HU-CCDC81_euk_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4496), putative

Species:

Leishmania mexicana

UniProt:

E9AU77_LEIMU

TriTrypDb:

LmxM.36.6410

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU77

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.658
CLV_C14_Caspase3-7	416	420	PF00656	0.549
CLV_NRD_NRD_1	188	190	PF00675	0.428
CLV_NRD_NRD_1	246	248	PF00675	0.543
CLV_NRD_NRD_1	272	274	PF00675	0.527
CLV_NRD_NRD_1	286	288	PF00675	0.517
CLV_NRD_NRD_1	294	296	PF00675	0.493
CLV_NRD_NRD_1	416	418	PF00675	0.621
CLV_NRD_NRD_1	438	440	PF00675	0.593
CLV_NRD_NRD_1	46	48	PF00675	0.355
CLV_NRD_NRD_1	509	511	PF00675	0.717
CLV_NRD_NRD_1	81	83	PF00675	0.416
CLV_PCSK_KEX2_1	188	190	PF00082	0.352
CLV_PCSK_KEX2_1	204	206	PF00082	0.478
CLV_PCSK_KEX2_1	271	273	PF00082	0.531
CLV_PCSK_KEX2_1	286	288	PF00082	0.526
CLV_PCSK_KEX2_1	294	296	PF00082	0.499
CLV_PCSK_KEX2_1	438	440	PF00082	0.593
CLV_PCSK_KEX2_1	46	48	PF00082	0.355
CLV_PCSK_KEX2_1	511	513	PF00082	0.591
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.496
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.591
CLV_PCSK_PC7_1	434	440	PF00082	0.588
CLV_PCSK_PC7_1	507	513	PF00082	0.595
CLV_PCSK_SKI1_1	137	141	PF00082	0.313
CLV_PCSK_SKI1_1	169	173	PF00082	0.272
CLV_PCSK_SKI1_1	248	252	PF00082	0.581
CLV_PCSK_SKI1_1	26	30	PF00082	0.426
CLV_PCSK_SKI1_1	413	417	PF00082	0.515
CLV_PCSK_SKI1_1	46	50	PF00082	0.225
DEG_Nend_Nbox_1	1	3	PF02207	0.502
DEG_SPOP_SBC_1	236	240	PF00917	0.488
DOC_ANK_TNKS_1	106	113	PF00023	0.531
DOC_CYCLIN_RxL_1	148	156	PF00134	0.325
DOC_CYCLIN_RxL_1	43	53	PF00134	0.355
DOC_MAPK_gen_1	149	157	PF00069	0.362
DOC_MAPK_gen_1	166	172	PF00069	0.461
DOC_MAPK_gen_1	80	90	PF00069	0.421
DOC_MAPK_MEF2A_6	149	157	PF00069	0.369
DOC_MAPK_MEF2A_6	166	174	PF00069	0.304
DOC_MAPK_MEF2A_6	36	43	PF00069	0.338
DOC_MAPK_RevD_3	153	167	PF00069	0.369
DOC_PP1_RVXF_1	80	87	PF00149	0.356
DOC_PP2B_LxvP_1	155	158	PF13499	0.304
DOC_PP4_FxxP_1	432	435	PF00568	0.603
DOC_USP7_MATH_1	209	213	PF00917	0.589
DOC_USP7_MATH_1	217	221	PF00917	0.476
DOC_USP7_MATH_1	222	226	PF00917	0.593
DOC_USP7_MATH_1	254	258	PF00917	0.553
DOC_USP7_MATH_1	274	278	PF00917	0.399
DOC_USP7_MATH_1	336	340	PF00917	0.601
DOC_USP7_MATH_2	104	110	PF00917	0.357
DOC_USP7_MATH_2	455	461	PF00917	0.664
DOC_WW_Pin1_4	252	257	PF00397	0.560
DOC_WW_Pin1_4	469	474	PF00397	0.715
LIG_14-3-3_CanoR_1	115	119	PF00244	0.304
LIG_14-3-3_CanoR_1	130	139	PF00244	0.304
LIG_14-3-3_CanoR_1	229	233	PF00244	0.635
LIG_14-3-3_CanoR_1	368	377	PF00244	0.789
LIG_14-3-3_CanoR_1	438	442	PF00244	0.586
LIG_14-3-3_CanoR_1	5	14	PF00244	0.396
LIG_BRCT_BRCA1_1	210	214	PF00533	0.584
LIG_BRCT_BRCA1_1	514	518	PF00533	0.531
LIG_FHA_1	222	228	PF00498	0.641
LIG_FHA_1	431	437	PF00498	0.517
LIG_FHA_1	478	484	PF00498	0.688
LIG_FHA_1	487	493	PF00498	0.661
LIG_FHA_1	7	13	PF00498	0.355
LIG_FHA_1	79	85	PF00498	0.364
LIG_FHA_1	98	104	PF00498	0.422
LIG_FHA_2	237	243	PF00498	0.657
LIG_FHA_2	277	283	PF00498	0.700
LIG_FHA_2	346	352	PF00498	0.580
LIG_FHA_2	414	420	PF00498	0.538
LIG_FHA_2	438	444	PF00498	0.601
LIG_FHA_2	485	491	PF00498	0.670
LIG_FHA_2	499	505	PF00498	0.562
LIG_IBAR_NPY_1	77	79	PF08397	0.455
LIG_LIR_Apic_2	429	435	PF02991	0.593
LIG_LIR_Apic_2	449	455	PF02991	0.574
LIG_LIR_Gen_1	111	121	PF02991	0.369
LIG_LIR_Gen_1	138	147	PF02991	0.304
LIG_LIR_Gen_1	197	206	PF02991	0.512
LIG_LIR_Gen_1	341	352	PF02991	0.614
LIG_LIR_Gen_1	35	45	PF02991	0.368
LIG_LIR_Gen_1	66	73	PF02991	0.425
LIG_LIR_Nem_3	111	116	PF02991	0.486
LIG_LIR_Nem_3	138	143	PF02991	0.331
LIG_LIR_Nem_3	197	202	PF02991	0.493
LIG_LIR_Nem_3	341	347	PF02991	0.617
LIG_LIR_Nem_3	35	41	PF02991	0.373
LIG_LIR_Nem_3	66	71	PF02991	0.420
LIG_Pex14_1	64	68	PF04695	0.371
LIG_Pex14_2	60	64	PF04695	0.323
LIG_SH2_CRK	344	348	PF00017	0.600
LIG_SH2_CRK	452	456	PF00017	0.589
LIG_SH2_GRB2like	92	95	PF00017	0.434
LIG_SH2_NCK_1	315	319	PF00017	0.636
LIG_SH2_NCK_1	344	348	PF00017	0.685
LIG_SH2_NCK_1	452	456	PF00017	0.589
LIG_SH2_PTP2	113	116	PF00017	0.304
LIG_SH2_PTP2	68	71	PF00017	0.369
LIG_SH2_SRC	305	308	PF00017	0.509
LIG_SH2_STAP1	315	319	PF00017	0.648
LIG_SH2_STAP1	92	96	PF00017	0.366
LIG_SH2_STAT5	113	116	PF00017	0.304
LIG_SH2_STAT5	142	145	PF00017	0.350
LIG_SH2_STAT5	315	318	PF00017	0.595
LIG_SH2_STAT5	68	71	PF00017	0.378
LIG_SH3_3	328	334	PF00018	0.689
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.621
LIG_SUMO_SIM_par_1	392	401	PF11976	0.681
LIG_TRAF2_1	265	268	PF00917	0.492
LIG_TYR_ITIM	313	318	PF00017	0.491
LIG_UBA3_1	30	36	PF00899	0.371
MOD_CDK_SPxxK_3	252	259	PF00069	0.552
MOD_CK1_1	212	218	PF00069	0.609
MOD_CK1_1	220	226	PF00069	0.690
MOD_CK1_1	228	234	PF00069	0.564
MOD_CK1_1	277	283	PF00069	0.541
MOD_CK1_1	339	345	PF00069	0.611
MOD_CK1_1	372	378	PF00069	0.793
MOD_CK1_1	400	406	PF00069	0.510
MOD_CK1_1	437	443	PF00069	0.582
MOD_CK1_1	465	471	PF00069	0.630
MOD_CK1_1	472	478	PF00069	0.579
MOD_CK1_1	482	488	PF00069	0.643
MOD_CK2_1	276	282	PF00069	0.705
MOD_CK2_1	29	35	PF00069	0.365
MOD_CK2_1	437	443	PF00069	0.603
MOD_Cter_Amidation	508	511	PF01082	0.599
MOD_GlcNHglycan	108	111	PF01048	0.488
MOD_GlcNHglycan	132	135	PF01048	0.314
MOD_GlcNHglycan	211	214	PF01048	0.565
MOD_GlcNHglycan	215	218	PF01048	0.612
MOD_GlcNHglycan	256	259	PF01048	0.689
MOD_GlcNHglycan	276	279	PF01048	0.394
MOD_GlcNHglycan	336	339	PF01048	0.669
MOD_GlcNHglycan	371	374	PF01048	0.655
MOD_GlcNHglycan	443	447	PF01048	0.621
MOD_GlcNHglycan	464	467	PF01048	0.651
MOD_GlcNHglycan	51	55	PF01048	0.431
MOD_GSK3_1	205	212	PF00069	0.520
MOD_GSK3_1	213	220	PF00069	0.592
MOD_GSK3_1	221	228	PF00069	0.572
MOD_GSK3_1	272	279	PF00069	0.424
MOD_GSK3_1	400	407	PF00069	0.512
MOD_GSK3_1	430	437	PF00069	0.590
MOD_GSK3_1	465	472	PF00069	0.653
MOD_GSK3_1	479	486	PF00069	0.690
MOD_N-GLC_1	21	26	PF02516	0.523
MOD_N-GLC_1	313	318	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.493
MOD_NEK2_1	153	158	PF00069	0.304
MOD_NEK2_1	450	455	PF00069	0.623
MOD_NEK2_1	50	55	PF00069	0.428
MOD_NEK2_2	161	166	PF00069	0.369
MOD_PIKK_1	450	456	PF00454	0.616
MOD_PKA_1	272	278	PF00069	0.502
MOD_PKA_2	106	112	PF00069	0.484
MOD_PKA_2	114	120	PF00069	0.300
MOD_PKA_2	220	226	PF00069	0.573
MOD_PKA_2	228	234	PF00069	0.590
MOD_PKA_2	272	278	PF00069	0.489
MOD_PKA_2	352	358	PF00069	0.683
MOD_PKA_2	437	443	PF00069	0.586
MOD_PKB_1	510	518	PF00069	0.604
MOD_Plk_4	339	345	PF00069	0.625
MOD_Plk_4	488	494	PF00069	0.578
MOD_Plk_4	522	528	PF00069	0.574
MOD_ProDKin_1	252	258	PF00069	0.559
MOD_ProDKin_1	469	475	PF00069	0.716
TRG_DiLeu_BaEn_1	66	71	PF01217	0.357
TRG_DiLeu_BaEn_4	66	72	PF01217	0.364
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.335
TRG_ENDOCYTIC_2	113	116	PF00928	0.304
TRG_ENDOCYTIC_2	199	202	PF00928	0.502
TRG_ENDOCYTIC_2	315	318	PF00928	0.497
TRG_ENDOCYTIC_2	344	347	PF00928	0.620
TRG_ENDOCYTIC_2	68	71	PF00928	0.378
TRG_ER_diArg_1	149	152	PF00400	0.326
TRG_ER_diArg_1	188	190	PF00400	0.328
TRG_ER_diArg_1	271	273	PF00400	0.610
TRG_ER_diArg_1	285	287	PF00400	0.452
TRG_ER_diArg_1	294	296	PF00400	0.461
TRG_ER_diArg_1	46	48	PF00400	0.355
TRG_ER_diArg_1	510	513	PF00400	0.592
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I476	Leptomonas seymouri	56%	94%
A0A3Q8IPX9	Leishmania donovani	90%	100%
A4HQG1	Leishmania braziliensis	76%	100%
A4IC97	Leishmania infantum	90%	100%
Q4Q0B7	Leishmania major	89%	100%