Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUE4_LEIMU

TriTrypDb:

LmxM.20.0040

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.564
CLV_NRD_NRD_1	124	126	PF00675	0.585
CLV_NRD_NRD_1	144	146	PF00675	0.468
CLV_NRD_NRD_1	197	199	PF00675	0.464
CLV_NRD_NRD_1	245	247	PF00675	0.563
CLV_NRD_NRD_1	279	281	PF00675	0.606
CLV_NRD_NRD_1	307	309	PF00675	0.587
CLV_NRD_NRD_1	318	320	PF00675	0.433
CLV_NRD_NRD_1	46	48	PF00675	0.563
CLV_PCSK_FUR_1	305	309	PF00082	0.573
CLV_PCSK_KEX2_1	113	115	PF00082	0.595
CLV_PCSK_KEX2_1	123	125	PF00082	0.643
CLV_PCSK_KEX2_1	143	145	PF00082	0.472
CLV_PCSK_KEX2_1	18	20	PF00082	0.559
CLV_PCSK_KEX2_1	197	199	PF00082	0.494
CLV_PCSK_KEX2_1	244	246	PF00082	0.548
CLV_PCSK_KEX2_1	279	281	PF00082	0.608
CLV_PCSK_KEX2_1	307	309	PF00082	0.667
CLV_PCSK_KEX2_1	46	48	PF00082	0.563
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.647
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.671
CLV_PCSK_PC7_1	140	146	PF00082	0.494
CLV_PCSK_SKI1_1	197	201	PF00082	0.476
CLV_PCSK_SKI1_1	280	284	PF00082	0.655
CLV_PCSK_SKI1_1	320	324	PF00082	0.536
DEG_APCC_DBOX_1	162	170	PF00400	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.473
DOC_CKS1_1	224	229	PF01111	0.321
DOC_MAPK_RevD_3	184	198	PF00069	0.411
DOC_USP7_MATH_1	130	134	PF00917	0.692
DOC_USP7_MATH_1	75	79	PF00917	0.768
DOC_USP7_UBL2_3	183	187	PF12436	0.284
DOC_USP7_UBL2_3	268	272	PF12436	0.557
DOC_WW_Pin1_4	220	225	PF00397	0.554
LIG_14-3-3_CanoR_1	124	132	PF00244	0.528
LIG_14-3-3_CanoR_1	173	178	PF00244	0.385
LIG_14-3-3_CanoR_1	235	243	PF00244	0.570
LIG_14-3-3_CanoR_1	46	56	PF00244	0.573
LIG_14-3-3_CanoR_1	63	71	PF00244	0.520
LIG_APCC_ABBAyCdc20_2	197	203	PF00400	0.468
LIG_BRCT_BRCA1_1	178	182	PF00533	0.564
LIG_BRCT_BRCA1_1	54	58	PF00533	0.553
LIG_Clathr_ClatBox_1	155	159	PF01394	0.579
LIG_deltaCOP1_diTrp_1	39	45	PF00928	0.676
LIG_eIF4E_1	161	167	PF01652	0.429
LIG_FHA_1	62	68	PF00498	0.487
LIG_FHA_1	71	77	PF00498	0.595
LIG_FHA_2	224	230	PF00498	0.546
LIG_LIR_Apic_2	97	103	PF02991	0.687
LIG_LIR_Gen_1	216	227	PF02991	0.594
LIG_LIR_Gen_1	256	264	PF02991	0.538
LIG_LIR_Nem_3	216	222	PF02991	0.604
LIG_LIR_Nem_3	229	233	PF02991	0.251
LIG_LIR_Nem_3	256	261	PF02991	0.541
LIG_LIR_Nem_3	39	45	PF02991	0.676
LIG_MLH1_MIPbox_1	178	182	PF16413	0.564
LIG_PDZ_Class_3	324	329	PF00595	0.389
LIG_Pex14_2	54	58	PF04695	0.653
LIG_REV1ctd_RIR_1	179	187	PF16727	0.333
LIG_RPA_C_Fungi	241	253	PF08784	0.545
LIG_SH2_SRC	100	103	PF00017	0.665
LIG_SH2_STAP1	258	262	PF00017	0.578
LIG_SH2_STAT5	134	137	PF00017	0.643
LIG_SH3_1	221	227	PF00018	0.327
LIG_SH3_3	221	227	PF00018	0.327
LIG_Sin3_3	286	293	PF02671	0.626
LIG_SUMO_SIM_par_1	154	159	PF11976	0.581
LIG_SUMO_SIM_par_1	72	79	PF11976	0.473
LIG_TRAF2_1	151	154	PF00917	0.463
LIG_TRAF2_1	325	328	PF00917	0.384
LIG_UBA3_1	108	115	PF00899	0.618
MOD_CK1_1	133	139	PF00069	0.579
MOD_CK1_1	220	226	PF00069	0.594
MOD_CK1_1	37	43	PF00069	0.683
MOD_CK1_1	65	71	PF00069	0.689
MOD_CK1_1	78	84	PF00069	0.687
MOD_CK2_1	223	229	PF00069	0.417
MOD_Cter_Amidation	195	198	PF01082	0.530
MOD_GlcNHglycan	178	181	PF01048	0.538
MOD_GlcNHglycan	193	197	PF01048	0.317
MOD_GlcNHglycan	2	5	PF01048	0.638
MOD_GlcNHglycan	64	67	PF01048	0.575
MOD_GlcNHglycan	90	93	PF01048	0.653
MOD_GSK3_1	52	59	PF00069	0.539
MOD_GSK3_1	61	68	PF00069	0.592
MOD_GSK3_1	75	82	PF00069	0.633
MOD_N-GLC_1	88	93	PF02516	0.707
MOD_N-GLC_2	275	277	PF02516	0.497
MOD_NEK2_1	56	61	PF00069	0.552
MOD_NEK2_1	62	67	PF00069	0.542
MOD_NEK2_1	76	81	PF00069	0.423
MOD_PIKK_1	124	130	PF00454	0.522
MOD_PIKK_1	204	210	PF00454	0.414
MOD_PKA_1	124	130	PF00069	0.522
MOD_PKA_1	143	149	PF00069	0.496
MOD_PKA_1	46	52	PF00069	0.661
MOD_PKA_2	124	130	PF00069	0.589
MOD_PKA_2	143	149	PF00069	0.503
MOD_PKA_2	46	52	PF00069	0.651
MOD_PKA_2	62	68	PF00069	0.477
MOD_PKB_1	171	179	PF00069	0.498
MOD_PKB_1	85	93	PF00069	0.748
MOD_Plk_4	130	136	PF00069	0.651
MOD_ProDKin_1	220	226	PF00069	0.551
TRG_DiLeu_BaEn_1	162	167	PF01217	0.429
TRG_DiLeu_BaEn_1	39	44	PF01217	0.691
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.533
TRG_ENDOCYTIC_2	258	261	PF00928	0.476
TRG_ER_diArg_1	112	114	PF00400	0.633
TRG_ER_diArg_1	124	126	PF00400	0.609
TRG_ER_diArg_1	143	145	PF00400	0.532
TRG_ER_diArg_1	171	174	PF00400	0.450
TRG_ER_diArg_1	243	246	PF00400	0.559
TRG_ER_diArg_1	278	280	PF00400	0.622
TRG_ER_diArg_1	305	308	PF00400	0.564
TRG_ER_diArg_1	316	319	PF00400	0.446
TRG_ER_diArg_1	45	47	PF00400	0.585
TRG_ER_diArg_1	84	87	PF00400	0.663
TRG_NLS_Bipartite_1	113	127	PF00514	0.602
TRG_NLS_Bipartite_1	307	323	PF00514	0.409
TRG_NLS_MonoExtN_4	317	323	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL4	Leptomonas seymouri	40%	100%
A0A3Q8IBH2	Leishmania donovani	83%	100%
A0A3R7NEK1	Trypanosoma rangeli	26%	100%
A4HYJ7	Leishmania infantum	83%	100%
C9ZHU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q9BJ45	Leishmania major	82%	100%
V5BAF9	Trypanosoma cruzi	26%	94%