Putative DNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain factor 1

Species:

Leishmania mexicana

UniProt:

E9AUC4_LEIMU

TriTrypDb:

LmxM.36.6880

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUC4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0070577	lysine-acetylated histone binding	4	1
GO:0140030	modification-dependent protein binding	3	1
GO:0140033	acetylation-dependent protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.572
CLV_NRD_NRD_1	186	188	PF00675	0.417
CLV_NRD_NRD_1	19	21	PF00675	0.499
CLV_NRD_NRD_1	206	208	PF00675	0.307
CLV_NRD_NRD_1	218	220	PF00675	0.604
CLV_NRD_NRD_1	36	38	PF00675	0.218
CLV_NRD_NRD_1	75	77	PF00675	0.366
CLV_PCSK_FUR_1	15	19	PF00082	0.447
CLV_PCSK_KEX2_1	17	19	PF00082	0.442
CLV_PCSK_KEX2_1	186	188	PF00082	0.416
CLV_PCSK_KEX2_1	206	208	PF00082	0.307
CLV_PCSK_KEX2_1	217	219	PF00082	0.600
CLV_PCSK_KEX2_1	36	38	PF00082	0.457
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.449
CLV_PCSK_PC7_1	13	19	PF00082	0.476
CLV_PCSK_PC7_1	213	219	PF00082	0.617
CLV_PCSK_SKI1_1	124	128	PF00082	0.505
CLV_PCSK_SKI1_1	152	156	PF00082	0.460
CLV_PCSK_SKI1_1	178	182	PF00082	0.458
CLV_PCSK_SKI1_1	186	190	PF00082	0.383
CLV_PCSK_SKI1_1	201	205	PF00082	0.564
CLV_PCSK_SKI1_1	207	211	PF00082	0.592
CLV_PCSK_SKI1_1	36	40	PF00082	0.202
CLV_Separin_Metazoa	153	157	PF03568	0.504
DEG_APCC_DBOX_1	35	43	PF00400	0.202
DOC_MAPK_MEF2A_6	112	121	PF00069	0.445
DOC_USP7_MATH_1	192	196	PF00917	0.513
DOC_USP7_MATH_1	209	213	PF00917	0.420
DOC_WW_Pin1_4	261	266	PF00397	0.603
LIG_14-3-3_CanoR_1	124	133	PF00244	0.567
LIG_14-3-3_CanoR_1	178	188	PF00244	0.501
LIG_14-3-3_CanoR_1	53	59	PF00244	0.470
LIG_Actin_WH2_2	114	132	PF00022	0.515
LIG_Actin_WH2_2	162	180	PF00022	0.565
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BIR_III_2	241	245	PF00653	0.530
LIG_BRCT_BRCA1_1	3	7	PF00533	0.421
LIG_deltaCOP1_diTrp_1	269	280	PF00928	0.708
LIG_GBD_Chelix_1	8	16	PF00786	0.580
LIG_Integrin_RGD_1	20	22	PF01839	0.285
LIG_LIR_Nem_3	22	27	PF02991	0.436
LIG_PDZ_Class_1	281	286	PF00595	0.564
LIG_PTB_Apo_2	95	102	PF02174	0.445
LIG_PTB_Phospho_1	95	101	PF10480	0.445
LIG_SH2_CRK	103	107	PF00017	0.449
LIG_SH2_SRC	26	29	PF00017	0.564
LIG_SH2_STAP1	61	65	PF00017	0.385
LIG_SH2_STAP1	81	85	PF00017	0.434
LIG_SH2_STAT5	101	104	PF00017	0.383
LIG_SH2_STAT5	26	29	PF00017	0.564
LIG_SH3_1	130	136	PF00018	0.564
LIG_SH3_3	130	136	PF00018	0.464
LIG_SH3_3	62	68	PF00018	0.385
MOD_CDC14_SPxK_1	264	267	PF00782	0.700
MOD_CDK_SPxK_1	261	267	PF00069	0.703
MOD_CK1_1	148	154	PF00069	0.560
MOD_CK1_1	167	173	PF00069	0.557
MOD_CK1_1	212	218	PF00069	0.636
MOD_CK2_1	191	197	PF00069	0.558
MOD_CK2_1	255	261	PF00069	0.690
MOD_GlcNHglycan	147	150	PF01048	0.553
MOD_GlcNHglycan	181	184	PF01048	0.479
MOD_GlcNHglycan	194	197	PF01048	0.479
MOD_GSK3_1	141	148	PF00069	0.577
MOD_N-GLC_2	98	100	PF02516	0.449
MOD_NEK2_1	164	169	PF00069	0.419
MOD_NEK2_1	280	285	PF00069	0.637
MOD_PKA_2	192	198	PF00069	0.533
MOD_PKA_2	212	218	PF00069	0.306
MOD_Plk_1	164	170	PF00069	0.525
MOD_Plk_2-3	40	46	PF00069	0.475
MOD_ProDKin_1	261	267	PF00069	0.605
MOD_SUMO_rev_2	194	203	PF00179	0.582
TRG_ENDOCYTIC_2	103	106	PF00928	0.449
TRG_ENDOCYTIC_2	161	164	PF00928	0.524
TRG_ENDOCYTIC_2	70	73	PF00928	0.368
TRG_ER_diArg_1	12	15	PF00400	0.476
TRG_ER_diArg_1	18	20	PF00400	0.468
TRG_ER_diArg_1	185	187	PF00400	0.404
TRG_ER_diArg_1	205	207	PF00400	0.311
TRG_ER_diArg_1	217	219	PF00400	0.600
TRG_ER_diArg_1	36	38	PF00400	0.145
TRG_NLS_MonoCore_2	16	21	PF00514	0.582
TRG_NLS_MonoExtC_3	16	22	PF00514	0.581
TRG_NLS_MonoExtN_4	15	21	PF00514	0.570
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD97	Leptomonas seymouri	75%	100%
A0A0S4KI88	Bodo saltans	26%	100%
A0A1X0NN00	Trypanosomatidae	37%	96%
A0A3Q8IM77	Leishmania donovani	93%	100%
A0A422NVW8	Trypanosoma rangeli	35%	97%
A4HQK9	Leishmania braziliensis	89%	100%
A4ICC9	Leishmania infantum	93%	100%
D0A3R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	95%
Q4Q066	Leishmania major	95%	100%
V5DDW0	Trypanosoma cruzi	33%	97%