4HBT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioesterase superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AUB6_LEIMU

TriTrypDb:

LmxM.36.6810

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUB6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016289	CoA hydrolase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0047617	acyl-CoA hydrolase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.349
CLV_PCSK_KEX2_1	60	62	PF00082	0.606
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.681
CLV_PCSK_SKI1_1	5	9	PF00082	0.566
DEG_APCC_DBOX_1	4	12	PF00400	0.550
DEG_APCC_DBOX_1	87	95	PF00400	0.248
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DEG_SPOP_SBC_1	150	154	PF00917	0.490
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.638
DOC_MAPK_gen_1	120	130	PF00069	0.408
DOC_USP7_MATH_1	74	78	PF00917	0.495
DOC_WW_Pin1_4	151	156	PF00397	0.553
DOC_WW_Pin1_4	38	43	PF00397	0.614
LIG_14-3-3_CanoR_1	28	35	PF00244	0.728
LIG_BRCT_BRCA1_1	106	110	PF00533	0.331
LIG_FHA_1	117	123	PF00498	0.309
LIG_FHA_1	146	152	PF00498	0.540
LIG_FHA_1	2	8	PF00498	0.663
LIG_IRF3_LxIS_1	99	104	PF10401	0.292
LIG_LIR_Gen_1	127	135	PF02991	0.296
LIG_LIR_Gen_1	80	89	PF02991	0.319
LIG_LIR_Nem_3	127	133	PF02991	0.296
LIG_LIR_Nem_3	80	85	PF02991	0.319
LIG_SH2_STAP1	30	34	PF00017	0.655
MOD_CDC14_SPxK_1	41	44	PF00782	0.663
MOD_CDK_SPK_2	151	156	PF00069	0.553
MOD_CDK_SPxK_1	38	44	PF00069	0.664
MOD_CK1_1	104	110	PF00069	0.363
MOD_CK1_1	63	69	PF00069	0.568
MOD_GlcNHglycan	106	109	PF01048	0.400
MOD_GlcNHglycan	136	142	PF01048	0.324
MOD_GlcNHglycan	30	33	PF01048	0.635
MOD_GSK3_1	124	131	PF00069	0.433
MOD_GSK3_1	145	152	PF00069	0.559
MOD_GSK3_1	34	41	PF00069	0.653
MOD_GSK3_1	97	104	PF00069	0.301
MOD_LATS_1	26	32	PF00433	0.543
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	101	106	PF00069	0.314
MOD_NEK2_1	34	39	PF00069	0.745
MOD_NEK2_1	7	12	PF00069	0.562
MOD_PKA_1	60	66	PF00069	0.669
MOD_PKA_2	145	151	PF00069	0.566
MOD_PKA_2	60	66	PF00069	0.679
MOD_Plk_1	101	107	PF00069	0.303
MOD_Plk_1	131	137	PF00069	0.304
MOD_Plk_2-3	97	103	PF00069	0.335
MOD_Plk_4	124	130	PF00069	0.351
MOD_Plk_4	34	40	PF00069	0.722
MOD_Plk_4	49	55	PF00069	0.619
MOD_ProDKin_1	151	157	PF00069	0.555
MOD_ProDKin_1	38	44	PF00069	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU0	Leptomonas seymouri	73%	100%
A0A0S4JPU2	Bodo saltans	33%	100%
A0A1X0NLI9	Trypanosomatidae	46%	100%
A0A3S7XCF9	Leishmania donovani	90%	100%
A0A422NVU3	Trypanosoma rangeli	49%	100%
A4HQK3	Leishmania braziliensis	79%	100%
A4ICC1	Leishmania infantum	91%	100%
D0A3Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q074	Leishmania major	91%	100%