NYD-SP28_assoc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sperm tail/Sperm tail C-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AU95_LEIMU

TriTrypDb:

LmxM.36.6590

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU95

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003352	regulation of cilium movement	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0048870	cell motility	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.462
CLV_NRD_NRD_1	132	134	PF00675	0.262
CLV_NRD_NRD_1	156	158	PF00675	0.161
CLV_NRD_NRD_1	204	206	PF00675	0.389
CLV_NRD_NRD_1	223	225	PF00675	0.296
CLV_NRD_NRD_1	230	232	PF00675	0.408
CLV_NRD_NRD_1	557	559	PF00675	0.464
CLV_NRD_NRD_1	596	598	PF00675	0.221
CLV_NRD_NRD_1	82	84	PF00675	0.229
CLV_PCSK_KEX2_1	156	158	PF00082	0.173
CLV_PCSK_KEX2_1	223	225	PF00082	0.333
CLV_PCSK_KEX2_1	260	262	PF00082	0.396
CLV_PCSK_KEX2_1	332	334	PF00082	0.452
CLV_PCSK_KEX2_1	556	558	PF00082	0.520
CLV_PCSK_KEX2_1	82	84	PF00082	0.229
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.396
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.452
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.614
CLV_PCSK_PC7_1	552	558	PF00082	0.528
CLV_PCSK_SKI1_1	358	362	PF00082	0.557
CLV_PCSK_SKI1_1	48	52	PF00082	0.406
CLV_PCSK_SKI1_1	612	616	PF00082	0.265
CLV_PCSK_SKI1_1	635	639	PF00082	0.576
DEG_APCC_KENBOX_2	299	303	PF00400	0.446
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.380
DOC_MAPK_gen_1	156	164	PF00069	0.455
DOC_MAPK_gen_1	364	373	PF00069	0.498
DOC_PP1_SILK_1	446	451	PF00149	0.511
DOC_PP2B_LxvP_1	119	122	PF13499	0.478
DOC_PP2B_LxvP_1	400	403	PF13499	0.379
DOC_PP2B_LxvP_1	630	633	PF13499	0.449
DOC_USP7_MATH_1	464	468	PF00917	0.530
DOC_USP7_MATH_1	67	71	PF00917	0.375
DOC_USP7_UBL2_3	217	221	PF12436	0.467
DOC_USP7_UBL2_3	365	369	PF12436	0.453
DOC_WW_Pin1_4	642	647	PF00397	0.561
LIG_14-3-3_CanoR_1	180	187	PF00244	0.397
LIG_14-3-3_CanoR_1	261	270	PF00244	0.411
LIG_14-3-3_CanoR_1	287	291	PF00244	0.445
LIG_14-3-3_CanoR_1	489	497	PF00244	0.532
LIG_14-3-3_CanoR_1	635	643	PF00244	0.498
LIG_APCC_ABBA_1	109	114	PF00400	0.513
LIG_CaM_IQ_9	191	207	PF13499	0.385
LIG_eIF4E_1	631	637	PF01652	0.497
LIG_FHA_1	189	195	PF00498	0.413
LIG_FHA_1	287	293	PF00498	0.615
LIG_FHA_1	340	346	PF00498	0.404
LIG_FHA_1	366	372	PF00498	0.557
LIG_FHA_1	482	488	PF00498	0.464
LIG_FHA_1	506	512	PF00498	0.457
LIG_FHA_2	335	341	PF00498	0.484
LIG_FHA_2	469	475	PF00498	0.561
LIG_FHA_2	536	542	PF00498	0.635
LIG_LIR_Apic_2	629	634	PF02991	0.504
LIG_LIR_Apic_2	642	646	PF02991	0.458
LIG_LIR_Gen_1	158	165	PF02991	0.362
LIG_LIR_Gen_1	250	259	PF02991	0.408
LIG_LIR_Gen_1	368	376	PF02991	0.421
LIG_LIR_Nem_3	158	164	PF02991	0.513
LIG_LIR_Nem_3	250	256	PF02991	0.408
LIG_LIR_Nem_3	368	373	PF02991	0.390
LIG_LIR_Nem_3	498	502	PF02991	0.469
LIG_LIR_Nem_3	625	631	PF02991	0.452
LIG_NRBOX	319	325	PF00104	0.514
LIG_PCNA_yPIPBox_3	310	324	PF02747	0.422
LIG_PCNA_yPIPBox_3	608	618	PF02747	0.421
LIG_SH2_CRK	631	635	PF00017	0.507
LIG_SH2_CRK	643	647	PF00017	0.474
LIG_SH2_GRB2like	621	624	PF00017	0.492
LIG_SH2_PTP2	161	164	PF00017	0.513
LIG_SH2_SRC	327	330	PF00017	0.368
LIG_SH2_SRC	631	634	PF00017	0.505
LIG_SH2_STAP1	190	194	PF00017	0.356
LIG_SH2_STAP1	396	400	PF00017	0.484
LIG_SH2_STAP1	55	59	PF00017	0.486
LIG_SH2_STAP1	628	632	PF00017	0.552
LIG_SH2_STAT3	186	189	PF00017	0.442
LIG_SH2_STAT3	230	233	PF00017	0.462
LIG_SH2_STAT3	290	293	PF00017	0.426
LIG_SH2_STAT3	590	593	PF00017	0.421
LIG_SH2_STAT5	161	164	PF00017	0.478
LIG_SH2_STAT5	186	189	PF00017	0.377
LIG_SH2_STAT5	190	193	PF00017	0.365
LIG_SH2_STAT5	208	211	PF00017	0.449
LIG_SH2_STAT5	281	284	PF00017	0.537
LIG_SH2_STAT5	352	355	PF00017	0.520
LIG_SH2_STAT5	370	373	PF00017	0.515
LIG_SH2_STAT5	499	502	PF00017	0.433
LIG_SH2_STAT5	524	527	PF00017	0.460
LIG_SH2_STAT5	590	593	PF00017	0.452
LIG_SH3_3	400	406	PF00018	0.380
LIG_SH3_3	427	433	PF00018	0.566
LIG_SUMO_SIM_anti_2	158	166	PF11976	0.392
LIG_SUMO_SIM_anti_2	505	513	PF11976	0.593
LIG_SUMO_SIM_par_1	137	144	PF11976	0.407
LIG_TRAF2_1	128	131	PF00917	0.489
LIG_TRAF2_1	413	416	PF00917	0.584
LIG_TRAF2_1	471	474	PF00917	0.512
LIG_TRAF2_1	530	533	PF00917	0.497
LIG_TYR_ITIM	394	399	PF00017	0.477
LIG_TYR_ITIM	497	502	PF00017	0.433
LIG_UBA3_1	444	450	PF00899	0.429
LIG_WRC_WIRS_1	359	364	PF05994	0.407
LIG_WW_3	632	636	PF00397	0.570
MOD_CDK_SPK_2	642	647	PF00069	0.416
MOD_CK1_1	548	554	PF00069	0.483
MOD_CK1_1	642	648	PF00069	0.595
MOD_CK2_1	138	144	PF00069	0.463
MOD_CK2_1	248	254	PF00069	0.450
MOD_CK2_1	41	47	PF00069	0.597
MOD_CK2_1	468	474	PF00069	0.567
MOD_CK2_1	488	494	PF00069	0.273
MOD_CK2_1	535	541	PF00069	0.578
MOD_GlcNHglycan	250	253	PF01048	0.515
MOD_GlcNHglycan	98	102	PF01048	0.229
MOD_GSK3_1	175	182	PF00069	0.589
MOD_GSK3_1	444	451	PF00069	0.441
MOD_GSK3_1	464	471	PF00069	0.346
MOD_GSK3_1	535	542	PF00069	0.591
MOD_GSK3_1	599	606	PF00069	0.513
MOD_GSK3_1	635	642	PF00069	0.509
MOD_N-GLC_1	487	492	PF02516	0.540
MOD_N-GLC_1	548	553	PF02516	0.605
MOD_N-GLC_1	622	627	PF02516	0.296
MOD_NEK2_1	1	6	PF00069	0.413
MOD_NEK2_1	175	180	PF00069	0.502
MOD_NEK2_1	219	224	PF00069	0.517
MOD_NEK2_1	274	279	PF00069	0.592
MOD_NEK2_1	316	321	PF00069	0.394
MOD_NEK2_1	334	339	PF00069	0.346
MOD_NEK2_1	444	449	PF00069	0.434
MOD_NEK2_1	568	573	PF00069	0.444
MOD_NEK2_1	622	627	PF00069	0.554
MOD_NEK2_1	641	646	PF00069	0.504
MOD_NEK2_1	96	101	PF00069	0.429
MOD_NEK2_2	138	143	PF00069	0.379
MOD_NEK2_2	67	72	PF00069	0.259
MOD_PIKK_1	2	8	PF00454	0.437
MOD_PIKK_1	352	358	PF00454	0.565
MOD_PIKK_1	448	454	PF00454	0.506
MOD_PIKK_1	469	475	PF00454	0.415
MOD_PIKK_1	585	591	PF00454	0.487
MOD_PIKK_1	635	641	PF00454	0.678
MOD_PIKK_1	77	83	PF00454	0.462
MOD_PKA_2	179	185	PF00069	0.452
MOD_PKA_2	222	228	PF00069	0.357
MOD_PKA_2	286	292	PF00069	0.450
MOD_PKA_2	488	494	PF00069	0.546
MOD_Plk_1	170	176	PF00069	0.514
MOD_Plk_1	197	203	PF00069	0.414
MOD_Plk_1	505	511	PF00069	0.498
MOD_Plk_1	622	628	PF00069	0.350
MOD_Plk_4	319	325	PF00069	0.371
MOD_ProDKin_1	642	648	PF00069	0.565
MOD_SUMO_rev_2	198	207	PF00179	0.402
MOD_SUMO_rev_2	210	219	PF00179	0.447
MOD_SUMO_rev_2	229	239	PF00179	0.284
MOD_SUMO_rev_2	254	262	PF00179	0.337
MOD_SUMO_rev_2	44	51	PF00179	0.545
MOD_SUMO_rev_2	526	536	PF00179	0.527
TRG_DiLeu_BaEn_1	135	140	PF01217	0.429
TRG_DiLeu_BaEn_1	160	165	PF01217	0.513
TRG_DiLeu_BaEn_1	171	176	PF01217	0.598
TRG_DiLeu_BaEn_1	215	220	PF01217	0.380
TRG_DiLeu_BaEn_1	507	512	PF01217	0.553
TRG_DiLeu_BaEn_1	613	618	PF01217	0.421
TRG_DiLeu_BaLyEn_6	632	637	PF01217	0.385
TRG_ENDOCYTIC_2	161	164	PF00928	0.513
TRG_ENDOCYTIC_2	253	256	PF00928	0.413
TRG_ENDOCYTIC_2	370	373	PF00928	0.488
TRG_ENDOCYTIC_2	396	399	PF00928	0.486
TRG_ENDOCYTIC_2	499	502	PF00928	0.433
TRG_ER_diArg_1	16	19	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	635	639	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAH6	Leptomonas seymouri	70%	100%
A0A0S4J8E8	Bodo saltans	41%	100%
A0A1X0NL92	Trypanosomatidae	48%	100%
A0A3R7KG47	Trypanosoma rangeli	45%	99%
A0A3S7XCE4	Leishmania donovani	93%	100%
A4HQI2	Leishmania braziliensis	81%	100%
D0A3N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AHZ1	Leishmania infantum	93%	100%
F1QRC1	Danio rerio	26%	97%
P0DL09	Chlamydomonas reinhardtii	27%	93%
Q32KY1	Bos taurus	25%	91%
Q3USS3	Mus musculus	25%	86%
Q4Q096	Leishmania major	94%	100%
Q7T0Y4	Xenopus laevis	28%	94%
V5BD07	Trypanosoma cruzi	51%	100%