LeishMANIAdb
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Putative small G-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative small G-protein
Gene product:
small G-protein, putative
Species:
Leishmania mexicana
UniProt:
E9AU60_LEIMU
TriTrypDb:
LmxM.36.6250
Length:
296

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005773 vacuole 5 1
GO:0005776 autophagosome 6 1
GO:0010008 endosome membrane 5 1
GO:0012506 vesicle membrane 4 1
GO:0016020 membrane 2 1
GO:0030659 cytoplasmic vesicle membrane 5 1
GO:0031090 organelle membrane 3 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0035869 ciliary transition zone 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097014 ciliary plasm 5 1
GO:0098588 bounding membrane of organelle 4 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AU60
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU60

Function

Biological processes
Term Name Level Count
GO:0000045 autophagosome assembly 6 1
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006996 organelle organization 4 1
GO:0007033 vacuole organization 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0070925 organelle assembly 5 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:1905037 autophagosome organization 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0003924 GTPase activity 7 9
GO:0005488 binding 1 9
GO:0005525 GTP binding 5 9
GO:0016462 pyrophosphatase activity 5 9
GO:0016787 hydrolase activity 2 9
GO:0016817 hydrolase activity, acting on acid anhydrides 3 9
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 9
GO:0019001 guanyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032561 guanyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 26 28 PF00675 0.291
CLV_NRD_NRD_1 37 39 PF00675 0.325
CLV_PCSK_KEX2_1 26 28 PF00082 0.280
CLV_PCSK_SKI1_1 273 277 PF00082 0.540
CLV_PCSK_SKI1_1 289 293 PF00082 0.655
CLV_PCSK_SKI1_1 48 52 PF00082 0.354
CLV_PCSK_SKI1_1 60 64 PF00082 0.350
DEG_Nend_Nbox_1 1 3 PF02207 0.508
DEG_SPOP_SBC_1 228 232 PF00917 0.577
DEG_SPOP_SBC_1 267 271 PF00917 0.491
DOC_MAPK_MEF2A_6 139 148 PF00069 0.279
DOC_PP2B_LxvP_1 144 147 PF13499 0.352
DOC_USP7_MATH_1 203 207 PF00917 0.773
DOC_USP7_MATH_1 227 231 PF00917 0.786
DOC_USP7_MATH_1 236 240 PF00917 0.729
DOC_USP7_MATH_1 267 271 PF00917 0.572
DOC_USP7_UBL2_3 288 292 PF12436 0.696
DOC_WW_Pin1_4 229 234 PF00397 0.648
LIG_14-3-3_CanoR_1 150 157 PF00244 0.303
LIG_14-3-3_CanoR_1 53 63 PF00244 0.363
LIG_FHA_1 114 120 PF00498 0.316
LIG_FHA_1 164 170 PF00498 0.301
LIG_FHA_1 20 26 PF00498 0.307
LIG_FHA_1 56 62 PF00498 0.300
LIG_FHA_2 120 126 PF00498 0.303
LIG_FHA_2 131 137 PF00498 0.303
LIG_FHA_2 151 157 PF00498 0.327
LIG_FHA_2 206 212 PF00498 0.682
LIG_FHA_2 274 280 PF00498 0.626
LIG_Integrin_RGD_1 30 32 PF01839 0.290
LIG_LIR_Gen_1 70 80 PF02991 0.281
LIG_LIR_Gen_1 96 102 PF02991 0.340
LIG_LIR_Nem_3 70 75 PF02991 0.329
LIG_LIR_Nem_3 96 101 PF02991 0.340
LIG_PDZ_Class_1 291 296 PF00595 0.562
LIG_SH3_3 108 114 PF00018 0.333
LIG_SUMO_SIM_par_1 10 16 PF11976 0.352
LIG_TRAF2_1 3 6 PF00917 0.399
LIG_TRAF2_1 67 70 PF00917 0.319
MOD_CAAXbox 293 296 PF01239 0.630
MOD_CK1_1 206 212 PF00069 0.655
MOD_CK1_1 239 245 PF00069 0.609
MOD_CK1_1 268 274 PF00069 0.560
MOD_CK1_1 54 60 PF00069 0.305
MOD_CK2_1 130 136 PF00069 0.303
MOD_CK2_1 205 211 PF00069 0.688
MOD_CK2_1 273 279 PF00069 0.675
MOD_GlcNHglycan 172 176 PF01048 0.571
MOD_GlcNHglycan 200 203 PF01048 0.618
MOD_GlcNHglycan 224 227 PF01048 0.515
MOD_GlcNHglycan 241 244 PF01048 0.558
MOD_GSK3_1 51 58 PF00069 0.324
MOD_N-GLC_1 157 162 PF02516 0.329
MOD_N-GLC_1 237 242 PF02516 0.611
MOD_N-GLC_1 273 278 PF02516 0.567
MOD_N-GLC_1 55 60 PF02516 0.333
MOD_NEK2_1 119 124 PF00069 0.303
MOD_NEK2_1 149 154 PF00069 0.333
MOD_NEK2_1 157 162 PF00069 0.318
MOD_NEK2_1 163 168 PF00069 0.346
MOD_NEK2_1 253 258 PF00069 0.593
MOD_NEK2_1 291 296 PF00069 0.604
MOD_NEK2_1 51 56 PF00069 0.309
MOD_NEK2_1 63 68 PF00069 0.212
MOD_NEK2_1 88 93 PF00069 0.303
MOD_PIKK_1 157 163 PF00454 0.333
MOD_PIKK_1 73 79 PF00454 0.303
MOD_PK_1 107 113 PF00069 0.344
MOD_PKA_2 149 155 PF00069 0.303
MOD_PKA_2 37 43 PF00069 0.317
MOD_PKA_2 52 58 PF00069 0.232
MOD_PKA_2 94 100 PF00069 0.303
MOD_Plk_1 157 163 PF00069 0.274
MOD_Plk_1 237 243 PF00069 0.610
MOD_Plk_1 273 279 PF00069 0.559
MOD_Plk_1 55 61 PF00069 0.274
MOD_Plk_4 94 100 PF00069 0.289
MOD_ProDKin_1 229 235 PF00069 0.648
TRG_DiLeu_BaEn_2 46 52 PF01217 0.363
TRG_ER_diArg_1 25 27 PF00400 0.280
TRG_NES_CRM1_1 161 172 PF08389 0.283
TRG_NLS_Bipartite_1 272 291 PF00514 0.489

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8I1 Leptomonas seymouri 32% 100%
A0A0N1HU31 Leptomonas seymouri 26% 100%
A0A0N1I9K4 Leptomonas seymouri 27% 100%
A0A0N1IC49 Leptomonas seymouri 62% 95%
A0A0N1IJ36 Leptomonas seymouri 28% 100%
A0A0S4IJB7 Bodo saltans 30% 100%
A0A0S4IM06 Bodo saltans 30% 100%
A0A0S4J1G8 Bodo saltans 31% 100%
A0A0S4J9T5 Bodo saltans 26% 100%
A0A0S4JF89 Bodo saltans 33% 100%
A0A1X0NLK7 Trypanosomatidae 65% 100%
A0A1X0NR18 Trypanosomatidae 33% 100%
A0A1X0NYR7 Trypanosomatidae 30% 100%
A0A1X0P706 Trypanosomatidae 28% 100%
A0A3Q8I8T8 Leishmania donovani 32% 100%
A0A3Q8ICX9 Leishmania donovani 30% 100%
A0A3Q8ID64 Leishmania donovani 33% 100%
A0A3Q8IE68 Leishmania donovani 34% 100%
A0A3Q8IK84 Leishmania donovani 33% 100%
A0A3Q8IRV7 Leishmania donovani 86% 100%
A0A3S5H5Y5 Leishmania donovani 33% 100%
A0A3S5H6H3 Leishmania donovani 31% 100%
A0A3S7WRA9 Leishmania donovani 33% 100%
A0A3S7WUY8 Leishmania donovani 31% 100%
A0A3S7WV84 Leishmania donovani 29% 100%
A0A3S7X3D1 Leishmania donovani 31% 100%
A0A3S7X5J2 Leishmania donovani 30% 100%
A0A422MUR1 Trypanosoma rangeli 31% 100%
A1KXP5 Leishmania donovani 28% 100%
A4D1S5 Homo sapiens 30% 100%
A4H506 Leishmania braziliensis 32% 100%
A4H679 Leishmania braziliensis 31% 100%
A4H6A4 Leishmania braziliensis 33% 100%
A4H6A5 Leishmania braziliensis 31% 100%
A4H9M3 Leishmania braziliensis 29% 100%
A4HEE8 Leishmania braziliensis 30% 100%
A4HFK0 Leishmania braziliensis 34% 100%
A4HHR8 Leishmania braziliensis 30% 100%
A4HIB4 Leishmania braziliensis 31% 100%
A4HK33 Leishmania braziliensis 31% 100%
A4HKH2 Leishmania braziliensis 31% 100%
A4HKJ3 Leishmania braziliensis 32% 100%
A4HLP5 Leishmania braziliensis 34% 100%
A4HQE5 Leishmania braziliensis 64% 100%
A4HT72 Leishmania infantum 33% 100%
A4HUK3 Leishmania infantum 33% 100%
A4HUM8 Leishmania infantum 32% 100%
A4HUM9 Leishmania infantum 31% 100%
A4HVF7 Leishmania infantum 28% 100%
A4HXY7 Leishmania infantum 29% 100%
A4I1I6 Leishmania infantum 30% 100%
A4I5J8 Leishmania infantum 31% 100%
A4I7N3 Leishmania infantum 30% 100%
A4I7Z9 Leishmania infantum 31% 100%
A4I825 Leishmania infantum 33% 100%
A4I946 Leishmania infantum 33% 100%
A4IC86 Leishmania infantum 86% 100%
B1A5Z4 Leishmania donovani 30% 100%
C8VQY7 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 31% 100%
C9ZVR3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZYS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AD53 Leishmania major 34% 100%
E9AGQ4 Leishmania infantum 31% 100%
E9AHE8 Leishmania infantum 34% 100%
E9AL68 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ANA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ANC6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9ANC7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AP56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ARM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ARQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AXM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AYX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B0U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2H2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2W1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2Y3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B420 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
H9BW96 Epinephelus coioides 33% 100%
O01803 Caenorhabditis elegans 31% 100%
O24461 Prunus armeniaca 32% 100%
O24466 Arabidopsis thaliana 31% 100%
O82480 Arabidopsis thaliana 32% 100%
O97572 Oryctolagus cuniculus 33% 100%
P05714 Rattus norvegicus 30% 100%
P09527 Rattus norvegicus 33% 100%
P18067 Canis lupus familiaris 33% 100%
P28186 Arabidopsis thaliana 33% 100%
P32939 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 100%
P35282 Mus musculus 30% 100%
P36017 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 100%
P36018 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
P36410 Dictyostelium discoideum 32% 100%
P36864 Volvox carteri 31% 100%
P51149 Homo sapiens 32% 100%
P51150 Mus musculus 32% 100%
P55745 Canis lupus familiaris 30% 100%
P56371 Mus musculus 30% 100%
Q17R06 Bos taurus 30% 100%
Q1PEX3 Arabidopsis thaliana 32% 100%
Q2TBH7 Bos taurus 30% 100%
Q39573 Chlamydomonas reinhardtii 30% 100%
Q3T0F5 Bos taurus 33% 100%
Q40787 Cenchrus ciliaris 33% 100%
Q4Q0D5 Leishmania major 79% 100%
Q4Q404 Leishmania major 33% 100%
Q4Q573 Leishmania major 33% 100%
Q4Q595 Leishmania major 31% 100%
Q4Q5N4 Leishmania major 30% 100%
Q4Q7C3 Leishmania major 30% 100%
Q4Q9V1 Leishmania major 30% 100%
Q4QDS9 Leishmania major 29% 100%
Q4QGD2 Leishmania major 29% 100%
Q4QH97 Leishmania major 31% 100%
Q4QH98 Leishmania major 31% 100%
Q4QHC3 Leishmania major 33% 100%
Q4QIN6 Leishmania major 33% 100%
Q54P07 Dictyostelium discoideum 27% 100%
Q55E31 Dictyostelium discoideum 30% 100%
Q5R9Y4 Pongo abelii 33% 100%
Q68Y52 Oryza sativa subsp. japonica 30% 100%
Q6AXT5 Rattus norvegicus 30% 100%
Q8HZJ5 Bos taurus 32% 100%
Q8T6H9 Leishmania braziliensis 32% 100%
Q99P58 Mus musculus 31% 100%
Q99P74 Rattus norvegicus 30% 100%
Q9C820 Arabidopsis thaliana 32% 100%
Q9FE79 Arabidopsis thaliana 34% 100%
Q9LZD4 Arabidopsis thaliana 33% 100%
Q9N2P5 Leishmania major 32% 100%
Q9UL25 Homo sapiens 31% 100%
Q9XI98 Arabidopsis thaliana 31% 100%
V5DKQ7 Trypanosoma cruzi 31% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS