LeishMANIAdb
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CPSF_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CPSF_A domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AUD0_LEIMU
TriTrypDb:
LmxM.36.6935
Length:
135

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUD0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUD0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 34 38 PF00082 0.556
CLV_PCSK_SKI1_1 46 50 PF00082 0.384
CLV_PCSK_SKI1_1 5 9 PF00082 0.682
DEG_Nend_UBRbox_1 1 4 PF02207 0.626
DOC_USP7_MATH_1 12 16 PF00917 0.628
DOC_USP7_MATH_1 64 68 PF00917 0.628
LIG_EH1_1 94 102 PF00400 0.571
LIG_FHA_1 114 120 PF00498 0.481
LIG_FHA_2 113 119 PF00498 0.520
LIG_SH2_PTP2 106 109 PF00017 0.587
LIG_SH2_SRC 106 109 PF00017 0.631
LIG_SH2_STAT5 106 109 PF00017 0.541
LIG_SH2_STAT5 113 116 PF00017 0.494
LIG_SH2_STAT5 83 86 PF00017 0.463
LIG_SH3_3 98 104 PF00018 0.539
MOD_CK1_1 124 130 PF00069 0.575
MOD_CK2_1 112 118 PF00069 0.538
MOD_CK2_1 13 19 PF00069 0.644
MOD_GSK3_1 109 116 PF00069 0.691
MOD_NEK2_1 1 6 PF00069 0.719
MOD_NEK2_2 18 23 PF00069 0.700
MOD_NEK2_2 41 46 PF00069 0.420
MOD_PIKK_1 64 70 PF00454 0.565
MOD_PKA_2 1 7 PF00069 0.633
MOD_Plk_1 18 24 PF00069 0.697
MOD_Plk_4 109 115 PF00069 0.613
MOD_Plk_4 124 130 PF00069 0.439
TRG_ENDOCYTIC_2 106 109 PF00928 0.606
TRG_ER_diArg_1 103 106 PF00400 0.482
TRG_ER_diArg_1 73 76 PF00400 0.508
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEU6 Leptomonas seymouri 72% 99%
A0A0S4KL81 Bodo saltans 34% 100%
A0A1X0NL52 Trypanosomatidae 45% 100%
A0A3S5IS15 Trypanosoma rangeli 50% 100%
A0A3S7XCF1 Leishmania donovani 93% 100%
A4HQL5 Leishmania braziliensis 86% 100%
A4ICD4 Leishmania infantum 93% 100%
D0A3R9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 78%
Q4Q060 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS