Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU78_LEIMU

TriTrypDb:

LmxM.36.6420

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AU78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.518
CLV_PCSK_KEX2_1	162	164	PF00082	0.518
CLV_PCSK_SKI1_1	34	38	PF00082	0.330
DEG_APCC_DBOX_1	6	14	PF00400	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.360
DOC_MAPK_MEF2A_6	34	43	PF00069	0.379
DOC_MAPK_MEF2A_6	7	15	PF00069	0.385
DOC_MAPK_MEF2A_6	71	78	PF00069	0.374
DOC_MAPK_NFAT4_5	71	79	PF00069	0.325
DOC_PP2B_LxvP_1	193	196	PF13499	0.663
DOC_PP4_FxxP_1	15	18	PF00568	0.325
DOC_WW_Pin1_4	176	181	PF00397	0.761
DOC_WW_Pin1_4	25	30	PF00397	0.584
LIG_14-3-3_CanoR_1	71	75	PF00244	0.195
LIG_14-3-3_CanoR_1	92	98	PF00244	0.546
LIG_EVH1_2	195	199	PF00568	0.590
LIG_FHA_1	152	158	PF00498	0.733
LIG_FHA_1	38	44	PF00498	0.325
LIG_FHA_1	71	77	PF00498	0.366
LIG_FHA_2	143	149	PF00498	0.641
LIG_LIR_Apic_2	14	18	PF02991	0.385
LIG_LIR_Gen_1	42	52	PF02991	0.418
LIG_LIR_Gen_1	58	68	PF02991	0.360
LIG_LIR_Gen_1	91	102	PF02991	0.545
LIG_LIR_Nem_3	42	48	PF02991	0.399
LIG_LIR_Nem_3	91	97	PF02991	0.537
LIG_LIR_Nem_3	99	104	PF02991	0.534
LIG_NRBOX	1	7	PF00104	0.321
LIG_Pex14_2	56	60	PF04695	0.318
LIG_SH2_SRC	101	104	PF00017	0.475
LIG_SH2_SRC	200	203	PF00017	0.707
LIG_SH2_STAP1	90	94	PF00017	0.574
LIG_SH2_STAT3	124	127	PF00017	0.574
LIG_SH2_STAT3	21	24	PF00017	0.363
LIG_SH2_STAT5	101	104	PF00017	0.579
LIG_SH2_STAT5	67	70	PF00017	0.357
LIG_SH2_STAT5	77	80	PF00017	0.338
LIG_SH2_STAT5	9	12	PF00017	0.411
LIG_SH3_3	178	184	PF00018	0.802
LIG_SUMO_SIM_anti_2	40	45	PF11976	0.306
LIG_SUMO_SIM_par_1	47	53	PF11976	0.328
LIG_WRC_WIRS_1	12	17	PF05994	0.385
LIG_WRC_WIRS_1	57	62	PF05994	0.205
LIG_WW_3	180	184	PF00397	0.677
MOD_CDK_SPxxK_3	176	183	PF00069	0.785
MOD_CK1_1	119	125	PF00069	0.500
MOD_CK1_1	150	156	PF00069	0.666
MOD_CK2_1	142	148	PF00069	0.637
MOD_GlcNHglycan	118	121	PF01048	0.329
MOD_GlcNHglycan	148	152	PF01048	0.387
MOD_GSK3_1	119	126	PF00069	0.572
MOD_GSK3_1	147	154	PF00069	0.625
MOD_N-GLC_1	37	42	PF02516	0.291
MOD_NEK2_1	147	152	PF00069	0.582
MOD_NEK2_1	55	60	PF00069	0.361
MOD_NEK2_1	76	81	PF00069	0.440
MOD_NEK2_1	93	98	PF00069	0.497
MOD_PIKK_1	119	125	PF00454	0.500
MOD_PIKK_1	162	168	PF00454	0.722
MOD_PKA_1	162	168	PF00069	0.706
MOD_PKA_2	162	168	PF00069	0.733
MOD_PKA_2	70	76	PF00069	0.186
MOD_Plk_1	37	43	PF00069	0.291
MOD_Plk_4	104	110	PF00069	0.538
MOD_Plk_4	11	17	PF00069	0.351
MOD_Plk_4	142	148	PF00069	0.591
MOD_Plk_4	194	200	PF00069	0.706
MOD_Plk_4	39	45	PF00069	0.381
MOD_Plk_4	56	62	PF00069	0.162
MOD_Plk_4	93	99	PF00069	0.626
MOD_ProDKin_1	176	182	PF00069	0.760
MOD_ProDKin_1	25	31	PF00069	0.584
TRG_ENDOCYTIC_2	101	104	PF00928	0.525
TRG_ENDOCYTIC_2	12	15	PF00928	0.416
TRG_ENDOCYTIC_2	90	93	PF00928	0.525
TRG_ER_diArg_1	161	163	PF00400	0.719
TRG_NES_CRM1_1	99	114	PF08389	0.447
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P600	Leptomonas seymouri	63%	74%
A0A1X0NN71	Trypanosomatidae	38%	79%
A0A3Q8IK72	Leishmania donovani	89%	100%
A4HQG2	Leishmania braziliensis	72%	100%
A4IC98	Leishmania infantum	89%	100%
Q4Q0B6	Leishmania major	88%	100%
V5B8C5	Trypanosoma cruzi	35%	100%