Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUA6_LEIMU

TriTrypDb:

LmxM.36.6700

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.647
CLV_C14_Caspase3-7	6	10	PF00656	0.548
CLV_NRD_NRD_1	367	369	PF00675	0.573
CLV_NRD_NRD_1	395	397	PF00675	0.610
CLV_NRD_NRD_1	84	86	PF00675	0.433
CLV_PCSK_FUR_1	82	86	PF00082	0.460
CLV_PCSK_KEX2_1	288	290	PF00082	0.455
CLV_PCSK_KEX2_1	332	334	PF00082	0.287
CLV_PCSK_KEX2_1	353	355	PF00082	0.619
CLV_PCSK_KEX2_1	395	397	PF00082	0.607
CLV_PCSK_KEX2_1	82	84	PF00082	0.423
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.455
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.317
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.645
CLV_PCSK_SKI1_1	188	192	PF00082	0.453
CLV_PCSK_SKI1_1	220	224	PF00082	0.410
CLV_PCSK_SKI1_1	71	75	PF00082	0.423
DEG_SCF_FBW7_1	435	441	PF00400	0.449
DEG_SPOP_SBC_1	208	212	PF00917	0.629
DEG_SPOP_SBC_1	280	284	PF00917	0.612
DOC_CDC14_PxL_1	252	260	PF14671	0.597
DOC_CKS1_1	407	412	PF01111	0.451
DOC_CKS1_1	435	440	PF01111	0.449
DOC_CYCLIN_RxL_1	182	195	PF00134	0.572
DOC_CYCLIN_RxL_1	390	402	PF00134	0.422
DOC_CYCLIN_RxL_1	458	469	PF00134	0.594
DOC_MAPK_DCC_7	250	260	PF00069	0.572
DOC_MAPK_MEF2A_6	108	116	PF00069	0.420
DOC_MAPK_MEF2A_6	144	151	PF00069	0.530
DOC_PP1_RVXF_1	393	400	PF00149	0.412
DOC_PP2B_LxvP_1	137	140	PF13499	0.580
DOC_USP7_MATH_1	107	111	PF00917	0.572
DOC_USP7_MATH_1	234	238	PF00917	0.645
DOC_USP7_MATH_1	264	268	PF00917	0.684
DOC_USP7_MATH_1	270	274	PF00917	0.738
DOC_USP7_MATH_1	276	280	PF00917	0.732
DOC_USP7_MATH_1	319	323	PF00917	0.756
DOC_USP7_MATH_1	438	442	PF00917	0.441
DOC_USP7_MATH_1	44	48	PF00917	0.637
DOC_WW_Pin1_4	122	127	PF00397	0.438
DOC_WW_Pin1_4	406	411	PF00397	0.455
DOC_WW_Pin1_4	434	439	PF00397	0.449
DOC_WW_Pin1_4	88	93	PF00397	0.647
LIG_14-3-3_CanoR_1	108	116	PF00244	0.420
LIG_14-3-3_CanoR_1	144	148	PF00244	0.580
LIG_14-3-3_CanoR_1	333	343	PF00244	0.344
LIG_14-3-3_CanoR_1	443	448	PF00244	0.641
LIG_14-3-3_CanoR_1	71	79	PF00244	0.575
LIG_14-3-3_CanoR_1	83	89	PF00244	0.623
LIG_Actin_WH2_2	145	160	PF00022	0.554
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BRCT_BRCA1_1	159	163	PF00533	0.546
LIG_deltaCOP1_diTrp_1	178	184	PF00928	0.437
LIG_eIF4E_1	72	78	PF01652	0.483
LIG_FHA_1	144	150	PF00498	0.560
LIG_FHA_1	208	214	PF00498	0.627
LIG_FHA_1	28	34	PF00498	0.540
LIG_FHA_1	282	288	PF00498	0.581
LIG_FHA_1	324	330	PF00498	0.580
LIG_FHA_1	407	413	PF00498	0.458
LIG_FHA_1	417	423	PF00498	0.366
LIG_FHA_1	435	441	PF00498	0.288
LIG_FHA_1	72	78	PF00498	0.562
LIG_FHA_2	280	286	PF00498	0.661
LIG_FHA_2	416	422	PF00498	0.419
LIG_FHA_2	89	95	PF00498	0.609
LIG_GBD_Chelix_1	459	467	PF00786	0.390
LIG_GLEBS_BUB3_1	123	131	PF00400	0.588
LIG_LIR_Gen_1	16	25	PF02991	0.519
LIG_LIR_Gen_1	466	473	PF02991	0.662
LIG_LIR_LC3C_4	111	116	PF02991	0.614
LIG_LIR_Nem_3	16	21	PF02991	0.510
LIG_LIR_Nem_3	224	229	PF02991	0.584
LIG_LIR_Nem_3	466	471	PF02991	0.650
LIG_PDZ_Class_2	468	473	PF00595	0.573
LIG_Pex14_1	132	136	PF04695	0.629
LIG_Pex14_2	163	167	PF04695	0.535
LIG_Pex14_2	295	299	PF04695	0.638
LIG_Rb_pABgroove_1	395	403	PF01858	0.397
LIG_SH2_CRK	165	169	PF00017	0.630
LIG_SH2_CRK	252	256	PF00017	0.593
LIG_SH2_CRK	336	340	PF00017	0.413
LIG_SH2_PTP2	18	21	PF00017	0.511
LIG_SH2_STAP1	336	340	PF00017	0.363
LIG_SH2_STAP1	401	405	PF00017	0.393
LIG_SH2_STAT5	136	139	PF00017	0.649
LIG_SH2_STAT5	18	21	PF00017	0.509
LIG_SH2_STAT5	36	39	PF00017	0.466
LIG_SH2_STAT5	426	429	PF00017	0.413
LIG_SH2_STAT5	59	62	PF00017	0.511
LIG_SH2_STAT5	72	75	PF00017	0.528
LIG_SH3_3	18	24	PF00018	0.569
LIG_SUMO_SIM_par_1	256	261	PF11976	0.610
LIG_SUMO_SIM_par_1	30	35	PF11976	0.641
LIG_TRAF2_1	125	128	PF00917	0.649
LIG_TRFH_1	468	472	PF08558	0.453
LIG_TYR_ITIM	334	339	PF00017	0.413
LIG_WW_1	370	373	PF00397	0.573
MOD_CK1_1	201	207	PF00069	0.771
MOD_CK1_1	238	244	PF00069	0.481
MOD_CK1_1	27	33	PF00069	0.409
MOD_CK1_1	279	285	PF00069	0.681
MOD_CK1_1	61	67	PF00069	0.584
MOD_CK2_1	122	128	PF00069	0.583
MOD_CK2_1	172	178	PF00069	0.273
MOD_CK2_1	211	217	PF00069	0.580
MOD_CK2_1	88	94	PF00069	0.549
MOD_CK2_1	95	101	PF00069	0.455
MOD_GlcNHglycan	15	18	PF01048	0.362
MOD_GlcNHglycan	213	216	PF01048	0.592
MOD_GlcNHglycan	26	29	PF01048	0.378
MOD_GlcNHglycan	266	269	PF01048	0.604
MOD_GlcNHglycan	272	275	PF01048	0.687
MOD_GlcNHglycan	278	281	PF01048	0.622
MOD_GlcNHglycan	311	314	PF01048	0.682
MOD_GlcNHglycan	316	319	PF01048	0.654
MOD_GlcNHglycan	321	324	PF01048	0.428
MOD_GlcNHglycan	336	339	PF01048	0.280
MOD_GlcNHglycan	364	367	PF01048	0.668
MOD_GlcNHglycan	385	388	PF01048	0.537
MOD_GlcNHglycan	46	49	PF01048	0.329
MOD_GlcNHglycan	60	63	PF01048	0.420
MOD_GSK3_1	207	214	PF00069	0.681
MOD_GSK3_1	224	231	PF00069	0.400
MOD_GSK3_1	23	30	PF00069	0.426
MOD_GSK3_1	234	241	PF00069	0.505
MOD_GSK3_1	276	283	PF00069	0.631
MOD_GSK3_1	319	326	PF00069	0.599
MOD_GSK3_1	434	441	PF00069	0.351
MOD_GSK3_1	84	91	PF00069	0.610
MOD_NEK2_1	131	136	PF00069	0.505
MOD_NEK2_1	157	162	PF00069	0.448
MOD_NEK2_1	235	240	PF00069	0.439
MOD_NEK2_1	314	319	PF00069	0.753
MOD_NEK2_1	334	339	PF00069	0.388
MOD_NEK2_1	385	390	PF00069	0.470
MOD_NEK2_1	415	420	PF00069	0.560
MOD_NEK2_1	463	468	PF00069	0.543
MOD_NEK2_1	8	13	PF00069	0.510
MOD_NEK2_1	95	100	PF00069	0.504
MOD_PIKK_1	438	444	PF00454	0.560
MOD_PKA_1	84	90	PF00069	0.519
MOD_PKA_2	107	113	PF00069	0.263
MOD_PKA_2	143	149	PF00069	0.405
MOD_PKA_2	157	163	PF00069	0.498
MOD_PKA_2	84	90	PF00069	0.519
MOD_PKB_1	82	90	PF00069	0.626
MOD_Plk_1	201	207	PF00069	0.688
MOD_Plk_1	461	467	PF00069	0.528
MOD_Plk_1	8	14	PF00069	0.440
MOD_Plk_2-3	172	178	PF00069	0.262
MOD_Plk_4	143	149	PF00069	0.511
MOD_Plk_4	172	178	PF00069	0.435
MOD_Plk_4	235	241	PF00069	0.431
MOD_Plk_4	28	34	PF00069	0.327
MOD_Plk_4	323	329	PF00069	0.520
MOD_Plk_4	463	469	PF00069	0.566
MOD_Plk_4	8	14	PF00069	0.480
MOD_Plk_4	95	101	PF00069	0.464
MOD_ProDKin_1	122	128	PF00069	0.277
MOD_ProDKin_1	406	412	PF00069	0.576
MOD_ProDKin_1	434	440	PF00069	0.449
MOD_ProDKin_1	88	94	PF00069	0.564
MOD_SUMO_rev_2	365	371	PF00179	0.438
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.461
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.361
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.522
TRG_ENDOCYTIC_2	165	168	PF00928	0.534
TRG_ENDOCYTIC_2	18	21	PF00928	0.377
TRG_ENDOCYTIC_2	252	255	PF00928	0.485
TRG_ENDOCYTIC_2	336	339	PF00928	0.363
TRG_ENDOCYTIC_2	401	404	PF00928	0.371
TRG_ER_diArg_1	394	396	PF00400	0.525
TRG_ER_diArg_1	82	85	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR4	Leptomonas seymouri	66%	98%
A0A0S4ISX7	Bodo saltans	27%	98%
A0A1X0NN06	Trypanosomatidae	44%	100%
A0A3Q8IM62	Leishmania donovani	93%	100%
A0A3R7MQC3	Trypanosoma rangeli	44%	100%
A4HQJ3	Leishmania braziliensis	83%	100%
D0A3P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AI02	Leishmania infantum	93%	100%
Q4Q085	Leishmania major	92%	100%
V5BHM6	Trypanosoma cruzi	42%	100%