Myb-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU89_LEIMU

TriTrypDb:

LmxM.36.6530

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1

Expansion

Sequence features

E9AU89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU89

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0070897	transcription preinitiation complex assembly	7	1
GO:0070898	RNA polymerase III preinitiation complex assembly	8	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0001025	RNA polymerase III general transcription initiation factor binding	5	1
GO:0001156	TFIIIC-class transcription factor complex binding	6	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008134	transcription factor binding	3	1
GO:0140296	general transcription initiation factor binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.746
CLV_NRD_NRD_1	211	213	PF00675	0.360
CLV_NRD_NRD_1	315	317	PF00675	0.731
CLV_NRD_NRD_1	319	321	PF00675	0.748
CLV_PCSK_FUR_1	167	171	PF00082	0.745
CLV_PCSK_FUR_1	209	213	PF00082	0.513
CLV_PCSK_FUR_1	316	320	PF00082	0.551
CLV_PCSK_KEX2_1	169	171	PF00082	0.746
CLV_PCSK_KEX2_1	211	213	PF00082	0.424
CLV_PCSK_KEX2_1	215	217	PF00082	0.383
CLV_PCSK_KEX2_1	317	319	PF00082	0.746
CLV_PCSK_KEX2_1	334	336	PF00082	0.697
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.411
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.746
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.697
CLV_PCSK_PC7_1	211	217	PF00082	0.411
CLV_PCSK_PC7_1	314	320	PF00082	0.742
CLV_PCSK_SKI1_1	212	216	PF00082	0.513
CLV_PCSK_SKI1_1	334	338	PF00082	0.804
CLV_PCSK_SKI1_1	74	78	PF00082	0.621
DEG_Nend_UBRbox_2	1	3	PF02207	0.704
DEG_SIAH_1	93	101	PF03145	0.704
DEG_SPOP_SBC_1	76	80	PF00917	0.743
DOC_CKS1_1	32	37	PF01111	0.654
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.803
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.678
DOC_MAPK_FxFP_2	36	39	PF00069	0.635
DOC_MAPK_FxFP_2	6	9	PF00069	0.665
DOC_MAPK_MEF2A_6	288	296	PF00069	0.731
DOC_PP1_RVXF_1	175	181	PF00149	0.411
DOC_PP2B_LxvP_1	292	295	PF13499	0.802
DOC_PP4_FxxP_1	36	39	PF00568	0.635
DOC_PP4_FxxP_1	6	9	PF00568	0.665
DOC_USP7_MATH_1	124	128	PF00917	0.823
DOC_USP7_MATH_1	280	284	PF00917	0.615
DOC_USP7_MATH_1	86	90	PF00917	0.723
DOC_USP7_MATH_1	94	98	PF00917	0.738
DOC_USP7_UBL2_3	334	338	PF12436	0.732
DOC_WW_Pin1_4	108	113	PF00397	0.727
DOC_WW_Pin1_4	19	24	PF00397	0.690
DOC_WW_Pin1_4	27	32	PF00397	0.677
LIG_14-3-3_CanoR_1	74	84	PF00244	0.687
LIG_14-3-3_CanoR_1	93	99	PF00244	0.693
LIG_APCC_ABBA_1	374	379	PF00400	0.499
LIG_CtBP_PxDLS_1	238	242	PF00389	0.513
LIG_FHA_1	320	326	PF00498	0.593
LIG_FHA_1	335	341	PF00498	0.720
LIG_FHA_2	208	214	PF00498	0.299
LIG_FHA_2	298	304	PF00498	0.729
LIG_LIR_Apic_2	3	9	PF02991	0.679
LIG_LIR_Apic_2	34	39	PF02991	0.746
LIG_LIR_Gen_1	187	195	PF02991	0.411
LIG_LIR_Gen_1	197	207	PF02991	0.411
LIG_LIR_Nem_3	187	192	PF02991	0.411
LIG_LIR_Nem_3	197	202	PF02991	0.411
LIG_PCNA_yPIPBox_3	62	73	PF02747	0.739
LIG_SH2_CRK	189	193	PF00017	0.513
LIG_SH2_STAT5	117	120	PF00017	0.683
LIG_SH3_2	312	317	PF14604	0.737
LIG_SH3_3	120	126	PF00018	0.734
LIG_SH3_3	201	207	PF00018	0.411
LIG_SH3_3	291	297	PF00018	0.733
LIG_SH3_3	309	315	PF00018	0.601
LIG_SH3_3	55	61	PF00018	0.661
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.411
LIG_SxIP_EBH_1	20	34	PF03271	0.477
LIG_TRAF2_1	130	133	PF00917	0.737
LIG_TRAF2_2	10	15	PF00917	0.667
LIG_WRC_WIRS_1	185	190	PF05994	0.411
LIG_WW_2	123	126	PF00397	0.727
MOD_CDC14_SPxK_1	30	33	PF00782	0.690
MOD_CDK_SPxK_1	27	33	PF00069	0.689
MOD_CK1_1	127	133	PF00069	0.739
MOD_CK1_1	19	25	PF00069	0.595
MOD_CK2_1	126	132	PF00069	0.737
MOD_CK2_1	178	184	PF00069	0.397
MOD_GlcNHglycan	118	121	PF01048	0.659
MOD_GlcNHglycan	126	129	PF01048	0.705
MOD_GlcNHglycan	156	159	PF01048	0.626
MOD_GlcNHglycan	198	202	PF01048	0.411
MOD_GlcNHglycan	282	285	PF01048	0.698
MOD_GSK3_1	108	115	PF00069	0.711
MOD_GSK3_1	19	26	PF00069	0.705
MOD_GSK3_1	190	197	PF00069	0.384
MOD_GSK3_1	27	34	PF00069	0.626
MOD_GSK3_1	330	337	PF00069	0.820
MOD_N-GLC_1	65	70	PF02516	0.739
MOD_NEK2_1	77	82	PF00069	0.763
MOD_PIKK_1	101	107	PF00454	0.809
MOD_PIKK_1	190	196	PF00454	0.364
MOD_PIKK_1	56	62	PF00454	0.646
MOD_PKA_1	319	325	PF00069	0.760
MOD_PKA_1	334	340	PF00069	0.654
MOD_PKA_2	319	325	PF00069	0.833
MOD_PKA_2	334	340	PF00069	0.581
MOD_Plk_1	197	203	PF00069	0.411
MOD_Plk_1	65	71	PF00069	0.658
MOD_Plk_2-3	351	357	PF00069	0.612
MOD_Plk_4	351	357	PF00069	0.628
MOD_Plk_4	43	49	PF00069	0.557
MOD_ProDKin_1	108	114	PF00069	0.729
MOD_ProDKin_1	19	25	PF00069	0.690
MOD_ProDKin_1	27	33	PF00069	0.677
MOD_SUMO_for_1	287	290	PF00179	0.713
MOD_SUMO_rev_2	326	336	PF00179	0.836
TRG_DiLeu_BaEn_2	266	272	PF01217	0.715
TRG_DiLeu_BaEn_4	267	273	PF01217	0.717
TRG_ENDOCYTIC_2	189	192	PF00928	0.411
TRG_ER_diArg_1	166	169	PF00400	0.750
TRG_ER_diArg_1	209	212	PF00400	0.420
TRG_ER_diArg_1	315	318	PF00400	0.809
TRG_NLS_MonoCore_2	315	320	PF00514	0.663
TRG_NLS_MonoExtC_3	315	320	PF00514	0.666
TRG_NLS_MonoExtN_4	314	320	PF00514	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV5	Leptomonas seymouri	55%	100%
A0A3Q8IM42	Leishmania donovani	92%	100%
A4HQH6	Leishmania braziliensis	80%	99%
A4ICB2	Leishmania infantum	92%	100%
Q4Q0A2	Leishmania major	93%	100%