A0A3S7WVT1	Leishmania donovani	94%	100%
A0A422N7U6	Trypanosoma rangeli	38%	100%
A4HBI0	Leishmania braziliensis	86%	100%
A4HYK2	Leishmania infantum	94%	100%
C9ZHV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
Q4QD32	Leishmania major	94%	100%
V5BAF5	Trypanosoma cruzi	45%	99%