Methyltransf_11 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUD4_LEIMU

TriTrypDb:

LmxM.36.6970

Length:

298

Annotations

LeishMANIAdb annotations

Might be part of a yet-unknown kinetoplastid enzyme

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AUD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.565
CLV_NRD_NRD_1	267	269	PF00675	0.611
CLV_NRD_NRD_1	67	69	PF00675	0.539
CLV_PCSK_KEX2_1	129	131	PF00082	0.578
CLV_PCSK_KEX2_1	67	69	PF00082	0.540
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.661
CLV_PCSK_SKI1_1	132	136	PF00082	0.560
CLV_PCSK_SKI1_1	187	191	PF00082	0.551
CLV_PCSK_SKI1_1	215	219	PF00082	0.596
CLV_PCSK_SKI1_1	254	258	PF00082	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.757
DOC_CYCLIN_RxL_1	184	192	PF00134	0.444
DOC_CYCLIN_RxL_1	71	82	PF00134	0.324
DOC_MAPK_gen_1	129	138	PF00069	0.367
DOC_MAPK_MEF2A_6	129	138	PF00069	0.380
DOC_MAPK_MEF2A_6	198	206	PF00069	0.396
DOC_MAPK_NFAT4_5	131	139	PF00069	0.360
DOC_PP1_RVXF_1	99	105	PF00149	0.306
DOC_SPAK_OSR1_1	39	43	PF12202	0.398
DOC_USP7_MATH_1	16	20	PF00917	0.725
DOC_USP7_MATH_1	226	230	PF00917	0.436
DOC_USP7_UBL2_3	84	88	PF12436	0.345
DOC_WW_Pin1_4	79	84	PF00397	0.333
LIG_14-3-3_CanoR_1	131	137	PF00244	0.350
LIG_14-3-3_CanoR_1	39	48	PF00244	0.420
LIG_BRCT_BRCA1_1	229	233	PF00533	0.394
LIG_deltaCOP1_diTrp_1	143	153	PF00928	0.335
LIG_FHA_1	152	158	PF00498	0.290
LIG_FHA_1	260	266	PF00498	0.277
LIG_FHA_1	277	283	PF00498	0.526
LIG_IRF3_LxIS_1	48	55	PF10401	0.475
LIG_LIR_Gen_1	150	157	PF02991	0.333
LIG_LIR_Gen_1	200	208	PF02991	0.328
LIG_LIR_Gen_1	28	34	PF02991	0.588
LIG_LIR_Nem_3	150	156	PF02991	0.334
LIG_LIR_Nem_3	19	23	PF02991	0.655
LIG_LIR_Nem_3	211	216	PF02991	0.376
LIG_LIR_Nem_3	28	33	PF02991	0.562
LIG_LYPXL_yS_3	213	216	PF13949	0.435
LIG_MYND_1	10	14	PF01753	0.728
LIG_PCNA_PIPBox_1	253	262	PF02747	0.412
LIG_PCNA_yPIPBox_3	250	260	PF02747	0.419
LIG_SH2_CRK	169	173	PF00017	0.308
LIG_SH2_CRK	20	24	PF00017	0.667
LIG_SH2_CRK	261	265	PF00017	0.363
LIG_SH2_CRK	30	34	PF00017	0.557
LIG_SH2_CRK	63	67	PF00017	0.308
LIG_SH2_SRC	20	23	PF00017	0.682
LIG_SH2_STAP1	169	173	PF00017	0.308
LIG_SH2_STAP1	261	265	PF00017	0.306
LIG_SH2_STAP1	30	34	PF00017	0.603
LIG_SH2_STAT5	196	199	PF00017	0.338
LIG_SH2_STAT5	261	264	PF00017	0.296
LIG_SH2_STAT5	73	76	PF00017	0.316
LIG_SH3_1	269	275	PF00018	0.399
LIG_SH3_2	272	277	PF14604	0.424
LIG_SH3_2	288	293	PF14604	0.374
LIG_SH3_3	20	26	PF00018	0.635
LIG_SH3_3	261	267	PF00018	0.400
LIG_SH3_3	269	275	PF00018	0.457
LIG_SH3_3	282	288	PF00018	0.389
LIG_SUMO_SIM_par_1	77	82	PF11976	0.312
LIG_TYR_ITIM	61	66	PF00017	0.344
LIG_UBA3_1	245	250	PF00899	0.378
MOD_CDK_SPK_2	79	84	PF00069	0.333
MOD_CK1_1	224	230	PF00069	0.428
MOD_CK1_1	292	298	PF00069	0.396
MOD_CK1_1	4	10	PF00069	0.754
MOD_CK1_1	44	50	PF00069	0.439
MOD_CK2_1	120	126	PF00069	0.381
MOD_GlcNHglycan	191	194	PF01048	0.579
MOD_GlcNHglycan	295	298	PF01048	0.809
MOD_GlcNHglycan	3	6	PF01048	0.543
MOD_GlcNHglycan	54	57	PF01048	0.409
MOD_GSK3_1	147	154	PF00069	0.291
MOD_GSK3_1	289	296	PF00069	0.467
MOD_GSK3_1	40	47	PF00069	0.421
MOD_N-GLC_1	151	156	PF02516	0.418
MOD_N-GLC_1	181	186	PF02516	0.596
MOD_N-GLC_1	227	232	PF02516	0.642
MOD_N-GLC_2	72	74	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	189	194	PF00069	0.405
MOD_NEK2_1	259	264	PF00069	0.269
MOD_NEK2_1	40	45	PF00069	0.328
MOD_NEK2_1	52	57	PF00069	0.399
MOD_PIKK_1	158	164	PF00454	0.417
MOD_PKA_2	241	247	PF00069	0.393
MOD_PKA_2	292	298	PF00069	0.396
MOD_PKB_1	130	138	PF00069	0.414
MOD_Plk_1	151	157	PF00069	0.219
MOD_Plk_1	227	233	PF00069	0.399
MOD_Plk_2-3	120	126	PF00069	0.451
MOD_Plk_4	152	158	PF00069	0.374
MOD_Plk_4	229	235	PF00069	0.378
MOD_Plk_4	241	247	PF00069	0.354
MOD_Plk_4	259	265	PF00069	0.276
MOD_ProDKin_1	79	85	PF00069	0.343
MOD_SUMO_for_1	10	13	PF00179	0.758
MOD_SUMO_for_1	249	252	PF00179	0.406
MOD_SUMO_rev_2	103	111	PF00179	0.344
MOD_SUMO_rev_2	177	186	PF00179	0.401
MOD_SUMO_rev_2	82	91	PF00179	0.416
TRG_DiLeu_BaEn_2	198	204	PF01217	0.419
TRG_ENDOCYTIC_2	169	172	PF00928	0.308
TRG_ENDOCYTIC_2	20	23	PF00928	0.638
TRG_ENDOCYTIC_2	213	216	PF00928	0.402
TRG_ENDOCYTIC_2	260	263	PF00928	0.340
TRG_ENDOCYTIC_2	30	33	PF00928	0.574
TRG_ENDOCYTIC_2	63	66	PF00928	0.314
TRG_ER_diArg_1	130	132	PF00400	0.412
TRG_ER_diArg_1	37	40	PF00400	0.587
TRG_ER_diArg_1	66	68	PF00400	0.343
TRG_NES_CRM1_1	95	108	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8V1	Leptomonas seymouri	72%	100%
A0A0S4KJI8	Bodo saltans	35%	100%
A0A1X0NLH2	Trypanosomatidae	54%	100%
A0A3Q8IKF0	Leishmania donovani	92%	100%
A0A422NVW1	Trypanosoma rangeli	55%	100%
A4HQL9	Leishmania braziliensis	82%	100%
A4ICD7	Leishmania infantum	91%	100%
D0A3S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q056	Leishmania major	91%	100%
V5AXP5	Trypanosoma cruzi	52%	100%