CULLIN_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUA8_LEIMU

TriTrypDb:

LmxM.36.6730

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	768	772	PF00656	0.638
CLV_NRD_NRD_1	29	31	PF00675	0.736
CLV_NRD_NRD_1	461	463	PF00675	0.691
CLV_NRD_NRD_1	548	550	PF00675	0.810
CLV_NRD_NRD_1	622	624	PF00675	0.658
CLV_NRD_NRD_1	816	818	PF00675	0.663
CLV_NRD_NRD_1	828	830	PF00675	0.420
CLV_NRD_NRD_1	833	835	PF00675	0.393
CLV_PCSK_KEX2_1	192	194	PF00082	0.694
CLV_PCSK_KEX2_1	29	31	PF00082	0.736
CLV_PCSK_KEX2_1	346	348	PF00082	0.835
CLV_PCSK_KEX2_1	400	402	PF00082	0.842
CLV_PCSK_KEX2_1	515	517	PF00082	0.785
CLV_PCSK_KEX2_1	548	550	PF00082	0.810
CLV_PCSK_KEX2_1	622	624	PF00082	0.658
CLV_PCSK_KEX2_1	827	829	PF00082	0.625
CLV_PCSK_KEX2_1	833	835	PF00082	0.586
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.694
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.835
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.842
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.785
CLV_PCSK_PC1ET2_1	833	835	PF00082	0.691
CLV_PCSK_PC7_1	829	835	PF00082	0.651
CLV_PCSK_SKI1_1	248	252	PF00082	0.643
CLV_PCSK_SKI1_1	282	286	PF00082	0.605
CLV_PCSK_SKI1_1	341	345	PF00082	0.842
CLV_PCSK_SKI1_1	346	350	PF00082	0.750
CLV_PCSK_SKI1_1	451	455	PF00082	0.648
CLV_PCSK_SKI1_1	549	553	PF00082	0.804
CLV_PCSK_SKI1_1	58	62	PF00082	0.686
CLV_PCSK_SKI1_1	699	703	PF00082	0.630
CLV_PCSK_SKI1_1	727	731	PF00082	0.618
CLV_PCSK_SKI1_1	75	79	PF00082	0.395
CLV_PCSK_SKI1_1	796	800	PF00082	0.664
CLV_PCSK_SKI1_1	817	821	PF00082	0.666
CLV_PCSK_SKI1_1	829	833	PF00082	0.417
DEG_APCC_DBOX_1	105	113	PF00400	0.674
DEG_APCC_DBOX_1	247	255	PF00400	0.641
DEG_APCC_DBOX_1	548	556	PF00400	0.806
DEG_APCC_DBOX_1	763	771	PF00400	0.623
DEG_MDM2_SWIB_1	260	268	PF02201	0.616
DEG_SPOP_SBC_1	128	132	PF00917	0.793
DOC_CKS1_1	316	321	PF01111	0.856
DOC_CKS1_1	652	657	PF01111	0.656
DOC_CYCLIN_RxL_1	447	458	PF00134	0.646
DOC_CYCLIN_RxL_1	70	82	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	730	736	PF00134	0.590
DOC_MAPK_gen_1	387	394	PF00069	0.692
DOC_MAPK_gen_1	681	688	PF00069	0.620
DOC_MAPK_gen_1	99	109	PF00069	0.675
DOC_MAPK_MEF2A_6	222	229	PF00069	0.621
DOC_MAPK_MEF2A_6	643	651	PF00069	0.569
DOC_MAPK_MEF2A_6	727	736	PF00069	0.604
DOC_MAPK_MEF2A_6	792	799	PF00069	0.657
DOC_MAPK_NFAT4_5	222	230	PF00069	0.622
DOC_MAPK_NFAT4_5	792	800	PF00069	0.659
DOC_PP1_RVXF_1	714	720	PF00149	0.574
DOC_PP1_RVXF_1	794	800	PF00149	0.656
DOC_PP2B_LxvP_1	730	733	PF13499	0.593
DOC_PP2B_LxvP_1	756	759	PF13499	0.652
DOC_PP4_FxxP_1	701	704	PF00568	0.638
DOC_USP7_MATH_1	312	316	PF00917	0.820
DOC_USP7_MATH_1	322	326	PF00917	0.707
DOC_USP7_MATH_1	33	37	PF00917	0.746
DOC_USP7_MATH_1	332	336	PF00917	0.503
DOC_USP7_MATH_1	438	442	PF00917	0.635
DOC_USP7_MATH_1	518	522	PF00917	0.826
DOC_USP7_MATH_1	803	807	PF00917	0.617
DOC_USP7_UBL2_3	352	356	PF12436	0.855
DOC_WW_Pin1_4	315	320	PF00397	0.852
DOC_WW_Pin1_4	330	335	PF00397	0.597
DOC_WW_Pin1_4	410	415	PF00397	0.838
DOC_WW_Pin1_4	497	502	PF00397	0.652
DOC_WW_Pin1_4	532	537	PF00397	0.857
DOC_WW_Pin1_4	651	656	PF00397	0.635
DOC_WW_Pin1_4	658	663	PF00397	0.674
DOC_WW_Pin1_4	810	815	PF00397	0.657
LIG_14-3-3_CanoR_1	178	184	PF00244	0.638
LIG_14-3-3_CanoR_1	436	446	PF00244	0.637
LIG_14-3-3_CanoR_1	548	552	PF00244	0.813
LIG_14-3-3_CanoR_1	66	73	PF00244	0.671
LIG_14-3-3_CanoR_1	660	666	PF00244	0.804
LIG_14-3-3_CanoR_1	683	687	PF00244	0.617
LIG_14-3-3_CanoR_1	764	768	PF00244	0.629
LIG_14-3-3_CanoR_1	87	95	PF00244	0.702
LIG_Actin_WH2_2	229	245	PF00022	0.615
LIG_Actin_WH2_2	439	457	PF00022	0.639
LIG_Actin_WH2_2	763	779	PF00022	0.623
LIG_APCC_ABBA_1	110	115	PF00400	0.684
LIG_APCC_ABBA_1	702	707	PF00400	0.643
LIG_BIR_III_2	331	335	PF00653	0.858
LIG_BIR_III_4	230	234	PF00653	0.612
LIG_CaM_IQ_9	94	110	PF13499	0.680
LIG_Clathr_ClatBox_1	599	603	PF01394	0.609
LIG_deltaCOP1_diTrp_1	23	31	PF00928	0.720
LIG_eIF4E_1	705	711	PF01652	0.631
LIG_FHA_1	168	174	PF00498	0.628
LIG_FHA_1	213	219	PF00498	0.656
LIG_FHA_1	271	277	PF00498	0.597
LIG_FHA_1	383	389	PF00498	0.655
LIG_FHA_1	438	444	PF00498	0.633
LIG_FHA_1	497	503	PF00498	0.646
LIG_FHA_1	507	513	PF00498	0.490
LIG_FHA_1	635	641	PF00498	0.624
LIG_FHA_1	683	689	PF00498	0.629
LIG_FHA_1	92	98	PF00498	0.695
LIG_FHA_2	151	157	PF00498	0.638
LIG_FHA_2	179	185	PF00498	0.632
LIG_FHA_2	464	470	PF00498	0.668
LIG_FHA_2	622	628	PF00498	0.653
LIG_FHA_2	719	725	PF00498	0.594
LIG_LIR_Apic_2	698	704	PF02991	0.643
LIG_LIR_Gen_1	153	162	PF02991	0.637
LIG_LIR_Gen_1	16	27	PF02991	0.728
LIG_LIR_Gen_1	165	173	PF02991	0.416
LIG_LIR_Gen_1	40	48	PF02991	0.738
LIG_LIR_Gen_1	508	518	PF02991	0.720
LIG_LIR_Gen_1	594	602	PF02991	0.614
LIG_LIR_Gen_1	626	634	PF02991	0.637
LIG_LIR_Gen_1	712	722	PF02991	0.577
LIG_LIR_Gen_1	804	815	PF02991	0.637
LIG_LIR_Nem_3	153	157	PF02991	0.638
LIG_LIR_Nem_3	40	44	PF02991	0.743
LIG_LIR_Nem_3	508	513	PF02991	0.665
LIG_LIR_Nem_3	594	599	PF02991	0.619
LIG_LIR_Nem_3	626	632	PF02991	0.637
LIG_LIR_Nem_3	641	645	PF02991	0.303
LIG_LIR_Nem_3	712	717	PF02991	0.583
LIG_LIR_Nem_3	804	810	PF02991	0.614
LIG_MYND_1	700	704	PF01753	0.637
LIG_NRBOX	675	681	PF00104	0.620
LIG_Pex14_1	719	723	PF04695	0.577
LIG_Pex14_2	204	208	PF04695	0.622
LIG_Pex14_2	260	264	PF04695	0.618
LIG_PTAP_UEV_1	413	418	PF05743	0.791
LIG_REV1ctd_RIR_1	829	835	PF16727	0.651
LIG_SH2_CRK	714	718	PF00017	0.573
LIG_SH2_NCK_1	180	184	PF00017	0.635
LIG_SH2_NCK_1	45	49	PF00017	0.741
LIG_SH2_NCK_1	607	611	PF00017	0.640
LIG_SH2_SRC	607	610	PF00017	0.629
LIG_SH2_STAP1	158	162	PF00017	0.637
LIG_SH2_STAP1	607	611	PF00017	0.640
LIG_SH2_STAT5	113	116	PF00017	0.689
LIG_SH2_STAT5	180	183	PF00017	0.634
LIG_SH2_STAT5	283	286	PF00017	0.601
LIG_SH2_STAT5	488	491	PF00017	0.636
LIG_SH2_STAT5	705	708	PF00017	0.649
LIG_SH3_1	116	122	PF00018	0.701
LIG_SH3_3	116	122	PF00018	0.701
LIG_SH3_3	306	312	PF00018	0.781
LIG_SH3_3	316	322	PF00018	0.685
LIG_SH3_3	411	417	PF00018	0.814
LIG_SH3_3	694	700	PF00018	0.640
LIG_SUMO_SIM_anti_2	471	477	PF11976	0.667
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.672
LIG_SUMO_SIM_anti_2	597	606	PF11976	0.607
LIG_SUMO_SIM_par_1	108	115	PF11976	0.683
LIG_SUMO_SIM_par_1	597	606	PF11976	0.607
LIG_TRAF2_1	624	627	PF00917	0.663
LIG_TRAF2_1	806	809	PF00917	0.622
LIG_UBA3_1	420	427	PF00899	0.683
LIG_UBA3_1	577	582	PF00899	0.599
LIG_WRC_WIRS_1	151	156	PF05994	0.634
LIG_WRC_WIRS_1	289	294	PF05994	0.630
LIG_WRC_WIRS_1	629	634	PF05994	0.631
LIG_WW_3	516	520	PF00397	0.809
MOD_CDK_SPxK_1	315	321	PF00069	0.855
MOD_CDK_SPxK_1	534	540	PF00069	0.858
MOD_CDK_SPxxK_3	810	817	PF00069	0.654
MOD_CK1_1	132	138	PF00069	0.776
MOD_CK1_1	167	173	PF00069	0.628
MOD_CK1_1	182	188	PF00069	0.375
MOD_CK1_1	210	216	PF00069	0.648
MOD_CK1_1	256	262	PF00069	0.655
MOD_CK1_1	315	321	PF00069	0.855
MOD_CK1_1	335	341	PF00069	0.505
MOD_CK1_1	382	388	PF00069	0.649
MOD_CK1_1	406	412	PF00069	0.867
MOD_CK1_1	550	556	PF00069	0.800
MOD_CK2_1	178	184	PF00069	0.638
MOD_CK2_1	339	345	PF00069	0.846
MOD_CK2_1	463	469	PF00069	0.671
MOD_CK2_1	523	529	PF00069	0.857
MOD_CK2_1	621	627	PF00069	0.660
MOD_CK2_1	7	13	PF00069	0.760
MOD_CK2_1	763	769	PF00069	0.628
MOD_CK2_1	803	809	PF00069	0.628
MOD_CK2_1	86	92	PF00069	0.705
MOD_Cter_Amidation	513	516	PF01082	0.735
MOD_Cter_Amidation	815	818	PF01082	0.670
MOD_GlcNHglycan	131	134	PF01048	0.792
MOD_GlcNHglycan	326	329	PF01048	0.883
MOD_GlcNHglycan	337	340	PF01048	0.661
MOD_GlcNHglycan	403	406	PF01048	0.866
MOD_GlcNHglycan	408	411	PF01048	0.777
MOD_GlcNHglycan	423	426	PF01048	0.319
MOD_GlcNHglycan	616	619	PF01048	0.733
MOD_GlcNHglycan	663	666	PF01048	0.806
MOD_GlcNHglycan	756	759	PF01048	0.652
MOD_GlcNHglycan	82	86	PF01048	0.691
MOD_GSK3_1	124	131	PF00069	0.764
MOD_GSK3_1	158	165	PF00069	0.636
MOD_GSK3_1	178	185	PF00069	0.288
MOD_GSK3_1	207	214	PF00069	0.645
MOD_GSK3_1	250	257	PF00069	0.652
MOD_GSK3_1	311	318	PF00069	0.819
MOD_GSK3_1	33	40	PF00069	0.738
MOD_GSK3_1	330	337	PF00069	0.525
MOD_GSK3_1	347	354	PF00069	0.550
MOD_GSK3_1	406	413	PF00069	0.862
MOD_GSK3_1	532	539	PF00069	0.858
MOD_GSK3_1	614	621	PF00069	0.716
MOD_GSK3_1	654	661	PF00069	0.740
MOD_NEK2_1	124	129	PF00069	0.754
MOD_NEK2_1	250	255	PF00069	0.645
MOD_NEK2_1	323	328	PF00069	0.882
MOD_NEK2_1	421	426	PF00069	0.671
MOD_NEK2_1	468	473	PF00069	0.667
MOD_NEK2_1	505	510	PF00069	0.659
MOD_NEK2_1	531	536	PF00069	0.860
MOD_NEK2_1	7	12	PF00069	0.761
MOD_NEK2_1	71	76	PF00069	0.687
MOD_NEK2_1	718	723	PF00069	0.575
MOD_NEK2_1	776	781	PF00069	0.621
MOD_NEK2_1	798	803	PF00069	0.671
MOD_NEK2_1	91	96	PF00069	0.347
MOD_NEK2_2	339	344	PF00069	0.848
MOD_PIKK_1	182	188	PF00454	0.637
MOD_PIKK_1	518	524	PF00454	0.832
MOD_PKA_1	346	352	PF00069	0.843
MOD_PKA_2	346	352	PF00069	0.843
MOD_PKA_2	518	524	PF00069	0.832
MOD_PKA_2	547	553	PF00069	0.813
MOD_PKA_2	621	627	PF00069	0.660
MOD_PKA_2	682	688	PF00069	0.616
MOD_PKA_2	71	77	PF00069	0.689
MOD_PKA_2	763	769	PF00069	0.628
MOD_PKA_2	86	92	PF00069	0.442
MOD_Plk_1	158	164	PF00069	0.642
MOD_Plk_1	468	474	PF00069	0.670
MOD_Plk_1	672	678	PF00069	0.646
MOD_Plk_1	7	13	PF00069	0.760
MOD_Plk_1	91	97	PF00069	0.698
MOD_Plk_2-3	8	14	PF00069	0.754
MOD_Plk_4	124	130	PF00069	0.762
MOD_Plk_4	256	262	PF00069	0.655
MOD_Plk_4	263	269	PF00069	0.488
MOD_Plk_4	416	422	PF00069	0.730
MOD_Plk_4	468	474	PF00069	0.670
MOD_Plk_4	718	724	PF00069	0.580
MOD_ProDKin_1	315	321	PF00069	0.855
MOD_ProDKin_1	330	336	PF00069	0.596
MOD_ProDKin_1	410	416	PF00069	0.830
MOD_ProDKin_1	497	503	PF00069	0.646
MOD_ProDKin_1	532	538	PF00069	0.858
MOD_ProDKin_1	651	657	PF00069	0.645
MOD_ProDKin_1	658	664	PF00069	0.677
MOD_ProDKin_1	810	816	PF00069	0.651
TRG_DiLeu_BaEn_1	105	110	PF01217	0.666
TRG_DiLeu_BaEn_1	246	251	PF01217	0.633
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.603
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.664
TRG_ENDOCYTIC_2	180	183	PF00928	0.634
TRG_ENDOCYTIC_2	714	717	PF00928	0.575
TRG_ER_diArg_1	106	109	PF00400	0.669
TRG_ER_diArg_1	29	31	PF00400	0.736
TRG_ER_diArg_1	464	467	PF00400	0.670
TRG_ER_diArg_1	622	625	PF00400	0.656
TRG_ER_diArg_1	826	829	PF00400	0.621
TRG_NES_CRM1_1	592	606	PF08389	0.609
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.736
TRG_Pf-PMV_PEXEL_1	451	456	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.693