Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AUE1_LEIMU

TriTrypDb:

LmxM.20.0020

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	6
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:1990904	ribonucleoprotein complex	2	6
GO:0005634	nucleus	5	1
GO:0005656	nuclear pre-replicative complex	3	1
GO:0005730	nucleolus	5	1
GO:0032993	protein-DNA complex	2	1
GO:0036387	pre-replicative complex	3	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097344	Rix1 complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AUE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUE1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.544
CLV_C14_Caspase3-7	243	247	PF00656	0.518
CLV_C14_Caspase3-7	374	378	PF00656	0.634
CLV_NRD_NRD_1	355	357	PF00675	0.580
CLV_NRD_NRD_1	400	402	PF00675	0.521
CLV_PCSK_KEX2_1	355	357	PF00082	0.588
CLV_PCSK_KEX2_1	359	361	PF00082	0.577
CLV_PCSK_KEX2_1	400	402	PF00082	0.579
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.650
CLV_PCSK_PC7_1	355	361	PF00082	0.698
CLV_PCSK_SKI1_1	155	159	PF00082	0.420
CLV_PCSK_SKI1_1	198	202	PF00082	0.559
CLV_PCSK_SKI1_1	224	228	PF00082	0.477
CLV_PCSK_SKI1_1	297	301	PF00082	0.471
CLV_PCSK_SKI1_1	318	322	PF00082	0.559
CLV_PCSK_SKI1_1	32	36	PF00082	0.460
CLV_PCSK_SKI1_1	356	360	PF00082	0.713
CLV_PCSK_SKI1_1	66	70	PF00082	0.446
DEG_APCC_DBOX_1	9	17	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.368
DOC_ANK_TNKS_1	22	29	PF00023	0.553
DOC_CYCLIN_RxL_1	150	162	PF00134	0.251
DOC_PP2B_LxvP_1	254	257	PF13499	0.620
DOC_USP7_MATH_1	122	126	PF00917	0.503
DOC_USP7_MATH_1	128	132	PF00917	0.484
DOC_USP7_MATH_1	240	244	PF00917	0.645
DOC_WW_Pin1_4	261	266	PF00397	0.486
DOC_WW_Pin1_4	272	277	PF00397	0.564
DOC_WW_Pin1_4	35	40	PF00397	0.509
DOC_WW_Pin1_4	66	71	PF00397	0.450
LIG_14-3-3_CanoR_1	198	203	PF00244	0.562
LIG_14-3-3_CanoR_1	343	349	PF00244	0.622
LIG_14-3-3_CanoR_1	403	411	PF00244	0.489
LIG_Clathr_ClatBox_1	13	17	PF01394	0.452
LIG_DCNL_PONY_1	1	4	PF03556	0.491
LIG_FHA_1	16	22	PF00498	0.417
LIG_FHA_1	183	189	PF00498	0.503
LIG_FHA_1	67	73	PF00498	0.357
LIG_FHA_1	81	87	PF00498	0.484
LIG_FHA_1	91	97	PF00498	0.482
LIG_FHA_2	127	133	PF00498	0.481
LIG_FHA_2	199	205	PF00498	0.443
LIG_FHA_2	279	285	PF00498	0.442
LIG_FHA_2	349	355	PF00498	0.624
LIG_Integrin_isoDGR_2	295	297	PF01839	0.505
LIG_SH2_CRK	37	41	PF00017	0.542
LIG_SH2_NCK_1	37	41	PF00017	0.509
LIG_SH2_SRC	233	236	PF00017	0.604
LIG_SH2_SRC	25	28	PF00017	0.543
LIG_SH3_1	270	276	PF00018	0.472
LIG_SH3_2	334	339	PF14604	0.639
LIG_SH3_3	270	276	PF00018	0.402
LIG_SH3_3	331	337	PF00018	0.576
LIG_SUMO_SIM_par_1	12	18	PF11976	0.461
LIG_TRAF2_1	372	375	PF00917	0.700
LIG_TYR_ITIM	35	40	PF00017	0.523
LIG_Vh1_VBS_1	72	90	PF01044	0.563
MOD_CK1_1	131	137	PF00069	0.482
MOD_CK1_1	182	188	PF00069	0.484
MOD_CK1_1	274	280	PF00069	0.533
MOD_CK1_1	38	44	PF00069	0.499
MOD_CK1_1	57	63	PF00069	0.246
MOD_CK2_1	126	132	PF00069	0.474
MOD_CK2_1	278	284	PF00069	0.453
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.538
MOD_GlcNHglycan	100	103	PF01048	0.493
MOD_GlcNHglycan	120	123	PF01048	0.127
MOD_GlcNHglycan	257	260	PF01048	0.567
MOD_GlcNHglycan	405	408	PF01048	0.581
MOD_GlcNHglycan	56	59	PF01048	0.444
MOD_GSK3_1	118	125	PF00069	0.483
MOD_GSK3_1	159	166	PF00069	0.527
MOD_GSK3_1	178	185	PF00069	0.350
MOD_GSK3_1	274	281	PF00069	0.465
MOD_GSK3_1	72	79	PF00069	0.463
MOD_GSK3_1	86	93	PF00069	0.487
MOD_N-GLC_1	90	95	PF02516	0.340
MOD_NEK2_1	104	109	PF00069	0.543
MOD_NEK2_1	126	131	PF00069	0.477
MOD_NEK2_1	163	168	PF00069	0.498
MOD_NEK2_1	171	176	PF00069	0.435
MOD_NEK2_1	54	59	PF00069	0.432
MOD_NEK2_1	64	69	PF00069	0.379
MOD_NEK2_1	72	77	PF00069	0.368
MOD_OFUCOSY	271	278	PF10250	0.253
MOD_OFUCOSY	347	352	PF10250	0.430
MOD_PIKK_1	15	21	PF00454	0.520
MOD_PIKK_1	219	225	PF00454	0.459
MOD_PIKK_1	342	348	PF00454	0.636
MOD_PIKK_1	38	44	PF00454	0.489
MOD_PIKK_1	57	63	PF00454	0.264
MOD_PKA_1	403	409	PF00069	0.633
MOD_PKA_2	342	348	PF00069	0.657
MOD_PKB_1	401	409	PF00069	0.646
MOD_Plk_1	122	128	PF00069	0.483
MOD_Plk_1	131	137	PF00069	0.492
MOD_Plk_1	214	220	PF00069	0.438
MOD_Plk_4	122	128	PF00069	0.472
MOD_Plk_4	166	172	PF00069	0.512
MOD_Plk_4	17	23	PF00069	0.491
MOD_Plk_4	214	220	PF00069	0.467
MOD_Plk_4	80	86	PF00069	0.502
MOD_Plk_4	90	96	PF00069	0.512
MOD_ProDKin_1	261	267	PF00069	0.482
MOD_ProDKin_1	272	278	PF00069	0.557
MOD_ProDKin_1	35	41	PF00069	0.516
MOD_ProDKin_1	66	72	PF00069	0.341
MOD_SUMO_for_1	386	389	PF00179	0.428
TRG_DiLeu_BaEn_4	389	395	PF01217	0.297
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.514
TRG_ENDOCYTIC_2	37	40	PF00928	0.535
TRG_ER_diArg_1	147	150	PF00400	0.579
TRG_ER_diArg_1	400	403	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD5	Leptomonas seymouri	66%	100%
A0A0S4IM90	Bodo saltans	31%	90%
A0A1X0NWV7	Trypanosomatidae	34%	93%
A0A3S7WVV8	Leishmania donovani	94%	100%
A0A422N846	Trypanosoma rangeli	37%	98%
A4HBH0	Leishmania braziliensis	84%	100%
A4HYJ4	Leishmania infantum	94%	100%
A4IDR0	Leishmania infantum	24%	82%
C9ZHT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	95%
D3ZW91	Rattus norvegicus	24%	88%
Q499N3	Rattus norvegicus	25%	97%
Q4QD42	Leishmania major	93%	100%
Q4VBE8	Mus musculus	24%	97%
Q6C953	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	98%
Q7ZVF0	Danio rerio	25%	100%
Q8BHD1	Mus musculus	22%	88%