Rib72 protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rib72 protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AU74_LEIMU

TriTrypDb:

LmxM.36.6380

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005819	spindle	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0072686	mitotic spindle	6	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU74

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0061640	cytoskeleton-dependent cytokinesis	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.673
CLV_C14_Caspase3-7	44	48	PF00656	0.590
CLV_C14_Caspase3-7	586	590	PF00656	0.481
CLV_NRD_NRD_1	107	109	PF00675	0.214
CLV_NRD_NRD_1	216	218	PF00675	0.460
CLV_NRD_NRD_1	261	263	PF00675	0.316
CLV_NRD_NRD_1	297	299	PF00675	0.220
CLV_NRD_NRD_1	31	33	PF00675	0.528
CLV_NRD_NRD_1	380	382	PF00675	0.651
CLV_NRD_NRD_1	475	477	PF00675	0.318
CLV_NRD_NRD_1	667	669	PF00675	0.396
CLV_NRD_NRD_1	728	730	PF00675	0.329
CLV_NRD_NRD_1	736	738	PF00675	0.350
CLV_PCSK_FUR_1	295	299	PF00082	0.268
CLV_PCSK_FUR_1	508	512	PF00082	0.313
CLV_PCSK_KEX2_1	216	218	PF00082	0.382
CLV_PCSK_KEX2_1	261	263	PF00082	0.281
CLV_PCSK_KEX2_1	295	297	PF00082	0.214
CLV_PCSK_KEX2_1	31	33	PF00082	0.547
CLV_PCSK_KEX2_1	379	381	PF00082	0.573
CLV_PCSK_KEX2_1	397	399	PF00082	0.676
CLV_PCSK_KEX2_1	475	477	PF00082	0.316
CLV_PCSK_KEX2_1	510	512	PF00082	0.405
CLV_PCSK_KEX2_1	621	623	PF00082	0.656
CLV_PCSK_KEX2_1	667	669	PF00082	0.370
CLV_PCSK_KEX2_1	728	730	PF00082	0.357
CLV_PCSK_KEX2_1	736	738	PF00082	0.365
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.281
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.610
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.630
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.425
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.561
CLV_PCSK_PC7_1	617	623	PF00082	0.544
CLV_PCSK_SKI1_1	108	112	PF00082	0.239
CLV_PCSK_SKI1_1	176	180	PF00082	0.467
CLV_PCSK_SKI1_1	250	254	PF00082	0.240
CLV_PCSK_SKI1_1	304	308	PF00082	0.257
CLV_PCSK_SKI1_1	340	344	PF00082	0.366
CLV_PCSK_SKI1_1	413	417	PF00082	0.496
CLV_PCSK_SKI1_1	43	47	PF00082	0.488
CLV_PCSK_SKI1_1	566	570	PF00082	0.463
CLV_PCSK_SKI1_1	70	74	PF00082	0.450
CLV_PCSK_SKI1_1	736	740	PF00082	0.492
DEG_SPOP_SBC_1	553	557	PF00917	0.504
DOC_ANK_TNKS_1	141	148	PF00023	0.481
DOC_CDC14_PxL_1	9	17	PF14671	0.443
DOC_CKS1_1	124	129	PF01111	0.457
DOC_CKS1_1	233	238	PF01111	0.449
DOC_CKS1_1	700	705	PF01111	0.568
DOC_CKS1_1	717	722	PF01111	0.358
DOC_CYCLIN_RxL_1	656	665	PF00134	0.399
DOC_CYCLIN_yClb1_LxF_4	250	256	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.399
DOC_MAPK_gen_1	142	150	PF00069	0.439
DOC_MAPK_gen_1	261	268	PF00069	0.468
DOC_MAPK_gen_1	296	308	PF00069	0.506
DOC_MAPK_MEF2A_6	358	367	PF00069	0.286
DOC_PP1_RVXF_1	263	269	PF00149	0.516
DOC_PP1_RVXF_1	83	90	PF00149	0.425
DOC_PP2B_LxvP_1	460	463	PF13499	0.434
DOC_PP4_FxxP_1	338	341	PF00568	0.516
DOC_SPAK_OSR1_1	659	663	PF12202	0.335
DOC_USP7_MATH_1	117	121	PF00917	0.516
DOC_USP7_MATH_1	271	275	PF00917	0.527
DOC_USP7_MATH_1	477	481	PF00917	0.411
DOC_USP7_MATH_1	553	557	PF00917	0.571
DOC_USP7_MATH_1	57	61	PF00917	0.618
DOC_USP7_MATH_1	616	620	PF00917	0.624
DOC_USP7_MATH_1	636	640	PF00917	0.372
DOC_USP7_MATH_1	671	675	PF00917	0.467
DOC_USP7_MATH_1	678	682	PF00917	0.469
DOC_USP7_UBL2_3	413	417	PF12436	0.415
DOC_USP7_UBL2_3	697	701	PF12436	0.528
DOC_WW_Pin1_4	123	128	PF00397	0.414
DOC_WW_Pin1_4	232	237	PF00397	0.424
DOC_WW_Pin1_4	699	704	PF00397	0.581
DOC_WW_Pin1_4	716	721	PF00397	0.273
LIG_14-3-3_CanoR_1	330	336	PF00244	0.481
LIG_14-3-3_CanoR_1	398	406	PF00244	0.573
LIG_14-3-3_CanoR_1	544	552	PF00244	0.378
LIG_14-3-3_CanoR_1	667	671	PF00244	0.327
LIG_14-3-3_CanoR_1	673	683	PF00244	0.254
LIG_Actin_RPEL_3	722	741	PF02755	0.306
LIG_Actin_WH2_2	474	490	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_Clathr_ClatBox_1	661	665	PF01394	0.224
LIG_deltaCOP1_diTrp_1	593	601	PF00928	0.493
LIG_FHA_1	102	108	PF00498	0.461
LIG_FHA_1	124	130	PF00498	0.432
LIG_FHA_1	40	46	PF00498	0.495
LIG_FHA_1	452	458	PF00498	0.425
LIG_FHA_1	525	531	PF00498	0.354
LIG_FHA_1	555	561	PF00498	0.560
LIG_FHA_1	667	673	PF00498	0.443
LIG_FHA_1	717	723	PF00498	0.397
LIG_FHA_1	92	98	PF00498	0.481
LIG_FHA_2	233	239	PF00498	0.444
LIG_FHA_2	331	337	PF00498	0.487
LIG_FHA_2	34	40	PF00498	0.631
LIG_FHA_2	42	48	PF00498	0.567
LIG_FHA_2	575	581	PF00498	0.440
LIG_FHA_2	703	709	PF00498	0.411
LIG_FHA_2	79	85	PF00498	0.516
LIG_IRF3_LxIS_1	605	612	PF10401	0.429
LIG_LIR_Apic_2	336	341	PF02991	0.516
LIG_LIR_Gen_1	165	174	PF02991	0.439
LIG_LIR_Gen_1	177	187	PF02991	0.441
LIG_LIR_Gen_1	19	27	PF02991	0.460
LIG_LIR_Gen_1	509	520	PF02991	0.447
LIG_LIR_Gen_1	593	601	PF02991	0.477
LIG_LIR_Gen_1	7	16	PF02991	0.455
LIG_LIR_Nem_3	165	169	PF02991	0.480
LIG_LIR_Nem_3	175	181	PF02991	0.406
LIG_LIR_Nem_3	19	23	PF02991	0.422
LIG_LIR_Nem_3	244	248	PF02991	0.526
LIG_LIR_Nem_3	288	293	PF02991	0.516
LIG_LIR_Nem_3	339	345	PF02991	0.414
LIG_LIR_Nem_3	546	552	PF02991	0.381
LIG_LIR_Nem_3	593	598	PF02991	0.486
LIG_LIR_Nem_3	7	12	PF02991	0.464
LIG_LIR_Nem_3	78	82	PF02991	0.444
LIG_PDZ_Class_2	736	741	PF00595	0.377
LIG_Pex14_2	174	178	PF04695	0.536
LIG_Pex14_2	255	259	PF04695	0.414
LIG_Pex14_2	264	268	PF04695	0.414
LIG_Pex14_2	338	342	PF04695	0.425
LIG_Pex14_2	601	605	PF04695	0.378
LIG_Pex14_2	610	614	PF04695	0.444
LIG_Rb_pABgroove_1	273	281	PF01858	0.516
LIG_SH2_CRK	717	721	PF00017	0.486
LIG_SH2_CRK	9	13	PF00017	0.449
LIG_SH2_NCK_1	166	170	PF00017	0.465
LIG_SH2_STAP1	248	252	PF00017	0.516
LIG_SH2_STAP1	421	425	PF00017	0.457
LIG_SH2_STAP1	93	97	PF00017	0.516
LIG_SH2_STAT3	537	540	PF00017	0.476
LIG_SH2_STAT5	114	117	PF00017	0.427
LIG_SH2_STAT5	267	270	PF00017	0.420
LIG_SH2_STAT5	34	37	PF00017	0.507
LIG_SH2_STAT5	449	452	PF00017	0.435
LIG_SH2_STAT5	500	503	PF00017	0.492
LIG_SH2_STAT5	512	515	PF00017	0.395
LIG_SH2_STAT5	524	527	PF00017	0.371
LIG_SH2_STAT5	537	540	PF00017	0.377
LIG_SH2_STAT5	93	96	PF00017	0.428
LIG_SH3_3	10	16	PF00018	0.422
LIG_SH3_3	121	127	PF00018	0.481
LIG_SH3_3	313	319	PF00018	0.544
LIG_SH3_3	362	368	PF00018	0.415
LIG_SUMO_SIM_anti_2	120	126	PF11976	0.465
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.439
LIG_SUMO_SIM_par_1	452	459	PF11976	0.426
LIG_SUMO_SIM_par_1	660	665	PF11976	0.492
LIG_SUMO_SIM_par_1	668	674	PF11976	0.505
LIG_TRAF2_1	435	438	PF00917	0.516
LIG_TRAF2_1	731	734	PF00917	0.484
LIG_TYR_ITIM	164	169	PF00017	0.409
LIG_UBA3_1	501	510	PF00899	0.460
LIG_WRC_WIRS_1	672	677	PF05994	0.487
MOD_CDK_SPxxK_3	232	239	PF00069	0.413
MOD_CK1_1	232	238	PF00069	0.468
MOD_CK1_1	309	315	PF00069	0.526
MOD_CK1_1	543	549	PF00069	0.376
MOD_CK1_1	554	560	PF00069	0.415
MOD_CK1_1	674	680	PF00069	0.400
MOD_CK1_1	78	84	PF00069	0.549
MOD_CK2_1	119	125	PF00069	0.465
MOD_CK2_1	16	22	PF00069	0.487
MOD_CK2_1	232	238	PF00069	0.433
MOD_CK2_1	406	412	PF00069	0.534
MOD_CK2_1	453	459	PF00069	0.425
MOD_CK2_1	57	63	PF00069	0.650
MOD_CK2_1	574	580	PF00069	0.488
MOD_CK2_1	674	680	PF00069	0.471
MOD_CK2_1	702	708	PF00069	0.400
MOD_CK2_1	97	103	PF00069	0.414
MOD_Cter_Amidation	29	32	PF01082	0.558
MOD_Cter_Amidation	377	380	PF01082	0.637
MOD_Cter_Amidation	395	398	PF01082	0.554
MOD_GlcNHglycan	131	134	PF01048	0.214
MOD_GlcNHglycan	198	202	PF01048	0.482
MOD_GlcNHglycan	394	397	PF01048	0.612
MOD_GlcNHglycan	408	411	PF01048	0.492
MOD_GlcNHglycan	464	467	PF01048	0.214
MOD_GlcNHglycan	52	56	PF01048	0.601
MOD_GlcNHglycan	59	62	PF01048	0.506
MOD_GlcNHglycan	638	641	PF01048	0.589
MOD_GlcNHglycan	676	679	PF01048	0.419
MOD_GlcNHglycan	680	683	PF01048	0.439
MOD_GSK3_1	119	126	PF00069	0.425
MOD_GSK3_1	222	229	PF00069	0.513
MOD_GSK3_1	400	407	PF00069	0.558
MOD_GSK3_1	520	527	PF00069	0.418
MOD_GSK3_1	554	561	PF00069	0.569
MOD_GSK3_1	674	681	PF00069	0.447
MOD_GSK3_1	97	104	PF00069	0.481
MOD_NEK2_1	197	202	PF00069	0.465
MOD_NEK2_1	399	404	PF00069	0.580
MOD_NEK2_1	406	411	PF00069	0.452
MOD_NEK2_1	416	421	PF00069	0.174
MOD_NEK2_1	51	56	PF00069	0.656
MOD_NEK2_1	520	525	PF00069	0.412
MOD_NEK2_1	609	614	PF00069	0.614
MOD_NEK2_2	157	162	PF00069	0.441
MOD_NEK2_2	41	46	PF00069	0.556
MOD_NEK2_2	477	482	PF00069	0.339
MOD_NEK2_2	671	676	PF00069	0.475
MOD_PIKK_1	524	530	PF00454	0.385
MOD_PIKK_1	554	560	PF00454	0.572
MOD_PIKK_1	616	622	PF00454	0.660
MOD_PKA_2	382	388	PF00069	0.476
MOD_PKA_2	543	549	PF00069	0.375
MOD_PKA_2	616	622	PF00069	0.609
MOD_PKA_2	666	672	PF00069	0.411
MOD_Plk_1	197	203	PF00069	0.468
MOD_Plk_1	373	379	PF00069	0.600
MOD_Plk_1	4	10	PF00069	0.502
MOD_Plk_1	451	457	PF00069	0.414
MOD_Plk_1	520	526	PF00069	0.477
MOD_Plk_2-3	453	459	PF00069	0.425
MOD_Plk_4	119	125	PF00069	0.469
MOD_Plk_4	135	141	PF00069	0.452
MOD_Plk_4	229	235	PF00069	0.438
MOD_Plk_4	4	10	PF00069	0.521
MOD_Plk_4	400	406	PF00069	0.510
MOD_Plk_4	453	459	PF00069	0.425
MOD_Plk_4	520	526	PF00069	0.436
MOD_Plk_4	533	539	PF00069	0.427
MOD_ProDKin_1	123	129	PF00069	0.414
MOD_ProDKin_1	232	238	PF00069	0.418
MOD_ProDKin_1	699	705	PF00069	0.582
MOD_ProDKin_1	716	722	PF00069	0.279
MOD_SUMO_rev_2	78	87	PF00179	0.441
TRG_DiLeu_BaEn_1	708	713	PF01217	0.387
TRG_DiLeu_BaEn_2	439	445	PF01217	0.414
TRG_ENDOCYTIC_2	166	169	PF00928	0.405
TRG_ENDOCYTIC_2	267	270	PF00928	0.468
TRG_ENDOCYTIC_2	290	293	PF00928	0.516
TRG_ENDOCYTIC_2	34	37	PF00928	0.512
TRG_ENDOCYTIC_2	512	515	PF00928	0.478
TRG_ENDOCYTIC_2	9	12	PF00928	0.458
TRG_ER_diArg_1	105	108	PF00400	0.416
TRG_ER_diArg_1	215	217	PF00400	0.403
TRG_ER_diArg_1	294	297	PF00400	0.414
TRG_ER_diArg_1	380	383	PF00400	0.651
TRG_ER_diArg_1	728	730	PF00400	0.332
TRG_ER_diArg_1	735	737	PF00400	0.363
TRG_NLS_MonoExtC_3	378	383	PF00514	0.576
TRG_NLS_MonoExtN_4	106	112	PF00514	0.425
TRG_NLS_MonoExtN_4	261	266	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	728	733	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ98	Leptomonas seymouri	25%	96%
A0A0N1I3M2	Leptomonas seymouri	26%	97%
A0A0N1PBW1	Leptomonas seymouri	73%	99%
A0A0S4IJW8	Bodo saltans	26%	90%
A0A0S4IQM0	Bodo saltans	39%	100%
A0A0S4J8J7	Bodo saltans	26%	81%
A0A1X0NEV8	Trypanosomatidae	27%	93%
A0A1X0NLI2	Trypanosomatidae	50%	100%
A0A1X0NMQ3	Trypanosomatidae	27%	95%
A0A1X0P419	Trypanosomatidae	25%	98%
A0A3Q8IDH4	Leishmania donovani	24%	96%
A0A3Q8IPU3	Leishmania donovani	26%	98%
A0A3R7KM50	Trypanosoma rangeli	26%	93%
A0A3R7L048	Trypanosoma rangeli	26%	98%
A0A3S7XC76	Leishmania donovani	96%	100%
A0A422N0Z6	Trypanosoma rangeli	27%	95%
A0A422NK00	Trypanosoma rangeli	52%	100%
A4HE78	Leishmania braziliensis	27%	100%
A4HFK9	Leishmania braziliensis	26%	100%
A4HQF8	Leishmania braziliensis	88%	100%
A4I1J2	Leishmania infantum	24%	96%
A4IC94	Leishmania infantum	96%	100%
C9ZJX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	92%
C9ZPE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	95%
D0A3K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A5T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	99%
E1BKH1	Bos taurus	28%	100%
E9AD64	Leishmania major	26%	98%
E9AHF6	Leishmania infantum	27%	98%
E9AMI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	86%
E9AXM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	96%
E9AYY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	98%
Q32TF8	Danio rerio	27%	99%
Q32TG3	Gallus gallus	26%	99%
Q4Q0C0	Leishmania major	95%	100%
Q4Q9U5	Leishmania major	26%	100%
Q5JST6	Homo sapiens	25%	99%
Q9D485	Mus musculus	23%	99%
Q9D9T8	Mus musculus	29%	100%
V5ASV2	Trypanosoma cruzi	51%	100%
V5D3X9	Trypanosoma cruzi	26%	95%
V5DA42	Trypanosoma cruzi	27%	98%