PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cop9 signalosome complex subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AU85_LEIMU

TriTrypDb:

LmxM.36.6510

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU85

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.415
CLV_C14_Caspase3-7	18	22	PF00656	0.397
CLV_C14_Caspase3-7	28	32	PF00656	0.311
CLV_C14_Caspase3-7	365	369	PF00656	0.476
CLV_C14_Caspase3-7	374	378	PF00656	0.560
CLV_NRD_NRD_1	175	177	PF00675	0.448
CLV_NRD_NRD_1	205	207	PF00675	0.349
CLV_PCSK_FUR_1	173	177	PF00082	0.432
CLV_PCSK_KEX2_1	175	177	PF00082	0.448
CLV_PCSK_KEX2_1	205	207	PF00082	0.349
CLV_PCSK_KEX2_1	380	382	PF00082	0.551
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.503
CLV_PCSK_SKI1_1	111	115	PF00082	0.346
CLV_PCSK_SKI1_1	230	234	PF00082	0.333
CLV_PCSK_SKI1_1	300	304	PF00082	0.355
CLV_PCSK_SKI1_1	330	334	PF00082	0.445
CLV_PCSK_SKI1_1	381	385	PF00082	0.346
DEG_APCC_DBOX_1	205	213	PF00400	0.265
DEG_APCC_DBOX_1	229	237	PF00400	0.335
DOC_ANK_TNKS_1	175	182	PF00023	0.423
DOC_CYCLIN_RxL_1	318	329	PF00134	0.413
DOC_MAPK_gen_1	391	398	PF00069	0.557
DOC_MAPK_MEF2A_6	391	398	PF00069	0.557
DOC_PP1_RVXF_1	109	116	PF00149	0.369
DOC_PP2B_LxvP_1	261	264	PF13499	0.401
DOC_USP7_MATH_1	211	215	PF00917	0.343
DOC_USP7_MATH_1	248	252	PF00917	0.306
DOC_USP7_MATH_1	289	293	PF00917	0.374
DOC_USP7_MATH_1	4	8	PF00917	0.458
DOC_WW_Pin1_4	129	134	PF00397	0.447
LIG_14-3-3_CanoR_1	111	116	PF00244	0.337
LIG_14-3-3_CanoR_1	136	144	PF00244	0.322
LIG_14-3-3_CanoR_1	210	216	PF00244	0.351
LIG_14-3-3_CanoR_1	34	39	PF00244	0.420
LIG_14-3-3_CanoR_1	381	389	PF00244	0.399
LIG_14-3-3_CanoR_1	79	88	PF00244	0.511
LIG_APCC_ABBA_1	323	328	PF00400	0.387
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BIR_III_4	21	25	PF00653	0.353
LIG_BRCT_BRCA1_1	121	125	PF00533	0.379
LIG_BRCT_BRCA1_1	4	8	PF00533	0.566
LIG_deltaCOP1_diTrp_1	70	78	PF00928	0.388
LIG_FHA_1	356	362	PF00498	0.436
LIG_FHA_2	102	108	PF00498	0.476
LIG_FHA_2	130	136	PF00498	0.355
LIG_FHA_2	16	22	PF00498	0.422
LIG_FHA_2	26	32	PF00498	0.396
LIG_FHA_2	331	337	PF00498	0.408
LIG_FHA_2	372	378	PF00498	0.590
LIG_Integrin_isoDGR_2	39	41	PF01839	0.375
LIG_Integrin_RGD_1	19	21	PF01839	0.375
LIG_LIR_Apic_2	70	76	PF02991	0.388
LIG_LIR_Gen_1	101	109	PF02991	0.359
LIG_LIR_Gen_1	132	141	PF02991	0.373
LIG_LIR_Gen_1	165	174	PF02991	0.338
LIG_LIR_Gen_1	214	219	PF02991	0.235
LIG_LIR_Gen_1	314	323	PF02991	0.390
LIG_LIR_Gen_1	357	367	PF02991	0.465
LIG_LIR_Gen_1	42	53	PF02991	0.376
LIG_LIR_Gen_1	7	17	PF02991	0.508
LIG_LIR_Nem_3	101	106	PF02991	0.458
LIG_LIR_Nem_3	122	128	PF02991	0.382
LIG_LIR_Nem_3	132	137	PF02991	0.351
LIG_LIR_Nem_3	165	170	PF02991	0.415
LIG_LIR_Nem_3	214	218	PF02991	0.413
LIG_LIR_Nem_3	314	318	PF02991	0.394
LIG_LIR_Nem_3	357	363	PF02991	0.429
LIG_LIR_Nem_3	376	382	PF02991	0.482
LIG_LIR_Nem_3	42	48	PF02991	0.380
LIG_LIR_Nem_3	7	13	PF02991	0.522
LIG_MLH1_MIPbox_1	122	126	PF16413	0.456
LIG_NRBOX	336	342	PF00104	0.391
LIG_PDZ_Class_2	393	398	PF00595	0.381
LIG_SH2_CRK	128	132	PF00017	0.357
LIG_SH2_CRK	167	171	PF00017	0.500
LIG_SH2_CRK	266	270	PF00017	0.380
LIG_SH2_CRK	49	53	PF00017	0.261
LIG_SH2_GRB2like	219	222	PF00017	0.282
LIG_SH2_NCK_1	103	107	PF00017	0.441
LIG_SH2_SRC	219	222	PF00017	0.282
LIG_SH2_SRC	293	296	PF00017	0.280
LIG_SH2_STAP1	49	53	PF00017	0.261
LIG_SH2_STAT3	273	276	PF00017	0.459
LIG_SH2_STAT5	103	106	PF00017	0.430
LIG_SH2_STAT5	194	197	PF00017	0.338
LIG_SH2_STAT5	208	211	PF00017	0.355
LIG_SH2_STAT5	268	271	PF00017	0.353
LIG_SH2_STAT5	293	296	PF00017	0.363
LIG_TYR_ITSM	99	106	PF00017	0.417
LIG_WRC_WIRS_1	212	217	PF05994	0.423
MOD_CDK_SPxxK_3	129	136	PF00069	0.442
MOD_CK1_1	147	153	PF00069	0.430
MOD_CK1_1	2	8	PF00069	0.604
MOD_CK1_1	80	86	PF00069	0.577
MOD_CK2_1	330	336	PF00069	0.429
MOD_GlcNHglycan	157	160	PF01048	0.450
MOD_GlcNHglycan	177	180	PF01048	0.474
MOD_GlcNHglycan	21	25	PF01048	0.390
MOD_GlcNHglycan	220	224	PF01048	0.352
MOD_GlcNHglycan	364	367	PF01048	0.448
MOD_GlcNHglycan	49	52	PF01048	0.364
MOD_GlcNHglycan	83	86	PF01048	0.553
MOD_GSK3_1	120	127	PF00069	0.516
MOD_GSK3_1	162	169	PF00069	0.550
MOD_GSK3_1	340	347	PF00069	0.419
MOD_GSK3_1	43	50	PF00069	0.362
MOD_GSK3_1	77	84	PF00069	0.506
MOD_GSK3_1	98	105	PF00069	0.531
MOD_N-GLC_1	306	311	PF02516	0.249
MOD_NEK2_1	120	125	PF00069	0.489
MOD_NEK2_1	144	149	PF00069	0.378
MOD_NEK2_1	166	171	PF00069	0.325
MOD_NEK2_1	33	38	PF00069	0.320
MOD_NEK2_1	340	345	PF00069	0.449
MOD_NEK2_1	78	83	PF00069	0.394
MOD_PIKK_1	180	186	PF00454	0.495
MOD_PIKK_1	250	256	PF00454	0.357
MOD_PIKK_1	344	350	PF00454	0.362
MOD_PIKK_1	368	374	PF00454	0.434
MOD_PIKK_1	43	49	PF00454	0.366
MOD_PKA_1	175	181	PF00069	0.427
MOD_PKA_2	135	141	PF00069	0.408
MOD_PKA_2	144	150	PF00069	0.405
MOD_PKA_2	175	181	PF00069	0.493
MOD_PKA_2	33	39	PF00069	0.340
MOD_PKA_2	78	84	PF00069	0.423
MOD_PKB_1	173	181	PF00069	0.604
MOD_Plk_1	306	312	PF00069	0.252
MOD_Plk_4	120	126	PF00069	0.360
MOD_Plk_4	162	168	PF00069	0.473
MOD_Plk_4	211	217	PF00069	0.362
MOD_Plk_4	289	295	PF00069	0.321
MOD_Plk_4	340	346	PF00069	0.457
MOD_ProDKin_1	129	135	PF00069	0.442
MOD_SUMO_rev_2	322	332	PF00179	0.423
TRG_DiLeu_BaEn_1	336	341	PF01217	0.393
TRG_ENDOCYTIC_2	103	106	PF00928	0.354
TRG_ENDOCYTIC_2	128	131	PF00928	0.377
TRG_ENDOCYTIC_2	167	170	PF00928	0.417
TRG_ENDOCYTIC_2	266	269	PF00928	0.373
TRG_ENDOCYTIC_2	49	52	PF00928	0.265
TRG_ER_diArg_1	173	176	PF00400	0.630
TRG_ER_FFAT_2	357	368	PF00635	0.332
TRG_NES_CRM1_1	207	220	PF08389	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K5	Leptomonas seymouri	55%	100%
A0A3S7XCD5	Leishmania donovani	87%	100%
A4HQH2	Leishmania braziliensis	77%	100%
A4ICA8	Leishmania infantum	87%	100%
Q4Q0A6	Leishmania major	86%	100%