Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU88_LEIMU

TriTrypDb:

LmxM.36.6525

Length:

593

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.690
CLV_C14_Caspase3-7	408	412	PF00656	0.576
CLV_NRD_NRD_1	425	427	PF00675	0.592
CLV_NRD_NRD_1	473	475	PF00675	0.558
CLV_NRD_NRD_1	580	582	PF00675	0.664
CLV_PCSK_KEX2_1	171	173	PF00082	0.528
CLV_PCSK_KEX2_1	425	427	PF00082	0.559
CLV_PCSK_KEX2_1	473	475	PF00082	0.558
CLV_PCSK_KEX2_1	521	523	PF00082	0.628
CLV_PCSK_KEX2_1	580	582	PF00082	0.503
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.581
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.628
CLV_PCSK_SKI1_1	158	162	PF00082	0.610
CLV_PCSK_SKI1_1	172	176	PF00082	0.361
CLV_PCSK_SKI1_1	413	417	PF00082	0.608
CLV_PCSK_SKI1_1	437	441	PF00082	0.523
DEG_APCC_DBOX_1	412	420	PF00400	0.633
DEG_SPOP_SBC_1	335	339	PF00917	0.413
DOC_CDC14_PxL_1	388	396	PF14671	0.548
DOC_CKS1_1	533	538	PF01111	0.766
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	534	540	PF00134	0.636
DOC_MAPK_DCC_7	504	514	PF00069	0.644
DOC_MAPK_gen_1	120	129	PF00069	0.508
DOC_MAPK_gen_1	521	527	PF00069	0.581
DOC_MAPK_gen_1	580	587	PF00069	0.509
DOC_MAPK_MEF2A_6	120	129	PF00069	0.472
DOC_PP1_RVXF_1	156	162	PF00149	0.615
DOC_PP2B_LxvP_1	215	218	PF13499	0.454
DOC_PP2B_LxvP_1	285	288	PF13499	0.398
DOC_PP2B_LxvP_1	534	537	PF13499	0.628
DOC_PP4_FxxP_1	114	117	PF00568	0.554
DOC_PP4_FxxP_1	149	152	PF00568	0.456
DOC_PP4_FxxP_1	239	242	PF00568	0.575
DOC_PP4_FxxP_1	360	363	PF00568	0.619
DOC_SPAK_OSR1_1	359	363	PF12202	0.555
DOC_USP7_MATH_1	115	119	PF00917	0.640
DOC_USP7_MATH_1	335	339	PF00917	0.413
DOC_USP7_MATH_1	539	543	PF00917	0.691
DOC_USP7_MATH_1	551	555	PF00917	0.624
DOC_WW_Pin1_4	113	118	PF00397	0.617
DOC_WW_Pin1_4	121	126	PF00397	0.745
DOC_WW_Pin1_4	153	158	PF00397	0.633
DOC_WW_Pin1_4	316	321	PF00397	0.481
DOC_WW_Pin1_4	532	537	PF00397	0.637
LIG_14-3-3_CanoR_1	172	180	PF00244	0.487
LIG_14-3-3_CanoR_1	207	216	PF00244	0.566
LIG_14-3-3_CanoR_1	33	38	PF00244	0.560
LIG_14-3-3_CanoR_1	397	401	PF00244	0.632
LIG_14-3-3_CanoR_1	425	429	PF00244	0.673
LIG_14-3-3_CanoR_1	431	437	PF00244	0.634
LIG_14-3-3_CanoR_1	51	59	PF00244	0.407
LIG_14-3-3_CanoR_1	522	526	PF00244	0.738
LIG_BRCT_BRCA1_1	145	149	PF00533	0.641
LIG_BRCT_BRCA1_1	356	360	PF00533	0.502
LIG_deltaCOP1_diTrp_1	355	360	PF00928	0.550
LIG_DLG_GKlike_1	33	41	PF00625	0.449
LIG_FHA_1	122	128	PF00498	0.702
LIG_FHA_1	134	140	PF00498	0.698
LIG_FHA_1	308	314	PF00498	0.538
LIG_FHA_1	33	39	PF00498	0.536
LIG_FHA_1	335	341	PF00498	0.408
LIG_FHA_1	533	539	PF00498	0.742
LIG_FHA_1	561	567	PF00498	0.653
LIG_FHA_2	173	179	PF00498	0.485
LIG_FHA_2	43	49	PF00498	0.486
LIG_FHA_2	433	439	PF00498	0.579
LIG_FHA_2	442	448	PF00498	0.422
LIG_FHA_2	456	462	PF00498	0.407
LIG_LIR_Apic_2	111	117	PF02991	0.556
LIG_LIR_Apic_2	146	152	PF02991	0.458
LIG_LIR_Apic_2	236	242	PF02991	0.640
LIG_LIR_Apic_2	357	363	PF02991	0.539
LIG_LIR_Gen_1	175	185	PF02991	0.423
LIG_LIR_Gen_1	231	242	PF02991	0.503
LIG_LIR_Gen_1	346	354	PF02991	0.393
LIG_LIR_Nem_3	175	180	PF02991	0.460
LIG_LIR_Nem_3	183	188	PF02991	0.387
LIG_LIR_Nem_3	231	237	PF02991	0.534
LIG_NRBOX	54	60	PF00104	0.541
LIG_PCNA_PIPBox_1	433	442	PF02747	0.551
LIG_Pex14_1	356	360	PF04695	0.558
LIG_SH2_STAP1	349	353	PF00017	0.506
LIG_SH2_STAT5	141	144	PF00017	0.589
LIG_SH2_STAT5	234	237	PF00017	0.511
LIG_SH2_STAT5	30	33	PF00017	0.551
LIG_SH2_STAT5	361	364	PF00017	0.704
LIG_SH3_1	426	432	PF00018	0.567
LIG_SH3_3	317	323	PF00018	0.430
LIG_SH3_3	426	432	PF00018	0.567
LIG_SH3_3	504	510	PF00018	0.681
LIG_SH3_3	530	536	PF00018	0.754
LIG_SH3_3	555	561	PF00018	0.639
LIG_SH3_CIN85_PxpxPR_1	153	158	PF14604	0.519
LIG_SUMO_SIM_anti_2	309	315	PF11976	0.405
LIG_SUMO_SIM_par_1	392	399	PF11976	0.557
LIG_TRAF2_1	517	520	PF00917	0.525
LIG_TRAF2_1	65	68	PF00917	0.446
LIG_WRC_WIRS_1	340	345	PF05994	0.424
LIG_WRC_WIRS_1	82	87	PF05994	0.591
MOD_CDK_SPK_2	153	158	PF00069	0.572
MOD_CDK_SPxxK_3	113	120	PF00069	0.547
MOD_CK1_1	113	119	PF00069	0.727
MOD_CK1_1	145	151	PF00069	0.634
MOD_CK1_1	164	170	PF00069	0.573
MOD_CK1_1	22	28	PF00069	0.613
MOD_CK1_1	271	277	PF00069	0.594
MOD_CK1_1	32	38	PF00069	0.547
MOD_CK1_1	401	407	PF00069	0.711
MOD_CK1_1	497	503	PF00069	0.637
MOD_CK2_1	208	214	PF00069	0.553
MOD_CK2_1	344	350	PF00069	0.360
MOD_CK2_1	441	447	PF00069	0.474
MOD_CK2_1	449	455	PF00069	0.454
MOD_CK2_1	551	557	PF00069	0.746
MOD_CK2_1	587	593	PF00069	0.555
MOD_CK2_1	9	15	PF00069	0.575
MOD_GlcNHglycan	149	152	PF01048	0.654
MOD_GlcNHglycan	180	183	PF01048	0.398
MOD_GlcNHglycan	230	233	PF01048	0.520
MOD_GlcNHglycan	266	269	PF01048	0.577
MOD_GlcNHglycan	403	406	PF01048	0.683
MOD_GlcNHglycan	407	410	PF01048	0.612
MOD_GlcNHglycan	426	429	PF01048	0.676
MOD_GlcNHglycan	451	454	PF01048	0.575
MOD_GlcNHglycan	491	494	PF01048	0.703
MOD_GlcNHglycan	553	556	PF01048	0.644
MOD_GSK3_1	140	147	PF00069	0.555
MOD_GSK3_1	224	231	PF00069	0.627
MOD_GSK3_1	233	240	PF00069	0.585
MOD_GSK3_1	260	267	PF00069	0.691
MOD_GSK3_1	29	36	PF00069	0.472
MOD_GSK3_1	335	342	PF00069	0.386
MOD_GSK3_1	344	351	PF00069	0.349
MOD_GSK3_1	361	368	PF00069	0.440
MOD_GSK3_1	38	45	PF00069	0.478
MOD_GSK3_1	401	408	PF00069	0.608
MOD_GSK3_1	485	492	PF00069	0.581
MOD_GSK3_1	5	12	PF00069	0.603
MOD_GSK3_1	539	546	PF00069	0.601
MOD_GSK3_1	81	88	PF00069	0.741
MOD_N-GLC_1	208	213	PF02516	0.613
MOD_N-GLC_1	401	406	PF02516	0.683
MOD_N-GLC_1	494	499	PF02516	0.636
MOD_NEK2_1	133	138	PF00069	0.702
MOD_NEK2_1	144	149	PF00069	0.531
MOD_NEK2_1	161	166	PF00069	0.470
MOD_NEK2_1	187	192	PF00069	0.396
MOD_NEK2_1	228	233	PF00069	0.469
MOD_NEK2_1	260	265	PF00069	0.702
MOD_NEK2_1	277	282	PF00069	0.441
MOD_NEK2_1	31	36	PF00069	0.520
MOD_NEK2_1	343	348	PF00069	0.429
MOD_NEK2_1	366	371	PF00069	0.523
MOD_NEK2_1	38	43	PF00069	0.522
MOD_NEK2_1	395	400	PF00069	0.718
MOD_NEK2_1	5	10	PF00069	0.589
MOD_NEK2_1	85	90	PF00069	0.728
MOD_NEK2_2	432	437	PF00069	0.577
MOD_PIKK_1	417	423	PF00454	0.530
MOD_PIKK_1	50	56	PF00454	0.501
MOD_PKA_1	521	527	PF00069	0.627
MOD_PKA_2	300	306	PF00069	0.697
MOD_PKA_2	32	38	PF00069	0.569
MOD_PKA_2	396	402	PF00069	0.724
MOD_PKA_2	424	430	PF00069	0.628
MOD_PKA_2	497	503	PF00069	0.711
MOD_PKA_2	50	56	PF00069	0.443
MOD_PKA_2	521	527	PF00069	0.736
MOD_Plk_1	223	229	PF00069	0.537
MOD_Plk_1	237	243	PF00069	0.424
MOD_Plk_1	460	466	PF00069	0.518
MOD_Plk_1	587	593	PF00069	0.621
MOD_Plk_4	180	186	PF00069	0.370
MOD_Plk_4	268	274	PF00069	0.547
MOD_Plk_4	33	39	PF00069	0.497
MOD_Plk_4	336	342	PF00069	0.381
MOD_Plk_4	344	350	PF00069	0.342
MOD_Plk_4	587	593	PF00069	0.574
MOD_ProDKin_1	113	119	PF00069	0.614
MOD_ProDKin_1	121	127	PF00069	0.746
MOD_ProDKin_1	153	159	PF00069	0.631
MOD_ProDKin_1	316	322	PF00069	0.491
MOD_ProDKin_1	532	538	PF00069	0.640
MOD_SUMO_rev_2	377	385	PF00179	0.644
MOD_SUMO_rev_2	497	506	PF00179	0.657
TRG_DiLeu_BaEn_1	68	73	PF01217	0.473
TRG_DiLeu_BaEn_4	68	74	PF01217	0.581
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.647
TRG_ENDOCYTIC_2	141	144	PF00928	0.703
TRG_ENDOCYTIC_2	185	188	PF00928	0.365
TRG_ENDOCYTIC_2	234	237	PF00928	0.529
TRG_ENDOCYTIC_2	349	352	PF00928	0.398
TRG_ER_diArg_1	204	207	PF00400	0.456
TRG_ER_diArg_1	472	474	PF00400	0.556
TRG_ER_diArg_1	579	581	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K6	Leptomonas seymouri	52%	97%
A0A1X0NLK5	Trypanosomatidae	35%	100%
A0A3R7NFJ5	Trypanosoma rangeli	34%	100%
A0A3S7XCD6	Leishmania donovani	93%	100%
A4HQH5	Leishmania braziliensis	75%	99%
A4ICB1	Leishmania infantum	93%	87%
D0A3M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q0A3	Leishmania major	90%	100%
V5DDT5	Trypanosoma cruzi	34%	100%