Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUE7_LEIMU

TriTrypDb:

LmxM.20.0070

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.384
CLV_NRD_NRD_1	124	126	PF00675	0.615
CLV_NRD_NRD_1	96	98	PF00675	0.435
CLV_PCSK_FUR_1	94	98	PF00082	0.451
CLV_PCSK_KEX2_1	108	110	PF00082	0.481
CLV_PCSK_KEX2_1	122	124	PF00082	0.566
CLV_PCSK_KEX2_1	22	24	PF00082	0.480
CLV_PCSK_KEX2_1	96	98	PF00082	0.435
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.507
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.543
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.596
CLV_PCSK_PC7_1	104	110	PF00082	0.510
CLV_PCSK_SKI1_1	108	112	PF00082	0.575
CLV_PCSK_SKI1_1	138	142	PF00082	0.443
CLV_PCSK_SKI1_1	19	23	PF00082	0.500
DEG_APCC_DBOX_1	4	12	PF00400	0.672
DOC_CYCLIN_RxL_1	104	112	PF00134	0.540
DOC_CYCLIN_RxL_1	135	143	PF00134	0.486
DOC_MAPK_gen_1	94	103	PF00069	0.449
DOC_MAPK_MEF2A_6	147	154	PF00069	0.435
DOC_USP7_MATH_1	38	42	PF00917	0.564
DOC_WW_Pin1_4	164	169	PF00397	0.310
DOC_WW_Pin1_4	191	196	PF00397	0.563
DOC_WW_Pin1_4	3	8	PF00397	0.722
LIG_14-3-3_CanoR_1	115	120	PF00244	0.488
LIG_14-3-3_CanoR_1	129	134	PF00244	0.613
LIG_14-3-3_CanoR_1	138	143	PF00244	0.423
LIG_14-3-3_CanoR_1	147	153	PF00244	0.422
LIG_Actin_WH2_2	4	21	PF00022	0.592
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BRCT_BRCA1_1	86	90	PF00533	0.533
LIG_FHA_1	170	176	PF00498	0.513
LIG_FHA_1	180	186	PF00498	0.443
LIG_FHA_1	195	201	PF00498	0.426
LIG_FHA_1	73	79	PF00498	0.494
LIG_FHA_2	43	49	PF00498	0.501
LIG_FHA_2	50	56	PF00498	0.463
LIG_LIR_Gen_1	133	144	PF02991	0.497
LIG_LIR_Gen_1	157	165	PF02991	0.503
LIG_LIR_Gen_1	45	51	PF02991	0.475
LIG_LIR_Nem_3	133	139	PF02991	0.520
LIG_LIR_Nem_3	157	162	PF02991	0.494
LIG_LIR_Nem_3	197	202	PF02991	0.507
LIG_LIR_Nem_3	45	50	PF02991	0.488
LIG_NRBOX	141	147	PF00104	0.465
LIG_NRBOX	87	93	PF00104	0.537
LIG_SH2_CRK	136	140	PF00017	0.485
LIG_SH2_CRK	159	163	PF00017	0.469
LIG_SH2_NCK_1	170	174	PF00017	0.524
LIG_SH2_PTP2	149	152	PF00017	0.491
LIG_SH2_PTP2	199	202	PF00017	0.475
LIG_SH2_STAP1	136	140	PF00017	0.485
LIG_SH2_STAT5	144	147	PF00017	0.351
LIG_SH2_STAT5	149	152	PF00017	0.379
LIG_SH2_STAT5	199	202	PF00017	0.452
LIG_SH3_3	147	153	PF00018	0.452
LIG_SH3_3	31	37	PF00018	0.482
LIG_SH3_3	8	14	PF00018	0.579
LIG_SUMO_SIM_par_1	138	143	PF11976	0.463
MOD_CK1_1	169	175	PF00069	0.510
MOD_CK1_1	194	200	PF00069	0.615
MOD_CK1_1	3	9	PF00069	0.691
MOD_CK1_1	42	48	PF00069	0.519
MOD_GlcNHglycan	186	189	PF01048	0.542
MOD_GlcNHglycan	41	44	PF01048	0.592
MOD_GlcNHglycan	63	66	PF01048	0.591
MOD_GSK3_1	109	116	PF00069	0.586
MOD_GSK3_1	13	20	PF00069	0.580
MOD_GSK3_1	38	45	PF00069	0.535
MOD_GSK3_1	68	75	PF00069	0.497
MOD_GSK3_1	82	89	PF00069	0.467
MOD_N-GLC_1	179	184	PF02516	0.470
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	148	153	PF00069	0.457
MOD_NEK2_1	17	22	PF00069	0.413
MOD_NEK2_1	49	54	PF00069	0.483
MOD_NEK2_1	61	66	PF00069	0.494
MOD_NEK2_1	82	87	PF00069	0.454
MOD_PKA_2	32	38	PF00069	0.604
MOD_Plk_1	179	185	PF00069	0.446
MOD_Plk_4	13	19	PF00069	0.545
MOD_Plk_4	42	48	PF00069	0.494
MOD_Plk_4	86	92	PF00069	0.423
MOD_ProDKin_1	164	170	PF00069	0.311
MOD_ProDKin_1	191	197	PF00069	0.574
MOD_ProDKin_1	3	9	PF00069	0.721
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.575
TRG_ENDOCYTIC_2	136	139	PF00928	0.490
TRG_ENDOCYTIC_2	149	152	PF00928	0.374
TRG_ENDOCYTIC_2	159	162	PF00928	0.414
TRG_ENDOCYTIC_2	199	202	PF00928	0.452
TRG_ENDOCYTIC_2	47	50	PF00928	0.462
TRG_ER_diArg_1	123	125	PF00400	0.649
TRG_ER_diArg_1	96	98	PF00400	0.447
TRG_NES_CRM1_1	143	157	PF08389	0.454
TRG_NLS_Bipartite_1	108	126	PF00514	0.663
TRG_NLS_MonoCore_2	121	126	PF00514	0.614
TRG_NLS_MonoExtC_3	121	127	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX14	Leptomonas seymouri	75%	100%
A0A0S4IPP5	Bodo saltans	25%	99%
A0A1X0NWK9	Trypanosomatidae	36%	100%
A0A3R7K4I3	Trypanosoma rangeli	38%	100%
A0A3S5H778	Leishmania donovani	92%	100%
A4HBH6	Leishmania braziliensis	87%	100%
A4HYK0	Leishmania infantum	92%	100%
C9ZHU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QD37	Leishmania major	95%	100%