Poly(A)-specific ribonuclease PARN

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania mexicana

UniProt:

E9AU71_LEIMU

TriTrypDb:

LmxM.36.6350

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AU71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU71

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	16
GO:0005488	binding	1	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901363	heterocyclic compound binding	2	16
GO:0000175	3'-5'-RNA exonuclease activity	7	3
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0004532	RNA exonuclease activity	5	3
GO:0004540	RNA nuclease activity	4	3
GO:0008408	3'-5' exonuclease activity	6	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	3
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0004535	poly(A)-specific ribonuclease activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.267
CLV_NRD_NRD_1	186	188	PF00675	0.246
CLV_NRD_NRD_1	225	227	PF00675	0.317
CLV_NRD_NRD_1	249	251	PF00675	0.286
CLV_NRD_NRD_1	321	323	PF00675	0.321
CLV_NRD_NRD_1	444	446	PF00675	0.629
CLV_NRD_NRD_1	481	483	PF00675	0.533
CLV_PCSK_KEX2_1	178	180	PF00082	0.283
CLV_PCSK_KEX2_1	186	188	PF00082	0.283
CLV_PCSK_KEX2_1	224	226	PF00082	0.327
CLV_PCSK_KEX2_1	320	322	PF00082	0.321
CLV_PCSK_KEX2_1	481	483	PF00082	0.435
CLV_PCSK_KEX2_1	54	56	PF00082	0.282
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.250
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.291
CLV_PCSK_SKI1_1	134	138	PF00082	0.253
CLV_PCSK_SKI1_1	281	285	PF00082	0.342
DEG_APCC_DBOX_1	95	103	PF00400	0.529
DEG_MDM2_SWIB_1	239	247	PF02201	0.432
DEG_Nend_UBRbox_2	1	3	PF02207	0.351
DOC_CKS1_1	135	140	PF01111	0.338
DOC_MAPK_gen_1	186	194	PF00069	0.446
DOC_MAPK_gen_1	231	239	PF00069	0.529
DOC_MAPK_gen_1	469	476	PF00069	0.456
DOC_MIT_MIM_1	477	487	PF04212	0.419
DOC_PP4_FxxP_1	43	46	PF00568	0.452
DOC_USP7_MATH_1	160	164	PF00917	0.530
DOC_USP7_MATH_1	388	392	PF00917	0.468
DOC_USP7_MATH_1	416	420	PF00917	0.330
DOC_USP7_UBL2_3	207	211	PF12436	0.338
DOC_USP7_UBL2_3	349	353	PF12436	0.529
DOC_WW_Pin1_4	134	139	PF00397	0.338
DOC_WW_Pin1_4	268	273	PF00397	0.414
DOC_WW_Pin1_4	489	494	PF00397	0.567
LIG_14-3-3_CanoR_1	178	184	PF00244	0.468
LIG_14-3-3_CanoR_1	191	195	PF00244	0.549
LIG_14-3-3_CanoR_1	320	326	PF00244	0.529
LIG_14-3-3_CanoR_1	445	450	PF00244	0.528
LIG_14-3-3_CanoR_1	481	487	PF00244	0.447
LIG_14-3-3_CanoR_1	96	102	PF00244	0.534
LIG_APCC_ABBA_1	136	141	PF00400	0.400
LIG_BIR_III_2	305	309	PF00653	0.421
LIG_BRCT_BRCA1_1	326	330	PF00533	0.461
LIG_BRCT_BRCA1_1	39	43	PF00533	0.421
LIG_BRCT_BRCA1_1	390	394	PF00533	0.502
LIG_FHA_1	115	121	PF00498	0.525
LIG_FHA_1	406	412	PF00498	0.376
LIG_FHA_1	431	437	PF00498	0.605
LIG_FHA_1	76	82	PF00498	0.518
LIG_FHA_2	128	134	PF00498	0.395
LIG_FHA_2	159	165	PF00498	0.442
LIG_FHA_2	30	36	PF00498	0.460
LIG_FHA_2	300	306	PF00498	0.487
LIG_FHA_2	308	314	PF00498	0.531
LIG_FHA_2	70	76	PF00498	0.483
LIG_GBD_Chelix_1	176	184	PF00786	0.252
LIG_GBD_Chelix_1	366	374	PF00786	0.296
LIG_LIR_Apic_2	331	337	PF02991	0.445
LIG_LIR_Apic_2	40	46	PF02991	0.450
LIG_LIR_Gen_1	23	31	PF02991	0.415
LIG_LIR_Gen_1	274	284	PF02991	0.513
LIG_LIR_Gen_1	391	401	PF02991	0.215
LIG_LIR_Gen_1	4	13	PF02991	0.504
LIG_LIR_Gen_1	460	470	PF02991	0.345
LIG_LIR_Gen_1	59	69	PF02991	0.460
LIG_LIR_Nem_3	23	27	PF02991	0.387
LIG_LIR_Nem_3	274	280	PF02991	0.457
LIG_LIR_Nem_3	356	362	PF02991	0.456
LIG_LIR_Nem_3	391	397	PF02991	0.351
LIG_LIR_Nem_3	4	9	PF02991	0.466
LIG_LIR_Nem_3	460	466	PF02991	0.334
LIG_LIR_Nem_3	59	64	PF02991	0.454
LIG_MAD2	244	252	PF02301	0.529
LIG_MLH1_MIPbox_1	390	394	PF16413	0.304
LIG_PCNA_yPIPBox_3	96	105	PF02747	0.421
LIG_Pex14_2	239	243	PF04695	0.451
LIG_SH2_CRK	334	338	PF00017	0.515
LIG_SH2_STAP1	131	135	PF00017	0.536
LIG_SH2_STAP1	188	192	PF00017	0.452
LIG_SH2_STAP1	359	363	PF00017	0.455
LIG_SH2_STAT3	201	204	PF00017	0.513
LIG_SH2_STAT5	201	204	PF00017	0.489
LIG_SH2_STAT5	277	280	PF00017	0.543
LIG_SH2_STAT5	393	396	PF00017	0.448
LIG_SH2_STAT5	87	90	PF00017	0.454
LIG_SH3_3	7	13	PF00018	0.514
LIG_SUMO_SIM_par_1	499	506	PF11976	0.361
LIG_SUMO_SIM_par_1	8	14	PF11976	0.477
LIG_TRAF2_1	130	133	PF00917	0.476
LIG_TRFH_1	334	338	PF08558	0.529
LIG_WRC_WIRS_1	101	106	PF05994	0.421
LIG_WRC_WIRS_1	180	185	PF05994	0.421
LIG_WRC_WIRS_1	463	468	PF05994	0.462
MOD_CK1_1	100	106	PF00069	0.510
MOD_CK1_1	190	196	PF00069	0.544
MOD_CK1_1	324	330	PF00069	0.452
MOD_CK1_1	492	498	PF00069	0.554
MOD_CK2_1	127	133	PF00069	0.469
MOD_CK2_1	158	164	PF00069	0.534
MOD_CK2_1	179	185	PF00069	0.362
MOD_CK2_1	217	223	PF00069	0.517
MOD_CK2_1	307	313	PF00069	0.529
MOD_CK2_1	69	75	PF00069	0.472
MOD_GlcNHglycan	117	120	PF01048	0.265
MOD_GlcNHglycan	345	348	PF01048	0.289
MOD_GlcNHglycan	386	389	PF01048	0.431
MOD_GlcNHglycan	390	393	PF01048	0.441
MOD_GlcNHglycan	91	94	PF01048	0.325
MOD_GSK3_1	287	294	PF00069	0.467
MOD_GSK3_1	324	331	PF00069	0.569
MOD_GSK3_1	34	41	PF00069	0.449
MOD_GSK3_1	384	391	PF00069	0.369
MOD_GSK3_1	426	433	PF00069	0.484
MOD_GSK3_1	457	464	PF00069	0.465
MOD_GSK3_1	492	499	PF00069	0.487
MOD_GSK3_1	71	78	PF00069	0.466
MOD_N-GLC_1	343	348	PF02516	0.332
MOD_N-GLC_1	75	80	PF02516	0.221
MOD_N-GLC_1	89	94	PF02516	0.329
MOD_N-GLC_1	97	102	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	147	152	PF00069	0.338
MOD_NEK2_1	206	211	PF00069	0.498
MOD_NEK2_1	246	251	PF00069	0.450
MOD_NEK2_1	284	289	PF00069	0.549
MOD_NEK2_1	97	102	PF00069	0.566
MOD_PIKK_1	271	277	PF00454	0.384
MOD_PIKK_1	328	334	PF00454	0.570
MOD_PIKK_1	431	437	PF00454	0.417
MOD_PKA_1	321	327	PF00069	0.338
MOD_PKA_1	445	451	PF00069	0.421
MOD_PKA_1	461	467	PF00069	0.296
MOD_PKA_2	190	196	PF00069	0.376
MOD_PKA_2	321	327	PF00069	0.432
MOD_Plk_1	1	7	PF00069	0.349
MOD_Plk_1	127	133	PF00069	0.453
MOD_Plk_1	343	349	PF00069	0.429
MOD_Plk_1	75	81	PF00069	0.520
MOD_Plk_1	97	103	PF00069	0.421
MOD_Plk_2-3	127	133	PF00069	0.338
MOD_Plk_2-3	217	223	PF00069	0.452
MOD_Plk_2-3	75	81	PF00069	0.518
MOD_Plk_4	147	153	PF00069	0.409
MOD_Plk_4	179	185	PF00069	0.530
MOD_Plk_4	287	293	PF00069	0.496
MOD_Plk_4	405	411	PF00069	0.379
MOD_Plk_4	46	52	PF00069	0.375
MOD_Plk_4	496	502	PF00069	0.389
MOD_Plk_4	97	103	PF00069	0.531
MOD_ProDKin_1	134	140	PF00069	0.338
MOD_ProDKin_1	268	274	PF00069	0.414
MOD_ProDKin_1	489	495	PF00069	0.562
MOD_SUMO_rev_2	127	136	PF00179	0.486
MOD_SUMO_rev_2	274	283	PF00179	0.494
MOD_SUMO_rev_2	290	297	PF00179	0.425
TRG_ENDOCYTIC_2	277	280	PF00928	0.445
TRG_ENDOCYTIC_2	463	466	PF00928	0.461
TRG_ENDOCYTIC_2	61	64	PF00928	0.460
TRG_ER_diArg_1	178	180	PF00400	0.520
TRG_ER_diArg_1	186	188	PF00400	0.522
TRG_ER_diArg_1	225	227	PF00400	0.536
TRG_ER_diArg_1	320	322	PF00400	0.522
TRG_ER_diArg_1	481	483	PF00400	0.533
TRG_NES_CRM1_1	2	14	PF08389	0.303
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	445	450	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	56%	99%
A0A0N1ILJ1	Leptomonas seymouri	26%	84%
A0A0S4IMW3	Bodo saltans	23%	100%
A0A0S4IR41	Bodo saltans	22%	80%
A0A0S4J225	Bodo saltans	35%	70%
A0A1X0NLC6	Trypanosomatidae	33%	99%
A0A3Q8ICI3	Leishmania donovani	26%	85%
A0A3R7K5K5	Trypanosoma rangeli	36%	98%
A0A3S7XC77	Leishmania donovani	90%	100%
A0A422N5N5	Trypanosoma rangeli	28%	86%
A4HCS6	Leishmania braziliensis	27%	100%
A4HQF5	Leishmania braziliensis	75%	100%
A4I0A0	Leishmania infantum	26%	85%
A4IC91	Leishmania infantum	91%	100%
B2RXZ1	Mus musculus	23%	96%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	87%
C9ZZC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	82%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	86%
H9JAQ7	Bombyx mori	25%	96%
O95453	Homo sapiens	25%	80%
P69341	Bos taurus	25%	80%
Q21412	Caenorhabditis elegans	23%	90%
Q4Q0C3	Leishmania major	88%	100%
Q4QBB3	Leishmania major	27%	100%
Q5R6R6	Pongo abelii	25%	98%
Q5RC51	Pongo abelii	25%	80%
Q7ZU92	Danio rerio	27%	77%
Q8NA58	Homo sapiens	25%	98%
Q8VDG3	Mus musculus	25%	82%
Q90ZA1	Xenopus laevis	25%	81%
V5ASU9	Trypanosoma cruzi	35%	99%
V5BCG2	Trypanosoma cruzi	26%	100%