LeishMANIAdb
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NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NUC153 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AU86_LEIMU
TriTrypDb:
LmxM.36.6520
Length:
620

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AU86
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU86

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006364 rRNA processing 8 12
GO:0006396 RNA processing 6 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0016072 rRNA metabolic process 7 12
GO:0034470 ncRNA processing 7 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 278 282 PF00656 0.445
CLV_C14_Caspase3-7 303 307 PF00656 0.666
CLV_C14_Caspase3-7 384 388 PF00656 0.547
CLV_C14_Caspase3-7 590 594 PF00656 0.598
CLV_C14_Caspase3-7 597 601 PF00656 0.512
CLV_NRD_NRD_1 182 184 PF00675 0.366
CLV_NRD_NRD_1 324 326 PF00675 0.472
CLV_NRD_NRD_1 441 443 PF00675 0.454
CLV_NRD_NRD_1 493 495 PF00675 0.486
CLV_NRD_NRD_1 531 533 PF00675 0.574
CLV_NRD_NRD_1 54 56 PF00675 0.380
CLV_PCSK_FUR_1 317 321 PF00082 0.620
CLV_PCSK_KEX2_1 182 184 PF00082 0.457
CLV_PCSK_KEX2_1 319 321 PF00082 0.515
CLV_PCSK_KEX2_1 323 325 PF00082 0.517
CLV_PCSK_KEX2_1 441 443 PF00082 0.454
CLV_PCSK_KEX2_1 493 495 PF00082 0.486
CLV_PCSK_KEX2_1 53 55 PF00082 0.378
CLV_PCSK_KEX2_1 531 533 PF00082 0.570
CLV_PCSK_KEX2_1 566 568 PF00082 0.534
CLV_PCSK_KEX2_1 586 588 PF00082 0.578
CLV_PCSK_KEX2_1 97 99 PF00082 0.465
CLV_PCSK_PC1ET2_1 319 321 PF00082 0.542
CLV_PCSK_PC1ET2_1 566 568 PF00082 0.554
CLV_PCSK_PC1ET2_1 586 588 PF00082 0.617
CLV_PCSK_PC1ET2_1 97 99 PF00082 0.465
CLV_PCSK_PC7_1 320 326 PF00082 0.599
CLV_PCSK_SKI1_1 164 168 PF00082 0.526
CLV_PCSK_SKI1_1 443 447 PF00082 0.476
CLV_PCSK_SKI1_1 450 454 PF00082 0.458
CLV_PCSK_SKI1_1 499 503 PF00082 0.471
CLV_PCSK_SKI1_1 509 513 PF00082 0.473
CLV_PCSK_SKI1_1 97 101 PF00082 0.407
DEG_APCC_DBOX_1 471 479 PF00400 0.600
DEG_SCF_TRCP1_1 362 368 PF00400 0.512
DOC_ANK_TNKS_1 588 595 PF00023 0.621
DOC_MAPK_gen_1 512 523 PF00069 0.456
DOC_MAPK_MEF2A_6 104 112 PF00069 0.448
DOC_PP1_RVXF_1 263 269 PF00149 0.416
DOC_PP4_FxxP_1 198 201 PF00568 0.326
DOC_PP4_FxxP_1 234 237 PF00568 0.438
DOC_USP7_MATH_1 250 254 PF00917 0.447
DOC_USP7_MATH_1 298 302 PF00917 0.564
DOC_USP7_MATH_1 598 602 PF00917 0.623
DOC_USP7_MATH_1 8 12 PF00917 0.611
DOC_USP7_UBL2_3 315 319 PF12436 0.624
DOC_USP7_UBL2_3 439 443 PF12436 0.490
DOC_USP7_UBL2_3 446 450 PF12436 0.472
DOC_USP7_UBL2_3 491 495 PF12436 0.499
DOC_USP7_UBL2_3 613 617 PF12436 0.514
DOC_WW_Pin1_4 197 202 PF00397 0.336
DOC_WW_Pin1_4 233 238 PF00397 0.524
LIG_14-3-3_CanoR_1 265 269 PF00244 0.451
LIG_14-3-3_CanoR_1 275 280 PF00244 0.451
LIG_14-3-3_CanoR_1 371 377 PF00244 0.567
LIG_14-3-3_CanoR_1 587 596 PF00244 0.671
LIG_BIR_II_1 1 5 PF00653 0.584
LIG_CaM_IQ_9 412 428 PF13499 0.596
LIG_CaM_IQ_9 524 540 PF13499 0.621
LIG_CSL_BTD_1 41 44 PF09270 0.640
LIG_FHA_1 408 414 PF00498 0.386
LIG_FHA_1 522 528 PF00498 0.630
LIG_FHA_1 614 620 PF00498 0.406
LIG_FHA_2 14 20 PF00498 0.653
LIG_FHA_2 284 290 PF00498 0.488
LIG_FHA_2 528 534 PF00498 0.583
LIG_FHA_2 595 601 PF00498 0.494
LIG_LIR_Apic_2 197 201 PF02991 0.326
LIG_LIR_Apic_2 231 237 PF02991 0.442
LIG_LIR_Gen_1 62 71 PF02991 0.342
LIG_LIR_Nem_3 178 184 PF02991 0.500
LIG_LIR_Nem_3 62 66 PF02991 0.350
LIG_LIR_Nem_3 70 75 PF02991 0.375
LIG_NRP_CendR_1 617 620 PF00754 0.414
LIG_Pex14_2 264 268 PF04695 0.399
LIG_REV1ctd_RIR_1 607 618 PF16727 0.618
LIG_SH2_CRK 326 330 PF00017 0.486
LIG_SH2_CRK 72 76 PF00017 0.389
LIG_SH2_NCK_1 193 197 PF00017 0.333
LIG_SH2_STAP1 326 330 PF00017 0.451
LIG_SH2_STAP1 72 76 PF00017 0.389
LIG_SH2_STAT5 227 230 PF00017 0.388
LIG_SH2_STAT5 295 298 PF00017 0.522
LIG_SH3_3 147 153 PF00018 0.749
LIG_SUMO_SIM_par_1 84 89 PF11976 0.483
LIG_TRAF2_1 28 31 PF00917 0.704
LIG_TRAF2_1 286 289 PF00917 0.668
LIG_WRC_WIRS_1 195 200 PF05994 0.339
LIG_WRC_WIRS_1 251 256 PF05994 0.432
MOD_CDK_SPxxK_3 233 240 PF00069 0.520
MOD_CK1_1 2 8 PF00069 0.693
MOD_CK1_1 200 206 PF00069 0.370
MOD_CK1_1 236 242 PF00069 0.622
MOD_CK1_1 257 263 PF00069 0.502
MOD_CK1_1 9 15 PF00069 0.637
MOD_CK2_1 13 19 PF00069 0.617
MOD_CK2_1 283 289 PF00069 0.619
MOD_CK2_1 298 304 PF00069 0.492
MOD_CK2_1 370 376 PF00069 0.605
MOD_CK2_1 486 492 PF00069 0.514
MOD_CK2_1 527 533 PF00069 0.583
MOD_Cter_Amidation 584 587 PF01082 0.614
MOD_Cter_Amidation 95 98 PF01082 0.388
MOD_GlcNHglycan 128 133 PF01048 0.796
MOD_GlcNHglycan 217 221 PF01048 0.384
MOD_GlcNHglycan 256 259 PF01048 0.466
MOD_GlcNHglycan 361 365 PF01048 0.516
MOD_GlcNHglycan 488 491 PF01048 0.510
MOD_GlcNHglycan 6 9 PF01048 0.736
MOD_GSK3_1 148 155 PF00069 0.712
MOD_GSK3_1 2 9 PF00069 0.660
MOD_GSK3_1 250 257 PF00069 0.470
MOD_GSK3_1 275 282 PF00069 0.440
MOD_GSK3_1 407 414 PF00069 0.661
MOD_GSK3_1 546 553 PF00069 0.561
MOD_GSK3_1 594 601 PF00069 0.642
MOD_GSK3_1 86 93 PF00069 0.494
MOD_N-GLC_1 9 14 PF02516 0.557
MOD_NEK2_1 254 259 PF00069 0.395
MOD_NEK2_1 279 284 PF00069 0.545
MOD_NEK2_1 445 450 PF00069 0.594
MOD_NEK2_1 521 526 PF00069 0.551
MOD_NEK2_1 559 564 PF00069 0.641
MOD_NEK2_1 575 580 PF00069 0.376
MOD_NEK2_1 86 91 PF00069 0.524
MOD_NEK2_2 250 255 PF00069 0.446
MOD_PIKK_1 257 263 PF00454 0.404
MOD_PIKK_1 521 527 PF00454 0.678
MOD_PIKK_1 559 565 PF00454 0.606
MOD_PKA_1 613 619 PF00069 0.397
MOD_PKA_2 264 270 PF00069 0.414
MOD_PKA_2 370 376 PF00069 0.553
MOD_PKA_2 486 492 PF00069 0.668
MOD_Plk_1 230 236 PF00069 0.355
MOD_Plk_1 365 371 PF00069 0.589
MOD_Plk_1 400 406 PF00069 0.556
MOD_Plk_1 599 605 PF00069 0.619
MOD_Plk_1 86 92 PF00069 0.487
MOD_Plk_2-3 143 149 PF00069 0.687
MOD_Plk_2-3 230 236 PF00069 0.355
MOD_Plk_4 392 398 PF00069 0.676
MOD_Plk_4 86 92 PF00069 0.487
MOD_ProDKin_1 197 203 PF00069 0.334
MOD_ProDKin_1 233 239 PF00069 0.521
MOD_SUMO_rev_2 311 316 PF00179 0.574
MOD_SUMO_rev_2 405 413 PF00179 0.511
MOD_SUMO_rev_2 590 597 PF00179 0.642
TRG_DiLeu_BaEn_4 30 36 PF01217 0.638
TRG_ENDOCYTIC_2 192 195 PF00928 0.350
TRG_ENDOCYTIC_2 208 211 PF00928 0.364
TRG_ENDOCYTIC_2 326 329 PF00928 0.447
TRG_ENDOCYTIC_2 72 75 PF00928 0.379
TRG_ER_diArg_1 181 183 PF00400 0.462
TRG_ER_diArg_1 322 325 PF00400 0.484
TRG_ER_diArg_1 440 442 PF00400 0.465
TRG_ER_diArg_1 53 55 PF00400 0.398
TRG_ER_diLys_1 615 620 PF00400 0.531
TRG_NES_CRM1_1 367 381 PF08389 0.726
TRG_NES_CRM1_1 70 84 PF08389 0.354
TRG_NLS_Bipartite_1 494 516 PF00514 0.483
TRG_NLS_MonoExtC_3 445 450 PF00514 0.467
TRG_NLS_MonoExtC_3 511 516 PF00514 0.500
TRG_NLS_MonoExtC_3 585 591 PF00514 0.643
TRG_NLS_MonoExtC_3 612 617 PF00514 0.395
TRG_NLS_MonoExtN_4 443 450 PF00514 0.487
TRG_NLS_MonoExtN_4 509 516 PF00514 0.467
TRG_NLS_MonoExtN_4 583 590 PF00514 0.632
TRG_NLS_MonoExtN_4 613 618 PF00514 0.486
TRG_Pf-PMV_PEXEL_1 98 103 PF00026 0.434

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2Z4 Leptomonas seymouri 72% 85%
A0A0S4IQI8 Bodo saltans 49% 84%
A0A1X0NN45 Trypanosomatidae 53% 84%
A0A3S5IRC1 Trypanosoma rangeli 54% 91%
A0A3S7XCB2 Leishmania donovani 91% 100%
A4HQH3 Leishmania braziliensis 81% 100%
A4ICA9 Leishmania infantum 90% 99%
D0A3M2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 87%
Q4Q0A5 Leishmania major 89% 100%
V5AXL9 Trypanosoma cruzi 54% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS