ACB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AU92_LEIMU

TriTrypDb:

LmxM.36.6560

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU92

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	11
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0033218	amide binding	2	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0120227	acyl-CoA binding	3	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901567	fatty acid derivative binding	3	11
GO:1901681	sulfur compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	121	125	PF00082	0.635
CLV_PCSK_SKI1_1	211	215	PF00082	0.586
CLV_PCSK_SKI1_1	286	290	PF00082	0.729
CLV_PCSK_SKI1_1	34	38	PF00082	0.335
CLV_Separin_Metazoa	206	210	PF03568	0.529
DEG_Nend_UBRbox_2	1	3	PF02207	0.542
DOC_CYCLIN_RxL_1	209	221	PF00134	0.554
DOC_PP1_RVXF_1	32	38	PF00149	0.355
DOC_USP7_MATH_1	100	104	PF00917	0.624
DOC_USP7_MATH_1	135	139	PF00917	0.729
DOC_USP7_MATH_1	140	144	PF00917	0.739
DOC_USP7_MATH_1	162	166	PF00917	0.771
DOC_USP7_MATH_1	52	56	PF00917	0.378
DOC_WW_Pin1_4	106	111	PF00397	0.469
DOC_WW_Pin1_4	131	136	PF00397	0.680
DOC_WW_Pin1_4	157	162	PF00397	0.742
DOC_WW_Pin1_4	23	28	PF00397	0.505
DOC_WW_Pin1_4	245	250	PF00397	0.654
DOC_WW_Pin1_4	311	316	PF00397	0.701
LIG_14-3-3_CanoR_1	286	293	PF00244	0.739
LIG_14-3-3_CanoR_1	73	78	PF00244	0.377
LIG_BIR_III_2	251	255	PF00653	0.462
LIG_BRCT_BRCA1_1	318	322	PF00533	0.601
LIG_Clathr_ClatBox_1	91	95	PF01394	0.379
LIG_eIF4E_1	202	208	PF01652	0.575
LIG_FHA_2	161	167	PF00498	0.679
LIG_FHA_2	246	252	PF00498	0.470
LIG_LIR_Gen_1	75	84	PF02991	0.347
LIG_MYND_1	259	263	PF01753	0.693
LIG_Pex14_2	83	87	PF04695	0.447
LIG_PTB_Apo_2	196	203	PF02174	0.545
LIG_PTB_Phospho_1	196	202	PF10480	0.544
LIG_SH2_STAT5	15	18	PF00017	0.408
LIG_SH2_STAT5	19	22	PF00017	0.436
LIG_SH2_STAT5	202	205	PF00017	0.454
LIG_SH3_3	111	117	PF00018	0.647
LIG_SH3_3	257	263	PF00018	0.603
LIG_SH3_3	272	278	PF00018	0.586
LIG_SH3_3	309	315	PF00018	0.741
LIG_TRAF2_1	164	167	PF00917	0.765
LIG_Vh1_VBS_1	189	207	PF01044	0.549
LIG_WRC_WIRS_1	74	79	PF05994	0.285
MOD_CK1_1	101	107	PF00069	0.680
MOD_CK1_1	134	140	PF00069	0.615
MOD_CK1_1	160	166	PF00069	0.701
MOD_CK1_1	172	178	PF00069	0.539
MOD_CK1_1	193	199	PF00069	0.588
MOD_CK1_1	221	227	PF00069	0.692
MOD_CK1_1	267	273	PF00069	0.707
MOD_CK1_1	284	290	PF00069	0.605
MOD_CK1_1	316	322	PF00069	0.667
MOD_CK2_1	160	166	PF00069	0.783
MOD_CK2_1	175	181	PF00069	0.571
MOD_CK2_1	284	290	PF00069	0.726
MOD_CK2_1	72	78	PF00069	0.335
MOD_CMANNOS	321	324	PF00535	0.546
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.652
MOD_GlcNHglycan	100	103	PF01048	0.623
MOD_GlcNHglycan	104	107	PF01048	0.755
MOD_GlcNHglycan	177	180	PF01048	0.642
MOD_GlcNHglycan	192	195	PF01048	0.610
MOD_GlcNHglycan	220	223	PF01048	0.643
MOD_GlcNHglycan	243	246	PF01048	0.630
MOD_GlcNHglycan	269	272	PF01048	0.550
MOD_GlcNHglycan	283	286	PF01048	0.593
MOD_GlcNHglycan	315	318	PF01048	0.691
MOD_GSK3_1	102	109	PF00069	0.671
MOD_GSK3_1	131	138	PF00069	0.600
MOD_GSK3_1	171	178	PF00069	0.634
MOD_GSK3_1	228	235	PF00069	0.694
MOD_GSK3_1	23	30	PF00069	0.530
MOD_GSK3_1	241	248	PF00069	0.781
MOD_GSK3_1	313	320	PF00069	0.682
MOD_GSK3_1	48	55	PF00069	0.372
MOD_GSK3_1	94	101	PF00069	0.627
MOD_N-GLC_1	228	233	PF02516	0.740
MOD_N-GLC_1	267	272	PF02516	0.644
MOD_N-GLC_1	95	100	PF02516	0.610
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	218	223	PF00069	0.548
MOD_NEK2_1	94	99	PF00069	0.621
MOD_PKA_2	281	287	PF00069	0.691
MOD_PKA_2	293	299	PF00069	0.677
MOD_PKA_2	72	78	PF00069	0.434
MOD_Plk_1	1	7	PF00069	0.587
MOD_Plk_4	317	323	PF00069	0.640
MOD_Plk_4	52	58	PF00069	0.335
MOD_ProDKin_1	106	112	PF00069	0.463
MOD_ProDKin_1	131	137	PF00069	0.685
MOD_ProDKin_1	157	163	PF00069	0.746
MOD_ProDKin_1	23	29	PF00069	0.498
MOD_ProDKin_1	245	251	PF00069	0.655
MOD_ProDKin_1	311	317	PF00069	0.696
MOD_SUMO_rev_2	118	125	PF00179	0.601
TRG_DiLeu_BaEn_4	24	30	PF01217	0.480
TRG_DiLeu_LyEn_5	24	29	PF01217	0.535
TRG_ENDOCYTIC_2	9	12	PF00928	0.369
TRG_ER_diArg_1	208	211	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA6	Leptomonas seymouri	46%	100%
A0A1X0NL99	Trypanosomatidae	36%	100%
A0A3S7XC89	Leishmania donovani	89%	100%
A0A422P468	Trypanosoma rangeli	28%	100%
A4HQH9	Leishmania braziliensis	68%	100%
E9AHY9	Leishmania infantum	90%	100%
Q4Q099	Leishmania major	87%	100%
V5A2D1	Trypanosoma cruzi	36%	100%
V5B4W0	Trypanosoma cruzi	36%	100%