SAS-6_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUA0_LEIMU

TriTrypDb:

LmxM.36.6640

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043229	intracellular organelle	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AUA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.491
CLV_PCSK_KEX2_1	190	192	PF00082	0.625
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.625
CLV_PCSK_SKI1_1	57	61	PF00082	0.514
CLV_Separin_Metazoa	165	169	PF03568	0.489
DEG_APCC_DBOX_1	178	186	PF00400	0.471
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.546
DOC_MAPK_HePTP_8	147	159	PF00069	0.546
DOC_MAPK_MEF2A_6	150	159	PF00069	0.532
DOC_MAPK_MEF2A_6	65	74	PF00069	0.571
DOC_PP2B_LxvP_1	155	158	PF13499	0.532
DOC_USP7_MATH_1	18	22	PF00917	0.565
DOC_USP7_MATH_1	23	27	PF00917	0.616
DOC_USP7_MATH_1	75	79	PF00917	0.483
DOC_WW_Pin1_4	159	164	PF00397	0.448
DOC_WW_Pin1_4	190	195	PF00397	0.698
LIG_14-3-3_CanoR_1	174	182	PF00244	0.468
LIG_14-3-3_CanoR_1	42	51	PF00244	0.636
LIG_14-3-3_CanoR_1	65	71	PF00244	0.593
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	77	81	PF00533	0.563
LIG_FHA_1	136	142	PF00498	0.596
LIG_FHA_1	184	190	PF00498	0.483
LIG_FHA_1	83	89	PF00498	0.556
LIG_FHA_2	58	64	PF00498	0.553
LIG_FHA_2	74	80	PF00498	0.584
LIG_LIR_Gen_1	105	114	PF02991	0.532
LIG_LIR_Gen_1	9	20	PF02991	0.592
LIG_LIR_Gen_1	90	99	PF02991	0.604
LIG_LIR_Nem_3	105	109	PF02991	0.459
LIG_LIR_Nem_3	148	152	PF02991	0.532
LIG_LIR_Nem_3	78	84	PF02991	0.546
LIG_LIR_Nem_3	9	15	PF02991	0.482
LIG_LIR_Nem_3	90	96	PF02991	0.463
LIG_NRBOX	109	115	PF00104	0.563
LIG_NRP_CendR_1	196	197	PF00754	0.733
LIG_PTB_Apo_2	143	150	PF02174	0.532
LIG_PTB_Phospho_1	143	149	PF10480	0.532
LIG_SH2_CRK	149	153	PF00017	0.546
LIG_SH2_CRK	175	179	PF00017	0.465
LIG_SH2_CRK	84	88	PF00017	0.546
LIG_SH2_STAP1	30	34	PF00017	0.447
LIG_SH2_STAP1	84	88	PF00017	0.546
LIG_SH2_STAT5	84	87	PF00017	0.533
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.584
LIG_TRAF2_1	61	64	PF00917	0.589
LIG_TYR_ITIM	147	152	PF00017	0.546
LIG_UBA3_1	110	115	PF00899	0.546
MOD_CDC14_SPxK_1	193	196	PF00782	0.740
MOD_CDK_SPxK_1	190	196	PF00069	0.710
MOD_CDK_SPxxK_3	190	197	PF00069	0.723
MOD_CK1_1	47	53	PF00069	0.593
MOD_CK2_1	159	165	PF00069	0.472
MOD_CK2_1	3	9	PF00069	0.603
MOD_CK2_1	57	63	PF00069	0.576
MOD_GlcNHglycan	175	178	PF01048	0.476
MOD_GlcNHglycan	46	49	PF01048	0.569
MOD_GSK3_1	43	50	PF00069	0.651
MOD_N-GLC_2	118	120	PF02516	0.332
MOD_NEK2_1	109	114	PF00069	0.532
MOD_NEK2_1	82	87	PF00069	0.532
MOD_PIKK_1	3	9	PF00454	0.603
MOD_PK_1	150	156	PF00069	0.612
MOD_PKA_2	173	179	PF00069	0.462
MOD_Plk_2-3	73	79	PF00069	0.532
MOD_Plk_4	109	115	PF00069	0.551
MOD_Plk_4	150	156	PF00069	0.612
MOD_ProDKin_1	159	165	PF00069	0.453
MOD_ProDKin_1	190	196	PF00069	0.710
MOD_SUMO_rev_2	142	152	PF00179	0.532
TRG_DiLeu_BaEn_1	98	103	PF01217	0.532
TRG_DiLeu_BaEn_2	104	110	PF01217	0.603
TRG_DiLeu_BaEn_2	122	128	PF01217	0.438
TRG_ENDOCYTIC_2	149	152	PF00928	0.532
TRG_ENDOCYTIC_2	175	178	PF00928	0.461
TRG_ENDOCYTIC_2	84	87	PF00928	0.546
TRG_ER_diArg_1	178	181	PF00400	0.468
TRG_ER_diArg_1	94	97	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A5	Leptomonas seymouri	95%	100%
A0A0S4IMA0	Bodo saltans	55%	98%
A0A1X0NLJ6	Trypanosomatidae	70%	98%
A0A3Q8IQ43	Leishmania donovani	99%	100%
A0A3R7NPT4	Trypanosoma rangeli	68%	98%
A4HQI7	Leishmania braziliensis	98%	100%
D0A3N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	86%
E9AHZ6	Leishmania infantum	99%	100%
Q4Q091	Leishmania major	99%	100%