Glucose transporter, lmgt3

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose transporter 3

Species:

Leishmania mexicana

UniProt:

E9AU62_LEIMU

TriTrypDb:

LmxM.36.6280

Length:

566

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 40
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	41
GO:0110165	cellular anatomical entity	1	41
GO:0005886	plasma membrane	3	3
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3

Expansion

Sequence features

E9AU62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU62

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008643	carbohydrate transport	5	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0071702	organic substance transport	4	16
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0022857	transmembrane transporter activity	2	41
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	538	542	PF00656	0.664
CLV_NRD_NRD_1	112	114	PF00675	0.560
CLV_PCSK_KEX2_1	112	114	PF00082	0.483
CLV_PCSK_KEX2_1	244	246	PF00082	0.335
CLV_PCSK_KEX2_1	539	541	PF00082	0.479
CLV_PCSK_KEX2_1	544	546	PF00082	0.566
CLV_PCSK_KEX2_1	553	555	PF00082	0.546
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.347
CLV_PCSK_PC1ET2_1	539	541	PF00082	0.479
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.566
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.546
CLV_PCSK_PC7_1	540	546	PF00082	0.423
CLV_PCSK_SKI1_1	401	405	PF00082	0.265
CLV_PCSK_SKI1_1	545	549	PF00082	0.504
DEG_ODPH_VHL_1	371	382	PF01847	0.347
DOC_CKS1_1	546	551	PF01111	0.562
DOC_CYCLIN_RxL_1	398	408	PF00134	0.535
DOC_MAPK_gen_1	242	251	PF00069	0.484
DOC_MAPK_HePTP_8	214	226	PF00069	0.435
DOC_MAPK_MEF2A_6	184	192	PF00069	0.482
DOC_MAPK_MEF2A_6	217	226	PF00069	0.321
DOC_MAPK_MEF2A_6	242	251	PF00069	0.494
DOC_MAPK_NFAT4_5	217	225	PF00069	0.389
DOC_PP1_RVXF_1	182	188	PF00149	0.477
DOC_PP4_FxxP_1	173	176	PF00568	0.443
DOC_PP4_FxxP_1	532	535	PF00568	0.351
DOC_SPAK_OSR1_1	217	221	PF12202	0.418
DOC_USP7_MATH_1	176	180	PF00917	0.471
DOC_USP7_MATH_1	425	429	PF00917	0.345
DOC_USP7_UBL2_3	430	434	PF12436	0.362
DOC_USP7_UBL2_3	539	543	PF12436	0.675
DOC_WW_Pin1_4	30	35	PF00397	0.630
DOC_WW_Pin1_4	545	550	PF00397	0.560
LIG_14-3-3_CanoR_1	112	118	PF00244	0.353
LIG_14-3-3_CanoR_1	135	141	PF00244	0.315
LIG_14-3-3_CanoR_1	184	188	PF00244	0.494
LIG_14-3-3_CanoR_1	472	477	PF00244	0.477
LIG_14-3-3_CanoR_1	82	88	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_BRCT_BRCA1_1	155	159	PF00533	0.285
LIG_BRCT_BRCA1_1	271	275	PF00533	0.305
LIG_BRCT_BRCA1_1	293	297	PF00533	0.454
LIG_BRCT_BRCA1_1	32	36	PF00533	0.566
LIG_BRCT_BRCA1_1	394	398	PF00533	0.420
LIG_BRCT_BRCA1_1	556	560	PF00533	0.562
LIG_BRCT_BRCA1_1	57	61	PF00533	0.351
LIG_BRCT_BRCA1_1	65	69	PF00533	0.288
LIG_deltaCOP1_diTrp_1	209	218	PF00928	0.326
LIG_FHA_1	244	250	PF00498	0.491
LIG_FHA_1	254	260	PF00498	0.251
LIG_FHA_1	299	305	PF00498	0.424
LIG_FHA_1	347	353	PF00498	0.352
LIG_FHA_1	438	444	PF00498	0.371
LIG_FHA_1	478	484	PF00498	0.377
LIG_FHA_1	494	500	PF00498	0.393
LIG_FHA_2	271	277	PF00498	0.304
LIG_GBD_Chelix_1	177	185	PF00786	0.446
LIG_LIR_Apic_2	171	176	PF02991	0.452
LIG_LIR_Gen_1	114	124	PF02991	0.347
LIG_LIR_Gen_1	186	195	PF02991	0.345
LIG_LIR_Gen_1	209	219	PF02991	0.308
LIG_LIR_Gen_1	294	304	PF02991	0.382
LIG_LIR_Gen_1	330	341	PF02991	0.487
LIG_LIR_Nem_3	114	120	PF02991	0.321
LIG_LIR_Nem_3	186	190	PF02991	0.349
LIG_LIR_Nem_3	207	213	PF02991	0.250
LIG_LIR_Nem_3	294	300	PF02991	0.364
LIG_LIR_Nem_3	330	334	PF02991	0.572
LIG_LIR_Nem_3	58	64	PF02991	0.326
LIG_LYPXL_S_1	423	427	PF13949	0.332
LIG_LYPXL_yS_3	424	427	PF13949	0.269
LIG_MLH1_MIPbox_1	271	275	PF16413	0.292
LIG_NRBOX	184	190	PF00104	0.561
LIG_NRBOX	295	301	PF00104	0.425
LIG_Pex14_2	293	297	PF04695	0.444
LIG_Pex14_2	406	410	PF04695	0.435
LIG_Pex14_2	445	449	PF04695	0.286
LIG_Pex14_2	465	469	PF04695	0.451
LIG_Pex14_2	532	536	PF04695	0.372
LIG_PTB_Apo_2	486	493	PF02174	0.321
LIG_PTB_Phospho_1	486	492	PF10480	0.359
LIG_SH2_CRK	117	121	PF00017	0.355
LIG_SH2_CRK	65	69	PF00017	0.284
LIG_SH2_NCK_1	117	121	PF00017	0.276
LIG_SH2_STAP1	117	121	PF00017	0.351
LIG_SH2_STAP1	65	69	PF00017	0.313
LIG_SH2_STAT3	234	237	PF00017	0.497
LIG_SH2_STAT5	103	106	PF00017	0.324
LIG_SH2_STAT5	115	118	PF00017	0.290
LIG_SH2_STAT5	234	237	PF00017	0.448
LIG_SH2_STAT5	274	277	PF00017	0.238
LIG_SH2_STAT5	333	336	PF00017	0.602
LIG_SH2_STAT5	396	399	PF00017	0.531
LIG_SH2_STAT5	458	461	PF00017	0.374
LIG_SH3_1	543	549	PF00018	0.549
LIG_SH3_3	16	22	PF00018	0.698
LIG_SH3_3	226	232	PF00018	0.311
LIG_SH3_3	419	425	PF00018	0.310
LIG_SH3_3	487	493	PF00018	0.321
LIG_SH3_3	543	549	PF00018	0.722
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.315
LIG_TRAF2_1	141	144	PF00917	0.330
LIG_TRFH_1	531	535	PF08558	0.351
MOD_CK1_1	149	155	PF00069	0.314
MOD_CK1_1	298	304	PF00069	0.398
MOD_CK1_1	408	414	PF00069	0.396
MOD_CK1_1	428	434	PF00069	0.336
MOD_CK2_1	116	122	PF00069	0.316
MOD_CK2_1	138	144	PF00069	0.323
MOD_CK2_1	149	155	PF00069	0.286
MOD_CK2_1	201	207	PF00069	0.421
MOD_CK2_1	329	335	PF00069	0.524
MOD_Cter_Amidation	541	544	PF01082	0.496
MOD_Cter_Amidation	551	554	PF01082	0.570
MOD_Cter_Amidation	561	564	PF01082	0.335
MOD_DYRK1A_RPxSP_1	545	549	PF00069	0.561
MOD_GlcNHglycan	140	143	PF01048	0.495
MOD_GlcNHglycan	148	151	PF01048	0.460
MOD_GlcNHglycan	155	158	PF01048	0.431
MOD_GlcNHglycan	499	502	PF01048	0.449
MOD_GlcNHglycan	503	506	PF01048	0.448
MOD_GlcNHglycan	555	559	PF01048	0.520
MOD_GSK3_1	107	114	PF00069	0.313
MOD_GSK3_1	146	153	PF00069	0.278
MOD_GSK3_1	291	298	PF00069	0.350
MOD_GSK3_1	346	353	PF00069	0.327
MOD_GSK3_1	361	368	PF00069	0.272
MOD_GSK3_1	384	391	PF00069	0.343
MOD_GSK3_1	392	399	PF00069	0.317
MOD_GSK3_1	405	412	PF00069	0.248
MOD_GSK3_1	493	500	PF00069	0.318
MOD_GSK3_1	9	16	PF00069	0.729
MOD_N-GLC_1	96	101	PF02516	0.514
MOD_N-GLC_2	489	491	PF02516	0.376
MOD_NEK2_1	159	164	PF00069	0.329
MOD_NEK2_1	168	173	PF00069	0.266
MOD_NEK2_1	177	182	PF00069	0.193
MOD_NEK2_1	269	274	PF00069	0.271
MOD_NEK2_1	308	313	PF00069	0.461
MOD_NEK2_1	346	351	PF00069	0.320
MOD_NEK2_1	37	42	PF00069	0.644
MOD_NEK2_1	385	390	PF00069	0.347
MOD_NEK2_1	405	410	PF00069	0.126
MOD_NEK2_1	69	74	PF00069	0.289
MOD_NEK2_2	107	112	PF00069	0.322
MOD_NEK2_2	292	297	PF00069	0.418
MOD_NEK2_2	396	401	PF00069	0.501
MOD_OFUCOSY	104	111	PF10250	0.487
MOD_PIKK_1	458	464	PF00454	0.354
MOD_PIKK_1	474	480	PF00454	0.319
MOD_PKA_2	111	117	PF00069	0.364
MOD_PKA_2	136	142	PF00069	0.340
MOD_PKA_2	183	189	PF00069	0.508
MOD_PKB_1	470	478	PF00069	0.477
MOD_Plk_1	329	335	PF00069	0.526
MOD_Plk_4	159	165	PF00069	0.340
MOD_Plk_4	168	174	PF00069	0.292
MOD_Plk_4	183	189	PF00069	0.457
MOD_Plk_4	195	201	PF00069	0.192
MOD_Plk_4	270	276	PF00069	0.327
MOD_Plk_4	292	298	PF00069	0.323
MOD_Plk_4	329	335	PF00069	0.479
MOD_Plk_4	361	367	PF00069	0.274
MOD_Plk_4	392	398	PF00069	0.334
MOD_Plk_4	405	411	PF00069	0.289
MOD_Plk_4	64	70	PF00069	0.338
MOD_ProDKin_1	30	36	PF00069	0.620
MOD_ProDKin_1	545	551	PF00069	0.560
TRG_AP2beta_CARGO_1	207	217	PF09066	0.335
TRG_DiLeu_BaEn_1	209	214	PF01217	0.335
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.514
TRG_ENDOCYTIC_2	117	120	PF00928	0.351
TRG_ENDOCYTIC_2	331	334	PF00928	0.553
TRG_ENDOCYTIC_2	424	427	PF00928	0.269
TRG_ENDOCYTIC_2	457	460	PF00928	0.409
TRG_ENDOCYTIC_2	65	68	PF00928	0.263
TRG_ER_diArg_1	135	138	PF00400	0.292
TRG_ER_diArg_1	469	472	PF00400	0.483
TRG_ER_diLys_1	563	566	PF00400	0.555
TRG_NLS_MonoExtN_4	540	547	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
A0A0N0P2E1	Leptomonas seymouri	53%	100%
A0A0N0P3Z7	Leptomonas seymouri	46%	74%
A0A0N0P4D8	Leptomonas seymouri	50%	77%
A0A0N1IG16	Leptomonas seymouri	72%	100%
A0A0N1P9H5	Leptomonas seymouri	46%	100%
A0A0S4J363	Bodo saltans	28%	100%
A0A0S4JDF9	Bodo saltans	40%	100%
A0A0S4JEY7	Bodo saltans	39%	100%
A0A0S4JH90	Bodo saltans	36%	100%
A0A0S4JS00	Bodo saltans	33%	100%
A0A1X0NIR0	Trypanosomatidae	22%	100%
A0A1X0NLE0	Trypanosomatidae	57%	100%
A0A1X0NM05	Trypanosomatidae	57%	100%
A0A1X0NN62	Trypanosomatidae	53%	100%
A0A1X0P9L7	Trypanosomatidae	37%	100%
A0A381N054	Leishmania infantum	90%	100%
A0A3Q8IDK1	Leishmania donovani	44%	95%
A0A3Q8IK60	Leishmania donovani	90%	100%
A0A3Q8IWJ4	Leishmania donovani	91%	87%
A0A3R7KPU3	Trypanosoma rangeli	36%	100%
A0A3R7MGQ7	Trypanosoma rangeli	22%	100%
A0A3S7XC27	Leishmania donovani	91%	100%
A0A422MNQ4	Trypanosoma rangeli	57%	100%
A0A422MRN5	Trypanosoma rangeli	61%	100%
A4HDC6	Leishmania braziliensis	21%	100%
A4HL65	Leishmania braziliensis	43%	100%
A4HQD6	Leishmania braziliensis	84%	100%
A4HQD7	Leishmania braziliensis	85%	100%
A4HQE7	Leishmania braziliensis	88%	99%
A4I8N6	Leishmania infantum	44%	95%
A4IC83	Leishmania infantum	91%	87%
A6ZT02	Saccharomyces cerevisiae (strain YJM789)	21%	98%
B4P624	Drosophila yakuba	23%	66%
C0SPB2	Bacillus subtilis (strain 168)	22%	100%
C7GWV6	Saccharomyces cerevisiae (strain JAY291)	21%	98%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AU63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	93%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	90%
K0E3U9	Aspergillus rugulosus	23%	100%
O04249	Arabidopsis thaliana	23%	100%
O34718	Bacillus subtilis (strain 168)	22%	100%
O52733	Levilactobacillus brevis	22%	100%
O59932	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O62786	Sus scrofa	22%	100%
O65413	Arabidopsis thaliana	23%	100%
O74849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O74969	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P11166	Homo sapiens	24%	100%
P11167	Rattus norvegicus	24%	100%
P11168	Homo sapiens	22%	100%
P12336	Rattus norvegicus	23%	100%
P13355	Oryctolagus cuniculus	24%	100%
P13865	Leishmania enriettii	81%	100%
P14246	Mus musculus	21%	100%
P15686	Parachlorella kessleri	25%	100%
P17809	Mus musculus	24%	100%
P18631	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	100%
P20303	Sus scrofa	24%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P23586	Arabidopsis thaliana	25%	100%
P27674	Bos taurus	24%	100%
P32465	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
P32466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P32467	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	98%
P38142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P38695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	96%
P39003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P39004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P39924	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P40885	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P43581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P46333	Bacillus subtilis (strain 168)	22%	100%
P46896	Gallus gallus	22%	100%
P47185	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P49374	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
P53387	Kluyveromyces lactis	22%	100%
P53631	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P54854	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P54862	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P58351	Bos taurus	24%	100%
P58353	Bos taurus	22%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P79365	Ovis aries	24%	100%
Q01441	Leishmania donovani	44%	100%
Q06221	Trypanosoma brucei brucei	47%	100%
Q06222	Trypanosoma brucei brucei	48%	100%
Q07423	Ricinus communis	24%	100%
Q09037	Trypanosoma brucei brucei	46%	100%
Q10PW9	Oryza sativa subsp. japonica	22%	100%
Q27115	Trypanosoma vivax	46%	100%
Q39524	Parachlorella kessleri	23%	100%
Q39525	Parachlorella kessleri	26%	100%
Q41144	Ricinus communis	22%	100%
Q4Q0D0	Leishmania major	90%	100%
Q4Q0D1	Leishmania major	88%	100%
Q4Q0D2	Leishmania major	88%	100%
Q4Q4J1	Leishmania major	44%	100%
Q6AWX0	Arabidopsis thaliana	24%	100%
Q6ZKF0	Oryza sativa subsp. japonica	23%	100%
Q7EZD7	Oryza sativa subsp. japonica	24%	100%
Q851G4	Oryza sativa subsp. japonica	22%	100%
Q8GW61	Arabidopsis thaliana	22%	100%
Q8L6Z8	Arabidopsis thaliana	23%	100%
Q8L7R8	Arabidopsis thaliana	22%	100%
Q8TFG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q8WMN1	Ovis aries	23%	100%
Q92253	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	95%
Q92339	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q94AZ2	Arabidopsis thaliana	23%	100%
Q94EC4	Oryza sativa subsp. japonica	24%	100%
Q9LT15	Arabidopsis thaliana	21%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9SX48	Arabidopsis thaliana	23%	100%
Q9WV38	Mus musculus	21%	100%
Q9XSC2	Oryctolagus cuniculus	23%	100%