Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AUA3_LEIMU

TriTrypDb:

LmxM.36.6670

Length:

146

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0012505	endomembrane system	2	3
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AUA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.574
CLV_PCSK_KEX2_1	9	11	PF00082	0.533
CLV_PCSK_SKI1_1	142	146	PF00082	0.491
CLV_PCSK_SKI1_1	24	28	PF00082	0.580
CLV_PCSK_SKI1_1	35	39	PF00082	0.349
DOC_MAPK_MEF2A_6	124	132	PF00069	0.486
DOC_PP2B_PxIxI_1	125	131	PF00149	0.218
DOC_PP4_FxxP_1	70	73	PF00568	0.307
DOC_USP7_MATH_1	73	77	PF00917	0.326
DOC_USP7_UBL2_3	120	124	PF12436	0.367
DOC_USP7_UBL2_3	27	31	PF12436	0.575
DOC_WW_Pin1_4	104	109	PF00397	0.367
DOC_WW_Pin1_4	48	53	PF00397	0.197
LIG_14-3-3_CanoR_1	110	115	PF00244	0.167
LIG_BIR_II_1	1	5	PF00653	0.428
LIG_deltaCOP1_diTrp_1	115	121	PF00928	0.282
LIG_FHA_2	16	22	PF00498	0.436
LIG_FHA_2	36	42	PF00498	0.305
LIG_LIR_Gen_1	51	62	PF02991	0.332
LIG_LIR_Gen_1	76	85	PF02991	0.379
LIG_LIR_Nem_3	122	128	PF02991	0.370
LIG_LIR_Nem_3	2	6	PF02991	0.566
LIG_LIR_Nem_3	51	57	PF02991	0.390
LIG_LIR_Nem_3	76	80	PF02991	0.347
LIG_LYPXL_yS_3	125	128	PF13949	0.348
LIG_Pex14_1	117	121	PF04695	0.244
LIG_SH2_CRK	54	58	PF00017	0.409
LIG_SH2_STAP1	77	81	PF00017	0.408
LIG_SH2_STAT3	138	141	PF00017	0.453
LIG_SH3_3	127	133	PF00018	0.261
LIG_TRAF2_1	13	16	PF00917	0.456
LIG_TRAF2_1	95	98	PF00917	0.324
LIG_WRC_WIRS_1	34	39	PF05994	0.507
MOD_CDK_SPxK_1	104	110	PF00069	0.134
MOD_CK1_1	2	8	PF00069	0.545
MOD_CK2_1	10	16	PF00069	0.675
MOD_CK2_1	110	116	PF00069	0.390
MOD_CK2_1	35	41	PF00069	0.311
MOD_CK2_1	92	98	PF00069	0.262
MOD_CMANNOS	4	7	PF00535	0.422
MOD_GSK3_1	43	50	PF00069	0.270
MOD_N-GLC_1	48	53	PF02516	0.200
MOD_PKA_2	8	14	PF00069	0.654
MOD_Plk_2-3	16	22	PF00069	0.436
MOD_ProDKin_1	104	110	PF00069	0.367
MOD_ProDKin_1	48	54	PF00069	0.197
MOD_SUMO_rev_2	116	126	PF00179	0.464
MOD_SUMO_rev_2	19	28	PF00179	0.537
MOD_SUMO_rev_2	29	37	PF00179	0.454
TRG_ENDOCYTIC_2	125	128	PF00928	0.332
TRG_ENDOCYTIC_2	54	57	PF00928	0.286
TRG_ENDOCYTIC_2	77	80	PF00928	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C7	Leptomonas seymouri	66%	99%
A0A0N1I427	Leptomonas seymouri	45%	78%
A0A0S4IM89	Bodo saltans	53%	100%
A0A0S4IWT4	Bodo saltans	43%	85%
A0A0S4KHZ8	Bodo saltans	41%	95%
A0A1X0NM31	Trypanosomatidae	52%	100%
A0A1X0NTL9	Trypanosomatidae	33%	92%
A0A1X0P9U9	Trypanosomatidae	37%	87%
A0A3Q8IGX1	Leishmania donovani	90%	100%
A0A3R7L838	Trypanosoma rangeli	57%	100%
A0A3R7RC54	Trypanosoma rangeli	47%	81%
A0A3S7WTB2	Leishmania donovani	37%	90%
A0A3S7X865	Leishmania donovani	42%	82%
A0A422NSD0	Trypanosoma rangeli	31%	100%
A4H7Y9	Leishmania braziliensis	37%	100%
A4HB24	Leishmania braziliensis	42%	82%
A4HQJ0	Leishmania braziliensis	79%	100%
A4HWB7	Leishmania infantum	37%	90%
A4IA81	Leishmania infantum	42%	82%
C9ZM28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	95%
C9ZNV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
E9AHZ9	Leishmania infantum	90%	100%
E9AQ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B594	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	82%
O00264	Homo sapiens	34%	75%
O13995	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	88%
O55022	Mus musculus	35%	75%
P70580	Rattus norvegicus	34%	75%
Q12091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	96%
Q17QC0	Bos taurus	36%	75%
Q1JQA5	Bos taurus	36%	86%
Q4Q088	Leishmania major	88%	100%
Q4Q2N9	Leishmania major	42%	82%
Q4QFG4	Leishmania major	38%	100%
Q5RED0	Pongo abelii	34%	75%
Q5XIU9	Rattus norvegicus	30%	67%
Q5ZKN2	Gallus gallus	33%	76%
Q6IUR5	Rattus norvegicus	36%	85%
Q7YZW5	Caenorhabditis elegans	33%	80%
Q80UU9	Mus musculus	30%	67%
Q95250	Sus scrofa	36%	75%
Q9CQ45	Mus musculus	36%	85%
Q9UMX5	Homo sapiens	35%	85%
Q9XFM6	Arabidopsis thaliana	38%	66%
V5DM24	Trypanosoma cruzi	46%	82%