Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2962), putative

Species:

Leishmania mexicana

UniProt:

E9AU72_LEIMU

TriTrypDb:

LmxM.36.6360

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.284
CLV_NRD_NRD_1	184	186	PF00675	0.618
CLV_NRD_NRD_1	2	4	PF00675	0.659
CLV_NRD_NRD_1	204	206	PF00675	0.437
CLV_NRD_NRD_1	247	249	PF00675	0.613
CLV_PCSK_FUR_1	10	14	PF00082	0.621
CLV_PCSK_KEX2_1	12	14	PF00082	0.721
CLV_PCSK_KEX2_1	194	196	PF00082	0.583
CLV_PCSK_KEX2_1	2	4	PF00082	0.659
CLV_PCSK_KEX2_1	234	236	PF00082	0.609
CLV_PCSK_KEX2_1	247	249	PF00082	0.616
CLV_PCSK_KEX2_1	31	33	PF00082	0.305
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.693
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.639
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.569
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.353
CLV_PCSK_SKI1_1	168	172	PF00082	0.596
CLV_PCSK_SKI1_1	195	199	PF00082	0.649
CLV_PCSK_SKI1_1	3	7	PF00082	0.660
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DOC_MAPK_gen_1	185	192	PF00069	0.601
DOC_MAPK_gen_1	28	36	PF00069	0.418
DOC_MAPK_gen_1	42	51	PF00069	0.425
DOC_PP1_RVXF_1	193	200	PF00149	0.613
DOC_PP2B_LxvP_1	125	128	PF13499	0.400
DOC_USP7_MATH_1	154	158	PF00917	0.379
DOC_USP7_MATH_1	201	205	PF00917	0.659
DOC_USP7_MATH_1	238	242	PF00917	0.717
DOC_USP7_MATH_1	243	247	PF00917	0.543
DOC_USP7_UBL2_3	194	198	PF12436	0.667
DOC_USP7_UBL2_3	207	211	PF12436	0.648
DOC_USP7_UBL2_3	40	44	PF12436	0.317
DOC_WW_Pin1_4	143	148	PF00397	0.445
DOC_WW_Pin1_4	161	166	PF00397	0.659
LIG_14-3-3_CanoR_1	205	211	PF00244	0.590
LIG_APCC_ABBA_1	80	85	PF00400	0.312
LIG_FAT_LD_1	171	179	PF03623	0.584
LIG_FHA_1	147	153	PF00498	0.284
LIG_FHA_1	215	221	PF00498	0.572
LIG_FHA_1	46	52	PF00498	0.312
LIG_FHA_1	66	72	PF00498	0.308
LIG_FHA_2	129	135	PF00498	0.403
LIG_NRBOX	170	176	PF00104	0.587
LIG_PDZ_Class_3	250	255	PF00595	0.583
LIG_REV1ctd_RIR_1	52	62	PF16727	0.284
LIG_SH2_STAP1	66	70	PF00017	0.400
LIG_SH2_STAT5	66	69	PF00017	0.371
LIG_SH2_STAT5	83	86	PF00017	0.190
LIG_SH3_3	12	18	PF00018	0.362
LIG_SH3_3	187	193	PF00018	0.649
LIG_SUMO_SIM_anti_2	134	141	PF11976	0.286
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.299
LIG_TRAF2_1	226	229	PF00917	0.643
MOD_CDK_SPxxK_3	161	168	PF00069	0.620
MOD_CK2_1	5	11	PF00069	0.657
MOD_GlcNHglycan	120	123	PF01048	0.400
MOD_GlcNHglycan	236	239	PF01048	0.648
MOD_GlcNHglycan	240	243	PF01048	0.616
MOD_GlcNHglycan	250	253	PF01048	0.635
MOD_GlcNHglycan	7	10	PF01048	0.687
MOD_GlcNHglycan	89	94	PF01048	0.300
MOD_GSK3_1	206	213	PF00069	0.604
MOD_GSK3_1	234	241	PF00069	0.505
MOD_LATS_1	17	23	PF00433	0.400
MOD_NEK2_1	108	113	PF00069	0.360
MOD_NEK2_1	45	50	PF00069	0.419
MOD_NEK2_1	5	10	PF00069	0.653
MOD_NEK2_1	64	69	PF00069	0.405
MOD_PK_1	19	25	PF00069	0.400
MOD_PK_1	206	212	PF00069	0.540
MOD_PKA_1	206	212	PF00069	0.527
MOD_PKA_1	234	240	PF00069	0.621
MOD_PKA_2	234	240	PF00069	0.621
MOD_Plk_1	108	114	PF00069	0.400
MOD_Plk_1	19	25	PF00069	0.400
MOD_Plk_1	45	51	PF00069	0.412
MOD_Plk_1	72	78	PF00069	0.393
MOD_Plk_1	89	95	PF00069	0.234
MOD_Plk_4	148	154	PF00069	0.368
MOD_Plk_4	72	78	PF00069	0.358
MOD_ProDKin_1	143	149	PF00069	0.445
MOD_ProDKin_1	161	167	PF00069	0.654
MOD_SUMO_for_1	43	46	PF00179	0.400
TRG_DiLeu_BaEn_4	89	95	PF01217	0.368
TRG_ER_diArg_1	1	3	PF00400	0.670
TRG_ER_diArg_1	177	180	PF00400	0.603
TRG_ER_diArg_1	220	223	PF00400	0.660
TRG_ER_diArg_1	247	249	PF00400	0.549
TRG_NLS_Bipartite_1	194	209	PF00514	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I784	Leptomonas seymouri	70%	100%
A0A1X0NLZ7	Trypanosomatidae	43%	100%
A0A3Q8IJD2	Leishmania donovani	92%	97%
A0A422MX73	Trypanosoma rangeli	42%	100%
A4HQF6	Leishmania braziliensis	84%	100%
A4IC92	Leishmania infantum	91%	97%
D0A3K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q0C2	Leishmania major	91%	100%