Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU59_LEIMU

TriTrypDb:

LmxM.36.6240

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU59

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.539
CLV_C14_Caspase3-7	367	371	PF00656	0.612
CLV_C14_Caspase3-7	577	581	PF00656	0.637
CLV_C14_Caspase3-7	726	730	PF00656	0.633
CLV_NRD_NRD_1	226	228	PF00675	0.370
CLV_NRD_NRD_1	667	669	PF00675	0.787
CLV_NRD_NRD_1	702	704	PF00675	0.649
CLV_NRD_NRD_1	705	707	PF00675	0.635
CLV_PCSK_FUR_1	224	228	PF00082	0.378
CLV_PCSK_KEX2_1	226	228	PF00082	0.370
CLV_PCSK_KEX2_1	482	484	PF00082	0.622
CLV_PCSK_KEX2_1	49	51	PF00082	0.543
CLV_PCSK_KEX2_1	667	669	PF00082	0.648
CLV_PCSK_KEX2_1	683	685	PF00082	0.514
CLV_PCSK_KEX2_1	702	704	PF00082	0.660
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.622
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.511
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.514
CLV_PCSK_PC7_1	45	51	PF00082	0.503
CLV_PCSK_SKI1_1	226	230	PF00082	0.553
CLV_PCSK_SKI1_1	249	253	PF00082	0.366
CLV_PCSK_SKI1_1	445	449	PF00082	0.655
CLV_PCSK_SKI1_1	57	61	PF00082	0.373
CLV_PCSK_SKI1_1	683	687	PF00082	0.558
CLV_Separin_Metazoa	335	339	PF03568	0.530
DEG_SCF_TRCP1_1	25	30	PF00400	0.496
DEG_SCF_TRCP1_1	354	359	PF00400	0.521
DEG_SPOP_SBC_1	124	128	PF00917	0.496
DEG_SPOP_SBC_1	341	345	PF00917	0.517
DEG_SPOP_SBC_1	461	465	PF00917	0.694
DEG_SPOP_SBC_1	652	656	PF00917	0.521
DOC_CKS1_1	588	593	PF01111	0.678
DOC_CKS1_1	83	88	PF01111	0.362
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.628
DOC_MAPK_gen_1	49	60	PF00069	0.422
DOC_MAPK_MEF2A_6	53	60	PF00069	0.440
DOC_MAPK_RevD_3	670	684	PF00069	0.503
DOC_PP2B_LxvP_1	101	104	PF13499	0.514
DOC_PP2B_LxvP_1	186	189	PF13499	0.390
DOC_PP2B_LxvP_1	524	527	PF13499	0.686
DOC_PP2B_LxvP_1	533	536	PF13499	0.590
DOC_PP2B_LxvP_1	537	540	PF13499	0.551
DOC_USP7_MATH_1	124	128	PF00917	0.510
DOC_USP7_MATH_1	341	345	PF00917	0.548
DOC_USP7_MATH_1	364	368	PF00917	0.644
DOC_USP7_MATH_1	372	376	PF00917	0.564
DOC_USP7_MATH_1	392	396	PF00917	0.646
DOC_USP7_MATH_1	461	465	PF00917	0.670
DOC_USP7_MATH_1	472	476	PF00917	0.549
DOC_USP7_MATH_1	487	491	PF00917	0.573
DOC_USP7_MATH_1	519	523	PF00917	0.663
DOC_USP7_MATH_1	595	599	PF00917	0.703
DOC_USP7_MATH_1	635	639	PF00917	0.522
DOC_USP7_UBL2_3	683	687	PF12436	0.547
DOC_WW_Pin1_4	306	311	PF00397	0.592
DOC_WW_Pin1_4	345	350	PF00397	0.615
DOC_WW_Pin1_4	387	392	PF00397	0.677
DOC_WW_Pin1_4	457	462	PF00397	0.695
DOC_WW_Pin1_4	522	527	PF00397	0.662
DOC_WW_Pin1_4	587	592	PF00397	0.650
DOC_WW_Pin1_4	82	87	PF00397	0.452
LIG_14-3-3_CanoR_1	173	179	PF00244	0.387
LIG_14-3-3_CanoR_1	226	233	PF00244	0.532
LIG_14-3-3_CanoR_1	278	286	PF00244	0.446
LIG_14-3-3_CanoR_1	342	352	PF00244	0.637
LIG_14-3-3_CanoR_1	405	413	PF00244	0.623
LIG_14-3-3_CanoR_1	436	444	PF00244	0.577
LIG_14-3-3_CanoR_1	462	469	PF00244	0.574
LIG_14-3-3_CanoR_1	604	610	PF00244	0.657
LIG_14-3-3_CanoR_1	74	79	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_eIF4E_1	160	166	PF01652	0.411
LIG_FHA_1	139	145	PF00498	0.547
LIG_FHA_1	183	189	PF00498	0.392
LIG_FHA_1	227	233	PF00498	0.571
LIG_FHA_1	250	256	PF00498	0.375
LIG_FHA_1	312	318	PF00498	0.599
LIG_FHA_1	388	394	PF00498	0.623
LIG_FHA_1	415	421	PF00498	0.644
LIG_FHA_1	492	498	PF00498	0.681
LIG_FHA_1	609	615	PF00498	0.663
LIG_FHA_1	643	649	PF00498	0.642
LIG_FHA_1	680	686	PF00498	0.534
LIG_FHA_1	719	725	PF00498	0.538
LIG_FHA_1	86	92	PF00498	0.425
LIG_FHA_2	106	112	PF00498	0.374
LIG_FHA_2	278	284	PF00498	0.440
LIG_GBD_Chelix_1	550	558	PF00786	0.555
LIG_Integrin_RGD_1	23	25	PF01839	0.517
LIG_LIR_Gen_1	111	118	PF02991	0.408
LIG_LIR_Gen_1	732	738	PF02991	0.582
LIG_LIR_Nem_3	111	116	PF02991	0.391
LIG_LIR_Nem_3	2	6	PF02991	0.499
LIG_LIR_Nem_3	580	586	PF02991	0.530
LIG_LIR_Nem_3	732	736	PF02991	0.585
LIG_MAD2	235	243	PF02301	0.493
LIG_MAD2	613	621	PF02301	0.620
LIG_NRBOX	288	294	PF00104	0.484
LIG_PDZ_Class_2	733	738	PF00595	0.639
LIG_PTB_Apo_2	727	734	PF02174	0.641
LIG_RPA_C_Fungi	471	483	PF08784	0.613
LIG_SH2_STAP1	196	200	PF00017	0.333
LIG_SH2_STAP1	6	10	PF00017	0.381
LIG_SH2_STAT3	180	183	PF00017	0.399
LIG_SH2_STAT5	84	87	PF00017	0.440
LIG_SH3_3	325	331	PF00018	0.593
LIG_SH3_3	388	394	PF00018	0.511
LIG_SH3_3	524	530	PF00018	0.583
LIG_SH3_3	532	538	PF00018	0.622
LIG_SH3_3	539	545	PF00018	0.630
LIG_SH3_3	559	565	PF00018	0.458
LIG_SH3_3	585	591	PF00018	0.634
LIG_SUMO_SIM_anti_2	636	641	PF11976	0.534
LIG_SUMO_SIM_par_1	343	355	PF11976	0.523
LIG_SUMO_SIM_par_1	378	384	PF11976	0.507
LIG_TRAF2_1	181	184	PF00917	0.398
LIG_TRAF2_1	280	283	PF00917	0.437
LIG_WW_2	535	538	PF00397	0.508
MOD_CDK_SPK_2	457	462	PF00069	0.651
MOD_CK1_1	123	129	PF00069	0.601
MOD_CK1_1	14	20	PF00069	0.550
MOD_CK1_1	2	8	PF00069	0.551
MOD_CK1_1	256	262	PF00069	0.388
MOD_CK1_1	26	32	PF00069	0.594
MOD_CK1_1	306	312	PF00069	0.645
MOD_CK1_1	344	350	PF00069	0.687
MOD_CK1_1	355	361	PF00069	0.667
MOD_CK1_1	414	420	PF00069	0.636
MOD_CK1_1	453	459	PF00069	0.634
MOD_CK1_1	460	466	PF00069	0.663
MOD_CK1_1	467	473	PF00069	0.689
MOD_CK1_1	522	528	PF00069	0.690
MOD_CK2_1	173	179	PF00069	0.452
MOD_CK2_1	198	204	PF00069	0.569
MOD_CK2_1	277	283	PF00069	0.435
MOD_CK2_1	436	442	PF00069	0.580
MOD_GlcNHglycan	122	125	PF01048	0.626
MOD_GlcNHglycan	209	212	PF01048	0.610
MOD_GlcNHglycan	25	28	PF01048	0.675
MOD_GlcNHglycan	255	258	PF01048	0.366
MOD_GlcNHglycan	34	37	PF01048	0.553
MOD_GlcNHglycan	354	357	PF01048	0.657
MOD_GlcNHglycan	394	397	PF01048	0.649
MOD_GlcNHglycan	40	43	PF01048	0.371
MOD_GlcNHglycan	406	409	PF01048	0.798
MOD_GlcNHglycan	452	455	PF01048	0.608
MOD_GlcNHglycan	469	472	PF01048	0.529
MOD_GlcNHglycan	511	514	PF01048	0.788
MOD_GlcNHglycan	521	524	PF01048	0.615
MOD_GlcNHglycan	592	595	PF01048	0.756
MOD_GlcNHglycan	622	625	PF01048	0.686
MOD_GlcNHglycan	658	661	PF01048	0.647
MOD_GSK3_1	11	18	PF00069	0.526
MOD_GSK3_1	120	127	PF00069	0.585
MOD_GSK3_1	2	9	PF00069	0.569
MOD_GSK3_1	23	30	PF00069	0.729
MOD_GSK3_1	249	256	PF00069	0.430
MOD_GSK3_1	309	316	PF00069	0.774
MOD_GSK3_1	340	347	PF00069	0.722
MOD_GSK3_1	348	355	PF00069	0.667
MOD_GSK3_1	359	366	PF00069	0.570
MOD_GSK3_1	404	411	PF00069	0.762
MOD_GSK3_1	432	439	PF00069	0.633
MOD_GSK3_1	453	460	PF00069	0.780
MOD_GSK3_1	461	468	PF00069	0.660
MOD_GSK3_1	487	494	PF00069	0.612
MOD_GSK3_1	63	70	PF00069	0.399
MOD_GSK3_1	642	649	PF00069	0.453
MOD_GSK3_1	652	659	PF00069	0.593
MOD_N-GLC_1	18	23	PF02516	0.555
MOD_N-GLC_1	198	203	PF02516	0.573
MOD_N-GLC_1	352	357	PF02516	0.688
MOD_N-GLC_1	414	419	PF02516	0.678
MOD_N-GLC_1	424	429	PF02516	0.603
MOD_N-GLC_1	729	734	PF02516	0.611
MOD_NEK2_1	304	309	PF00069	0.606
MOD_NEK2_1	352	357	PF00069	0.685
MOD_NEK2_1	497	502	PF00069	0.539
MOD_NEK2_1	60	65	PF00069	0.385
MOD_NEK2_2	244	249	PF00069	0.474
MOD_NEK2_2	356	361	PF00069	0.643
MOD_NEK2_2	364	369	PF00069	0.593
MOD_NEK2_2	602	607	PF00069	0.570
MOD_PIKK_1	27	33	PF00454	0.594
MOD_PIKK_1	608	614	PF00454	0.607
MOD_PKA_1	226	232	PF00069	0.379
MOD_PKA_1	49	55	PF00069	0.434
MOD_PKA_2	174	180	PF00069	0.387
MOD_PKA_2	226	232	PF00069	0.383
MOD_PKA_2	277	283	PF00069	0.435
MOD_PKA_2	341	347	PF00069	0.520
MOD_PKA_2	404	410	PF00069	0.626
MOD_PKA_2	461	467	PF00069	0.612
MOD_PKA_2	49	55	PF00069	0.534
MOD_PKA_2	60	66	PF00069	0.341
MOD_PKA_2	73	79	PF00069	0.404
MOD_PKB_1	120	128	PF00069	0.572
MOD_PKB_1	224	232	PF00069	0.382
MOD_Plk_1	18	24	PF00069	0.627
MOD_Plk_1	244	250	PF00069	0.402
MOD_Plk_1	560	566	PF00069	0.652
MOD_Plk_1	635	641	PF00069	0.513
MOD_Plk_2-3	729	735	PF00069	0.577
MOD_Plk_4	272	278	PF00069	0.363
MOD_Plk_4	6	12	PF00069	0.480
MOD_Plk_4	635	641	PF00069	0.516
MOD_Plk_4	67	73	PF00069	0.427
MOD_ProDKin_1	306	312	PF00069	0.594
MOD_ProDKin_1	345	351	PF00069	0.614
MOD_ProDKin_1	387	393	PF00069	0.681
MOD_ProDKin_1	457	463	PF00069	0.696
MOD_ProDKin_1	522	528	PF00069	0.663
MOD_ProDKin_1	587	593	PF00069	0.652
MOD_ProDKin_1	82	88	PF00069	0.456
MOD_SUMO_for_1	181	184	PF00179	0.398
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.487
TRG_ER_diArg_1	172	175	PF00400	0.425
TRG_ER_diArg_1	224	227	PF00400	0.386
TRG_ER_diArg_1	666	668	PF00400	0.644
TRG_NLS_Bipartite_1	667	687	PF00514	0.508
TRG_NLS_MonoExtC_3	682	687	PF00514	0.511
TRG_NLS_MonoExtC_3	705	710	PF00514	0.700
TRG_NLS_MonoExtN_4	681	687	PF00514	0.562
TRG_NLS_MonoExtN_4	703	710	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAD4	Leptomonas seymouri	44%	99%
A0A3Q8IJC2	Leishmania donovani	88%	100%
A4HQE4	Leishmania braziliensis	66%	100%
A4IE35	Leishmania infantum	88%	100%
Q4Q0D6	Leishmania major	85%	100%