Tyrosine-protein phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUE8_LEIMU

TriTrypDb:

LmxM.20.0080

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.490
CLV_NRD_NRD_1	157	159	PF00675	0.554
CLV_NRD_NRD_1	20	22	PF00675	0.556
CLV_NRD_NRD_1	405	407	PF00675	0.452
CLV_NRD_NRD_1	484	486	PF00675	0.545
CLV_NRD_NRD_1	85	87	PF00675	0.428
CLV_PCSK_KEX2_1	157	159	PF00082	0.554
CLV_PCSK_KEX2_1	405	407	PF00082	0.467
CLV_PCSK_KEX2_1	484	486	PF00082	0.500
CLV_PCSK_PC7_1	401	407	PF00082	0.443
CLV_PCSK_SKI1_1	125	129	PF00082	0.586
CLV_PCSK_SKI1_1	157	161	PF00082	0.555
CLV_PCSK_SKI1_1	269	273	PF00082	0.642
CLV_PCSK_SKI1_1	34	38	PF00082	0.558
CLV_PCSK_SKI1_1	401	405	PF00082	0.438
CLV_PCSK_SKI1_1	477	481	PF00082	0.660
CLV_PCSK_SKI1_1	501	505	PF00082	0.422
DEG_Nend_UBRbox_3	1	3	PF02207	0.701
DOC_CKS1_1	218	223	PF01111	0.566
DOC_CKS1_1	285	290	PF01111	0.801
DOC_CKS1_1	303	308	PF01111	0.458
DOC_CKS1_1	437	442	PF01111	0.690
DOC_CKS1_1	497	502	PF01111	0.444
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.750
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.516
DOC_MAPK_gen_1	157	165	PF00069	0.542
DOC_MAPK_HePTP_8	134	146	PF00069	0.487
DOC_MAPK_MEF2A_6	129	138	PF00069	0.407
DOC_MAPK_MEF2A_6	167	176	PF00069	0.544
DOC_MAPK_MEF2A_6	504	513	PF00069	0.567
DOC_PP1_RVXF_1	155	162	PF00149	0.554
DOC_PP1_RVXF_1	373	380	PF00149	0.445
DOC_USP7_MATH_1	153	157	PF00917	0.533
DOC_USP7_MATH_1	24	28	PF00917	0.603
DOC_USP7_MATH_1	371	375	PF00917	0.495
DOC_USP7_MATH_1	442	446	PF00917	0.676
DOC_USP7_UBL2_3	121	125	PF12436	0.671
DOC_USP7_UBL2_3	457	461	PF12436	0.726
DOC_USP7_UBL2_3	515	519	PF12436	0.540
DOC_USP7_UBL2_3	529	533	PF12436	0.614
DOC_WW_Pin1_4	217	222	PF00397	0.602
DOC_WW_Pin1_4	225	230	PF00397	0.547
DOC_WW_Pin1_4	275	280	PF00397	0.666
DOC_WW_Pin1_4	284	289	PF00397	0.651
DOC_WW_Pin1_4	302	307	PF00397	0.456
DOC_WW_Pin1_4	436	441	PF00397	0.658
DOC_WW_Pin1_4	496	501	PF00397	0.462
DOC_WW_Pin1_4	505	510	PF00397	0.416
DOC_WW_Pin1_4	69	74	PF00397	0.450
LIG_14-3-3_CanoR_1	157	162	PF00244	0.550
LIG_14-3-3_CanoR_1	199	207	PF00244	0.508
LIG_14-3-3_CanoR_1	247	255	PF00244	0.463
LIG_14-3-3_CanoR_1	269	279	PF00244	0.765
LIG_14-3-3_CanoR_1	333	342	PF00244	0.406
LIG_14-3-3_CanoR_1	78	83	PF00244	0.520
LIG_BRCT_BRCA1_1	27	31	PF00533	0.607
LIG_BRCT_BRCA1_1	358	362	PF00533	0.443
LIG_BRCT_BRCA1_1	418	422	PF00533	0.560
LIG_CaM_IQ_9	317	333	PF13499	0.669
LIG_Clathr_ClatBox_1	548	552	PF01394	0.443
LIG_eIF4E_1	248	254	PF01652	0.556
LIG_eIF4E_1	543	549	PF01652	0.381
LIG_FHA_1	102	108	PF00498	0.469
LIG_FHA_1	221	227	PF00498	0.501
LIG_FHA_1	235	241	PF00498	0.430
LIG_FHA_1	249	255	PF00498	0.462
LIG_FHA_1	260	266	PF00498	0.641
LIG_FHA_1	315	321	PF00498	0.670
LIG_FHA_1	506	512	PF00498	0.421
LIG_FHA_1	533	539	PF00498	0.568
LIG_FHA_1	62	68	PF00498	0.452
LIG_FHA_2	497	503	PF00498	0.443
LIG_LIR_Apic_2	215	221	PF02991	0.620
LIG_LIR_Gen_1	201	212	PF02991	0.564
LIG_LIR_Gen_1	228	238	PF02991	0.524
LIG_LIR_Gen_1	382	391	PF02991	0.406
LIG_LIR_Gen_1	470	479	PF02991	0.607
LIG_LIR_Gen_1	544	551	PF02991	0.381
LIG_LIR_Gen_1	81	90	PF02991	0.565
LIG_LIR_LC3C_4	250	255	PF02991	0.494
LIG_LIR_Nem_3	189	195	PF02991	0.601
LIG_LIR_Nem_3	201	207	PF02991	0.561
LIG_LIR_Nem_3	228	234	PF02991	0.521
LIG_LIR_Nem_3	382	386	PF02991	0.397
LIG_LIR_Nem_3	470	475	PF02991	0.602
LIG_LIR_Nem_3	544	548	PF02991	0.368
LIG_LIR_Nem_3	81	85	PF02991	0.514
LIG_NBox_RRM_1	428	438	PF00076	0.657
LIG_PCNA_PIPBox_1	355	364	PF02747	0.518
LIG_PCNA_TLS_4	466	473	PF02747	0.652
LIG_Pex14_1	379	383	PF04695	0.394
LIG_PTB_Apo_2	533	540	PF02174	0.503
LIG_PTB_Phospho_1	533	539	PF10480	0.503
LIG_SH2_CRK	231	235	PF00017	0.531
LIG_SH2_CRK	539	543	PF00017	0.459
LIG_SH2_CRK	545	549	PF00017	0.340
LIG_SH2_CRK	82	86	PF00017	0.554
LIG_SH2_GRB2like	524	527	PF00017	0.552
LIG_SH2_SRC	524	527	PF00017	0.552
LIG_SH2_SRC	539	542	PF00017	0.452
LIG_SH2_SRC	543	546	PF00017	0.375
LIG_SH2_STAP1	231	235	PF00017	0.531
LIG_SH2_STAP1	543	547	PF00017	0.386
LIG_SH2_STAT5	11	14	PF00017	0.472
LIG_SH2_STAT5	248	251	PF00017	0.547
LIG_SH2_STAT5	407	410	PF00017	0.559
LIG_SH2_STAT5	524	527	PF00017	0.552
LIG_SH3_3	136	142	PF00018	0.535
LIG_SH3_3	276	282	PF00018	0.742
LIG_SH3_3	285	291	PF00018	0.708
LIG_SH3_3	300	306	PF00018	0.636
LIG_SH3_3	434	440	PF00018	0.679
LIG_SH3_5	537	541	PF00018	0.540
LIG_SUMO_SIM_anti_2	101	109	PF11976	0.417
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.474
LIG_SUMO_SIM_anti_2	173	179	PF11976	0.404
MOD_CDK_SPK_2	225	230	PF00069	0.482
MOD_CDK_SPK_2	496	501	PF00069	0.462
MOD_CK1_1	179	185	PF00069	0.484
MOD_CK1_1	216	222	PF00069	0.565
MOD_CK1_1	270	276	PF00069	0.630
MOD_CK1_1	299	305	PF00069	0.743
MOD_CK1_1	314	320	PF00069	0.584
MOD_CK1_1	336	342	PF00069	0.530
MOD_CK1_1	360	366	PF00069	0.373
MOD_CK1_1	532	538	PF00069	0.567
MOD_CK1_1	61	67	PF00069	0.432
MOD_CK1_1	72	78	PF00069	0.447
MOD_CK2_1	233	239	PF00069	0.508
MOD_CK2_1	312	318	PF00069	0.712
MOD_CK2_1	347	353	PF00069	0.519
MOD_CK2_1	464	470	PF00069	0.614
MOD_CK2_1	496	502	PF00069	0.436
MOD_CK2_1	92	98	PF00069	0.536
MOD_CMANNOS	222	225	PF00535	0.396
MOD_GlcNHglycan	22	25	PF01048	0.501
MOD_GlcNHglycan	269	272	PF01048	0.609
MOD_GlcNHglycan	27	30	PF01048	0.491
MOD_GlcNHglycan	279	282	PF01048	0.657
MOD_GlcNHglycan	298	301	PF01048	0.643
MOD_GlcNHglycan	314	317	PF01048	0.592
MOD_GlcNHglycan	444	447	PF01048	0.742
MOD_GlcNHglycan	450	453	PF01048	0.564
MOD_GlcNHglycan	60	63	PF01048	0.521
MOD_GSK3_1	140	147	PF00069	0.490
MOD_GSK3_1	153	160	PF00069	0.479
MOD_GSK3_1	16	23	PF00069	0.488
MOD_GSK3_1	212	219	PF00069	0.619
MOD_GSK3_1	225	232	PF00069	0.498
MOD_GSK3_1	344	351	PF00069	0.530
MOD_GSK3_1	356	363	PF00069	0.403
MOD_GSK3_1	371	378	PF00069	0.542
MOD_GSK3_1	487	494	PF00069	0.581
MOD_GSK3_1	74	81	PF00069	0.489
MOD_LATS_1	527	533	PF00433	0.601
MOD_N-GLC_1	179	184	PF02516	0.536
MOD_N-GLC_1	216	221	PF02516	0.634
MOD_N-GLC_1	259	264	PF02516	0.704
MOD_N-GLC_1	312	317	PF02516	0.701
MOD_N-GLC_1	34	39	PF02516	0.539
MOD_N-GLC_1	410	415	PF02516	0.548
MOD_N-GLC_1	505	510	PF02516	0.416
MOD_N-GLC_1	69	74	PF02516	0.450
MOD_NEK2_1	144	149	PF00069	0.453
MOD_NEK2_1	212	217	PF00069	0.687
MOD_NEK2_1	249	254	PF00069	0.529
MOD_NEK2_1	422	427	PF00069	0.544
MOD_NEK2_1	479	484	PF00069	0.670
MOD_NEK2_1	92	97	PF00069	0.473
MOD_NEK2_2	491	496	PF00069	0.571
MOD_PIKK_1	286	292	PF00454	0.795
MOD_PIKK_1	327	333	PF00454	0.671
MOD_PIKK_1	416	422	PF00454	0.492
MOD_PIKK_1	80	86	PF00454	0.439
MOD_PKA_1	157	163	PF00069	0.546
MOD_PKA_2	157	163	PF00069	0.546
MOD_PKA_2	198	204	PF00069	0.557
MOD_PKA_2	20	26	PF00069	0.467
MOD_PKA_2	213	219	PF00069	0.673
MOD_Plk_1	100	106	PF00069	0.531
MOD_Plk_1	259	265	PF00069	0.706
MOD_Plk_1	34	40	PF00069	0.542
MOD_Plk_4	229	235	PF00069	0.543
MOD_Plk_4	249	255	PF00069	0.503
MOD_Plk_4	336	342	PF00069	0.575
MOD_Plk_4	386	392	PF00069	0.423
MOD_Plk_4	491	497	PF00069	0.438
MOD_ProDKin_1	217	223	PF00069	0.591
MOD_ProDKin_1	225	231	PF00069	0.544
MOD_ProDKin_1	275	281	PF00069	0.668
MOD_ProDKin_1	284	290	PF00069	0.651
MOD_ProDKin_1	302	308	PF00069	0.457
MOD_ProDKin_1	436	442	PF00069	0.659
MOD_ProDKin_1	496	502	PF00069	0.451
MOD_ProDKin_1	505	511	PF00069	0.414
MOD_ProDKin_1	69	75	PF00069	0.450
MOD_SUMO_rev_2	118	127	PF00179	0.625
MOD_SUMO_rev_2	14	24	PF00179	0.578
MOD_SUMO_rev_2	345	350	PF00179	0.621
TRG_DiLeu_BaEn_2	467	473	PF01217	0.610
TRG_ENDOCYTIC_2	192	195	PF00928	0.579
TRG_ENDOCYTIC_2	231	234	PF00928	0.524
TRG_ENDOCYTIC_2	545	548	PF00928	0.354
TRG_ENDOCYTIC_2	556	559	PF00928	0.381
TRG_ENDOCYTIC_2	82	85	PF00928	0.517
TRG_ENDOCYTIC_2	89	92	PF00928	0.497
TRG_ER_diArg_1	157	159	PF00400	0.554
TRG_ER_diArg_1	404	406	PF00400	0.441
TRG_ER_diArg_1	483	485	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N5	Leptomonas seymouri	83%	99%
A0A1X0NX92	Trypanosomatidae	35%	90%
A0A3Q8IEP3	Leishmania donovani	97%	100%
A0A422N7W1	Trypanosoma rangeli	35%	91%
A4HBH7	Leishmania braziliensis	92%	100%
C9ZHU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
E9AGT8	Leishmania infantum	97%	100%
Q4QD36	Leishmania major	98%	100%
V5C0D6	Trypanosoma cruzi	33%	92%