CG7219 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CG7219 protein

Gene product:

hypothetical protein, conserved,CG1104 protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AUB5_LEIMU

TriTrypDb:

LmxM.36.6800

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUB5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0032446	protein modification by small protein conjugation	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071569	protein ufmylation	7	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006950	response to stress	2	1
GO:0009894	regulation of catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019222	regulation of metabolic process	3	1
GO:0030162	regulation of proteolysis	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1
GO:1990564	protein polyufmylation	8	1
GO:1990592	protein K69-linked ufmylation	9	1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0061666	UFM1 ligase activity	5	12
GO:0071568	UFM1 transferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	300	302	PF00675	0.611
CLV_NRD_NRD_1	303	305	PF00675	0.595
CLV_NRD_NRD_1	581	583	PF00675	0.424
CLV_PCSK_KEX2_1	11	13	PF00082	0.437
CLV_PCSK_KEX2_1	204	206	PF00082	0.362
CLV_PCSK_KEX2_1	242	244	PF00082	0.362
CLV_PCSK_KEX2_1	581	583	PF00082	0.426
CLV_PCSK_KEX2_1	61	63	PF00082	0.266
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.420
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.232
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.331
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.411
CLV_PCSK_SKI1_1	152	156	PF00082	0.391
CLV_PCSK_SKI1_1	360	364	PF00082	0.386
CLV_PCSK_SKI1_1	416	420	PF00082	0.512
CLV_PCSK_SKI1_1	490	494	PF00082	0.571
CLV_PCSK_SKI1_1	572	576	PF00082	0.427
CLV_PCSK_SKI1_1	726	730	PF00082	0.464
CLV_Separin_Metazoa	195	199	PF03568	0.331
DEG_APCC_DBOX_1	581	589	PF00400	0.419
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DOC_CDC14_PxL_1	348	356	PF14671	0.462
DOC_CYCLIN_RxL_1	149	157	PF00134	0.210
DOC_CYCLIN_RxL_1	569	579	PF00134	0.497
DOC_CYCLIN_yClb5_NLxxxL_5	37	46	PF00134	0.287
DOC_MAPK_gen_1	39	47	PF00069	0.285
DOC_MAPK_gen_1	427	433	PF00069	0.623
DOC_MAPK_gen_1	581	588	PF00069	0.510
DOC_MAPK_gen_1	623	633	PF00069	0.406
DOC_MAPK_MEF2A_6	227	235	PF00069	0.167
DOC_MAPK_MEF2A_6	317	325	PF00069	0.664
DOC_MAPK_MEF2A_6	360	367	PF00069	0.406
DOC_MAPK_MEF2A_6	39	47	PF00069	0.361
DOC_MAPK_MEF2A_6	624	633	PF00069	0.404
DOC_MAPK_NFAT4_5	40	48	PF00069	0.387
DOC_MIT_MIM_1	8	16	PF04212	0.411
DOC_PP1_RVXF_1	507	514	PF00149	0.339
DOC_PP2B_LxvP_1	208	211	PF13499	0.281
DOC_PP2B_LxvP_1	445	448	PF13499	0.507
DOC_PP4_FxxP_1	618	621	PF00568	0.457
DOC_USP7_MATH_1	211	215	PF00917	0.438
DOC_USP7_MATH_1	353	357	PF00917	0.487
DOC_USP7_MATH_1	422	426	PF00917	0.532
DOC_USP7_MATH_1	644	648	PF00917	0.592
DOC_USP7_UBL2_3	176	180	PF12436	0.167
DOC_USP7_UBL2_3	302	306	PF12436	0.660
LIG_14-3-3_CanoR_1	12	17	PF00244	0.383
LIG_14-3-3_CanoR_1	322	326	PF00244	0.636
LIG_14-3-3_CanoR_1	528	538	PF00244	0.371
LIG_14-3-3_CanoR_1	581	586	PF00244	0.457
LIG_14-3-3_CanoR_1	687	695	PF00244	0.468
LIG_14-3-3_CanoR_1	726	731	PF00244	0.421
LIG_APCC_ABBA_1	371	376	PF00400	0.530
LIG_APCC_ABBA_1	574	579	PF00400	0.392
LIG_BRCT_BRCA1_1	146	150	PF00533	0.360
LIG_BRCT_BRCA1_2	146	152	PF00533	0.331
LIG_CaM_IQ_9	10	26	PF13499	0.322
LIG_eIF4E_1	203	209	PF01652	0.411
LIG_FHA_1	102	108	PF00498	0.298
LIG_FHA_1	242	248	PF00498	0.426
LIG_FHA_1	400	406	PF00498	0.557
LIG_FHA_1	497	503	PF00498	0.525
LIG_FHA_1	661	667	PF00498	0.438
LIG_FHA_1	727	733	PF00498	0.619
LIG_FHA_2	155	161	PF00498	0.167
LIG_FHA_2	408	414	PF00498	0.372
LIG_FHA_2	54	60	PF00498	0.411
LIG_FHA_2	601	607	PF00498	0.495
LIG_FHA_2	719	725	PF00498	0.521
LIG_GBD_Chelix_1	466	474	PF00786	0.470
LIG_LIR_Apic_2	276	281	PF02991	0.521
LIG_LIR_Gen_1	138	146	PF02991	0.309
LIG_LIR_Gen_1	175	186	PF02991	0.393
LIG_LIR_Gen_1	499	508	PF02991	0.428
LIG_LIR_Gen_1	56	65	PF02991	0.266
LIG_LIR_Gen_1	628	638	PF02991	0.472
LIG_LIR_Nem_3	175	181	PF02991	0.346
LIG_LIR_Nem_3	207	212	PF02991	0.421
LIG_LIR_Nem_3	253	259	PF02991	0.264
LIG_LIR_Nem_3	378	384	PF02991	0.490
LIG_LIR_Nem_3	390	395	PF02991	0.438
LIG_LIR_Nem_3	450	455	PF02991	0.452
LIG_LIR_Nem_3	461	466	PF02991	0.357
LIG_LIR_Nem_3	499	504	PF02991	0.435
LIG_LIR_Nem_3	56	60	PF02991	0.266
LIG_LIR_Nem_3	628	633	PF02991	0.533
LIG_LYPXL_S_1	391	395	PF13949	0.559
LIG_LYPXL_yS_3	392	395	PF13949	0.558
LIG_NRBOX	41	47	PF00104	0.253
LIG_PCNA_PIPBox_1	143	152	PF02747	0.287
LIG_SH2_CRK	259	263	PF00017	0.266
LIG_SH2_NCK_1	278	282	PF00017	0.607
LIG_SH2_PTP2	234	237	PF00017	0.331
LIG_SH2_PTP2	630	633	PF00017	0.395
LIG_SH2_SRC	117	120	PF00017	0.266
LIG_SH2_STAP1	174	178	PF00017	0.325
LIG_SH2_STAT3	174	177	PF00017	0.325
LIG_SH2_STAT5	117	120	PF00017	0.266
LIG_SH2_STAT5	174	177	PF00017	0.281
LIG_SH2_STAT5	234	237	PF00017	0.304
LIG_SH2_STAT5	256	259	PF00017	0.271
LIG_SH2_STAT5	273	276	PF00017	0.510
LIG_SH2_STAT5	347	350	PF00017	0.422
LIG_SH2_STAT5	54	57	PF00017	0.288
LIG_SH2_STAT5	630	633	PF00017	0.501
LIG_SH3_3	561	567	PF00018	0.543
LIG_SH3_3	671	677	PF00018	0.395
LIG_SH3_3	75	81	PF00018	0.281
LIG_SUMO_SIM_par_1	103	108	PF11976	0.393
LIG_SUMO_SIM_par_1	243	248	PF11976	0.167
LIG_SUMO_SIM_par_1	402	408	PF11976	0.572
LIG_TRAF2_1	192	195	PF00917	0.331
LIG_TRAF2_1	410	413	PF00917	0.473
LIG_TRAF2_1	492	495	PF00917	0.389
LIG_TRAF2_1	721	724	PF00917	0.444
LIG_TYR_ITIM	257	262	PF00017	0.266
LIG_UBA3_1	373	379	PF00899	0.585
LIG_UBA3_1	585	593	PF00899	0.416
MOD_CK1_1	172	178	PF00069	0.347
MOD_CK1_1	292	298	PF00069	0.740
MOD_CK1_1	660	666	PF00069	0.381
MOD_CK2_1	154	160	PF00069	0.167
MOD_CK2_1	407	413	PF00069	0.303
MOD_CK2_1	53	59	PF00069	0.411
MOD_CK2_1	600	606	PF00069	0.457
MOD_CK2_1	633	639	PF00069	0.470
MOD_CK2_1	693	699	PF00069	0.588
MOD_CK2_1	710	716	PF00069	0.483
MOD_CK2_1	718	724	PF00069	0.420
MOD_CK2_1	94	100	PF00069	0.296
MOD_Cter_Amidation	302	305	PF01082	0.613
MOD_GlcNHglycan	294	297	PF01048	0.743
MOD_GlcNHglycan	327	330	PF01048	0.586
MOD_GlcNHglycan	396	399	PF01048	0.624
MOD_GlcNHglycan	407	410	PF01048	0.490
MOD_GlcNHglycan	424	427	PF01048	0.458
MOD_GlcNHglycan	476	479	PF01048	0.559
MOD_GlcNHglycan	522	525	PF01048	0.503
MOD_GlcNHglycan	557	560	PF01048	0.315
MOD_GlcNHglycan	606	610	PF01048	0.442
MOD_GSK3_1	131	138	PF00069	0.308
MOD_GSK3_1	150	157	PF00069	0.176
MOD_GSK3_1	19	26	PF00069	0.429
MOD_GSK3_1	288	295	PF00069	0.631
MOD_GSK3_1	321	328	PF00069	0.561
MOD_GSK3_1	401	408	PF00069	0.459
MOD_GSK3_1	422	429	PF00069	0.514
MOD_GSK3_1	551	558	PF00069	0.491
MOD_GSK3_1	577	584	PF00069	0.466
MOD_GSK3_1	656	663	PF00069	0.455
MOD_GSK3_1	726	733	PF00069	0.567
MOD_N-GLC_1	544	549	PF02516	0.393
MOD_N-GLC_1	555	560	PF02516	0.420
MOD_NEK2_1	135	140	PF00069	0.348
MOD_NEK2_1	150	155	PF00069	0.244
MOD_NEK2_1	212	217	PF00069	0.337
MOD_NEK2_1	250	255	PF00069	0.323
MOD_NEK2_1	474	479	PF00069	0.517
MOD_NEK2_1	486	491	PF00069	0.376
MOD_NEK2_1	504	509	PF00069	0.435
MOD_NEK2_1	577	582	PF00069	0.531
MOD_NEK2_1	600	605	PF00069	0.386
MOD_NEK2_1	607	612	PF00069	0.350
MOD_NEK2_1	657	662	PF00069	0.349
MOD_NEK2_2	82	87	PF00069	0.337
MOD_PIKK_1	135	141	PF00454	0.393
MOD_PIKK_1	562	568	PF00454	0.575
MOD_PK_1	593	599	PF00069	0.442
MOD_PK_1	642	648	PF00069	0.445
MOD_PKA_1	581	587	PF00069	0.459
MOD_PKA_2	321	327	PF00069	0.654
MOD_PKA_2	581	587	PF00069	0.467
MOD_PKA_2	633	639	PF00069	0.284
MOD_Plk_1	169	175	PF00069	0.397
MOD_Plk_1	544	550	PF00069	0.400
MOD_Plk_1	593	599	PF00069	0.516
MOD_Plk_2-3	53	59	PF00069	0.266
MOD_Plk_4	145	151	PF00069	0.266
MOD_Plk_4	169	175	PF00069	0.411
MOD_Plk_4	212	218	PF00069	0.335
MOD_Plk_4	353	359	PF00069	0.468
MOD_Plk_4	396	402	PF00069	0.472
MOD_Plk_4	581	587	PF00069	0.427
MOD_Plk_4	633	639	PF00069	0.311
MOD_Plk_4	660	666	PF00069	0.346
MOD_Plk_4	94	100	PF00069	0.378
MOD_SUMO_for_1	60	63	PF00179	0.411
MOD_SUMO_for_1	688	691	PF00179	0.459
MOD_SUMO_rev_2	2	7	PF00179	0.322
MOD_SUMO_rev_2	408	418	PF00179	0.430
MOD_SUMO_rev_2	635	644	PF00179	0.510
TRG_DiLeu_BaEn_1	108	113	PF01217	0.281
TRG_DiLeu_BaEn_1	396	401	PF01217	0.557
TRG_DiLeu_BaEn_4	100	106	PF01217	0.287
TRG_DiLeu_BaEn_4	194	200	PF01217	0.331
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.410
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.506
TRG_ENDOCYTIC_2	234	237	PF00928	0.425
TRG_ENDOCYTIC_2	259	262	PF00928	0.266
TRG_ENDOCYTIC_2	392	395	PF00928	0.558
TRG_ENDOCYTIC_2	452	455	PF00928	0.466
TRG_ENDOCYTIC_2	630	633	PF00928	0.519
TRG_ER_diArg_1	161	164	PF00400	0.331
TRG_NES_CRM1_1	361	376	PF08389	0.483
TRG_NLS_MonoExtC_3	300	305	PF00514	0.622
TRG_NLS_MonoExtN_4	301	308	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM39	Leptomonas seymouri	66%	99%
A0A0S4JTJ6	Bodo saltans	35%	94%
A0A1X0NLV8	Trypanosomatidae	42%	98%
A0A3S7XCH5	Leishmania donovani	90%	99%
A0A422NVV8	Trypanosoma rangeli	42%	99%
A4HQK2	Leishmania braziliensis	81%	100%
A4ICC0	Leishmania infantum	89%	99%
D0A3Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
Q4Q075	Leishmania major	90%	100%
V5AXN4	Trypanosoma cruzi	40%	99%