LeishMANIAdb
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Glucose transporter, lmgt1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucose transporter, lmgt1
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania mexicana
UniProt:
E9AU64_LEIMU
TriTrypDb:
Length:
610

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 39
NetGPI no yes: 0, no: 39
Cellular components
Term Name Level Count
GO:0016020 membrane 2 40
GO:0110165 cellular anatomical entity 1 40
GO:0005886 plasma membrane 3 3
GO:0051286 cell tip 3 3
GO:0060187 cell pole 2 3

Expansion

Sequence features

E9AU64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU64

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 16
GO:0008643 carbohydrate transport 5 16
GO:0051179 localization 1 16
GO:0051234 establishment of localization 2 16
GO:0071702 organic substance transport 4 16
GO:0009987 cellular process 1 1
GO:0015749 monosaccharide transmembrane transport 4 1
GO:0034219 carbohydrate transmembrane transport 3 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 40
GO:0015144 carbohydrate transmembrane transporter activity 3 15
GO:0022857 transmembrane transporter activity 2 40
GO:0015145 monosaccharide transmembrane transporter activity 5 2
GO:0015149 hexose transmembrane transporter activity 6 2
GO:0051119 sugar transmembrane transporter activity 4 2
GO:0005353 fructose transmembrane transporter activity 7 1
GO:0005354 galactose transmembrane transporter activity 7 1
GO:0015578 mannose transmembrane transporter activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 582 586 PF00656 0.652
CLV_NRD_NRD_1 156 158 PF00675 0.561
CLV_PCSK_KEX2_1 156 158 PF00082 0.484
CLV_PCSK_KEX2_1 288 290 PF00082 0.335
CLV_PCSK_KEX2_1 32 34 PF00082 0.356
CLV_PCSK_KEX2_1 583 585 PF00082 0.470
CLV_PCSK_KEX2_1 588 590 PF00082 0.559
CLV_PCSK_KEX2_1 597 599 PF00082 0.544
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.347
CLV_PCSK_PC1ET2_1 32 34 PF00082 0.356
CLV_PCSK_PC1ET2_1 583 585 PF00082 0.470
CLV_PCSK_PC1ET2_1 588 590 PF00082 0.559
CLV_PCSK_PC1ET2_1 597 599 PF00082 0.544
CLV_PCSK_PC7_1 584 590 PF00082 0.414
CLV_PCSK_SKI1_1 14 18 PF00082 0.376
CLV_PCSK_SKI1_1 33 37 PF00082 0.347
CLV_PCSK_SKI1_1 445 449 PF00082 0.264
CLV_PCSK_SKI1_1 589 593 PF00082 0.497
DEG_ODPH_VHL_1 415 426 PF01847 0.347
DOC_CKS1_1 590 595 PF01111 0.559
DOC_CYCLIN_RxL_1 442 452 PF00134 0.535
DOC_MAPK_DCC_7 32 40 PF00069 0.548
DOC_MAPK_gen_1 286 295 PF00069 0.483
DOC_MAPK_gen_1 32 40 PF00069 0.549
DOC_MAPK_HePTP_8 258 270 PF00069 0.435
DOC_MAPK_MEF2A_6 228 236 PF00069 0.481
DOC_MAPK_MEF2A_6 261 270 PF00069 0.319
DOC_MAPK_MEF2A_6 286 295 PF00069 0.493
DOC_MAPK_NFAT4_5 261 269 PF00069 0.388
DOC_PP1_RVXF_1 226 232 PF00149 0.475
DOC_PP2B_LxvP_1 2 5 PF13499 0.564
DOC_PP4_FxxP_1 217 220 PF00568 0.455
DOC_PP4_FxxP_1 576 579 PF00568 0.348
DOC_PP4_MxPP_1 1 4 PF00568 0.546
DOC_PP4_MxPP_1 54 57 PF00568 0.544
DOC_SPAK_OSR1_1 261 265 PF12202 0.417
DOC_USP7_MATH_1 19 23 PF00917 0.717
DOC_USP7_MATH_1 220 224 PF00917 0.473
DOC_USP7_MATH_1 24 28 PF00917 0.718
DOC_USP7_MATH_1 469 473 PF00917 0.345
DOC_USP7_UBL2_3 474 478 PF12436 0.299
DOC_USP7_UBL2_3 583 587 PF12436 0.662
DOC_WW_Pin1_4 33 38 PF00397 0.593
DOC_WW_Pin1_4 589 594 PF00397 0.557
DOC_WW_Pin1_4 68 73 PF00397 0.699
DOC_WW_Pin1_4 74 79 PF00397 0.619
LIG_14-3-3_CanoR_1 126 132 PF00244 0.363
LIG_14-3-3_CanoR_1 156 162 PF00244 0.354
LIG_14-3-3_CanoR_1 179 185 PF00244 0.315
LIG_14-3-3_CanoR_1 228 232 PF00244 0.493
LIG_14-3-3_CanoR_1 516 521 PF00244 0.475
LIG_BRCT_BRCA1_1 101 105 PF00533 0.348
LIG_BRCT_BRCA1_1 109 113 PF00533 0.287
LIG_BRCT_BRCA1_1 199 203 PF00533 0.284
LIG_BRCT_BRCA1_1 315 319 PF00533 0.304
LIG_BRCT_BRCA1_1 337 341 PF00533 0.455
LIG_BRCT_BRCA1_1 438 442 PF00533 0.420
LIG_BRCT_BRCA1_1 76 80 PF00533 0.557
LIG_deltaCOP1_diTrp_1 253 262 PF00928 0.326
LIG_FHA_1 288 294 PF00498 0.490
LIG_FHA_1 298 304 PF00498 0.249
LIG_FHA_1 343 349 PF00498 0.423
LIG_FHA_1 391 397 PF00498 0.350
LIG_FHA_1 482 488 PF00498 0.369
LIG_FHA_1 538 544 PF00498 0.278
LIG_FHA_2 315 321 PF00498 0.303
LIG_GBD_Chelix_1 221 229 PF00786 0.446
LIG_LIR_Apic_2 215 220 PF02991 0.455
LIG_LIR_Gen_1 158 168 PF02991 0.347
LIG_LIR_Gen_1 230 239 PF02991 0.340
LIG_LIR_Gen_1 253 263 PF02991 0.313
LIG_LIR_Gen_1 338 348 PF02991 0.381
LIG_LIR_Gen_1 374 385 PF02991 0.486
LIG_LIR_Gen_1 519 528 PF02991 0.281
LIG_LIR_Nem_3 102 108 PF02991 0.330
LIG_LIR_Nem_3 158 164 PF02991 0.260
LIG_LIR_Nem_3 230 234 PF02991 0.342
LIG_LIR_Nem_3 251 257 PF02991 0.254
LIG_LIR_Nem_3 338 344 PF02991 0.362
LIG_LIR_Nem_3 374 378 PF02991 0.568
LIG_LIR_Nem_3 519 523 PF02991 0.404
LIG_LIR_Nem_3 77 83 PF02991 0.497
LIG_LIR_Nem_3 84 89 PF02991 0.463
LIG_LYPXL_S_1 467 471 PF13949 0.330
LIG_LYPXL_yS_3 468 471 PF13949 0.268
LIG_MLH1_MIPbox_1 315 319 PF16413 0.291
LIG_NRBOX 228 234 PF00104 0.562
LIG_NRBOX 339 345 PF00104 0.424
LIG_Pex14_2 337 341 PF04695 0.445
LIG_Pex14_2 450 454 PF04695 0.435
LIG_Pex14_2 489 493 PF04695 0.283
LIG_Pex14_2 509 513 PF04695 0.480
LIG_Pex14_2 576 580 PF04695 0.370
LIG_PTB_Apo_2 530 537 PF02174 0.318
LIG_PTB_Phospho_1 530 536 PF10480 0.358
LIG_SH2_CRK 109 113 PF00017 0.289
LIG_SH2_CRK 161 165 PF00017 0.366
LIG_SH2_NCK_1 161 165 PF00017 0.277
LIG_SH2_SRC 405 408 PF00017 0.304
LIG_SH2_STAP1 109 113 PF00017 0.312
LIG_SH2_STAP1 161 165 PF00017 0.352
LIG_SH2_STAT3 278 281 PF00017 0.496
LIG_SH2_STAT5 147 150 PF00017 0.324
LIG_SH2_STAT5 159 162 PF00017 0.326
LIG_SH2_STAT5 278 281 PF00017 0.447
LIG_SH2_STAT5 318 321 PF00017 0.236
LIG_SH2_STAT5 377 380 PF00017 0.599
LIG_SH2_STAT5 440 443 PF00017 0.531
LIG_SH2_STAT5 45 48 PF00017 0.584
LIG_SH2_STAT5 502 505 PF00017 0.372
LIG_SH3_1 587 593 PF00018 0.542
LIG_SH3_2 10 15 PF14604 0.577
LIG_SH3_3 13 19 PF00018 0.733
LIG_SH3_3 2 8 PF00018 0.715
LIG_SH3_3 270 276 PF00018 0.312
LIG_SH3_3 463 469 PF00018 0.308
LIG_SH3_3 47 53 PF00018 0.762
LIG_SH3_3 531 537 PF00018 0.319
LIG_SH3_3 587 593 PF00018 0.713
LIG_SUMO_SIM_anti_2 342 348 PF11976 0.312
LIG_TRAF2_1 185 188 PF00917 0.329
LIG_TRAF2_1 39 42 PF00917 0.556
LIG_TRFH_1 575 579 PF08558 0.348
MOD_CDC14_SPxK_1 71 74 PF00782 0.522
MOD_CDK_SPxK_1 68 74 PF00069 0.641
MOD_CK1_1 193 199 PF00069 0.313
MOD_CK1_1 342 348 PF00069 0.397
MOD_CK1_1 452 458 PF00069 0.395
MOD_CK1_1 472 478 PF00069 0.335
MOD_CK1_1 602 608 PF00069 0.774
MOD_CK1_1 79 85 PF00069 0.532
MOD_CK2_1 160 166 PF00069 0.330
MOD_CK2_1 182 188 PF00069 0.323
MOD_CK2_1 193 199 PF00069 0.285
MOD_CK2_1 245 251 PF00069 0.436
MOD_CK2_1 373 379 PF00069 0.520
MOD_Cter_Amidation 585 588 PF01082 0.483
MOD_Cter_Amidation 595 598 PF01082 0.570
MOD_DYRK1A_RPxSP_1 589 593 PF00069 0.557
MOD_GlcNHglycan 184 187 PF01048 0.499
MOD_GlcNHglycan 192 195 PF01048 0.460
MOD_GlcNHglycan 199 202 PF01048 0.430
MOD_GlcNHglycan 247 250 PF01048 0.174
MOD_GlcNHglycan 543 546 PF01048 0.448
MOD_GlcNHglycan 547 550 PF01048 0.446
MOD_GlcNHglycan 604 607 PF01048 0.555
MOD_GSK3_1 151 158 PF00069 0.294
MOD_GSK3_1 19 26 PF00069 0.725
MOD_GSK3_1 190 197 PF00069 0.278
MOD_GSK3_1 335 342 PF00069 0.348
MOD_GSK3_1 390 397 PF00069 0.325
MOD_GSK3_1 40 47 PF00069 0.740
MOD_GSK3_1 428 435 PF00069 0.341
MOD_GSK3_1 436 443 PF00069 0.315
MOD_GSK3_1 449 456 PF00069 0.246
MOD_GSK3_1 537 544 PF00069 0.319
MOD_GSK3_1 598 605 PF00069 0.645
MOD_N-GLC_1 140 145 PF02516 0.513
MOD_N-GLC_2 533 535 PF02516 0.375
MOD_NEK2_1 113 118 PF00069 0.288
MOD_NEK2_1 203 208 PF00069 0.326
MOD_NEK2_1 212 217 PF00069 0.264
MOD_NEK2_1 221 226 PF00069 0.193
MOD_NEK2_1 313 318 PF00069 0.269
MOD_NEK2_1 352 357 PF00069 0.460
MOD_NEK2_1 390 395 PF00069 0.318
MOD_NEK2_1 40 45 PF00069 0.547
MOD_NEK2_1 429 434 PF00069 0.345
MOD_NEK2_1 449 454 PF00069 0.128
MOD_NEK2_1 600 605 PF00069 0.640
MOD_NEK2_1 81 86 PF00069 0.634
MOD_NEK2_2 151 156 PF00069 0.318
MOD_NEK2_2 336 341 PF00069 0.417
MOD_NEK2_2 440 445 PF00069 0.500
MOD_OFUCOSY 148 155 PF10250 0.486
MOD_PIKK_1 502 508 PF00454 0.352
MOD_PIKK_1 518 524 PF00454 0.317
MOD_PKA_2 155 161 PF00069 0.358
MOD_PKA_2 180 186 PF00069 0.340
MOD_PKA_2 227 233 PF00069 0.508
MOD_PKB_1 514 522 PF00069 0.475
MOD_Plk_1 373 379 PF00069 0.521
MOD_Plk_1 66 72 PF00069 0.537
MOD_Plk_4 108 114 PF00069 0.336
MOD_Plk_4 203 209 PF00069 0.341
MOD_Plk_4 212 218 PF00069 0.289
MOD_Plk_4 227 233 PF00069 0.452
MOD_Plk_4 239 245 PF00069 0.283
MOD_Plk_4 314 320 PF00069 0.327
MOD_Plk_4 336 342 PF00069 0.320
MOD_Plk_4 373 379 PF00069 0.475
MOD_Plk_4 436 442 PF00069 0.332
MOD_Plk_4 449 455 PF00069 0.286
MOD_Plk_4 76 82 PF00069 0.510
MOD_ProDKin_1 33 39 PF00069 0.591
MOD_ProDKin_1 589 595 PF00069 0.557
MOD_ProDKin_1 68 74 PF00069 0.698
TRG_AP2beta_CARGO_1 251 261 PF09066 0.335
TRG_DiLeu_BaEn_1 253 258 PF01217 0.335
TRG_DiLeu_BaLyEn_6 380 385 PF01217 0.513
TRG_ENDOCYTIC_2 109 112 PF00928 0.265
TRG_ENDOCYTIC_2 161 164 PF00928 0.365
TRG_ENDOCYTIC_2 375 378 PF00928 0.547
TRG_ENDOCYTIC_2 468 471 PF00928 0.268
TRG_ENDOCYTIC_2 501 504 PF00928 0.408
TRG_ER_diArg_1 179 182 PF00400 0.293
TRG_ER_diArg_1 513 516 PF00400 0.482
TRG_NLS_MonoExtN_4 12 18 PF00514 0.574
TRG_NLS_MonoExtN_4 584 591 PF00514 0.646

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VG78 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 25% 100%
A0A0N0P2E1 Leptomonas seymouri 53% 100%
A0A0N0P3Z7 Leptomonas seymouri 49% 80%
A0A0N0P4D8 Leptomonas seymouri 46% 83%
A0A0N1IG16 Leptomonas seymouri 71% 100%
A0A0N1P9H5 Leptomonas seymouri 45% 100%
A0A0S4J363 Bodo saltans 28% 100%
A0A0S4JDF9 Bodo saltans 39% 100%
A0A0S4JEY7 Bodo saltans 39% 100%
A0A0S4JH90 Bodo saltans 36% 100%
A0A0S4JS00 Bodo saltans 33% 100%
A0A1X0NLE0 Trypanosomatidae 57% 100%
A0A1X0NM05 Trypanosomatidae 56% 100%
A0A1X0NN62 Trypanosomatidae 51% 100%
A0A1X0P9L7 Trypanosomatidae 35% 100%
A0A381N054 Leishmania infantum 92% 100%
A0A3Q8IDK1 Leishmania donovani 43% 100%
A0A3Q8IK60 Leishmania donovani 92% 100%
A0A3Q8IWJ4 Leishmania donovani 90% 93%
A0A3R7KPU3 Trypanosoma rangeli 34% 100%
A0A3R7MGQ7 Trypanosoma rangeli 22% 100%
A0A3S7WY58 Leishmania donovani 23% 100%
A0A3S7XC27 Leishmania donovani 90% 100%
A0A422MNQ4 Trypanosoma rangeli 54% 100%
A4HDC6 Leishmania braziliensis 22% 100%
A4HL65 Leishmania braziliensis 43% 100%
A4HQD6 Leishmania braziliensis 82% 100%
A4HQD7 Leishmania braziliensis 86% 100%
A4HQE7 Leishmania braziliensis 91% 100%
A4I0Q6 Leishmania infantum 23% 100%
A4I8N6 Leishmania infantum 43% 100%
A4IC83 Leishmania infantum 90% 93%
C0SPB2 Bacillus subtilis (strain 168) 23% 100%
C9ZMM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
D0A3U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A3U3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AU62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 99%
E9AU63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AWQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B3K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 97%
K0E3U9 Aspergillus rugulosus 22% 100%
O34718 Bacillus subtilis (strain 168) 21% 100%
O59932 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 100%
O74849 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%
O74969 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
P11166 Homo sapiens 24% 100%
P12336 Rattus norvegicus 22% 100%
P13865 Leishmania enriettii 79% 100%
P14246 Mus musculus 20% 100%
P20303 Sus scrofa 24% 100%
P23585 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P32465 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P32466 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P38695 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P39003 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P39004 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P39924 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P42833 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 100%
P43581 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P46333 Bacillus subtilis (strain 168) 23% 100%
P46896 Gallus gallus 23% 100%
P47185 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P49374 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 23% 100%
P53387 Kluyveromyces lactis 22% 100%
P53631 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P54854 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
P58351 Bos taurus 24% 100%
Q01440 Leishmania donovani 23% 100%
Q01441 Leishmania donovani 43% 100%
Q06221 Trypanosoma brucei brucei 47% 100%
Q06222 Trypanosoma brucei brucei 48% 100%
Q09037 Trypanosoma brucei brucei 46% 100%
Q10PW9 Oryza sativa subsp. japonica 22% 100%
Q27115 Trypanosoma vivax 47% 100%
Q4Q0D0 Leishmania major 88% 100%
Q4Q0D1 Leishmania major 88% 100%
Q4Q0D2 Leishmania major 87% 100%
Q4Q4J1 Leishmania major 43% 100%
Q4QAR5 Leishmania major 23% 100%
Q8L6Z8 Arabidopsis thaliana 23% 100%
Q8L7R8 Arabidopsis thaliana 22% 100%
Q8TFG1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
Q92253 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 23% 100%
Q92339 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q94AZ2 Arabidopsis thaliana 23% 100%
Q94EC4 Oryza sativa subsp. japonica 24% 100%
Q9P3U6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%
Q9P3U7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q9SX48 Arabidopsis thaliana 23% 100%
Q9WV38 Mus musculus 20% 100%
Q9XSC2 Oryctolagus cuniculus 23% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS