DUF3489 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein, putative

Species:

Leishmania mexicana

UniProt:

E9AU99_LEIMU

TriTrypDb:

LmxM.36.6630

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AU99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU99

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0080156	mitochondrial mRNA modification	7	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1900864	mitochondrial RNA modification	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.601
CLV_NRD_NRD_1	158	160	PF00675	0.595
CLV_NRD_NRD_1	2	4	PF00675	0.626
CLV_PCSK_KEX2_1	158	160	PF00082	0.588
CLV_PCSK_KEX2_1	166	168	PF00082	0.544
CLV_PCSK_KEX2_1	2	4	PF00082	0.657
CLV_PCSK_KEX2_1	57	59	PF00082	0.663
CLV_PCSK_KEX2_1	84	86	PF00082	0.613
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.631
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.663
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.690
CLV_PCSK_SKI1_1	13	17	PF00082	0.540
CLV_PCSK_SKI1_1	163	167	PF00082	0.706
CLV_PCSK_SKI1_1	176	180	PF00082	0.604
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DOC_MAPK_gen_1	2	9	PF00069	0.721
DOC_MAPK_gen_1	57	64	PF00069	0.687
DOC_MAPK_MEF2A_6	2	11	PF00069	0.714
DOC_PP4_FxxP_1	80	83	PF00568	0.579
DOC_USP7_MATH_1	120	124	PF00917	0.694
DOC_USP7_UBL2_3	57	61	PF12436	0.682
DOC_WW_Pin1_4	101	106	PF00397	0.696
DOC_WW_Pin1_4	115	120	PF00397	0.591
DOC_WW_Pin1_4	13	18	PF00397	0.598
LIG_14-3-3_CanoR_1	158	162	PF00244	0.594
LIG_BIR_III_2	71	75	PF00653	0.674
LIG_Clathr_ClatBox_1	8	12	PF01394	0.596
LIG_FHA_2	108	114	PF00498	0.733
LIG_NRBOX	47	53	PF00104	0.660
LIG_PCNA_yPIPBox_3	42	56	PF02747	0.538
LIG_Pex14_1	76	80	PF04695	0.586
LIG_PTAP_UEV_1	108	113	PF05743	0.693
LIG_PTB_Apo_2	34	41	PF02174	0.571
LIG_SH2_GRB2like	35	38	PF00017	0.570
LIG_SH2_STAP1	35	39	PF00017	0.568
LIG_SH2_STAT5	149	152	PF00017	0.520
LIG_SH2_STAT5	184	187	PF00017	0.670
LIG_SH2_STAT5	39	42	PF00017	0.577
LIG_SH3_3	106	112	PF00018	0.666
LIG_SH3_3	87	93	PF00018	0.749
LIG_TRAF2_1	93	96	PF00917	0.616
MOD_CK2_1	107	113	PF00069	0.728
MOD_DYRK1A_RPxSP_1	13	17	PF00069	0.639
MOD_GlcNHglycan	131	134	PF01048	0.590
MOD_GlcNHglycan	159	162	PF01048	0.699
MOD_GSK3_1	120	127	PF00069	0.667
MOD_GSK3_1	16	23	PF00069	0.579
MOD_GSK3_1	176	183	PF00069	0.550
MOD_NEK2_1	20	25	PF00069	0.563
MOD_NEK2_1	30	35	PF00069	0.575
MOD_PKA_2	157	163	PF00069	0.696
MOD_Plk_1	96	102	PF00069	0.595
MOD_Plk_4	16	22	PF00069	0.606
MOD_Plk_4	180	186	PF00069	0.555
MOD_Plk_4	30	36	PF00069	0.515
MOD_Plk_4	96	102	PF00069	0.595
MOD_ProDKin_1	101	107	PF00069	0.694
MOD_ProDKin_1	115	121	PF00069	0.589
MOD_ProDKin_1	13	19	PF00069	0.593
MOD_SUMO_rev_2	63	72	PF00179	0.694
TRG_DiLeu_BaEn_1	170	175	PF01217	0.677
TRG_DiLeu_BaEn_3	95	101	PF01217	0.715
TRG_ENDOCYTIC_2	148	151	PF00928	0.686
TRG_ENDOCYTIC_2	77	80	PF00928	0.581
TRG_ER_diArg_1	1	3	PF00400	0.654
TRG_ER_diArg_1	157	159	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY3	Leptomonas seymouri	57%	91%
A0A0S4J9F6	Bodo saltans	31%	72%
A0A1X0NLX2	Trypanosomatidae	51%	97%
A0A3Q8IK45	Leishmania donovani	95%	100%
A0A422NK09	Trypanosoma rangeli	53%	100%
A4HQI6	Leishmania braziliensis	83%	100%
D0A3N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9AHZ5	Leishmania infantum	95%	100%
Q4Q092	Leishmania major	94%	100%