Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prolyl endopeptidase

Species:

Leishmania mexicana

UniProt:

E9AUB0_LEIMU

TriTrypDb:

LmxM.36.6750

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9AUB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUB0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0070012	oligopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.494
CLV_NRD_NRD_1	309	311	PF00675	0.278
CLV_NRD_NRD_1	358	360	PF00675	0.360
CLV_NRD_NRD_1	515	517	PF00675	0.291
CLV_PCSK_SKI1_1	10	14	PF00082	0.480
CLV_PCSK_SKI1_1	250	254	PF00082	0.194
CLV_PCSK_SKI1_1	482	486	PF00082	0.279
CLV_PCSK_SKI1_1	600	604	PF00082	0.200
DEG_Kelch_Keap1_1	157	162	PF01344	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DEG_SCF_FBW7_1	472	479	PF00400	0.317
DOC_CDC14_PxL_1	186	194	PF14671	0.495
DOC_CYCLIN_yClb5_NLxxxL_5	484	493	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.432
DOC_MAPK_gen_1	310	318	PF00069	0.465
DOC_MAPK_gen_1	368	374	PF00069	0.504
DOC_MAPK_gen_1	385	391	PF00069	0.437
DOC_MAPK_MEF2A_6	106	114	PF00069	0.511
DOC_MAPK_MEF2A_6	310	318	PF00069	0.521
DOC_MAPK_MEF2A_6	341	349	PF00069	0.495
DOC_MAPK_NFAT4_5	311	319	PF00069	0.425
DOC_PP1_RVXF_1	165	171	PF00149	0.521
DOC_PP1_RVXF_1	273	280	PF00149	0.619
DOC_PP1_RVXF_1	480	486	PF00149	0.296
DOC_PP2B_LxvP_1	226	229	PF13499	0.478
DOC_PP2B_LxvP_1	493	496	PF13499	0.318
DOC_PP2B_PxIxI_1	620	626	PF00149	0.318
DOC_PP4_FxxP_1	113	116	PF00568	0.465
DOC_PP4_FxxP_1	396	399	PF00568	0.465
DOC_PP4_FxxP_1	669	672	PF00568	0.432
DOC_USP7_MATH_1	399	403	PF00917	0.488
DOC_USP7_MATH_1	410	414	PF00917	0.478
DOC_USP7_MATH_1	636	640	PF00917	0.299
DOC_USP7_MATH_1	678	682	PF00917	0.316
DOC_USP7_MATH_1	73	77	PF00917	0.495
DOC_USP7_UBL2_3	603	607	PF12436	0.319
DOC_USP7_UBL2_3	671	675	PF12436	0.313
DOC_WW_Pin1_4	457	462	PF00397	0.346
DOC_WW_Pin1_4	472	477	PF00397	0.326
DOC_WW_Pin1_4	535	540	PF00397	0.330
DOC_WW_Pin1_4	606	611	PF00397	0.299
LIG_14-3-3_CanoR_1	10	16	PF00244	0.427
LIG_14-3-3_CanoR_1	101	106	PF00244	0.474
LIG_14-3-3_CanoR_1	65	72	PF00244	0.506
LIG_APCC_ABBA_1	345	350	PF00400	0.495
LIG_APCC_ABBA_1	414	419	PF00400	0.384
LIG_FHA_1	100	106	PF00498	0.552
LIG_FHA_1	109	115	PF00498	0.516
LIG_FHA_1	12	18	PF00498	0.432
LIG_FHA_1	122	128	PF00498	0.424
LIG_FHA_1	341	347	PF00498	0.490
LIG_FHA_1	520	526	PF00498	0.285
LIG_FHA_1	539	545	PF00498	0.299
LIG_FHA_1	65	71	PF00498	0.522
LIG_FHA_1	671	677	PF00498	0.301
LIG_FHA_1	678	684	PF00498	0.301
LIG_FHA_1	689	695	PF00498	0.299
LIG_FHA_2	19	25	PF00498	0.500
LIG_FHA_2	266	272	PF00498	0.543
LIG_FHA_2	318	324	PF00498	0.534
LIG_HCF-1_HBM_1	243	246	PF13415	0.546
LIG_LIR_Apic_2	111	116	PF02991	0.478
LIG_LIR_Apic_2	394	399	PF02991	0.465
LIG_LIR_Apic_2	591	596	PF02991	0.299
LIG_LIR_Gen_1	148	158	PF02991	0.477
LIG_LIR_Gen_1	24	32	PF02991	0.479
LIG_LIR_Gen_1	243	252	PF02991	0.482
LIG_LIR_Gen_1	278	287	PF02991	0.467
LIG_LIR_Gen_1	387	396	PF02991	0.560
LIG_LIR_Gen_1	428	437	PF02991	0.381
LIG_LIR_Gen_1	563	572	PF02991	0.432
LIG_LIR_Gen_1	681	688	PF02991	0.303
LIG_LIR_Nem_3	148	153	PF02991	0.454
LIG_LIR_Nem_3	24	29	PF02991	0.496
LIG_LIR_Nem_3	243	249	PF02991	0.482
LIG_LIR_Nem_3	278	282	PF02991	0.456
LIG_LIR_Nem_3	3	8	PF02991	0.444
LIG_LIR_Nem_3	378	384	PF02991	0.538
LIG_LIR_Nem_3	387	391	PF02991	0.497
LIG_LIR_Nem_3	428	433	PF02991	0.387
LIG_LIR_Nem_3	46	51	PF02991	0.512
LIG_LIR_Nem_3	563	568	PF02991	0.332
LIG_LIR_Nem_3	599	605	PF02991	0.320
LIG_LIR_Nem_3	606	611	PF02991	0.301
LIG_LYPXL_S_1	4	8	PF13949	0.398
LIG_LYPXL_yS_3	189	192	PF13949	0.495
LIG_LYPXL_yS_3	5	8	PF13949	0.424
LIG_LYPXL_yS_3	620	623	PF13949	0.299
LIG_PAM2_1	76	88	PF00658	0.560
LIG_PCNA_yPIPBox_3	245	253	PF02747	0.394
LIG_PCNA_yPIPBox_3	571	582	PF02747	0.313
LIG_Pex14_1	589	593	PF04695	0.299
LIG_REV1ctd_RIR_1	182	189	PF16727	0.465
LIG_SH2_CRK	290	294	PF00017	0.448
LIG_SH2_CRK	358	362	PF00017	0.511
LIG_SH2_CRK	608	612	PF00017	0.279
LIG_SH2_PTP2	152	155	PF00017	0.560
LIG_SH2_PTP2	430	433	PF00017	0.378
LIG_SH2_SRC	530	533	PF00017	0.413
LIG_SH2_STAP1	684	688	PF00017	0.318
LIG_SH2_STAT3	85	88	PF00017	0.480
LIG_SH2_STAT5	152	155	PF00017	0.524
LIG_SH2_STAT5	209	212	PF00017	0.565
LIG_SH2_STAT5	246	249	PF00017	0.495
LIG_SH2_STAT5	28	31	PF00017	0.524
LIG_SH2_STAT5	292	295	PF00017	0.464
LIG_SH2_STAT5	348	351	PF00017	0.470
LIG_SH2_STAT5	403	406	PF00017	0.521
LIG_SH2_STAT5	430	433	PF00017	0.387
LIG_SH2_STAT5	530	533	PF00017	0.413
LIG_SH2_STAT5	642	645	PF00017	0.299
LIG_SH3_3	226	232	PF00018	0.476
LIG_SH3_3	367	373	PF00018	0.394
LIG_SH3_3	615	621	PF00018	0.378
LIG_SH3_4	671	678	PF00018	0.299
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.495
LIG_SUMO_SIM_anti_2	342	348	PF11976	0.453
LIG_SUMO_SIM_par_1	622	627	PF11976	0.299
LIG_TRAF2_1	269	272	PF00917	0.480
LIG_TRAF2_1	320	323	PF00917	0.521
LIG_TRAF2_1	328	331	PF00917	0.521
LIG_TRAF2_1	596	599	PF00917	0.320
LIG_TYR_ITIM	618	623	PF00017	0.318
LIG_UBA3_1	260	265	PF00899	0.521
LIG_UBA3_1	313	317	PF00899	0.419
LIG_UBA3_1	345	353	PF00899	0.453
LIG_WRC_WIRS_1	283	288	PF05994	0.570
LIG_WRC_WIRS_1	388	393	PF05994	0.483
MOD_CDC14_SPxK_1	479	482	PF00782	0.354
MOD_CDK_SPxK_1	476	482	PF00069	0.354
MOD_CK1_1	174	180	PF00069	0.558
MOD_CK1_1	379	385	PF00069	0.476
MOD_CK1_1	455	461	PF00069	0.495
MOD_CK1_1	538	544	PF00069	0.318
MOD_CK1_1	76	82	PF00069	0.521
MOD_CK2_1	130	136	PF00069	0.470
MOD_CK2_1	139	145	PF00069	0.456
MOD_CK2_1	18	24	PF00069	0.495
MOD_CK2_1	265	271	PF00069	0.548
MOD_CK2_1	317	323	PF00069	0.466
MOD_CK2_1	51	57	PF00069	0.531
MOD_GlcNHglycan	119	122	PF01048	0.355
MOD_GlcNHglycan	173	176	PF01048	0.346
MOD_GlcNHglycan	203	206	PF01048	0.346
MOD_GlcNHglycan	422	425	PF01048	0.344
MOD_GlcNHglycan	438	441	PF01048	0.450
MOD_GSK3_1	117	124	PF00069	0.521
MOD_GSK3_1	126	133	PF00069	0.465
MOD_GSK3_1	141	148	PF00069	0.523
MOD_GSK3_1	302	309	PF00069	0.526
MOD_GSK3_1	375	382	PF00069	0.480
MOD_GSK3_1	387	394	PF00069	0.450
MOD_GSK3_1	436	443	PF00069	0.382
MOD_GSK3_1	470	477	PF00069	0.351
MOD_GSK3_1	535	542	PF00069	0.318
MOD_GSK3_1	72	79	PF00069	0.550
MOD_N-GLC_1	44	49	PF02516	0.274
MOD_N-GLC_1	94	99	PF02516	0.323
MOD_NEK2_1	139	144	PF00069	0.527
MOD_NEK2_1	391	396	PF00069	0.478
MOD_NEK2_1	470	475	PF00069	0.358
MOD_NEK2_1	545	550	PF00069	0.302
MOD_NEK2_1	99	104	PF00069	0.525
MOD_NEK2_2	412	417	PF00069	0.449
MOD_NEK2_2	636	641	PF00069	0.318
MOD_PKA_1	452	458	PF00069	0.468
MOD_PKA_2	100	106	PF00069	0.412
MOD_PKA_2	512	518	PF00069	0.432
MOD_PKA_2	64	70	PF00069	0.507
MOD_PKA_2	73	79	PF00069	0.458
MOD_Plk_1	238	244	PF00069	0.394
MOD_Plk_1	44	50	PF00069	0.394
MOD_Plk_1	52	58	PF00069	0.458
MOD_Plk_1	94	100	PF00069	0.495
MOD_Plk_4	108	114	PF00069	0.496
MOD_Plk_4	282	288	PF00069	0.502
MOD_Plk_4	296	302	PF00069	0.421
MOD_Plk_4	329	335	PF00069	0.477
MOD_Plk_4	340	346	PF00069	0.461
MOD_Plk_4	376	382	PF00069	0.490
MOD_Plk_4	392	398	PF00069	0.423
MOD_Plk_4	412	418	PF00069	0.262
MOD_Plk_4	94	100	PF00069	0.495
MOD_ProDKin_1	457	463	PF00069	0.341
MOD_ProDKin_1	472	478	PF00069	0.325
MOD_ProDKin_1	535	541	PF00069	0.330
MOD_ProDKin_1	606	612	PF00069	0.299
MOD_SUMO_rev_2	30	40	PF00179	0.495
MOD_SUMO_rev_2	319	326	PF00179	0.554
MOD_SUMO_rev_2	350	355	PF00179	0.465
MOD_SUMO_rev_2	592	602	PF00179	0.346
TRG_DiLeu_BaEn_2	35	41	PF01217	0.495
TRG_ENDOCYTIC_2	152	155	PF00928	0.560
TRG_ENDOCYTIC_2	189	192	PF00928	0.488
TRG_ENDOCYTIC_2	209	212	PF00928	0.378
TRG_ENDOCYTIC_2	246	249	PF00928	0.495
TRG_ENDOCYTIC_2	26	29	PF00928	0.478
TRG_ENDOCYTIC_2	290	293	PF00928	0.471
TRG_ENDOCYTIC_2	358	361	PF00928	0.495
TRG_ENDOCYTIC_2	430	433	PF00928	0.406
TRG_ENDOCYTIC_2	467	470	PF00928	0.322
TRG_ENDOCYTIC_2	5	8	PF00928	0.424
TRG_ENDOCYTIC_2	608	611	PF00928	0.288
TRG_ENDOCYTIC_2	620	623	PF00928	0.325
TRG_ENDOCYTIC_2	684	687	PF00928	0.299
TRG_ENDOCYTIC_2	86	89	PF00928	0.440
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	26%	95%
A0A0N0P803	Leptomonas seymouri	76%	100%
A0A0N1PDP3	Leptomonas seymouri	20%	80%
A0A0S4IIS9	Bodo saltans	59%	100%
A0A1X0NKN5	Trypanosomatidae	22%	76%
A0A1X0NLB6	Trypanosomatidae	63%	100%
A0A1X0NMH6	Trypanosomatidae	27%	97%
A0A3Q8IJI4	Leishmania donovani	90%	100%
A0A3S5H5P5	Leishmania donovani	21%	77%
A0A422N761	Trypanosoma rangeli	26%	98%
A4H4J9	Leishmania braziliensis	21%	100%
A4H5Q8	Leishmania braziliensis	24%	100%
A4HQJ7	Leishmania braziliensis	80%	100%
A4HSS5	Leishmania infantum	21%	77%
A4ICB5	Leishmania infantum	90%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	77%
D0A3P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D0A9G2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
E2JFG1	Amanita bisporigera	38%	92%
E2JFG2	Amanita bisporigera	36%	95%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	77%
H2E7Q7	Galerina marginata (strain CBS 339.88)	37%	94%
H2E7Q8	Galerina marginata (strain CBS 339.88)	35%	95%
O07834	Pseudoxanthomonas mexicana	27%	96%
O70196	Rattus norvegicus	43%	98%
P23687	Sus scrofa	43%	98%
P24555	Escherichia coli (strain K12)	24%	100%
P27028	Elizabethkingia meningoseptica	38%	99%
P27195	Elizabethkingia miricola	37%	99%
P48147	Homo sapiens	44%	98%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	21%	92%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	22%	99%
Q06903	Aeromonas hydrophila	39%	100%
Q4Q080	Leishmania major	89%	100%
Q4QJ45	Leishmania major	21%	100%
Q59536	Moraxella lacunata	25%	100%
Q86AS5	Dictyostelium discoideum	34%	92%
Q9QUR6	Mus musculus	44%	98%
Q9XTA2	Bos taurus	43%	98%
V5B5S3	Trypanosoma cruzi	22%	81%
V5B860	Trypanosoma cruzi	26%	97%
V5BM62	Trypanosoma cruzi	65%	100%