Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU98_LEIMU

TriTrypDb:

LmxM.36.6620

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AU98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.512
CLV_NRD_NRD_1	193	195	PF00675	0.318
CLV_NRD_NRD_1	388	390	PF00675	0.429
CLV_NRD_NRD_1	74	76	PF00675	0.406
CLV_PCSK_FUR_1	191	195	PF00082	0.320
CLV_PCSK_KEX2_1	193	195	PF00082	0.318
CLV_PCSK_KEX2_1	388	390	PF00082	0.429
CLV_PCSK_KEX2_1	74	76	PF00082	0.406
DOC_CDC14_PxL_1	359	367	PF14671	0.486
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.313
DOC_MAPK_gen_1	191	198	PF00069	0.631
DOC_MAPK_gen_1	74	82	PF00069	0.643
DOC_MAPK_HePTP_8	72	84	PF00069	0.490
DOC_MAPK_MEF2A_6	341	348	PF00069	0.266
DOC_MAPK_MEF2A_6	74	82	PF00069	0.635
DOC_MAPK_RevD_3	374	389	PF00069	0.357
DOC_PP4_FxxP_1	142	145	PF00568	0.436
DOC_WW_Pin1_4	12	17	PF00397	0.670
DOC_WW_Pin1_4	228	233	PF00397	0.492
LIG_14-3-3_CanoR_1	197	202	PF00244	0.374
LIG_14-3-3_CanoR_1	23	29	PF00244	0.635
LIG_14-3-3_CanoR_1	327	336	PF00244	0.711
LIG_14-3-3_CanoR_1	341	345	PF00244	0.232
LIG_14-3-3_CanoR_1	54	64	PF00244	0.272
LIG_14-3-3_CanoR_1	91	97	PF00244	0.645
LIG_Actin_WH2_2	283	298	PF00022	0.500
LIG_Actin_WH2_2	58	76	PF00022	0.365
LIG_BRCT_BRCA1_1	198	202	PF00533	0.357
LIG_EH_1	180	184	PF12763	0.656
LIG_EH1_1	211	219	PF00400	0.313
LIG_FHA_1	110	116	PF00498	0.351
LIG_FHA_1	203	209	PF00498	0.300
LIG_FHA_1	299	305	PF00498	0.384
LIG_FHA_1	312	318	PF00498	0.452
LIG_FHA_1	341	347	PF00498	0.433
LIG_FHA_1	400	406	PF00498	0.672
LIG_FHA_1	57	63	PF00498	0.372
LIG_FHA_1	9	15	PF00498	0.669
LIG_FHA_1	95	101	PF00498	0.680
LIG_FHA_2	279	285	PF00498	0.522
LIG_GBD_Chelix_1	365	373	PF00786	0.483
LIG_LIR_Gen_1	2	12	PF02991	0.665
LIG_LIR_Gen_1	248	257	PF02991	0.430
LIG_LIR_Gen_1	284	295	PF02991	0.500
LIG_LIR_Nem_3	106	110	PF02991	0.482
LIG_LIR_Nem_3	199	204	PF02991	0.388
LIG_LIR_Nem_3	2	7	PF02991	0.670
LIG_LIR_Nem_3	20	25	PF02991	0.543
LIG_LIR_Nem_3	248	252	PF02991	0.446
LIG_LIR_Nem_3	255	259	PF02991	0.398
LIG_LIR_Nem_3	273	279	PF02991	0.688
LIG_LIR_Nem_3	284	290	PF02991	0.466
LIG_NRBOX	165	171	PF00104	0.193
LIG_NRBOX	368	374	PF00104	0.324
LIG_PDZ_Class_2	403	408	PF00595	0.635
LIG_Pex14_2	243	247	PF04695	0.302
LIG_Pex14_2	318	322	PF04695	0.313
LIG_SH2_NCK_1	89	93	PF00017	0.666
LIG_SH2_PTP2	41	44	PF00017	0.357
LIG_SH2_SRC	41	44	PF00017	0.371
LIG_SH2_STAP1	137	141	PF00017	0.446
LIG_SH2_STAT5	125	128	PF00017	0.394
LIG_SH2_STAT5	130	133	PF00017	0.490
LIG_SH2_STAT5	227	230	PF00017	0.445
LIG_SH2_STAT5	234	237	PF00017	0.433
LIG_SH2_STAT5	24	27	PF00017	0.633
LIG_SH2_STAT5	265	268	PF00017	0.554
LIG_SH2_STAT5	311	314	PF00017	0.354
LIG_SH2_STAT5	41	44	PF00017	0.480
LIG_SH3_3	115	121	PF00018	0.351
LIG_SH3_3	170	176	PF00018	0.312
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.316
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.282
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.247
LIG_SUMO_SIM_par_1	114	119	PF11976	0.193
LIG_SUMO_SIM_par_1	250	255	PF11976	0.291
LIG_SUMO_SIM_par_1	301	307	PF11976	0.438
LIG_SUMO_SIM_par_1	345	350	PF11976	0.296
LIG_TRAF2_1	335	338	PF00917	0.523
LIG_TYR_ITIM	263	268	PF00017	0.520
LIG_TYR_ITIM	274	279	PF00017	0.647
LIG_TYR_ITIM	39	44	PF00017	0.434
LIG_WRC_WIRS_1	1	6	PF05994	0.680
MOD_CK1_1	255	261	PF00069	0.313
MOD_CK1_1	3	9	PF00069	0.639
MOD_CK1_1	358	364	PF00069	0.479
MOD_CK1_1	399	405	PF00069	0.640
MOD_GlcNHglycan	237	240	PF01048	0.647
MOD_GlcNHglycan	30	33	PF01048	0.308
MOD_GlcNHglycan	396	399	PF01048	0.503
MOD_GSK3_1	228	235	PF00069	0.420
MOD_GSK3_1	24	31	PF00069	0.587
MOD_GSK3_1	295	302	PF00069	0.370
MOD_GSK3_1	347	354	PF00069	0.320
MOD_GSK3_1	8	15	PF00069	0.649
MOD_GSK3_1	90	97	PF00069	0.652
MOD_N-GLC_1	225	230	PF02516	0.589
MOD_N-GLC_1	56	61	PF02516	0.313
MOD_NEK2_1	295	300	PF00069	0.313
MOD_NEK2_1	304	309	PF00069	0.452
MOD_NEK2_1	322	327	PF00069	0.226
MOD_NEK2_1	394	399	PF00069	0.620
MOD_NEK2_1	68	73	PF00069	0.303
MOD_PKA_2	196	202	PF00069	0.425
MOD_PKA_2	340	346	PF00069	0.459
MOD_PKA_2	90	96	PF00069	0.665
MOD_Plk_1	56	62	PF00069	0.313
MOD_Plk_4	103	109	PF00069	0.552
MOD_Plk_4	144	150	PF00069	0.332
MOD_Plk_4	17	23	PF00069	0.614
MOD_Plk_4	197	203	PF00069	0.294
MOD_Plk_4	252	258	PF00069	0.351
MOD_Plk_4	299	305	PF00069	0.332
MOD_Plk_4	58	64	PF00069	0.334
MOD_Plk_4	68	74	PF00069	0.313
MOD_ProDKin_1	12	18	PF00069	0.667
MOD_ProDKin_1	228	234	PF00069	0.488
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.247
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.614
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.687
TRG_ENDOCYTIC_2	180	183	PF00928	0.649
TRG_ENDOCYTIC_2	265	268	PF00928	0.554
TRG_ENDOCYTIC_2	276	279	PF00928	0.644
TRG_ENDOCYTIC_2	41	44	PF00928	0.434
TRG_ENDOCYTIC_2	89	92	PF00928	0.697
TRG_ER_diArg_1	191	194	PF00400	0.527
TRG_ER_diArg_1	388	390	PF00400	0.632
TRG_ER_diArg_1	73	75	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I240	Leptomonas seymouri	51%	100%
A0A1X0NN35	Trypanosomatidae	23%	100%
A0A3S7XCE6	Leishmania donovani	89%	100%
A4HQI5	Leishmania braziliensis	73%	100%
E9AHZ4	Leishmania infantum	89%	100%
Q4Q093	Leishmania major	89%	100%