PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania mexicana

UniProt:

E9AUD9_LEIMU

TriTrypDb:

LmxM.36.7000

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AUD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.426
CLV_NRD_NRD_1	37	39	PF00675	0.630
CLV_PCSK_KEX2_1	37	39	PF00082	0.630
CLV_PCSK_SKI1_1	155	159	PF00082	0.304
CLV_PCSK_SKI1_1	203	207	PF00082	0.291
DEG_Nend_Nbox_1	1	3	PF02207	0.625
DEG_SPOP_SBC_1	135	139	PF00917	0.390
DOC_MAPK_gen_1	20	28	PF00069	0.725
DOC_MAPK_gen_1	212	220	PF00069	0.282
DOC_MAPK_MEF2A_6	125	133	PF00069	0.512
DOC_PP1_RVXF_1	201	208	PF00149	0.254
DOC_PP1_RVXF_1	212	218	PF00149	0.242
DOC_PP1_SILK_1	151	156	PF00149	0.347
DOC_USP7_MATH_1	149	153	PF00917	0.593
LIG_14-3-3_CanoR_1	134	144	PF00244	0.457
LIG_14-3-3_CanoR_1	155	164	PF00244	0.310
LIG_14-3-3_CanoR_1	37	41	PF00244	0.626
LIG_EVH1_1	15	19	PF00568	0.460
LIG_FHA_1	145	151	PF00498	0.640
LIG_FHA_2	140	146	PF00498	0.625
LIG_FHA_2	156	162	PF00498	0.249
LIG_FHA_2	2	8	PF00498	0.689
LIG_FHA_2	211	217	PF00498	0.426
LIG_IBAR_NPY_1	44	46	PF08397	0.601
LIG_LIR_Apic_2	66	72	PF02991	0.465
LIG_LIR_Gen_1	216	225	PF02991	0.316
LIG_LIR_Nem_3	192	198	PF02991	0.426
LIG_LIR_Nem_3	216	220	PF02991	0.279
LIG_LIR_Nem_3	223	228	PF02991	0.275
LIG_SH2_CRK	69	73	PF00017	0.465
LIG_SH2_NCK_1	69	73	PF00017	0.447
LIG_SH2_PTP2	118	121	PF00017	0.409
LIG_SH2_STAT5	118	121	PF00017	0.388
LIG_SH2_STAT5	143	146	PF00017	0.584
LIG_SH2_STAT5	69	72	PF00017	0.433
LIG_SH3_3	13	19	PF00018	0.626
LIG_SH3_3	27	33	PF00018	0.563
LIG_SH3_3	82	88	PF00018	0.685
MOD_CK1_1	139	145	PF00069	0.659
MOD_CK2_1	106	112	PF00069	0.531
MOD_CK2_1	139	145	PF00069	0.599
MOD_CK2_1	155	161	PF00069	0.316
MOD_GlcNHglycan	56	59	PF01048	0.634
MOD_GSK3_1	135	142	PF00069	0.643
MOD_GSK3_1	89	96	PF00069	0.560
MOD_N-GLC_1	135	140	PF02516	0.423
MOD_NEK2_1	1	6	PF00069	0.640
MOD_PIKK_1	136	142	PF00454	0.662
MOD_PIKK_1	155	161	PF00454	0.263
MOD_PKA_1	203	209	PF00069	0.285
MOD_PKA_2	36	42	PF00069	0.635
MOD_Plk_4	139	145	PF00069	0.569
MOD_Plk_4	149	155	PF00069	0.331
MOD_Plk_4	203	209	PF00069	0.258
MOD_Plk_4	93	99	PF00069	0.617
MOD_SUMO_rev_2	163	172	PF00179	0.380
MOD_SUMO_rev_2	197	205	PF00179	0.258
TRG_ENDOCYTIC_2	118	121	PF00928	0.407
TRG_ER_diArg_1	212	215	PF00400	0.322
TRG_ER_diArg_1	36	38	PF00400	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D9	Leptomonas seymouri	76%	100%
A0A0S4JV55	Bodo saltans	37%	72%
A0A0S4KL40	Bodo saltans	56%	100%
A0A1X0NLP9	Trypanosomatidae	63%	100%
A0A1X0P536	Trypanosomatidae	30%	86%
A0A3Q8IC14	Leishmania donovani	32%	67%
A0A3Q8ILM8	Leishmania donovani	91%	100%
A0A3R7M5V2	Trypanosoma rangeli	62%	100%
A0A3R7NIU7	Trypanosoma rangeli	28%	91%
A0A3S5ISC8	Trypanosoma rangeli	36%	80%
A4HGI7	Leishmania braziliensis	87%	100%
A4HUB9	Leishmania infantum	32%	67%
A4ICE2	Leishmania infantum	92%	100%
C9ZYF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D0A7N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	77%
E9AN18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	67%
Q4Q051	Leishmania major	93%	100%
Q4QHK8	Leishmania major	32%	67%
V5BB20	Trypanosoma cruzi	38%	80%