AP complex subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta adaptin, putative

Species:

Leishmania mexicana

UniProt:

E9AUB2_LEIMU

TriTrypDb:

LmxM.36.6770

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	10
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0030119	AP-type membrane coat adaptor complex	3	2
GO:0030131	clathrin adaptor complex	4	2

Expansion

Sequence features

E9AUB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUB2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0030276	clathrin binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	569	573	PF00656	0.489
CLV_NRD_NRD_1	13	15	PF00675	0.516
CLV_NRD_NRD_1	146	148	PF00675	0.300
CLV_NRD_NRD_1	156	158	PF00675	0.275
CLV_NRD_NRD_1	30	32	PF00675	0.368
CLV_NRD_NRD_1	416	418	PF00675	0.366
CLV_NRD_NRD_1	432	434	PF00675	0.198
CLV_NRD_NRD_1	47	49	PF00675	0.425
CLV_NRD_NRD_1	5	7	PF00675	0.475
CLV_PCSK_KEX2_1	146	148	PF00082	0.320
CLV_PCSK_KEX2_1	30	32	PF00082	0.558
CLV_PCSK_KEX2_1	308	310	PF00082	0.425
CLV_PCSK_KEX2_1	416	418	PF00082	0.295
CLV_PCSK_KEX2_1	54	56	PF00082	0.305
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.412
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.305
CLV_PCSK_SKI1_1	102	106	PF00082	0.394
CLV_PCSK_SKI1_1	355	359	PF00082	0.305
CLV_PCSK_SKI1_1	504	508	PF00082	0.305
CLV_PCSK_SKI1_1	546	550	PF00082	0.574
CLV_PCSK_SKI1_1	742	746	PF00082	0.455
CLV_Separin_Metazoa	143	147	PF03568	0.320
DEG_APCC_DBOX_1	492	500	PF00400	0.425
DEG_Nend_UBRbox_2	1	3	PF02207	0.512
DOC_CKS1_1	360	365	PF01111	0.321
DOC_CYCLIN_RxL_1	350	362	PF00134	0.320
DOC_CYCLIN_RxL_1	97	109	PF00134	0.451
DOC_MAPK_DCC_7	342	351	PF00069	0.305
DOC_MAPK_gen_1	157	164	PF00069	0.332
DOC_MAPK_gen_1	181	187	PF00069	0.425
DOC_MAPK_gen_1	350	360	PF00069	0.292
DOC_MAPK_gen_1	433	441	PF00069	0.299
DOC_MAPK_gen_1	85	92	PF00069	0.305
DOC_MAPK_HePTP_8	316	328	PF00069	0.305
DOC_MAPK_MEF2A_6	127	134	PF00069	0.305
DOC_MAPK_MEF2A_6	319	328	PF00069	0.305
DOC_MAPK_MEF2A_6	342	351	PF00069	0.295
DOC_MAPK_MEF2A_6	353	360	PF00069	0.283
DOC_MAPK_MEF2A_6	433	440	PF00069	0.339
DOC_MAPK_MEF2A_6	64	73	PF00069	0.353
DOC_MAPK_MEF2A_6	85	92	PF00069	0.339
DOC_MAPK_NFAT4_5	353	361	PF00069	0.305
DOC_MAPK_RevD_3	71	86	PF00069	0.305
DOC_PP4_FxxP_1	590	593	PF00568	0.434
DOC_PP4_FxxP_1	597	600	PF00568	0.470
DOC_PP4_FxxP_1	729	732	PF00568	0.483
DOC_USP7_MATH_1	263	267	PF00917	0.468
DOC_USP7_MATH_1	361	365	PF00917	0.368
DOC_USP7_MATH_1	391	395	PF00917	0.412
DOC_USP7_MATH_1	458	462	PF00917	0.296
DOC_USP7_MATH_1	593	597	PF00917	0.435
DOC_USP7_MATH_1	623	627	PF00917	0.741
DOC_USP7_MATH_1	658	662	PF00917	0.662
DOC_USP7_MATH_1	678	682	PF00917	0.423
DOC_USP7_MATH_1	693	697	PF00917	0.619
DOC_USP7_UBL2_3	20	24	PF12436	0.617
DOC_USP7_UBL2_3	50	54	PF12436	0.294
DOC_WW_Pin1_4	115	120	PF00397	0.305
DOC_WW_Pin1_4	359	364	PF00397	0.321
DOC_WW_Pin1_4	676	681	PF00397	0.666
DOC_WW_Pin1_4	684	689	PF00397	0.713
DOC_WW_Pin1_4	698	703	PF00397	0.701
DOC_WW_Pin1_4	74	79	PF00397	0.203
LIG_14-3-3_CanoR_1	133	138	PF00244	0.451
LIG_14-3-3_CanoR_1	157	164	PF00244	0.332
LIG_14-3-3_CanoR_1	264	272	PF00244	0.307
LIG_14-3-3_CanoR_1	286	292	PF00244	0.349
LIG_14-3-3_CanoR_1	294	298	PF00244	0.318
LIG_14-3-3_CanoR_1	342	346	PF00244	0.319
LIG_14-3-3_CanoR_1	592	598	PF00244	0.514
LIG_Actin_WH2_2	130	148	PF00022	0.320
LIG_Actin_WH2_2	344	361	PF00022	0.451
LIG_Actin_WH2_2	567	582	PF00022	0.470
LIG_AP2alpha_1	672	676	PF02296	0.695
LIG_AP2alpha_2	670	672	PF02296	0.687
LIG_BIR_III_4	637	641	PF00653	0.469
LIG_BRCT_BRCA1_1	22	26	PF00533	0.523
LIG_BRCT_BRCA1_1	66	70	PF00533	0.307
LIG_BRCT_BRCA1_1	686	690	PF00533	0.781
LIG_Clathr_ClatBox_1	438	442	PF01394	0.390
LIG_FHA_1	257	263	PF00498	0.390
LIG_FHA_1	294	300	PF00498	0.408
LIG_FHA_1	311	317	PF00498	0.205
LIG_FHA_1	32	38	PF00498	0.265
LIG_FHA_1	360	366	PF00498	0.458
LIG_FHA_1	583	589	PF00498	0.413
LIG_FHA_1	627	633	PF00498	0.720
LIG_FHA_1	93	99	PF00498	0.425
LIG_FHA_2	484	490	PF00498	0.393
LIG_FHA_2	524	530	PF00498	0.370
LIG_FHA_2	567	573	PF00498	0.502
LIG_FHA_2	602	608	PF00498	0.695
LIG_FHA_2	611	617	PF00498	0.731
LIG_FHA_2	78	84	PF00498	0.390
LIG_LIR_Apic_2	596	600	PF02991	0.482
LIG_LIR_Gen_1	345	356	PF02991	0.337
LIG_LIR_Gen_1	468	473	PF02991	0.305
LIG_LIR_Gen_1	642	648	PF02991	0.756
LIG_LIR_Gen_1	65	76	PF02991	0.307
LIG_LIR_Nem_3	337	343	PF02991	0.299
LIG_LIR_Nem_3	345	351	PF02991	0.305
LIG_LIR_Nem_3	372	376	PF02991	0.376
LIG_LIR_Nem_3	468	472	PF02991	0.305
LIG_LIR_Nem_3	642	646	PF02991	0.710
LIG_LIR_Nem_3	65	71	PF02991	0.323
LIG_LIR_Nem_3	670	675	PF02991	0.699
LIG_LYPXL_yS_3	435	438	PF13949	0.307
LIG_MAD2	555	563	PF02301	0.569
LIG_MLH1_MIPbox_1	22	26	PF16413	0.523
LIG_MYND_1	418	422	PF01753	0.320
LIG_NRBOX	183	189	PF00104	0.320
LIG_NRBOX	353	359	PF00104	0.320
LIG_Pex14_1	234	238	PF04695	0.362
LIG_Pex14_2	672	676	PF04695	0.695
LIG_SH2_NCK_1	343	347	PF00017	0.451
LIG_SH2_SRC	89	92	PF00017	0.305
LIG_SH2_STAT3	25	28	PF00017	0.638
LIG_SH2_STAT5	140	143	PF00017	0.305
LIG_SH2_STAT5	155	158	PF00017	0.305
LIG_SH2_STAT5	238	241	PF00017	0.421
LIG_SH2_STAT5	25	28	PF00017	0.621
LIG_SH2_STAT5	315	318	PF00017	0.316
LIG_SH2_STAT5	340	343	PF00017	0.299
LIG_SH2_STAT5	469	472	PF00017	0.425
LIG_SH2_STAT5	68	71	PF00017	0.362
LIG_SH2_STAT5	89	92	PF00017	0.292
LIG_SH3_3	146	152	PF00018	0.362
LIG_SH3_3	323	329	PF00018	0.305
LIG_SH3_3	696	702	PF00018	0.767
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.393
LIG_SUMO_SIM_par_1	103	109	PF11976	0.425
LIG_SUMO_SIM_par_1	437	442	PF11976	0.312
LIG_SUMO_SIM_par_1	519	526	PF11976	0.162
LIG_TRFH_1	140	144	PF08558	0.320
LIG_TYR_ITIM	66	71	PF00017	0.425
LIG_TYR_ITIM	87	92	PF00017	0.305
LIG_UBA3_1	303	308	PF00899	0.355
LIG_WRC_WIRS_1	107	112	PF05994	0.305
LIG_WRC_WIRS_1	594	599	PF05994	0.440
MOD_CDK_SPxxK_3	115	122	PF00069	0.305
MOD_CK1_1	253	259	PF00069	0.387
MOD_CK1_1	285	291	PF00069	0.398
MOD_CK1_1	582	588	PF00069	0.456
MOD_CK1_1	626	632	PF00069	0.677
MOD_CK1_1	679	685	PF00069	0.701
MOD_CK2_1	133	139	PF00069	0.324
MOD_CK2_1	213	219	PF00069	0.408
MOD_CK2_1	246	252	PF00069	0.374
MOD_CK2_1	483	489	PF00069	0.393
MOD_CK2_1	601	607	PF00069	0.449
MOD_CK2_1	678	684	PF00069	0.602
MOD_CK2_1	704	710	PF00069	0.705
MOD_CK2_1	77	83	PF00069	0.390
MOD_GlcNHglycan	252	255	PF01048	0.384
MOD_GlcNHglycan	377	380	PF01048	0.429
MOD_GlcNHglycan	499	502	PF01048	0.302
MOD_GlcNHglycan	647	651	PF01048	0.719
MOD_GlcNHglycan	660	663	PF01048	0.702
MOD_GlcNHglycan	676	679	PF01048	0.590
MOD_GlcNHglycan	693	696	PF01048	0.676
MOD_GlcNHglycan	706	709	PF01048	0.655
MOD_GlcNHglycan	718	721	PF01048	0.643
MOD_GlcNHglycan	733	736	PF01048	0.719
MOD_GSK3_1	111	118	PF00069	0.314
MOD_GSK3_1	16	23	PF00069	0.537
MOD_GSK3_1	246	253	PF00069	0.382
MOD_GSK3_1	298	305	PF00069	0.317
MOD_GSK3_1	542	549	PF00069	0.425
MOD_GSK3_1	568	575	PF00069	0.495
MOD_GSK3_1	646	653	PF00069	0.654
MOD_GSK3_1	674	681	PF00069	0.708
MOD_GSK3_1	698	705	PF00069	0.720
MOD_GSK3_1	716	723	PF00069	0.728
MOD_N-GLC_1	41	46	PF02516	0.364
MOD_N-GLC_1	58	63	PF02516	0.390
MOD_NEK2_1	111	116	PF00069	0.311
MOD_NEK2_1	16	21	PF00069	0.550
MOD_NEK2_1	26	31	PF00069	0.494
MOD_NEK2_1	483	488	PF00069	0.390
MOD_NEK2_1	579	584	PF00069	0.402
MOD_PIKK_1	285	291	PF00454	0.412
MOD_PIKK_1	310	316	PF00454	0.339
MOD_PIKK_1	626	632	PF00454	0.769
MOD_PIKK_1	693	699	PF00454	0.780
MOD_PIKK_1	718	724	PF00454	0.727
MOD_PIKK_1	736	742	PF00454	0.752
MOD_PK_1	133	139	PF00069	0.339
MOD_PKA_2	132	138	PF00069	0.368
MOD_PKA_2	156	162	PF00069	0.320
MOD_PKA_2	246	252	PF00069	0.395
MOD_PKA_2	263	269	PF00069	0.272
MOD_PKA_2	285	291	PF00069	0.383
MOD_PKA_2	293	299	PF00069	0.399
MOD_PKA_2	341	347	PF00069	0.319
MOD_PKA_2	736	742	PF00069	0.752
MOD_Plk_1	138	144	PF00069	0.294
MOD_Plk_1	566	572	PF00069	0.495
MOD_Plk_1	58	64	PF00069	0.337
MOD_Plk_2-3	509	515	PF00069	0.381
MOD_Plk_2-3	572	578	PF00069	0.459
MOD_Plk_2-3	610	616	PF00069	0.655
MOD_Plk_4	106	112	PF00069	0.295
MOD_Plk_4	133	139	PF00069	0.390
MOD_Plk_4	253	259	PF00069	0.358
MOD_Plk_4	458	464	PF00069	0.342
MOD_Plk_4	483	489	PF00069	0.419
MOD_Plk_4	593	599	PF00069	0.448
MOD_Plk_4	64	70	PF00069	0.362
MOD_ProDKin_1	115	121	PF00069	0.305
MOD_ProDKin_1	359	365	PF00069	0.321
MOD_ProDKin_1	676	682	PF00069	0.665
MOD_ProDKin_1	684	690	PF00069	0.716
MOD_ProDKin_1	698	704	PF00069	0.702
MOD_ProDKin_1	74	80	PF00069	0.203
MOD_SUMO_for_1	349	352	PF00179	0.305
MOD_SUMO_rev_2	17	21	PF00179	0.649
MOD_SUMO_rev_2	451	461	PF00179	0.292
MOD_SUMO_rev_2	572	582	PF00179	0.451
MOD_SUMO_rev_2	79	87	PF00179	0.425
TRG_AP2beta_CARGO_1	345	355	PF09066	0.451
TRG_DiLeu_BaEn_1	352	357	PF01217	0.305
TRG_DiLeu_BaEn_1	83	88	PF01217	0.305
TRG_DiLeu_BaEn_2	467	473	PF01217	0.305
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.305
TRG_DiLeu_LyEn_5	352	357	PF01217	0.320
TRG_ENDOCYTIC_2	435	438	PF00928	0.307
TRG_ENDOCYTIC_2	469	472	PF00928	0.425
TRG_ENDOCYTIC_2	540	543	PF00928	0.305
TRG_ENDOCYTIC_2	594	597	PF00928	0.440
TRG_ENDOCYTIC_2	643	646	PF00928	0.742
TRG_ENDOCYTIC_2	68	71	PF00928	0.340
TRG_ENDOCYTIC_2	89	92	PF00928	0.305
TRG_ER_diArg_1	145	147	PF00400	0.320
TRG_ER_diArg_1	416	418	PF00400	0.370
TRG_NES_CRM1_1	495	509	PF08389	0.408
TRG_NLS_Bipartite_1	30	52	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B0	Leptomonas seymouri	82%	100%
A0A0N1IC81	Leptomonas seymouri	27%	96%
A0A0S4IS43	Bodo saltans	32%	79%
A0A0S4J8G3	Bodo saltans	27%	100%
A0A0S4JSJ9	Bodo saltans	58%	76%
A0A0S4KGY6	Bodo saltans	26%	87%
A0A1X0NL72	Trypanosomatidae	65%	77%
A0A1X0NUY1	Trypanosomatidae	31%	81%
A0A1X0P0E5	Trypanosomatidae	27%	95%
A0A3Q8I939	Leishmania donovani	30%	75%
A0A3Q8IK57	Leishmania donovani	95%	100%
A0A3R7L5L0	Trypanosoma rangeli	30%	82%
A0A3S5IS14	Trypanosoma rangeli	59%	78%
A0A422NKG4	Trypanosoma rangeli	27%	96%
A4HQJ9	Leishmania braziliensis	84%	100%
A4HV08	Leishmania infantum	30%	75%
A4ICB7	Leishmania infantum	95%	100%
D0A3P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
D0A442	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
E9ANP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	75%
O00203	Homo sapiens	25%	68%
O13939	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O35643	Mus musculus	37%	79%
O43005	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O43079	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
O81742	Arabidopsis thaliana	35%	84%
P27351	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P36000	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P46682	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	92%
P52303	Rattus norvegicus	38%	79%
P62944	Rattus norvegicus	33%	80%
P63009	Bos taurus	33%	80%
P63010	Homo sapiens	33%	80%
Q08DS7	Bos taurus	37%	78%
Q10567	Homo sapiens	35%	79%
Q13367	Homo sapiens	27%	69%
Q32PG1	Bos taurus	25%	69%
Q4Q078	Leishmania major	94%	100%
Q4QGY0	Leishmania major	30%	75%
Q54R84	Dictyostelium discoideum	26%	89%
Q54X82	Dictyostelium discoideum	38%	79%
Q759E2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	96%
Q7YRF1	Canis lupus familiaris	25%	68%
Q9DBG3	Mus musculus	33%	80%
Q9JME5	Mus musculus	27%	69%
Q9LDK9	Arabidopsis thaliana	28%	89%
Q9SUS3	Arabidopsis thaliana	38%	83%
Q9WV76	Mus musculus	28%	100%
Q9Y6B7	Homo sapiens	28%	100%
Q9Z1T1	Mus musculus	25%	68%
V5BRU9	Trypanosoma cruzi	31%	82%
V5BTB0	Trypanosoma cruzi	26%	96%
V5DDV1	Trypanosoma cruzi	58%	78%