LeishMANIAdb
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Leucine-rich repeat-containing protein 51

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat-containing protein 51
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AUC6_LEIMU
TriTrypDb:
LmxM.36.6900
Length:
708

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005929 cilium 4 6
GO:0042995 cell projection 2 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0110165 cellular anatomical entity 1 6
GO:0120025 plasma membrane bounded cell projection 3 6
GO:0000164 protein phosphatase type 1 complex 5 1
GO:0008287 protein serine/threonine phosphatase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:1902494 catalytic complex 2 1
GO:1903293 phosphatase complex 3 1

Expansion

Sequence features

E9AUC6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUC6

Function

Biological processes
Term Name Level Count
GO:0009893 positive regulation of metabolic process 4 1
GO:0010562 positive regulation of phosphorus metabolic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0031401 positive regulation of protein modification process 7 1
GO:0035303 regulation of dephosphorylation 7 1
GO:0035304 regulation of protein dephosphorylation 7 1
GO:0035306 positive regulation of dephosphorylation 8 1
GO:0035307 positive regulation of protein dephosphorylation 8 1
GO:0045937 positive regulation of phosphate metabolic process 7 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
Molecular functions
Term Name Level Count
GO:0004857 enzyme inhibitor activity 3 1
GO:0004864 protein phosphatase inhibitor activity 5 1
GO:0004865 protein serine/threonine phosphatase inhibitor activity 6 1
GO:0019208 phosphatase regulator activity 3 1
GO:0019212 phosphatase inhibitor activity 4 1
GO:0019888 protein phosphatase regulator activity 4 1
GO:0030234 enzyme regulator activity 2 1
GO:0098772 molecular function regulator activity 1 1
GO:0140678 molecular function inhibitor activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.592
CLV_C14_Caspase3-7 436 440 PF00656 0.739
CLV_C14_Caspase3-7 617 621 PF00656 0.545
CLV_C14_Caspase3-7 702 706 PF00656 0.812
CLV_NRD_NRD_1 150 152 PF00675 0.631
CLV_NRD_NRD_1 153 155 PF00675 0.594
CLV_NRD_NRD_1 204 206 PF00675 0.656
CLV_NRD_NRD_1 21 23 PF00675 0.644
CLV_NRD_NRD_1 372 374 PF00675 0.699
CLV_NRD_NRD_1 469 471 PF00675 0.800
CLV_NRD_NRD_1 596 598 PF00675 0.817
CLV_PCSK_FUR_1 151 155 PF00082 0.563
CLV_PCSK_KEX2_1 120 122 PF00082 0.531
CLV_PCSK_KEX2_1 150 152 PF00082 0.631
CLV_PCSK_KEX2_1 153 155 PF00082 0.594
CLV_PCSK_KEX2_1 158 160 PF00082 0.543
CLV_PCSK_KEX2_1 204 206 PF00082 0.656
CLV_PCSK_KEX2_1 372 374 PF00082 0.710
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.531
CLV_PCSK_PC1ET2_1 158 160 PF00082 0.598
CLV_PCSK_PC7_1 154 160 PF00082 0.586
CLV_PCSK_SKI1_1 121 125 PF00082 0.417
CLV_PCSK_SKI1_1 169 173 PF00082 0.491
CLV_PCSK_SKI1_1 197 201 PF00082 0.600
CLV_PCSK_SKI1_1 315 319 PF00082 0.619
CLV_PCSK_SKI1_1 344 348 PF00082 0.592
CLV_PCSK_SKI1_1 377 381 PF00082 0.706
CLV_PCSK_SKI1_1 63 67 PF00082 0.456
CLV_PCSK_SKI1_1 696 700 PF00082 0.750
DEG_APCC_DBOX_1 297 305 PF00400 0.628
DEG_Nend_UBRbox_2 1 3 PF02207 0.598
DEG_SCF_FBW7_1 416 423 PF00400 0.711
DEG_SPOP_SBC_1 214 218 PF00917 0.524
DEG_SPOP_SBC_1 241 245 PF00917 0.681
DEG_SPOP_SBC_1 415 419 PF00917 0.762
DEG_SPOP_SBC_1 689 693 PF00917 0.530
DOC_CDC14_PxL_1 333 341 PF14671 0.605
DOC_CYCLIN_RxL_1 310 323 PF00134 0.615
DOC_CYCLIN_RxL_1 341 350 PF00134 0.511
DOC_CYCLIN_RxL_1 693 703 PF00134 0.749
DOC_CYCLIN_yCln2_LP_2 224 227 PF00134 0.796
DOC_MAPK_DCC_7 310 319 PF00069 0.564
DOC_MAPK_gen_1 120 126 PF00069 0.420
DOC_MAPK_gen_1 22 30 PF00069 0.608
DOC_MAPK_gen_1 298 306 PF00069 0.620
DOC_MAPK_gen_1 310 319 PF00069 0.443
DOC_MAPK_gen_1 508 517 PF00069 0.640
DOC_MAPK_MEF2A_6 23 32 PF00069 0.597
DOC_MAPK_MEF2A_6 298 306 PF00069 0.620
DOC_MAPK_MEF2A_6 352 359 PF00069 0.629
DOC_MAPK_MEF2A_6 587 594 PF00069 0.561
DOC_MAPK_MEF2A_6 88 97 PF00069 0.553
DOC_PP2B_LxvP_1 224 227 PF13499 0.796
DOC_PP2B_LxvP_1 592 595 PF13499 0.778
DOC_PP4_FxxP_1 636 639 PF00568 0.531
DOC_USP7_MATH_1 106 110 PF00917 0.519
DOC_USP7_MATH_1 136 140 PF00917 0.545
DOC_USP7_MATH_1 214 218 PF00917 0.570
DOC_USP7_MATH_1 385 389 PF00917 0.724
DOC_USP7_MATH_1 420 424 PF00917 0.711
DOC_USP7_MATH_1 457 461 PF00917 0.628
DOC_USP7_MATH_1 520 524 PF00917 0.799
DOC_USP7_MATH_1 582 586 PF00917 0.648
DOC_USP7_MATH_1 606 610 PF00917 0.762
DOC_USP7_MATH_1 629 633 PF00917 0.689
DOC_USP7_MATH_1 690 694 PF00917 0.617
DOC_USP7_UBL2_3 116 120 PF12436 0.553
DOC_USP7_UBL2_3 467 471 PF12436 0.767
DOC_USP7_UBL2_3 684 688 PF12436 0.559
DOC_WW_Pin1_4 372 377 PF00397 0.778
DOC_WW_Pin1_4 381 386 PF00397 0.681
DOC_WW_Pin1_4 416 421 PF00397 0.652
DOC_WW_Pin1_4 450 455 PF00397 0.548
DOC_WW_Pin1_4 679 684 PF00397 0.550
LIG_14-3-3_CanoR_1 137 145 PF00244 0.460
LIG_14-3-3_CanoR_1 159 168 PF00244 0.533
LIG_14-3-3_CanoR_1 240 248 PF00244 0.592
LIG_14-3-3_CanoR_1 315 320 PF00244 0.579
LIG_14-3-3_CanoR_1 34 43 PF00244 0.476
LIG_14-3-3_CanoR_1 470 478 PF00244 0.730
LIG_14-3-3_CanoR_1 603 613 PF00244 0.707
LIG_14-3-3_CanoR_1 67 72 PF00244 0.567
LIG_ActinCP_TwfCPI_2 636 645 PF01115 0.531
LIG_BIR_III_4 323 327 PF00653 0.580
LIG_BRCT_BRCA1_1 244 248 PF00533 0.658
LIG_BRCT_BRCA1_1 38 42 PF00533 0.482
LIG_BRCT_BRCA1_1 491 495 PF00533 0.761
LIG_BRCT_BRCA1_1 537 541 PF00533 0.608
LIG_BRCT_BRCA1_1 646 650 PF00533 0.753
LIG_BRCT_BRCA1_1 660 664 PF00533 0.640
LIG_CaM_IQ_9 187 203 PF13499 0.701
LIG_DLG_GKlike_1 67 74 PF00625 0.461
LIG_eIF4E_1 3 9 PF01652 0.526
LIG_eIF4E_1 343 349 PF01652 0.511
LIG_eIF4E_1 87 93 PF01652 0.548
LIG_FHA_1 201 207 PF00498 0.599
LIG_FHA_1 326 332 PF00498 0.619
LIG_FHA_1 512 518 PF00498 0.572
LIG_FHA_1 605 611 PF00498 0.839
LIG_FHA_1 64 70 PF00498 0.540
LIG_FHA_2 106 112 PF00498 0.627
LIG_FHA_2 136 142 PF00498 0.613
LIG_FHA_2 184 190 PF00498 0.610
LIG_FHA_2 191 197 PF00498 0.482
LIG_FHA_2 359 365 PF00498 0.609
LIG_FHA_2 36 42 PF00498 0.575
LIG_FHA_2 400 406 PF00498 0.814
LIG_FHA_2 508 514 PF00498 0.529
LIG_LIR_Apic_2 635 639 PF02991 0.529
LIG_LIR_Apic_2 685 689 PF02991 0.549
LIG_LIR_Gen_1 139 149 PF02991 0.607
LIG_LIR_Gen_1 2 9 PF02991 0.534
LIG_LIR_Gen_1 24 32 PF02991 0.585
LIG_LIR_Gen_1 277 285 PF02991 0.619
LIG_LIR_Gen_1 330 341 PF02991 0.605
LIG_LIR_Gen_1 38 48 PF02991 0.353
LIG_LIR_Nem_3 127 131 PF02991 0.575
LIG_LIR_Nem_3 139 145 PF02991 0.392
LIG_LIR_Nem_3 14 19 PF02991 0.403
LIG_LIR_Nem_3 147 152 PF02991 0.493
LIG_LIR_Nem_3 2 6 PF02991 0.549
LIG_LIR_Nem_3 24 30 PF02991 0.516
LIG_LIR_Nem_3 277 281 PF02991 0.646
LIG_LIR_Nem_3 330 336 PF02991 0.608
LIG_LIR_Nem_3 38 43 PF02991 0.346
LIG_LIR_Nem_3 516 521 PF02991 0.588
LIG_LIR_Nem_3 60 65 PF02991 0.573
LIG_LIR_Nem_3 692 698 PF02991 0.826
LIG_MYND_1 223 227 PF01753 0.796
LIG_MYND_1 572 576 PF01753 0.751
LIG_NRBOX 88 94 PF00104 0.546
LIG_SH2_CRK 142 146 PF00017 0.593
LIG_SH2_CRK 343 347 PF00017 0.582
LIG_SH2_CRK 451 455 PF00017 0.549
LIG_SH2_CRK 686 690 PF00017 0.548
LIG_SH2_NCK_1 451 455 PF00017 0.549
LIG_SH2_NCK_1 686 690 PF00017 0.548
LIG_SH2_STAP1 142 146 PF00017 0.593
LIG_SH2_STAP1 464 468 PF00017 0.628
LIG_SH2_STAT5 48 51 PF00017 0.579
LIG_SH2_STAT5 53 56 PF00017 0.490
LIG_SH3_1 570 576 PF00018 0.759
LIG_SH3_3 220 226 PF00018 0.614
LIG_SH3_3 350 356 PF00018 0.597
LIG_SH3_3 442 448 PF00018 0.619
LIG_SH3_3 553 559 PF00018 0.650
LIG_SH3_3 563 569 PF00018 0.626
LIG_SH3_3 570 576 PF00018 0.719
LIG_SUMO_SIM_anti_2 252 257 PF11976 0.662
LIG_SUMO_SIM_par_1 355 361 PF11976 0.631
LIG_TRAF2_1 108 111 PF00917 0.560
LIG_TYR_ITIM 126 131 PF00017 0.569
LIG_WRC_WIRS_1 13 18 PF05994 0.417
LIG_WRC_WIRS_1 37 42 PF05994 0.475
LIG_WRC_WIRS_1 386 391 PF05994 0.724
LIG_WRC_WIRS_1 59 64 PF05994 0.574
LIG_WRC_WIRS_1 633 638 PF05994 0.725
LIG_WW_2 445 448 PF00397 0.713
LIG_WW_3 567 571 PF00397 0.548
LIG_WW_3 594 598 PF00397 0.848
MOD_CDK_SPK_2 372 377 PF00069 0.701
MOD_CDK_SPK_2 679 684 PF00069 0.550
MOD_CK1_1 242 248 PF00069 0.662
MOD_CK1_1 294 300 PF00069 0.552
MOD_CK1_1 358 364 PF00069 0.657
MOD_CK1_1 384 390 PF00069 0.724
MOD_CK1_1 399 405 PF00069 0.606
MOD_CK1_1 418 424 PF00069 0.511
MOD_CK1_1 452 458 PF00069 0.635
MOD_CK1_1 507 513 PF00069 0.668
MOD_CK1_1 533 539 PF00069 0.657
MOD_CK1_1 549 555 PF00069 0.619
MOD_CK1_1 605 611 PF00069 0.840
MOD_CK1_1 632 638 PF00069 0.791
MOD_CK1_1 643 649 PF00069 0.684
MOD_CK1_1 660 666 PF00069 0.572
MOD_CK1_1 70 76 PF00069 0.554
MOD_CK2_1 105 111 PF00069 0.630
MOD_CK2_1 135 141 PF00069 0.621
MOD_CK2_1 183 189 PF00069 0.690
MOD_CK2_1 190 196 PF00069 0.556
MOD_CK2_1 246 252 PF00069 0.719
MOD_CK2_1 35 41 PF00069 0.567
MOD_CK2_1 358 364 PF00069 0.616
MOD_CK2_1 387 393 PF00069 0.656
MOD_CK2_1 399 405 PF00069 0.646
MOD_CK2_1 420 426 PF00069 0.646
MOD_CK2_1 507 513 PF00069 0.528
MOD_CK2_1 608 614 PF00069 0.583
MOD_Cter_Amidation 118 121 PF01082 0.618
MOD_GlcNHglycan 138 141 PF01048 0.539
MOD_GlcNHglycan 217 220 PF01048 0.599
MOD_GlcNHglycan 244 247 PF01048 0.728
MOD_GlcNHglycan 248 251 PF01048 0.682
MOD_GlcNHglycan 349 352 PF01048 0.633
MOD_GlcNHglycan 381 384 PF01048 0.583
MOD_GlcNHglycan 420 423 PF01048 0.737
MOD_GlcNHglycan 455 458 PF01048 0.713
MOD_GlcNHglycan 604 607 PF01048 0.771
MOD_GlcNHglycan 616 619 PF01048 0.561
MOD_GlcNHglycan 650 653 PF01048 0.607
MOD_GlcNHglycan 660 663 PF01048 0.542
MOD_GlcNHglycan 672 675 PF01048 0.808
MOD_GSK3_1 160 167 PF00069 0.631
MOD_GSK3_1 242 249 PF00069 0.631
MOD_GSK3_1 315 322 PF00069 0.349
MOD_GSK3_1 377 384 PF00069 0.778
MOD_GSK3_1 385 392 PF00069 0.628
MOD_GSK3_1 414 421 PF00069 0.569
MOD_GSK3_1 449 456 PF00069 0.717
MOD_GSK3_1 462 469 PF00069 0.641
MOD_GSK3_1 507 514 PF00069 0.544
MOD_GSK3_1 542 549 PF00069 0.770
MOD_GSK3_1 601 608 PF00069 0.849
MOD_GSK3_1 625 632 PF00069 0.793
MOD_GSK3_1 63 70 PF00069 0.599
MOD_GSK3_1 640 647 PF00069 0.695
MOD_GSK3_1 656 663 PF00069 0.597
MOD_GSK3_1 666 673 PF00069 0.641
MOD_GSK3_1 675 682 PF00069 0.675
MOD_GSK3_1 690 697 PF00069 0.639
MOD_GSK3_1 699 706 PF00069 0.765
MOD_LATS_1 313 319 PF00433 0.545
MOD_N-GLC_1 408 413 PF02516 0.532
MOD_N-GLC_1 439 444 PF02516 0.733
MOD_NEK2_1 124 129 PF00069 0.523
MOD_NEK2_1 175 180 PF00069 0.683
MOD_NEK2_1 213 218 PF00069 0.519
MOD_NEK2_1 347 352 PF00069 0.621
MOD_NEK2_1 357 362 PF00069 0.542
MOD_NEK2_1 379 384 PF00069 0.721
MOD_NEK2_1 42 47 PF00069 0.482
MOD_NEK2_1 495 500 PF00069 0.744
MOD_NEK2_1 506 511 PF00069 0.606
MOD_NEK2_2 462 467 PF00069 0.555
MOD_PIKK_1 106 112 PF00454 0.432
MOD_PIKK_1 157 163 PF00454 0.687
MOD_PIKK_1 175 181 PF00454 0.667
MOD_PIKK_1 358 364 PF00454 0.653
MOD_PIKK_1 596 602 PF00454 0.775
MOD_PIKK_1 640 646 PF00454 0.667
MOD_PK_1 164 170 PF00069 0.560
MOD_PKA_2 136 142 PF00069 0.466
MOD_PKA_2 200 206 PF00069 0.588
MOD_PKA_2 239 245 PF00069 0.602
MOD_PKA_2 469 475 PF00069 0.823
MOD_PKA_2 596 602 PF00069 0.775
MOD_PKA_2 644 650 PF00069 0.629
MOD_PKB_1 195 203 PF00069 0.383
MOD_Plk_1 195 201 PF00069 0.524
MOD_Plk_1 462 468 PF00069 0.671
MOD_Plk_1 495 501 PF00069 0.610
MOD_Plk_4 257 263 PF00069 0.553
MOD_Plk_4 291 297 PF00069 0.526
MOD_Plk_4 525 531 PF00069 0.626
MOD_Plk_4 535 541 PF00069 0.565
MOD_Plk_4 644 650 PF00069 0.670
MOD_ProDKin_1 372 378 PF00069 0.781
MOD_ProDKin_1 381 387 PF00069 0.680
MOD_ProDKin_1 416 422 PF00069 0.652
MOD_ProDKin_1 450 456 PF00069 0.546
MOD_ProDKin_1 679 685 PF00069 0.550
MOD_SUMO_for_1 521 524 PF00179 0.505
MOD_SUMO_rev_2 155 160 PF00179 0.587
MOD_SUMO_rev_2 651 659 PF00179 0.541
TRG_DiLeu_BaLyEn_6 220 225 PF01217 0.792
TRG_DiLeu_BaLyEn_6 334 339 PF01217 0.449
TRG_ENDOCYTIC_2 128 131 PF00928 0.576
TRG_ENDOCYTIC_2 142 145 PF00928 0.351
TRG_ENDOCYTIC_2 3 6 PF00928 0.538
TRG_ENDOCYTIC_2 343 346 PF00928 0.582
TRG_ENDOCYTIC_2 86 89 PF00928 0.500
TRG_ER_diArg_1 149 151 PF00400 0.619
TRG_ER_diArg_1 152 154 PF00400 0.590
TRG_ER_diArg_1 204 206 PF00400 0.656
TRG_ER_diArg_1 309 312 PF00400 0.530
TRG_ER_diArg_1 371 373 PF00400 0.693
TRG_NLS_MonoExtN_4 467 474 PF00514 0.645
TRG_Pf-PMV_PEXEL_1 150 155 PF00026 0.637
TRG_Pf-PMV_PEXEL_1 63 68 PF00026 0.591
TRG_Pf-PMV_PEXEL_1 696 701 PF00026 0.751
TRG_Pf-PMV_PEXEL_1 72 77 PF00026 0.430

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7XCG9 Leishmania donovani 82% 100%
A4HQL1 Leishmania braziliensis 60% 100%
A4ICD1 Leishmania infantum 82% 100%
Q4Q064 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS