Glucose transporter, lmgt2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose transporter 2

Species:

Leishmania mexicana

UniProt:

E9AU63_LEIMU

TriTrypDb:

LmxM.36.6290

Length:

567

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 40
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	41
GO:0110165	cellular anatomical entity	1	41
GO:0005886	plasma membrane	3	3
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3

Expansion

Sequence features

E9AU63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU63

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008643	carbohydrate transport	5	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0071702	organic substance transport	4	16
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0022857	transmembrane transporter activity	2	41
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	539	543	PF00656	0.704
CLV_NRD_NRD_1	113	115	PF00675	0.610
CLV_PCSK_KEX2_1	113	115	PF00082	0.533
CLV_PCSK_KEX2_1	245	247	PF00082	0.383
CLV_PCSK_KEX2_1	540	542	PF00082	0.522
CLV_PCSK_KEX2_1	545	547	PF00082	0.610
CLV_PCSK_KEX2_1	554	556	PF00082	0.596
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.396
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.522
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.610
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.596
CLV_PCSK_PC7_1	541	547	PF00082	0.464
CLV_PCSK_SKI1_1	402	406	PF00082	0.313
CLV_PCSK_SKI1_1	546	550	PF00082	0.548
DEG_ODPH_VHL_1	372	383	PF01847	0.396
DOC_CKS1_1	547	552	PF01111	0.609
DOC_CYCLIN_RxL_1	399	409	PF00134	0.583
DOC_MAPK_gen_1	243	252	PF00069	0.531
DOC_MAPK_HePTP_8	215	227	PF00069	0.484
DOC_MAPK_MEF2A_6	185	193	PF00069	0.530
DOC_MAPK_MEF2A_6	218	227	PF00069	0.367
DOC_MAPK_MEF2A_6	243	252	PF00069	0.541
DOC_MAPK_NFAT4_5	218	226	PF00069	0.436
DOC_PP1_RVXF_1	183	189	PF00149	0.524
DOC_PP4_FxxP_1	174	177	PF00568	0.504
DOC_PP4_FxxP_1	533	536	PF00568	0.397
DOC_SPAK_OSR1_1	218	222	PF12202	0.466
DOC_USP7_MATH_1	177	181	PF00917	0.522
DOC_USP7_MATH_1	426	430	PF00917	0.394
DOC_USP7_UBL2_3	431	435	PF12436	0.348
DOC_USP7_UBL2_3	540	544	PF12436	0.712
DOC_WW_Pin1_4	546	551	PF00397	0.607
LIG_14-3-3_CanoR_1	10	19	PF00244	0.813
LIG_14-3-3_CanoR_1	113	119	PF00244	0.402
LIG_14-3-3_CanoR_1	136	142	PF00244	0.364
LIG_14-3-3_CanoR_1	185	189	PF00244	0.542
LIG_14-3-3_CanoR_1	44	48	PF00244	0.419
LIG_14-3-3_CanoR_1	473	478	PF00244	0.524
LIG_14-3-3_CanoR_1	83	89	PF00244	0.412
LIG_BIR_II_1	1	5	PF00653	0.817
LIG_BIR_III_2	33	37	PF00653	0.604
LIG_BRCT_BRCA1_1	156	160	PF00533	0.333
LIG_BRCT_BRCA1_1	272	276	PF00533	0.353
LIG_BRCT_BRCA1_1	294	298	PF00533	0.504
LIG_BRCT_BRCA1_1	395	399	PF00533	0.469
LIG_BRCT_BRCA1_1	58	62	PF00533	0.397
LIG_BRCT_BRCA1_1	66	70	PF00533	0.336
LIG_deltaCOP1_diTrp_1	210	219	PF00928	0.374
LIG_FHA_1	22	28	PF00498	0.649
LIG_FHA_1	245	251	PF00498	0.539
LIG_FHA_1	255	261	PF00498	0.298
LIG_FHA_1	300	306	PF00498	0.472
LIG_FHA_1	348	354	PF00498	0.399
LIG_FHA_1	439	445	PF00498	0.418
LIG_FHA_1	495	501	PF00498	0.326
LIG_FHA_2	272	278	PF00498	0.352
LIG_GBD_Chelix_1	178	186	PF00786	0.495
LIG_GBD_Chelix_1	47	55	PF00786	0.481
LIG_Integrin_isoDGR_2	8	10	PF01839	0.410
LIG_LIR_Apic_2	172	177	PF02991	0.504
LIG_LIR_Gen_1	115	125	PF02991	0.396
LIG_LIR_Gen_1	187	196	PF02991	0.389
LIG_LIR_Gen_1	210	220	PF02991	0.362
LIG_LIR_Gen_1	295	305	PF02991	0.430
LIG_LIR_Gen_1	331	342	PF02991	0.534
LIG_LIR_Gen_1	476	485	PF02991	0.329
LIG_LIR_Nem_3	115	121	PF02991	0.309
LIG_LIR_Nem_3	187	191	PF02991	0.391
LIG_LIR_Nem_3	208	214	PF02991	0.303
LIG_LIR_Nem_3	295	301	PF02991	0.410
LIG_LIR_Nem_3	331	335	PF02991	0.616
LIG_LIR_Nem_3	476	480	PF02991	0.453
LIG_LIR_Nem_3	59	65	PF02991	0.379
LIG_LYPXL_S_1	424	428	PF13949	0.379
LIG_LYPXL_yS_3	425	428	PF13949	0.317
LIG_MLH1_MIPbox_1	272	276	PF16413	0.340
LIG_NRBOX	185	191	PF00104	0.610
LIG_NRBOX	296	302	PF00104	0.473
LIG_Pex14_2	294	298	PF04695	0.493
LIG_Pex14_2	407	411	PF04695	0.484
LIG_Pex14_2	446	450	PF04695	0.332
LIG_Pex14_2	466	470	PF04695	0.529
LIG_Pex14_2	533	537	PF04695	0.419
LIG_PTB_Apo_2	487	494	PF02174	0.367
LIG_PTB_Phospho_1	487	493	PF10480	0.406
LIG_SH2_CRK	118	122	PF00017	0.415
LIG_SH2_CRK	66	70	PF00017	0.338
LIG_SH2_NCK_1	118	122	PF00017	0.326
LIG_SH2_SRC	362	365	PF00017	0.353
LIG_SH2_STAP1	118	122	PF00017	0.400
LIG_SH2_STAP1	66	70	PF00017	0.361
LIG_SH2_STAT3	235	238	PF00017	0.545
LIG_SH2_STAT5	104	107	PF00017	0.373
LIG_SH2_STAT5	116	119	PF00017	0.375
LIG_SH2_STAT5	235	238	PF00017	0.496
LIG_SH2_STAT5	275	278	PF00017	0.285
LIG_SH2_STAT5	334	337	PF00017	0.649
LIG_SH2_STAT5	397	400	PF00017	0.579
LIG_SH2_STAT5	458	461	PF00017	0.419
LIG_SH3_1	544	550	PF00018	0.592
LIG_SH3_3	227	233	PF00018	0.360
LIG_SH3_3	420	426	PF00018	0.357
LIG_SH3_3	488	494	PF00018	0.367
LIG_SH3_3	544	550	PF00018	0.763
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.361
LIG_TRFH_1	532	536	PF08558	0.397
MOD_CK1_1	11	17	PF00069	0.696
MOD_CK1_1	150	156	PF00069	0.362
MOD_CK1_1	299	305	PF00069	0.445
MOD_CK1_1	409	415	PF00069	0.443
MOD_CK1_1	429	435	PF00069	0.384
MOD_CK1_1	559	565	PF00069	0.828
MOD_CK2_1	117	123	PF00069	0.379
MOD_CK2_1	139	145	PF00069	0.372
MOD_CK2_1	150	156	PF00069	0.333
MOD_CK2_1	202	208	PF00069	0.485
MOD_CK2_1	330	336	PF00069	0.568
MOD_CK2_1	9	15	PF00069	0.819
MOD_Cter_Amidation	542	545	PF01082	0.531
MOD_Cter_Amidation	552	555	PF01082	0.621
MOD_DYRK1A_RPxSP_1	546	550	PF00069	0.608
MOD_GlcNHglycan	141	144	PF01048	0.548
MOD_GlcNHglycan	149	152	PF01048	0.509
MOD_GlcNHglycan	156	159	PF01048	0.478
MOD_GlcNHglycan	204	207	PF01048	0.222
MOD_GlcNHglycan	38	41	PF01048	0.483
MOD_GlcNHglycan	500	503	PF01048	0.497
MOD_GlcNHglycan	504	507	PF01048	0.495
MOD_GlcNHglycan	561	564	PF01048	0.615
MOD_GSK3_1	108	115	PF00069	0.342
MOD_GSK3_1	147	154	PF00069	0.327
MOD_GSK3_1	292	299	PF00069	0.396
MOD_GSK3_1	347	354	PF00069	0.373
MOD_GSK3_1	385	392	PF00069	0.390
MOD_GSK3_1	393	400	PF00069	0.364
MOD_GSK3_1	406	413	PF00069	0.295
MOD_GSK3_1	494	501	PF00069	0.368
MOD_GSK3_1	555	562	PF00069	0.702
MOD_N-GLC_1	97	102	PF02516	0.562
MOD_N-GLC_2	490	492	PF02516	0.423
MOD_NEK2_1	160	165	PF00069	0.375
MOD_NEK2_1	169	174	PF00069	0.312
MOD_NEK2_1	178	183	PF00069	0.241
MOD_NEK2_1	270	275	PF00069	0.318
MOD_NEK2_1	309	314	PF00069	0.508
MOD_NEK2_1	347	352	PF00069	0.366
MOD_NEK2_1	38	43	PF00069	0.700
MOD_NEK2_1	386	391	PF00069	0.394
MOD_NEK2_1	406	411	PF00069	0.177
MOD_NEK2_1	557	562	PF00069	0.698
MOD_NEK2_1	70	75	PF00069	0.337
MOD_NEK2_2	108	113	PF00069	0.367
MOD_NEK2_2	293	298	PF00069	0.466
MOD_NEK2_2	397	402	PF00069	0.548
MOD_OFUCOSY	105	112	PF10250	0.535
MOD_PIKK_1	459	465	PF00454	0.401
MOD_PIKK_1	475	481	PF00454	0.366
MOD_PKA_2	112	118	PF00069	0.407
MOD_PKA_2	137	143	PF00069	0.389
MOD_PKA_2	184	190	PF00069	0.556
MOD_PKA_2	43	49	PF00069	0.437
MOD_PKA_2	9	15	PF00069	0.823
MOD_PKB_1	471	479	PF00069	0.524
MOD_Plk_1	330	336	PF00069	0.570
MOD_Plk_4	160	166	PF00069	0.389
MOD_Plk_4	169	175	PF00069	0.338
MOD_Plk_4	184	190	PF00069	0.501
MOD_Plk_4	196	202	PF00069	0.332
MOD_Plk_4	271	277	PF00069	0.375
MOD_Plk_4	293	299	PF00069	0.369
MOD_Plk_4	330	336	PF00069	0.524
MOD_Plk_4	393	399	PF00069	0.381
MOD_Plk_4	406	412	PF00069	0.335
MOD_Plk_4	43	49	PF00069	0.453
MOD_Plk_4	65	71	PF00069	0.384
MOD_ProDKin_1	546	552	PF00069	0.607
TRG_AP2beta_CARGO_1	208	218	PF09066	0.384
TRG_DiLeu_BaEn_1	210	215	PF01217	0.383
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.562
TRG_ENDOCYTIC_2	118	121	PF00928	0.414
TRG_ENDOCYTIC_2	332	335	PF00928	0.597
TRG_ENDOCYTIC_2	425	428	PF00928	0.317
TRG_ENDOCYTIC_2	458	461	PF00928	0.457
TRG_ENDOCYTIC_2	66	69	PF00928	0.314
TRG_ER_diArg_1	136	139	PF00400	0.342
TRG_ER_diArg_1	470	473	PF00400	0.530
TRG_NLS_MonoExtN_4	541	548	PF00514	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
A0A0N0P2E1	Leptomonas seymouri	52%	100%
A0A0N0P3Z7	Leptomonas seymouri	47%	74%
A0A0N0P4D8	Leptomonas seymouri	49%	77%
A0A0N1IG16	Leptomonas seymouri	71%	100%
A0A0N1P9H5	Leptomonas seymouri	45%	100%
A0A0S4J363	Bodo saltans	28%	100%
A0A0S4JDF9	Bodo saltans	40%	100%
A0A0S4JEY7	Bodo saltans	39%	100%
A0A0S4JH90	Bodo saltans	36%	100%
A0A0S4JS00	Bodo saltans	33%	100%
A0A1X0NIR0	Trypanosomatidae	21%	100%
A0A1X0NLE0	Trypanosomatidae	57%	100%
A0A1X0NM05	Trypanosomatidae	56%	100%
A0A1X0NN62	Trypanosomatidae	53%	100%
A0A1X0P9L7	Trypanosomatidae	37%	100%
A0A381N054	Leishmania infantum	93%	100%
A0A3Q8IDK1	Leishmania donovani	43%	95%
A0A3Q8IK60	Leishmania donovani	93%	100%
A0A3Q8IWJ4	Leishmania donovani	93%	87%
A0A3R7KPU3	Trypanosoma rangeli	35%	100%
A0A3R7MGQ7	Trypanosoma rangeli	22%	100%
A0A3S7WY58	Leishmania donovani	23%	100%
A0A3S7XC27	Leishmania donovani	91%	100%
A0A422MNQ4	Trypanosoma rangeli	54%	100%
A0A422MRN5	Trypanosoma rangeli	61%	100%
A4HDC6	Leishmania braziliensis	21%	100%
A4HL65	Leishmania braziliensis	43%	100%
A4HQD6	Leishmania braziliensis	85%	100%
A4HQD7	Leishmania braziliensis	87%	100%
A4HQE7	Leishmania braziliensis	90%	100%
A4I0Q6	Leishmania infantum	23%	100%
A4I8N6	Leishmania infantum	43%	95%
A4IC83	Leishmania infantum	92%	87%
C0SPB2	Bacillus subtilis (strain 168)	23%	100%
C7GWV6	Saccharomyces cerevisiae (strain JAY291)	21%	98%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AU62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	93%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	90%
K0E3U9	Aspergillus rugulosus	22%	100%
O34718	Bacillus subtilis (strain 168)	21%	100%
O52733	Levilactobacillus brevis	23%	100%
O59932	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O65413	Arabidopsis thaliana	23%	100%
O74849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
O74969	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P11166	Homo sapiens	24%	100%
P11167	Rattus norvegicus	24%	100%
P11168	Homo sapiens	23%	100%
P12336	Rattus norvegicus	22%	100%
P13355	Oryctolagus cuniculus	24%	100%
P13865	Leishmania enriettii	82%	100%
P14246	Mus musculus	21%	100%
P15686	Parachlorella kessleri	24%	100%
P15729	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P17809	Mus musculus	24%	100%
P20303	Sus scrofa	24%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P23586	Arabidopsis thaliana	24%	100%
P27674	Bos taurus	24%	100%
P32465	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
P32466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P39003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P39004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P39924	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P40885	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P42833	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P43427	Rattus norvegicus	21%	100%
P43581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P46333	Bacillus subtilis (strain 168)	23%	100%
P46896	Gallus gallus	23%	100%
P47185	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P49374	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
P53387	Kluyveromyces lactis	22%	100%
P53631	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P54854	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P54862	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P58351	Bos taurus	24%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P79365	Ovis aries	24%	100%
Q01440	Leishmania donovani	23%	100%
Q01441	Leishmania donovani	43%	100%
Q06221	Trypanosoma brucei brucei	47%	100%
Q06222	Trypanosoma brucei brucei	48%	100%
Q07423	Ricinus communis	24%	100%
Q09037	Trypanosoma brucei brucei	46%	100%
Q10PW9	Oryza sativa subsp. japonica	22%	100%
Q27115	Trypanosoma vivax	45%	100%
Q39524	Parachlorella kessleri	23%	100%
Q39525	Parachlorella kessleri	26%	100%
Q41144	Ricinus communis	22%	100%
Q4Q0D0	Leishmania major	88%	100%
Q4Q0D1	Leishmania major	91%	100%
Q4Q0D2	Leishmania major	89%	100%
Q4Q4J1	Leishmania major	42%	100%
Q4QAR5	Leishmania major	23%	100%
Q7EZD7	Oryza sativa subsp. japonica	24%	100%
Q8GW61	Arabidopsis thaliana	23%	100%
Q8L7R8	Arabidopsis thaliana	22%	100%
Q8TFG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q92253	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	95%
Q92339	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q94AZ2	Arabidopsis thaliana	23%	100%
Q94EC3	Oryza sativa subsp. japonica	24%	100%
Q94EC4	Oryza sativa subsp. japonica	24%	100%
Q9LT15	Arabidopsis thaliana	20%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9SX48	Arabidopsis thaliana	24%	100%
Q9WV38	Mus musculus	20%	100%
Q9XSC2	Oryctolagus cuniculus	23%	100%