Similarity to endo-1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similarity to endo-1-like protein

Species:

Leishmania mexicana

UniProt:

E9AU90_LEIMU

TriTrypDb:

LmxM.36.6540

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU90

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	197	199	PF00082	0.297
CLV_PCSK_KEX2_1	54	56	PF00082	0.309
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.297
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.293
CLV_PCSK_SKI1_1	162	166	PF00082	0.281
DOC_CYCLIN_RxL_1	222	233	PF00134	0.493
DOC_MAPK_gen_1	162	171	PF00069	0.481
DOC_MAPK_MEF2A_6	162	171	PF00069	0.486
DOC_PP2B_LxvP_1	169	172	PF13499	0.579
DOC_USP7_MATH_1	151	155	PF00917	0.458
DOC_USP7_MATH_1	185	189	PF00917	0.459
DOC_USP7_MATH_1	33	37	PF00917	0.481
DOC_USP7_UBL2_3	14	18	PF12436	0.460
DOC_WW_Pin1_4	19	24	PF00397	0.593
LIG_14-3-3_CanoR_1	91	99	PF00244	0.390
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	52	56	PF00533	0.510
LIG_deltaCOP1_diTrp_1	80	87	PF00928	0.457
LIG_FHA_1	91	97	PF00498	0.459
LIG_FHA_2	215	221	PF00498	0.481
LIG_FHA_2	98	104	PF00498	0.542
LIG_GBD_Chelix_1	42	50	PF00786	0.281
LIG_LIR_Gen_1	100	109	PF02991	0.523
LIG_LIR_Gen_1	53	61	PF02991	0.478
LIG_LIR_Gen_1	62	73	PF02991	0.443
LIG_LIR_Nem_3	100	105	PF02991	0.487
LIG_LIR_Nem_3	45	50	PF02991	0.460
LIG_LIR_Nem_3	53	59	PF02991	0.486
LIG_LIR_Nem_3	62	68	PF02991	0.501
LIG_LIR_Nem_3	71	76	PF02991	0.523
LIG_LIR_Nem_3	89	95	PF02991	0.410
LIG_LYPXL_SIV_4	20	28	PF13949	0.367
LIG_Pex14_1	83	87	PF04695	0.439
LIG_REV1ctd_RIR_1	204	212	PF16727	0.481
LIG_REV1ctd_RIR_1	232	240	PF16727	0.481
LIG_SH2_NCK_1	21	25	PF00017	0.570
LIG_SH2_NCK_1	216	220	PF00017	0.364
LIG_SH2_STAT5	216	219	PF00017	0.481
LIG_SH2_STAT5	29	32	PF00017	0.401
LIG_SH2_STAT5	95	98	PF00017	0.407
LIG_SH3_3	187	193	PF00018	0.467
LIG_SH3_3	64	70	PF00018	0.481
LIG_SUMO_SIM_par_1	167	173	PF11976	0.511
LIG_SUMO_SIM_par_1	39	45	PF11976	0.439
LIG_TRFH_1	47	51	PF08558	0.459
LIG_UBA3_1	46	54	PF00899	0.493
LIG_WRC_WIRS_1	102	107	PF05994	0.493
MOD_CK1_1	154	160	PF00069	0.479
MOD_CK2_1	170	176	PF00069	0.439
MOD_CK2_1	214	220	PF00069	0.481
MOD_GlcNHglycan	1	4	PF01048	0.558
MOD_GSK3_1	86	93	PF00069	0.446
MOD_GSK3_1	97	104	PF00069	0.560
MOD_N-GLC_2	7	9	PF02516	0.596
MOD_NEK2_1	206	211	PF00069	0.364
MOD_NEK2_1	235	240	PF00069	0.517
MOD_NEK2_1	72	77	PF00069	0.374
MOD_NEK2_1	87	92	PF00069	0.402
MOD_PIKK_1	90	96	PF00454	0.481
MOD_PIKK_1	97	103	PF00454	0.539
MOD_PKA_2	90	96	PF00069	0.390
MOD_Plk_4	101	107	PF00069	0.478
MOD_Plk_4	151	157	PF00069	0.461
MOD_ProDKin_1	19	25	PF00069	0.591
MOD_SUMO_rev_2	214	224	PF00179	0.493
TRG_DiLeu_BaEn_1	62	67	PF01217	0.459
TRG_ENDOCYTIC_2	196	199	PF00928	0.401
TRG_ER_diLys_1	236	240	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P241	Leptomonas seymouri	61%	99%
A0A0S4KTD2	Bodo saltans	37%	100%
A0A2V5GSC6	Aspergillus violaceofuscus (strain CBS 115571)	29%	98%
A0A3S7XCB3	Leishmania donovani	88%	100%
A4HQH7	Leishmania braziliensis	72%	100%
A4ICB3	Leishmania infantum	88%	100%
B8M9K0	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	26%	94%
O14359	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	96%
Q4Q0A1	Leishmania major	89%	100%
Q5RBU3	Pongo abelii	24%	98%
Q5XH09	Xenopus laevis	25%	98%
Q6P7K0	Xenopus tropicalis	26%	98%
Q7TP52	Rattus norvegicus	25%	98%
Q8R1G2	Mus musculus	26%	98%
Q96DG6	Homo sapiens	25%	98%
Q9P7U1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	97%
Q9ZT66	Zea mays	28%	79%
W7MAD3	Gibberella moniliformis (strain M3125 / FGSC 7600)	29%	92%