Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-repressible phosphate permease

Species:

Leishmania mexicana

UniProt:

E9AUE3_LEIMU

TriTrypDb:

LmxM.20.0031

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

E9AUE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUE3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.199
CLV_C14_Caspase3-7	343	347	PF00656	0.542
CLV_C14_Caspase3-7	53	57	PF00656	0.163
CLV_NRD_NRD_1	246	248	PF00675	0.225
CLV_NRD_NRD_1	322	324	PF00675	0.329
CLV_NRD_NRD_1	548	550	PF00675	0.620
CLV_PCSK_KEX2_1	245	247	PF00082	0.269
CLV_PCSK_KEX2_1	322	324	PF00082	0.186
CLV_PCSK_KEX2_1	548	550	PF00082	0.526
CLV_PCSK_KEX2_1	566	568	PF00082	0.503
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.321
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.511
CLV_PCSK_PC7_1	562	568	PF00082	0.503
CLV_PCSK_SKI1_1	186	190	PF00082	0.270
CLV_PCSK_SKI1_1	202	206	PF00082	0.278
CLV_PCSK_SKI1_1	246	250	PF00082	0.207
CLV_PCSK_SKI1_1	39	43	PF00082	0.321
CLV_PCSK_SKI1_1	566	570	PF00082	0.511
DEG_SCF_FBW7_1	299	305	PF00400	0.360
DEG_SPOP_SBC_1	109	113	PF00917	0.303
DEG_SPOP_SBC_1	416	420	PF00917	0.274
DEG_SPOP_SBC_1	481	485	PF00917	0.349
DOC_CKS1_1	299	304	PF01111	0.360
DOC_CKS1_1	455	460	PF01111	0.568
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.218
DOC_MAPK_MEF2A_6	186	195	PF00069	0.460
DOC_MAPK_MEF2A_6	506	513	PF00069	0.570
DOC_MAPK_NFAT4_5	186	194	PF00069	0.399
DOC_MAPK_NFAT4_5	506	514	PF00069	0.564
DOC_PP1_RVXF_1	212	218	PF00149	0.301
DOC_PP2B_LxvP_1	106	109	PF13499	0.485
DOC_PP2B_LxvP_1	189	192	PF13499	0.218
DOC_PP4_FxxP_1	156	159	PF00568	0.334
DOC_USP7_MATH_1	109	113	PF00917	0.334
DOC_USP7_MATH_1	13	17	PF00917	0.351
DOC_USP7_MATH_1	302	306	PF00917	0.525
DOC_USP7_MATH_1	324	328	PF00917	0.434
DOC_USP7_MATH_1	406	410	PF00917	0.362
DOC_USP7_MATH_1	481	485	PF00917	0.349
DOC_USP7_MATH_1	525	529	PF00917	0.369
DOC_USP7_UBL2_3	245	249	PF12436	0.386
DOC_WW_Pin1_4	155	160	PF00397	0.334
DOC_WW_Pin1_4	298	303	PF00397	0.475
DOC_WW_Pin1_4	307	312	PF00397	0.522
DOC_WW_Pin1_4	331	336	PF00397	0.471
DOC_WW_Pin1_4	454	459	PF00397	0.493
LIG_14-3-3_CanoR_1	179	185	PF00244	0.443
LIG_14-3-3_CanoR_1	186	192	PF00244	0.480
LIG_14-3-3_CanoR_1	261	267	PF00244	0.542
LIG_14-3-3_CanoR_1	541	550	PF00244	0.316
LIG_Actin_WH2_2	166	181	PF00022	0.237
LIG_BRCT_BRCA1_1	236	240	PF00533	0.363
LIG_BRCT_BRCA1_1	28	32	PF00533	0.494
LIG_BRCT_BRCA1_1	458	462	PF00533	0.338
LIG_BRCT_BRCA1_1	527	531	PF00533	0.388
LIG_CaM_NSCaTE_8	425	432	PF13499	0.364
LIG_FHA_1	105	111	PF00498	0.455
LIG_FHA_1	160	166	PF00498	0.430
LIG_FHA_1	188	194	PF00498	0.526
LIG_FHA_1	196	202	PF00498	0.340
LIG_FHA_1	411	417	PF00498	0.317
LIG_FHA_1	422	428	PF00498	0.384
LIG_FHA_1	438	444	PF00498	0.323
LIG_FHA_1	483	489	PF00498	0.355
LIG_FHA_1	518	524	PF00498	0.341
LIG_FHA_1	63	69	PF00498	0.278
LIG_FHA_2	369	375	PF00498	0.465
LIG_HCF-1_HBM_1	80	83	PF13415	0.294
LIG_LIR_Apic_2	154	159	PF02991	0.334
LIG_LIR_Apic_2	476	481	PF02991	0.349
LIG_LIR_Gen_1	104	110	PF02991	0.537
LIG_LIR_Gen_1	384	394	PF02991	0.163
LIG_LIR_Gen_1	80	90	PF02991	0.252
LIG_LIR_LC3C_4	467	472	PF02991	0.361
LIG_LIR_Nem_3	104	108	PF02991	0.537
LIG_LIR_Nem_3	140	145	PF02991	0.278
LIG_LIR_Nem_3	237	243	PF02991	0.364
LIG_LIR_Nem_3	374	380	PF02991	0.479
LIG_LIR_Nem_3	384	390	PF02991	0.313
LIG_NRBOX	444	450	PF00104	0.494
LIG_Pex14_1	542	546	PF04695	0.315
LIG_Pex14_2	200	204	PF04695	0.335
LIG_REV1ctd_RIR_1	197	206	PF16727	0.163
LIG_SH2_CRK	377	381	PF00017	0.494
LIG_SH2_CRK	478	482	PF00017	0.391
LIG_SH2_CRK	87	91	PF00017	0.368
LIG_SH2_NCK_1	316	320	PF00017	0.386
LIG_SH2_STAP1	369	373	PF00017	0.474
LIG_SH2_STAP1	387	391	PF00017	0.382
LIG_SH2_STAT5	278	281	PF00017	0.474
LIG_SH2_STAT5	379	382	PF00017	0.334
LIG_SH3_3	296	302	PF00018	0.390
LIG_SH3_3	305	311	PF00018	0.460
LIG_SH3_3	452	458	PF00018	0.568
LIG_Sin3_3	468	475	PF02671	0.439
LIG_SUMO_SIM_anti_2	451	457	PF11976	0.568
LIG_SUMO_SIM_par_1	193	198	PF11976	0.371
LIG_SUMO_SIM_par_1	280	290	PF11976	0.370
LIG_SUMO_SIM_par_1	39	44	PF11976	0.504
LIG_SUMO_SIM_par_1	519	524	PF11976	0.360
LIG_UBA3_1	193	202	PF00899	0.163
LIG_WRC_WIRS_1	14	19	PF05994	0.361
LIG_WRC_WIRS_1	387	392	PF05994	0.323
LIG_WRC_WIRS_1	438	443	PF05994	0.391
LIG_WRC_WIRS_1	471	476	PF05994	0.363
MOD_CDK_SPxK_1	454	460	PF00069	0.493
MOD_CK1_1	112	118	PF00069	0.303
MOD_CK1_1	310	316	PF00069	0.487
MOD_CK1_1	318	324	PF00069	0.470
MOD_CK1_1	334	340	PF00069	0.461
MOD_CK1_1	395	401	PF00069	0.276
MOD_CK1_1	473	479	PF00069	0.349
MOD_CK2_1	135	141	PF00069	0.160
MOD_CK2_1	359	365	PF00069	0.442
MOD_CK2_1	368	374	PF00069	0.421
MOD_CK2_1	47	53	PF00069	0.345
MOD_GlcNHglycan	304	307	PF01048	0.322
MOD_GlcNHglycan	317	320	PF01048	0.205
MOD_GlcNHglycan	462	465	PF01048	0.330
MOD_GlcNHglycan	466	469	PF01048	0.327
MOD_GlcNHglycan	475	478	PF01048	0.293
MOD_GlcNHglycan	527	530	PF01048	0.346
MOD_GlcNHglycan	553	556	PF01048	0.526
MOD_GlcNHglycan	68	71	PF01048	0.471
MOD_GSK3_1	104	111	PF00069	0.458
MOD_GSK3_1	131	138	PF00069	0.204
MOD_GSK3_1	151	158	PF00069	0.344
MOD_GSK3_1	298	305	PF00069	0.512
MOD_GSK3_1	324	331	PF00069	0.390
MOD_GSK3_1	406	413	PF00069	0.247
MOD_GSK3_1	417	424	PF00069	0.283
MOD_GSK3_1	456	463	PF00069	0.471
MOD_GSK3_1	482	489	PF00069	0.316
MOD_GSK3_1	517	524	PF00069	0.365
MOD_GSK3_1	52	59	PF00069	0.343
MOD_GSK3_1	537	544	PF00069	0.275
MOD_GSK3_1	556	563	PF00069	0.298
MOD_GSK3_1	62	69	PF00069	0.297
MOD_LATS_1	560	566	PF00433	0.301
MOD_NEK2_1	18	23	PF00069	0.333
MOD_NEK2_1	32	37	PF00069	0.494
MOD_NEK2_1	368	373	PF00069	0.494
MOD_NEK2_1	41	46	PF00069	0.359
MOD_NEK2_1	436	441	PF00069	0.433
MOD_NEK2_1	470	475	PF00069	0.349
MOD_NEK2_1	521	526	PF00069	0.384
MOD_NEK2_2	406	411	PF00069	0.205
MOD_PIKK_1	135	141	PF00454	0.160
MOD_PIKK_1	41	47	PF00454	0.439
MOD_PKB_1	549	557	PF00069	0.314
MOD_Plk_1	324	330	PF00069	0.360
MOD_Plk_4	101	107	PF00069	0.354
MOD_Plk_4	13	19	PF00069	0.361
MOD_Plk_4	151	157	PF00069	0.320
MOD_Plk_4	334	340	PF00069	0.433
MOD_Plk_4	406	412	PF00069	0.199
MOD_Plk_4	417	423	PF00069	0.182
MOD_Plk_4	517	523	PF00069	0.249
MOD_ProDKin_1	155	161	PF00069	0.334
MOD_ProDKin_1	298	304	PF00069	0.475
MOD_ProDKin_1	307	313	PF00069	0.522
MOD_ProDKin_1	331	337	PF00069	0.471
MOD_ProDKin_1	454	460	PF00069	0.493
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.323
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.319
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.464
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.305
TRG_ENDOCYTIC_2	377	380	PF00928	0.461
TRG_ENDOCYTIC_2	387	390	PF00928	0.310
TRG_ENDOCYTIC_2	83	86	PF00928	0.337
TRG_ENDOCYTIC_2	87	90	PF00928	0.330
TRG_ER_diArg_1	246	248	PF00400	0.429
TRG_ER_diArg_1	548	551	PF00400	0.325
TRG_NLS_MonoExtC_3	244	249	PF00514	0.433
TRG_NLS_MonoExtN_4	242	249	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	68%	100%
A0A0S4JEW4	Bodo saltans	24%	90%
A0A1X0NXY5	Trypanosomatidae	57%	100%
A0A3Q8I8Y3	Leishmania donovani	61%	100%
A0A3Q8IBK1	Leishmania donovani	89%	100%
A0A3R7K4N2	Trypanosoma rangeli	52%	100%
A0A3S5H545	Leishmania donovani	47%	100%
A4H5Y5	Leishmania braziliensis	61%	91%
A4H6C2	Leishmania braziliensis	61%	91%
A4HBH2	Leishmania braziliensis	78%	100%
A4HH06	Leishmania braziliensis	45%	100%
A4HUP5	Leishmania infantum	61%	100%
A4HYJ6	Leishmania infantum	89%	100%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ACJ5	Leishmania major	46%	100%
E9AG39	Leishmania infantum	47%	100%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	91%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	91%
P0AFJ7	Escherichia coli (strain K12)	23%	100%
P0AFJ8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	23%	100%
P0AFJ9	Escherichia coli O157:H7	23%	100%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	97%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P43676	Escherichia coli (strain K12)	22%	100%
Q4QH82	Leishmania major	61%	91%
Q4QHL7	Leishmania major	61%	91%
Q5R9L5	Pongo abelii	26%	84%
Q8WUM9	Homo sapiens	26%	84%
V5DS90	Trypanosoma cruzi	55%	100%