Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase activating protein, putative

Species:

Leishmania mexicana

UniProt:

E9AU73_LEIMU

TriTrypDb:

LmxM.36.6370

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU73

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.357
CLV_C14_Caspase3-7	490	494	PF00656	0.395
CLV_NRD_NRD_1	274	276	PF00675	0.460
CLV_NRD_NRD_1	308	310	PF00675	0.341
CLV_NRD_NRD_1	68	70	PF00675	0.495
CLV_PCSK_KEX2_1	308	310	PF00082	0.374
CLV_PCSK_KEX2_1	505	507	PF00082	0.526
CLV_PCSK_KEX2_1	529	531	PF00082	0.484
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.526
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.476
CLV_PCSK_SKI1_1	153	157	PF00082	0.622
CLV_PCSK_SKI1_1	214	218	PF00082	0.445
CLV_PCSK_SKI1_1	270	274	PF00082	0.437
CLV_PCSK_SKI1_1	300	304	PF00082	0.277
CLV_PCSK_SKI1_1	403	407	PF00082	0.312
CLV_PCSK_SKI1_1	72	76	PF00082	0.443
CLV_Separin_Metazoa	462	466	PF03568	0.339
DEG_APCC_DBOX_1	241	249	PF00400	0.361
DEG_APCC_DBOX_1	434	442	PF00400	0.337
DEG_APCC_DBOX_1	444	452	PF00400	0.246
DEG_SPOP_SBC_1	125	129	PF00917	0.750
DEG_SPOP_SBC_1	161	165	PF00917	0.665
DOC_MAPK_gen_1	275	283	PF00069	0.512
DOC_MAPK_gen_1	308	314	PF00069	0.339
DOC_MAPK_MEF2A_6	403	412	PF00069	0.277
DOC_MAPK_MEF2A_6	546	554	PF00069	0.480
DOC_PP1_RVXF_1	308	315	PF00149	0.292
DOC_PP1_RVXF_1	390	396	PF00149	0.419
DOC_PP4_FxxP_1	224	227	PF00568	0.373
DOC_PP4_FxxP_1	229	232	PF00568	0.347
DOC_PP4_FxxP_1	302	305	PF00568	0.312
DOC_SPAK_OSR1_1	431	435	PF12202	0.357
DOC_USP7_MATH_1	117	121	PF00917	0.606
DOC_USP7_MATH_1	124	128	PF00917	0.568
DOC_USP7_MATH_1	131	135	PF00917	0.596
DOC_USP7_MATH_1	140	144	PF00917	0.519
DOC_USP7_MATH_1	194	198	PF00917	0.645
DOC_USP7_MATH_1	24	28	PF00917	0.403
DOC_USP7_MATH_1	31	35	PF00917	0.296
DOC_USP7_MATH_1	450	454	PF00917	0.483
DOC_USP7_UBL2_3	213	217	PF12436	0.564
DOC_USP7_UBL2_3	266	270	PF12436	0.449
DOC_USP7_UBL2_3	388	392	PF12436	0.357
DOC_USP7_UBL2_3	528	532	PF12436	0.452
DOC_USP7_UBL2_3	55	59	PF12436	0.554
DOC_WW_Pin1_4	162	167	PF00397	0.774
LIG_14-3-3_CanoR_1	513	522	PF00244	0.472
LIG_AP2alpha_1	421	425	PF02296	0.291
LIG_BIR_III_4	23	27	PF00653	0.511
LIG_BRCT_BRCA1_1	176	180	PF00533	0.628
LIG_BRCT_BRCA1_2	176	182	PF00533	0.587
LIG_Clathr_ClatBox_1	463	467	PF01394	0.467
LIG_deltaCOP1_diTrp_1	265	273	PF00928	0.346
LIG_eIF4E_1	228	234	PF01652	0.416
LIG_FHA_1	205	211	PF00498	0.615
LIG_FHA_1	343	349	PF00498	0.286
LIG_FHA_1	352	358	PF00498	0.277
LIG_FHA_1	444	450	PF00498	0.342
LIG_FHA_2	339	345	PF00498	0.419
LIG_LIR_Apic_2	222	227	PF02991	0.456
LIG_LIR_Apic_2	299	305	PF02991	0.312
LIG_LIR_Gen_1	20	30	PF02991	0.458
LIG_LIR_Gen_1	38	47	PF02991	0.286
LIG_LIR_Gen_1	417	426	PF02991	0.278
LIG_LIR_Gen_1	459	468	PF02991	0.335
LIG_LIR_Nem_3	20	25	PF02991	0.449
LIG_LIR_Nem_3	321	325	PF02991	0.287
LIG_LIR_Nem_3	38	42	PF02991	0.343
LIG_LIR_Nem_3	417	422	PF02991	0.287
LIG_LIR_Nem_3	553	557	PF02991	0.435
LIG_LIR_Nem_3	84	89	PF02991	0.469
LIG_LYPXL_SIV_4	324	332	PF13949	0.292
LIG_PCNA_PIPBox_1	383	392	PF02747	0.419
LIG_Pex14_1	373	377	PF04695	0.357
LIG_Pex14_1	396	400	PF04695	0.277
LIG_Pex14_2	35	39	PF04695	0.442
LIG_Pex14_2	415	419	PF04695	0.277
LIG_Pex14_2	421	425	PF04695	0.277
LIG_Pex14_2	432	436	PF04695	0.277
LIG_PTB_Apo_2	313	320	PF02174	0.371
LIG_PTB_Phospho_1	313	319	PF10480	0.419
LIG_SH2_CRK	218	222	PF00017	0.531
LIG_SH2_CRK	274	278	PF00017	0.441
LIG_SH2_PTP2	280	283	PF00017	0.381
LIG_SH2_STAP1	503	507	PF00017	0.432
LIG_SH2_STAT3	377	380	PF00017	0.357
LIG_SH2_STAT5	218	221	PF00017	0.434
LIG_SH2_STAT5	228	231	PF00017	0.359
LIG_SH2_STAT5	280	283	PF00017	0.351
LIG_SH2_STAT5	331	334	PF00017	0.322
LIG_SH2_STAT5	356	359	PF00017	0.312
LIG_SH2_STAT5	377	380	PF00017	0.357
LIG_SH2_STAT5	400	403	PF00017	0.277
LIG_SH3_3	120	126	PF00018	0.666
LIG_SUMO_SIM_anti_2	474	481	PF11976	0.481
LIG_SUMO_SIM_anti_2	493	500	PF11976	0.379
LIG_SUMO_SIM_par_1	336	342	PF11976	0.277
LIG_SUMO_SIM_par_1	446	456	PF11976	0.495
LIG_TYR_ITIM	278	283	PF00017	0.364
LIG_UBA3_1	448	452	PF00899	0.405
LIG_ULM_U2AF65_1	528	534	PF00076	0.448
LIG_WRC_WIRS_1	32	37	PF05994	0.348
LIG_WRC_WIRS_1	418	423	PF05994	0.438
MOD_CDK_SPK_2	162	167	PF00069	0.609
MOD_CK1_1	127	133	PF00069	0.616
MOD_CK1_1	195	201	PF00069	0.778
MOD_CK1_1	38	44	PF00069	0.395
MOD_CK1_1	78	84	PF00069	0.586
MOD_CK1_1	97	103	PF00069	0.684
MOD_CK2_1	338	344	PF00069	0.337
MOD_CK2_1	450	456	PF00069	0.434
MOD_CK2_1	78	84	PF00069	0.512
MOD_GlcNHglycan	119	122	PF01048	0.786
MOD_GlcNHglycan	129	132	PF01048	0.477
MOD_GlcNHglycan	133	136	PF01048	0.601
MOD_GlcNHglycan	194	197	PF01048	0.484
MOD_GlcNHglycan	198	201	PF01048	0.553
MOD_GlcNHglycan	370	373	PF01048	0.337
MOD_GlcNHglycan	77	80	PF01048	0.455
MOD_GlcNHglycan	96	99	PF01048	0.431
MOD_GSK3_1	127	134	PF00069	0.662
MOD_GSK3_1	140	147	PF00069	0.556
MOD_GSK3_1	180	187	PF00069	0.681
MOD_GSK3_1	192	199	PF00069	0.734
MOD_GSK3_1	31	38	PF00069	0.347
MOD_GSK3_1	338	345	PF00069	0.319
MOD_GSK3_1	96	103	PF00069	0.623
MOD_N-GLC_1	117	122	PF02516	0.794
MOD_NEK2_1	180	185	PF00069	0.671
MOD_NEK2_1	35	40	PF00069	0.375
MOD_NEK2_1	368	373	PF00069	0.277
MOD_NEK2_1	47	52	PF00069	0.411
MOD_NEK2_1	497	502	PF00069	0.448
MOD_NEK2_1	94	99	PF00069	0.598
MOD_NEK2_2	298	303	PF00069	0.277
MOD_PIKK_1	101	107	PF00454	0.733
MOD_PIKK_1	112	118	PF00454	0.699
MOD_PIKK_1	141	147	PF00454	0.768
MOD_PIKK_1	497	503	PF00454	0.494
MOD_PK_1	482	488	PF00069	0.462
MOD_Plk_1	298	304	PF00069	0.330
MOD_Plk_1	47	53	PF00069	0.540
MOD_Plk_2-3	417	423	PF00069	0.357
MOD_Plk_2-3	491	497	PF00069	0.427
MOD_Plk_4	104	110	PF00069	0.766
MOD_Plk_4	327	333	PF00069	0.291
MOD_Plk_4	396	402	PF00069	0.277
MOD_ProDKin_1	162	168	PF00069	0.771
MOD_SUMO_for_1	515	518	PF00179	0.495
MOD_SUMO_rev_2	521	531	PF00179	0.471
MOD_SUMO_rev_2	543	548	PF00179	0.501
TRG_DiLeu_BaEn_1	459	464	PF01217	0.467
TRG_DiLeu_BaEn_2	416	422	PF01217	0.337
TRG_DiLeu_LyEn_5	241	246	PF01217	0.433
TRG_ENDOCYTIC_2	228	231	PF00928	0.467
TRG_ENDOCYTIC_2	280	283	PF00928	0.346
TRG_ENDOCYTIC_2	319	322	PF00928	0.386
TRG_ENDOCYTIC_2	461	464	PF00928	0.322
TRG_ER_diArg_1	260	263	PF00400	0.368
TRG_NES_CRM1_1	230	241	PF08389	0.424
TRG_NLS_MonoCore_2	528	533	PF00514	0.481
TRG_NLS_MonoExtN_4	528	533	PF00514	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL31	Leptomonas seymouri	66%	90%
A0A0S4IUJ5	Bodo saltans	51%	98%
A0A1X0NLM8	Trypanosomatidae	54%	100%
A0A3Q8IRX0	Leishmania donovani	96%	100%
A0A3R7LIA2	Trypanosoma rangeli	53%	100%
A4HQF7	Leishmania braziliensis	77%	100%
A4IC93	Leishmania infantum	96%	100%
D0A3K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q4Q0C1	Leishmania major	96%	100%
V5B8C0	Trypanosoma cruzi	55%	98%