Putative eukaryotic translation initiation factor 3 subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit c

Species:

Leishmania mexicana

UniProt:

E9AUD5_LEIMU

TriTrypDb:

LmxM.36.6980

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUD5

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0031369	translation initiation factor binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.574
CLV_C14_Caspase3-7	430	434	PF00656	0.557
CLV_C14_Caspase3-7	7	11	PF00656	0.645
CLV_NRD_NRD_1	208	210	PF00675	0.659
CLV_NRD_NRD_1	229	231	PF00675	0.609
CLV_NRD_NRD_1	232	234	PF00675	0.650
CLV_NRD_NRD_1	330	332	PF00675	0.320
CLV_NRD_NRD_1	351	353	PF00675	0.335
CLV_NRD_NRD_1	597	599	PF00675	0.586
CLV_NRD_NRD_1	641	643	PF00675	0.588
CLV_NRD_NRD_1	93	95	PF00675	0.652
CLV_PCSK_KEX2_1	229	231	PF00082	0.601
CLV_PCSK_KEX2_1	332	334	PF00082	0.319
CLV_PCSK_KEX2_1	351	353	PF00082	0.336
CLV_PCSK_KEX2_1	641	643	PF00082	0.588
CLV_PCSK_KEX2_1	83	85	PF00082	0.551
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.336
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.551
CLV_PCSK_SKI1_1	132	136	PF00082	0.500
CLV_PCSK_SKI1_1	17	21	PF00082	0.815
CLV_PCSK_SKI1_1	233	237	PF00082	0.624
CLV_PCSK_SKI1_1	244	248	PF00082	0.536
CLV_PCSK_SKI1_1	309	313	PF00082	0.374
CLV_PCSK_SKI1_1	484	488	PF00082	0.376
CLV_PCSK_SKI1_1	497	501	PF00082	0.256
CLV_PCSK_SKI1_1	76	80	PF00082	0.565
DEG_Nend_UBRbox_3	1	3	PF02207	0.687
DEG_SPOP_SBC_1	5	9	PF00917	0.780
DOC_CYCLIN_yClb1_LxF_4	126	131	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	500	503	PF00134	0.536
DOC_MAPK_gen_1	132	140	PF00069	0.572
DOC_MAPK_gen_1	209	217	PF00069	0.545
DOC_MAPK_gen_1	229	237	PF00069	0.332
DOC_MAPK_MEF2A_6	338	345	PF00069	0.589
DOC_MAPK_MEF2A_6	380	389	PF00069	0.609
DOC_MAPK_RevD_3	339	352	PF00069	0.619
DOC_PP1_RVXF_1	126	132	PF00149	0.667
DOC_PP1_RVXF_1	307	314	PF00149	0.589
DOC_PP2B_LxvP_1	499	502	PF13499	0.518
DOC_USP7_MATH_1	5	9	PF00917	0.780
DOC_USP7_UBL2_3	146	150	PF12436	0.597
DOC_USP7_UBL2_3	247	251	PF12436	0.545
DOC_USP7_UBL2_3	595	599	PF12436	0.564
DOC_WW_Pin1_4	477	482	PF00397	0.593
DOC_WW_Pin1_4	546	551	PF00397	0.660
LIG_14-3-3_CanoR_1	618	627	PF00244	0.515
LIG_14-3-3_CanoR_1	641	645	PF00244	0.400
LIG_Actin_WH2_2	295	311	PF00022	0.589
LIG_Actin_WH2_2	375	392	PF00022	0.574
LIG_Actin_WH2_2	450	467	PF00022	0.559
LIG_Actin_WH2_2	556	573	PF00022	0.456
LIG_BRCT_BRCA1_1	249	253	PF00533	0.439
LIG_BRCT_BRCA1_1	341	345	PF00533	0.574
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.538
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.479
LIG_EH_1	29	33	PF12763	0.734
LIG_eIF4E_1	288	294	PF01652	0.619
LIG_FHA_1	142	148	PF00498	0.608
LIG_FHA_1	289	295	PF00498	0.611
LIG_FHA_1	364	370	PF00498	0.526
LIG_FHA_1	547	553	PF00498	0.680
LIG_FHA_1	595	601	PF00498	0.392
LIG_FHA_1	621	627	PF00498	0.480
LIG_FHA_2	175	181	PF00498	0.575
LIG_FHA_2	211	217	PF00498	0.572
LIG_FHA_2	35	41	PF00498	0.614
LIG_FHA_2	428	434	PF00498	0.532
LIG_FHA_2	584	590	PF00498	0.595
LIG_FHA_2	641	647	PF00498	0.407
LIG_IBAR_NPY_1	531	533	PF08397	0.612
LIG_LIR_Gen_1	178	188	PF02991	0.611
LIG_LIR_Gen_1	250	259	PF02991	0.340
LIG_LIR_Gen_1	297	307	PF02991	0.540
LIG_LIR_Gen_1	373	382	PF02991	0.611
LIG_LIR_Gen_1	586	592	PF02991	0.528
LIG_LIR_Gen_1	619	629	PF02991	0.580
LIG_LIR_Gen_1	661	672	PF02991	0.475
LIG_LIR_Nem_3	130	134	PF02991	0.477
LIG_LIR_Nem_3	178	184	PF02991	0.621
LIG_LIR_Nem_3	297	302	PF02991	0.537
LIG_LIR_Nem_3	304	310	PF02991	0.497
LIG_LIR_Nem_3	342	348	PF02991	0.618
LIG_LIR_Nem_3	373	379	PF02991	0.577
LIG_LIR_Nem_3	493	499	PF02991	0.504
LIG_LIR_Nem_3	586	591	PF02991	0.595
LIG_LIR_Nem_3	619	624	PF02991	0.445
LIG_LIR_Nem_3	661	667	PF02991	0.454
LIG_MLH1_MIPbox_1	249	253	PF16413	0.282
LIG_NRBOX	517	523	PF00104	0.581
LIG_NRP_CendR_1	727	730	PF00754	0.787
LIG_PCNA_PIPBox_1	110	119	PF02747	0.670
LIG_PCNA_PIPBox_1	406	415	PF02747	0.589
LIG_PCNA_yPIPBox_3	406	417	PF02747	0.589
LIG_PCNA_yPIPBox_3	442	453	PF02747	0.589
LIG_PCNA_yPIPBox_3	651	660	PF02747	0.526
LIG_Pex14_1	242	246	PF04695	0.428
LIG_Pex14_1	248	252	PF04695	0.434
LIG_Pex14_2	32	36	PF04695	0.749
LIG_Rb_pABgroove_1	339	347	PF01858	0.619
LIG_REV1ctd_RIR_1	250	259	PF16727	0.597
LIG_SH2_CRK	181	185	PF00017	0.592
LIG_SH2_CRK	360	364	PF00017	0.589
LIG_SH2_CRK	496	500	PF00017	0.553
LIG_SH2_CRK	543	547	PF00017	0.481
LIG_SH2_GRB2like	212	215	PF00017	0.573
LIG_SH2_NCK_1	543	547	PF00017	0.593
LIG_SH2_SRC	405	408	PF00017	0.570
LIG_SH2_STAP1	181	185	PF00017	0.595
LIG_SH2_STAT5	212	215	PF00017	0.530
LIG_SH2_STAT5	288	291	PF00017	0.584
LIG_SH2_STAT5	307	310	PF00017	0.401
LIG_SH2_STAT5	419	422	PF00017	0.584
LIG_SH2_STAT5	541	544	PF00017	0.480
LIG_SH2_STAT5	575	578	PF00017	0.482
LIG_SH2_STAT5	601	604	PF00017	0.520
LIG_SH2_STAT5	664	667	PF00017	0.449
LIG_SUMO_SIM_anti_2	136	145	PF11976	0.619
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.589
LIG_SUMO_SIM_anti_2	607	612	PF11976	0.507
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.401
LIG_SUMO_SIM_par_1	136	145	PF11976	0.581
LIG_TRAF2_1	303	306	PF00917	0.619
LIG_TRAF2_1	37	40	PF00917	0.683
LIG_TYR_ITIM	358	363	PF00017	0.589
LIG_TYR_ITIM	565	570	PF00017	0.539
LIG_WRC_WIRS_1	310	315	PF05994	0.574
LIG_WRC_WIRS_1	585	590	PF05994	0.578
MOD_CDK_SPxxK_3	477	484	PF00069	0.619
MOD_CK1_1	15	21	PF00069	0.666
MOD_CK1_1	238	244	PF00069	0.530
MOD_CK1_1	362	368	PF00069	0.589
MOD_CK1_1	516	522	PF00069	0.619
MOD_CK1_1	622	628	PF00069	0.555
MOD_CK1_1	649	655	PF00069	0.552
MOD_CK1_1	8	14	PF00069	0.648
MOD_CK2_1	130	136	PF00069	0.561
MOD_CK2_1	174	180	PF00069	0.672
MOD_CK2_1	210	216	PF00069	0.627
MOD_CK2_1	294	300	PF00069	0.589
MOD_CK2_1	34	40	PF00069	0.595
MOD_CK2_1	555	561	PF00069	0.635
MOD_CK2_1	590	596	PF00069	0.619
MOD_CK2_1	601	607	PF00069	0.344
MOD_CK2_1	640	646	PF00069	0.584
MOD_CK2_1	71	77	PF00069	0.508
MOD_CK2_1	8	14	PF00069	0.641
MOD_CMANNOS	33	36	PF00535	0.752
MOD_Cter_Amidation	207	210	PF01082	0.530
MOD_GlcNHglycan	186	191	PF01048	0.610
MOD_GlcNHglycan	216	220	PF01048	0.535
MOD_GlcNHglycan	224	227	PF01048	0.540
MOD_GlcNHglycan	395	398	PF01048	0.362
MOD_GlcNHglycan	518	521	PF01048	0.389
MOD_GlcNHglycan	592	595	PF01048	0.499
MOD_GlcNHglycan	654	657	PF01048	0.581
MOD_GSK3_1	247	254	PF00069	0.359
MOD_GSK3_1	284	291	PF00069	0.624
MOD_GSK3_1	359	366	PF00069	0.557
MOD_GSK3_1	371	378	PF00069	0.466
MOD_GSK3_1	389	396	PF00069	0.518
MOD_GSK3_1	4	11	PF00069	0.731
MOD_GSK3_1	425	432	PF00069	0.553
MOD_GSK3_1	542	549	PF00069	0.567
MOD_GSK3_1	583	590	PF00069	0.551
MOD_GSK3_1	616	623	PF00069	0.581
MOD_GSK3_1	646	653	PF00069	0.518
MOD_GSK3_1	680	687	PF00069	0.643
MOD_N-GLC_1	294	299	PF02516	0.389
MOD_N-GLC_1	616	621	PF02516	0.579
MOD_N-GLC_1	650	655	PF02516	0.549
MOD_N-GLC_1	670	675	PF02516	0.527
MOD_N-GLC_1	71	76	PF02516	0.605
MOD_NEK2_1	215	220	PF00069	0.436
MOD_NEK2_1	359	364	PF00069	0.576
MOD_NEK2_1	395	400	PF00069	0.593
MOD_NEK2_1	4	9	PF00069	0.729
MOD_NEK2_1	420	425	PF00069	0.560
MOD_NEK2_1	463	468	PF00069	0.623
MOD_NEK2_1	613	618	PF00069	0.515
MOD_NEK2_2	601	606	PF00069	0.464
MOD_PIKK_1	301	307	PF00454	0.568
MOD_PKA_1	229	235	PF00069	0.634
MOD_PKA_2	229	235	PF00069	0.607
MOD_PKA_2	389	395	PF00069	0.574
MOD_PKA_2	640	646	PF00069	0.397
MOD_Plk_1	15	21	PF00069	0.692
MOD_Plk_1	215	221	PF00069	0.508
MOD_Plk_1	266	272	PF00069	0.431
MOD_Plk_1	619	625	PF00069	0.567
MOD_Plk_1	649	655	PF00069	0.554
MOD_Plk_1	670	676	PF00069	0.525
MOD_Plk_1	71	77	PF00069	0.600
MOD_Plk_2-3	10	16	PF00069	0.790
MOD_Plk_2-3	130	136	PF00069	0.623
MOD_Plk_4	15	21	PF00069	0.811
MOD_Plk_4	284	290	PF00069	0.631
MOD_Plk_4	371	377	PF00069	0.507
MOD_Plk_4	482	488	PF00069	0.619
MOD_Plk_4	513	519	PF00069	0.528
MOD_ProDKin_1	477	483	PF00069	0.593
MOD_ProDKin_1	546	552	PF00069	0.670
MOD_SUMO_for_1	50	53	PF00179	0.684
MOD_SUMO_for_1	525	528	PF00179	0.553
MOD_SUMO_rev_2	124	134	PF00179	0.615
TRG_DiLeu_BaEn_1	136	141	PF01217	0.544
TRG_DiLeu_BaEn_1	495	500	PF01217	0.565
TRG_DiLeu_BaEn_1	607	612	PF01217	0.517
TRG_DiLeu_BaEn_2	87	93	PF01217	0.576
TRG_DiLeu_BaEn_4	142	148	PF01217	0.566
TRG_ENDOCYTIC_2	181	184	PF00928	0.600
TRG_ENDOCYTIC_2	212	215	PF00928	0.554
TRG_ENDOCYTIC_2	307	310	PF00928	0.518
TRG_ENDOCYTIC_2	360	363	PF00928	0.518
TRG_ENDOCYTIC_2	496	499	PF00928	0.518
TRG_ENDOCYTIC_2	543	546	PF00928	0.476
TRG_ENDOCYTIC_2	567	570	PF00928	0.445
TRG_ENDOCYTIC_2	664	667	PF00928	0.456
TRG_ER_diArg_1	228	230	PF00400	0.627
TRG_ER_diArg_1	331	334	PF00400	0.587
TRG_ER_diArg_1	640	642	PF00400	0.579
TRG_NLS_Bipartite_1	83	98	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I262	Leptomonas seymouri	76%	99%
A0A1X0NL84	Trypanosomatidae	38%	100%
A0A3Q8IWP7	Leishmania donovani	97%	100%
A0A422NVW4	Trypanosoma rangeli	39%	100%
A4HQM0	Leishmania braziliensis	92%	100%
A4ICD8	Leishmania infantum	97%	100%
Q0ZB76	Bombyx mori	23%	83%
Q4Q055	Leishmania major	97%	100%
Q54X97	Dictyostelium discoideum	23%	78%
Q6BJF7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	86%
Q6P1V4	Xenopus tropicalis	22%	79%
Q6PFQ2	Danio rerio	22%	79%
V5DDW8	Trypanosoma cruzi	39%	100%