LeishMANIAdb
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Peroxin-12

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxin-12
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AU67_LEIMU
TriTrypDb:
LmxM.36.6330
Length:
278

Annotations

LeishMANIAdb annotations

Appears to be a transporter for some unknown substrate

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

E9AU67
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU67

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016559 peroxisome fission 6 1
GO:0048285 organelle fission 5 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 263 267 PF00656 0.633
CLV_MEL_PAP_1 178 184 PF00089 0.526
CLV_NRD_NRD_1 156 158 PF00675 0.548
CLV_NRD_NRD_1 54 56 PF00675 0.299
CLV_PCSK_KEX2_1 156 158 PF00082 0.546
CLV_PCSK_KEX2_1 255 257 PF00082 0.523
CLV_PCSK_KEX2_1 56 58 PF00082 0.298
CLV_PCSK_PC1ET2_1 255 257 PF00082 0.392
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.254
CLV_PCSK_SKI1_1 10 14 PF00082 0.276
CLV_PCSK_SKI1_1 123 127 PF00082 0.595
CLV_PCSK_SKI1_1 131 135 PF00082 0.577
CLV_PCSK_SKI1_1 139 143 PF00082 0.578
CLV_PCSK_SKI1_1 231 235 PF00082 0.382
CLV_PCSK_SKI1_1 36 40 PF00082 0.280
CLV_PCSK_SKI1_1 56 60 PF00082 0.203
DEG_APCC_DBOX_1 230 238 PF00400 0.535
DOC_CYCLIN_RxL_1 139 147 PF00134 0.286
DOC_MAPK_DCC_7 231 239 PF00069 0.528
DOC_MAPK_HePTP_8 186 198 PF00069 0.364
DOC_MAPK_MEF2A_6 189 198 PF00069 0.362
DOC_MAPK_MEF2A_6 26 33 PF00069 0.500
DOC_PP1_RVXF_1 121 127 PF00149 0.386
DOC_PP4_FxxP_1 74 77 PF00568 0.551
DOC_USP7_MATH_1 247 251 PF00917 0.629
DOC_USP7_MATH_1 271 275 PF00917 0.664
DOC_WW_Pin1_4 166 171 PF00397 0.402
DOC_WW_Pin1_4 232 237 PF00397 0.612
DOC_WW_Pin1_4 241 246 PF00397 0.787
LIG_14-3-3_CanoR_1 10 15 PF00244 0.467
LIG_14-3-3_CanoR_1 139 145 PF00244 0.378
LIG_14-3-3_CanoR_1 156 161 PF00244 0.331
LIG_14-3-3_CanoR_1 173 179 PF00244 0.371
LIG_14-3-3_CanoR_1 76 82 PF00244 0.502
LIG_BIR_II_1 1 5 PF00653 0.715
LIG_BRCT_BRCA1_1 136 140 PF00533 0.290
LIG_BRCT_BRCA1_2 136 142 PF00533 0.285
LIG_deltaCOP1_diTrp_1 95 101 PF00928 0.331
LIG_FHA_1 145 151 PF00498 0.288
LIG_FHA_1 207 213 PF00498 0.338
LIG_FHA_1 228 234 PF00498 0.658
LIG_LIR_Apic_2 105 111 PF02991 0.210
LIG_LIR_Gen_1 193 202 PF02991 0.363
LIG_LIR_Gen_1 95 104 PF02991 0.393
LIG_LIR_Nem_3 105 110 PF02991 0.212
LIG_LIR_Nem_3 135 141 PF02991 0.280
LIG_LIR_Nem_3 193 198 PF02991 0.366
LIG_LIR_Nem_3 95 100 PF02991 0.383
LIG_PCNA_yPIPBox_3 3 15 PF02747 0.499
LIG_Pex14_1 200 204 PF04695 0.298
LIG_Pex14_1 97 101 PF04695 0.364
LIG_Pex14_2 136 140 PF04695 0.378
LIG_REV1ctd_RIR_1 104 110 PF16727 0.325
LIG_REV1ctd_RIR_1 138 146 PF16727 0.266
LIG_REV1ctd_RIR_1 56 64 PF16727 0.412
LIG_SH2_STAP1 48 52 PF00017 0.585
LIG_SH2_STAT5 120 123 PF00017 0.383
LIG_SH2_STAT5 195 198 PF00017 0.325
LIG_SH2_STAT5 232 235 PF00017 0.600
LIG_SUMO_SIM_anti_2 209 214 PF11976 0.160
LIG_SUMO_SIM_anti_2 37 43 PF11976 0.468
LIG_SUMO_SIM_par_1 17 23 PF11976 0.566
LIG_TRFH_1 232 236 PF08558 0.617
LIG_UBA3_1 220 228 PF00899 0.240
LIG_UBA3_1 233 241 PF00899 0.574
MOD_CDK_SPK_2 166 171 PF00069 0.416
MOD_CDK_SPxxK_3 166 173 PF00069 0.430
MOD_CK1_1 2 8 PF00069 0.636
MOD_CK1_1 37 43 PF00069 0.508
MOD_CK2_1 245 251 PF00069 0.647
MOD_CK2_1 61 67 PF00069 0.577
MOD_CMANNOS 224 227 PF00535 0.411
MOD_GlcNHglycan 114 117 PF01048 0.570
MOD_GlcNHglycan 217 220 PF01048 0.288
MOD_GlcNHglycan 271 274 PF01048 0.496
MOD_GSK3_1 112 119 PF00069 0.236
MOD_GSK3_1 140 147 PF00069 0.257
MOD_GSK3_1 152 159 PF00069 0.251
MOD_GSK3_1 241 248 PF00069 0.683
MOD_GSK3_1 265 272 PF00069 0.736
MOD_N-GLC_1 206 211 PF02516 0.454
MOD_NEK2_1 1 6 PF00069 0.629
MOD_NEK2_1 134 139 PF00069 0.365
MOD_NEK2_1 140 145 PF00069 0.255
MOD_NEK2_1 152 157 PF00069 0.348
MOD_NEK2_1 180 185 PF00069 0.332
MOD_NEK2_1 34 39 PF00069 0.503
MOD_NEK2_1 61 66 PF00069 0.484
MOD_NEK2_1 79 84 PF00069 0.413
MOD_PIKK_1 260 266 PF00454 0.622
MOD_PIKK_1 79 85 PF00454 0.507
MOD_PKA_1 156 162 PF00069 0.217
MOD_PKA_2 155 161 PF00069 0.334
MOD_PKA_2 180 186 PF00069 0.356
MOD_Plk_1 116 122 PF00069 0.345
MOD_Plk_1 206 212 PF00069 0.251
MOD_Plk_4 10 16 PF00069 0.623
MOD_Plk_4 102 108 PF00069 0.294
MOD_Plk_4 116 122 PF00069 0.230
MOD_Plk_4 34 40 PF00069 0.481
MOD_Plk_4 61 67 PF00069 0.599
MOD_ProDKin_1 166 172 PF00069 0.401
MOD_ProDKin_1 232 238 PF00069 0.619
MOD_ProDKin_1 241 247 PF00069 0.786
MOD_SUMO_for_1 240 243 PF00179 0.557
MOD_SUMO_rev_2 49 58 PF00179 0.416
TRG_ENDOCYTIC_2 138 141 PF00928 0.278
TRG_ENDOCYTIC_2 195 198 PF00928 0.284
TRG_ER_diArg_1 55 58 PF00400 0.592
TRG_Pf-PMV_PEXEL_1 162 166 PF00026 0.533
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDG3 Leptomonas seymouri 59% 100%
A0A0S4JRR1 Bodo saltans 31% 100%
A0A1X0NLN6 Trypanosomatidae 38% 100%
A0A3Q8ILX5 Leishmania donovani 88% 100%
A0A422N9F2 Trypanosoma rangeli 37% 100%
A4HQF0 Leishmania braziliensis 75% 100%
A4IC87 Leishmania infantum 88% 100%
D0A3T7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
Q4Q0C7 Leishmania major 88% 100%
V5D8S7 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS