Putative ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative ATPase

Gene product:

ATPase, putative

Species:

Leishmania mexicana

UniProt:

E9AUB4_LEIMU

TriTrypDb:

LmxM.36.6790

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUB4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.536
CLV_NRD_NRD_1	107	109	PF00675	0.549
CLV_NRD_NRD_1	161	163	PF00675	0.307
CLV_NRD_NRD_1	187	189	PF00675	0.394
CLV_NRD_NRD_1	30	32	PF00675	0.505
CLV_NRD_NRD_1	317	319	PF00675	0.361
CLV_NRD_NRD_1	529	531	PF00675	0.586
CLV_NRD_NRD_1	92	94	PF00675	0.601
CLV_PCSK_FUR_1	105	109	PF00082	0.406
CLV_PCSK_KEX2_1	104	106	PF00082	0.556
CLV_PCSK_KEX2_1	107	109	PF00082	0.573
CLV_PCSK_KEX2_1	131	133	PF00082	0.394
CLV_PCSK_KEX2_1	160	162	PF00082	0.304
CLV_PCSK_KEX2_1	186	188	PF00082	0.379
CLV_PCSK_KEX2_1	19	21	PF00082	0.452
CLV_PCSK_KEX2_1	196	198	PF00082	0.325
CLV_PCSK_KEX2_1	317	319	PF00082	0.367
CLV_PCSK_KEX2_1	92	94	PF00082	0.655
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.394
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.304
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.580
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.374
CLV_PCSK_SKI1_1	107	111	PF00082	0.604
CLV_PCSK_SKI1_1	196	200	PF00082	0.406
CLV_PCSK_SKI1_1	416	420	PF00082	0.304
DEG_APCC_DBOX_1	243	251	PF00400	0.394
DEG_APCC_DBOX_1	493	501	PF00400	0.501
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DOC_CYCLIN_RxL_1	113	124	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.381
DOC_MAPK_DCC_7	197	207	PF00069	0.413
DOC_MAPK_gen_1	175	183	PF00069	0.425
DOC_PP1_RVXF_1	414	420	PF00149	0.304
DOC_PP4_FxxP_1	303	306	PF00568	0.304
DOC_USP7_MATH_1	446	450	PF00917	0.712
DOC_USP7_MATH_1	73	77	PF00917	0.639
DOC_USP7_MATH_1	87	91	PF00917	0.574
DOC_WW_Pin1_4	153	158	PF00397	0.320
DOC_WW_Pin1_4	189	194	PF00397	0.442
DOC_WW_Pin1_4	213	218	PF00397	0.338
DOC_WW_Pin1_4	46	51	PF00397	0.345
DOC_WW_Pin1_4	522	527	PF00397	0.353
DOC_WW_Pin1_4	65	70	PF00397	0.582
LIG_14-3-3_CanoR_1	161	169	PF00244	0.393
LIG_14-3-3_CanoR_1	186	192	PF00244	0.424
LIG_14-3-3_CanoR_1	197	205	PF00244	0.376
LIG_14-3-3_CanoR_1	262	268	PF00244	0.451
LIG_14-3-3_CanoR_1	42	51	PF00244	0.487
LIG_BRCT_BRCA1_1	239	243	PF00533	0.391
LIG_BRCT_BRCA1_1	263	267	PF00533	0.320
LIG_BRCT_BRCA1_1	477	481	PF00533	0.616
LIG_deltaCOP1_diTrp_1	329	339	PF00928	0.393
LIG_FHA_1	115	121	PF00498	0.529
LIG_FHA_1	143	149	PF00498	0.339
LIG_FHA_1	214	220	PF00498	0.322
LIG_FHA_1	224	230	PF00498	0.254
LIG_FHA_1	381	387	PF00498	0.320
LIG_FHA_1	418	424	PF00498	0.304
LIG_FHA_1	47	53	PF00498	0.383
LIG_FHA_2	19	25	PF00498	0.433
LIG_FHA_2	514	520	PF00498	0.553
LIG_LIR_Apic_2	68	73	PF02991	0.590
LIG_LIR_Gen_1	222	232	PF02991	0.304
LIG_LIR_Gen_1	24	34	PF02991	0.445
LIG_LIR_Gen_1	264	274	PF02991	0.361
LIG_LIR_Gen_1	358	365	PF02991	0.316
LIG_LIR_Gen_1	422	433	PF02991	0.316
LIG_LIR_Gen_1	489	497	PF02991	0.420
LIG_LIR_Gen_1	517	528	PF02991	0.482
LIG_LIR_Nem_3	222	227	PF02991	0.304
LIG_LIR_Nem_3	24	29	PF02991	0.421
LIG_LIR_Nem_3	264	270	PF02991	0.339
LIG_LIR_Nem_3	358	362	PF02991	0.304
LIG_LIR_Nem_3	422	428	PF02991	0.300
LIG_LIR_Nem_3	489	493	PF02991	0.454
LIG_LIR_Nem_3	517	523	PF02991	0.464
LIG_PCNA_yPIPBox_3	203	213	PF02747	0.395
LIG_Pex14_2	239	243	PF04695	0.359
LIG_SH2_CRK	70	74	PF00017	0.602
LIG_SH2_GRB2like	411	414	PF00017	0.413
LIG_SH2_STAP1	26	30	PF00017	0.414
LIG_SH2_STAP1	59	63	PF00017	0.556
LIG_SH2_STAT3	54	57	PF00017	0.409
LIG_SH2_STAT5	135	138	PF00017	0.361
LIG_SH2_STAT5	505	508	PF00017	0.379
LIG_SH2_STAT5	54	57	PF00017	0.435
LIG_SH2_STAT5	70	73	PF00017	0.683
LIG_SH3_3	342	348	PF00018	0.425
LIG_SUMO_SIM_par_1	145	152	PF11976	0.341
LIG_SUMO_SIM_par_1	382	387	PF11976	0.339
LIG_SUMO_SIM_par_1	403	409	PF11976	0.304
LIG_UBA3_1	301	309	PF00899	0.374
LIG_WRC_WIRS_1	165	170	PF05994	0.320
LIG_WRC_WIRS_1	224	229	PF05994	0.320
LIG_WRC_WIRS_1	487	492	PF05994	0.452
MOD_CDK_SPK_2	189	194	PF00069	0.451
MOD_CDK_SPxxK_3	153	160	PF00069	0.389
MOD_CDK_SPxxK_3	189	196	PF00069	0.451
MOD_CDK_SPxxK_3	65	72	PF00069	0.640
MOD_CK1_1	14	20	PF00069	0.516
MOD_CK1_1	167	173	PF00069	0.339
MOD_CK1_1	189	195	PF00069	0.446
MOD_CK1_1	431	437	PF00069	0.404
MOD_CK1_1	68	74	PF00069	0.630
MOD_CK2_1	167	173	PF00069	0.425
MOD_CK2_1	18	24	PF00069	0.452
MOD_CK2_1	189	195	PF00069	0.451
MOD_CK2_1	463	469	PF00069	0.600
MOD_CMANNOS	9	12	PF00535	0.397
MOD_GlcNHglycan	199	202	PF01048	0.399
MOD_GlcNHglycan	263	266	PF01048	0.425
MOD_GlcNHglycan	370	373	PF01048	0.440
MOD_GlcNHglycan	448	451	PF01048	0.687
MOD_GlcNHglycan	454	457	PF01048	0.628
MOD_GlcNHglycan	469	475	PF01048	0.516
MOD_GlcNHglycan	501	504	PF01048	0.501
MOD_GlcNHglycan	519	523	PF01048	0.402
MOD_GlcNHglycan	75	78	PF01048	0.637
MOD_GSK3_1	10	17	PF00069	0.474
MOD_GSK3_1	110	117	PF00069	0.643
MOD_GSK3_1	160	167	PF00069	0.367
MOD_GSK3_1	380	387	PF00069	0.367
MOD_GSK3_1	419	426	PF00069	0.429
MOD_GSK3_1	42	49	PF00069	0.490
MOD_GSK3_1	428	435	PF00069	0.375
MOD_GSK3_1	446	453	PF00069	0.631
MOD_GSK3_1	459	466	PF00069	0.725
MOD_GSK3_1	488	495	PF00069	0.287
MOD_GSK3_1	518	525	PF00069	0.325
MOD_N-GLC_1	393	398	PF02516	0.433
MOD_NEK2_1	181	186	PF00069	0.451
MOD_NEK2_1	248	253	PF00069	0.327
MOD_NEK2_1	417	422	PF00069	0.384
MOD_NEK2_1	428	433	PF00069	0.376
MOD_NEK2_1	488	493	PF00069	0.291
MOD_NEK2_1	518	523	PF00069	0.471
MOD_NEK2_1	85	90	PF00069	0.500
MOD_NEK2_2	87	92	PF00069	0.611
MOD_PIKK_1	181	187	PF00454	0.335
MOD_PKA_1	160	166	PF00069	0.389
MOD_PKA_1	186	192	PF00069	0.425
MOD_PKA_2	160	166	PF00069	0.367
MOD_PKA_2	186	192	PF00069	0.370
MOD_PKA_2	261	267	PF00069	0.451
MOD_PKB_1	40	48	PF00069	0.493
MOD_Plk_1	334	340	PF00069	0.361
MOD_Plk_1	429	435	PF00069	0.403
MOD_Plk_1	450	456	PF00069	0.685
MOD_Plk_1	518	524	PF00069	0.425
MOD_Plk_2-3	223	229	PF00069	0.304
MOD_Plk_2-3	463	469	PF00069	0.697
MOD_Plk_4	142	148	PF00069	0.281
MOD_Plk_4	164	170	PF00069	0.304
MOD_Plk_4	334	340	PF00069	0.322
MOD_Plk_4	380	386	PF00069	0.320
MOD_Plk_4	501	507	PF00069	0.536
MOD_ProDKin_1	153	159	PF00069	0.320
MOD_ProDKin_1	189	195	PF00069	0.442
MOD_ProDKin_1	213	219	PF00069	0.338
MOD_ProDKin_1	46	52	PF00069	0.342
MOD_ProDKin_1	522	528	PF00069	0.357
MOD_ProDKin_1	65	71	PF00069	0.590
TRG_DiLeu_BaEn_1	245	250	PF01217	0.276
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.359
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.357
TRG_ENDOCYTIC_2	26	29	PF00928	0.392
TRG_ER_diArg_1	104	107	PF00400	0.528
TRG_ER_diArg_1	186	188	PF00400	0.392
TRG_ER_diArg_1	316	318	PF00400	0.361
TRG_ER_diArg_1	40	43	PF00400	0.443
TRG_ER_diArg_1	493	496	PF00400	0.519
TRG_ER_diArg_1	6	9	PF00400	0.638
TRG_ER_diArg_1	91	93	PF00400	0.628
TRG_NLS_MonoExtN_4	157	164	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	27%	100%
A0A0N1I0J7	Leptomonas seymouri	65%	100%
A0A0S4J9H9	Bodo saltans	27%	100%
A0A0S4JPV5	Bodo saltans	43%	100%
A0A1X0NK74	Trypanosomatidae	28%	100%
A0A1X0NN10	Trypanosomatidae	47%	100%
A0A3R7K771	Trypanosoma rangeli	28%	100%
A0A3R7L848	Trypanosoma rangeli	47%	100%
A0A3S5H5L6	Leishmania donovani	30%	100%
A0A3S7XCB8	Leishmania donovani	92%	100%
A4H4F1	Leishmania braziliensis	28%	100%
A4HSM8	Leishmania infantum	31%	100%
A4ICB9	Leishmania infantum	92%	100%
D0A3Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AIY4	Leishmania braziliensis	80%	99%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P32317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P46441	Haematobia irritans	28%	100%
Q32PX9	Rattus norvegicus	31%	100%
Q3V384	Mus musculus	30%	100%
Q4Q076	Leishmania major	89%	99%
Q4QJ96	Leishmania major	30%	100%
Q5TYS0	Danio rerio	28%	100%
Q8WV93	Homo sapiens	29%	100%
V5BD25	Trypanosoma cruzi	47%	100%
V5D7E6	Trypanosoma cruzi	30%	100%