TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU50_LEIMU

TriTrypDb:

LmxM.36.6150

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AU50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	308	310	PF00675	0.429
CLV_NRD_NRD_1	335	337	PF00675	0.401
CLV_PCSK_KEX2_1	335	337	PF00082	0.317
CLV_PCSK_SKI1_1	279	283	PF00082	0.516
CLV_PCSK_SKI1_1	293	297	PF00082	0.319
CLV_PCSK_SKI1_1	313	317	PF00082	0.264
CLV_PCSK_SKI1_1	335	339	PF00082	0.313
CLV_PCSK_SKI1_1	345	349	PF00082	0.335
CLV_TASPASE1	58	64	PF01112	0.687
DEG_Nend_Nbox_1	1	3	PF02207	0.730
DEG_SPOP_SBC_1	245	249	PF00917	0.644
DEG_SPOP_SBC_1	273	277	PF00917	0.718
DOC_CYCLIN_RxL_1	50	60	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.584
DOC_MAPK_FxFP_2	350	353	PF00069	0.214
DOC_MAPK_gen_1	102	111	PF00069	0.511
DOC_MAPK_gen_1	293	303	PF00069	0.556
DOC_MAPK_MEF2A_6	70	79	PF00069	0.524
DOC_MAPK_RevD_3	322	336	PF00069	0.520
DOC_PP4_FxxP_1	153	156	PF00568	0.730
DOC_PP4_FxxP_1	284	287	PF00568	0.550
DOC_PP4_FxxP_1	350	353	PF00568	0.453
DOC_USP7_MATH_1	110	114	PF00917	0.727
DOC_USP7_MATH_1	162	166	PF00917	0.728
DOC_USP7_MATH_1	187	191	PF00917	0.683
DOC_USP7_MATH_1	273	277	PF00917	0.768
DOC_WW_Pin1_4	152	157	PF00397	0.707
DOC_WW_Pin1_4	322	327	PF00397	0.540
DOC_WW_Pin1_4	36	41	PF00397	0.517
LIG_14-3-3_CanoR_1	105	110	PF00244	0.518
LIG_CtBP_PxDLS_1	218	222	PF00389	0.686
LIG_deltaCOP1_diTrp_1	101	107	PF00928	0.666
LIG_deltaCOP1_diTrp_1	146	153	PF00928	0.696
LIG_EH1_1	315	323	PF00400	0.565
LIG_FHA_1	190	196	PF00498	0.750
LIG_FHA_1	254	260	PF00498	0.636
LIG_FHA_1	40	46	PF00498	0.651
LIG_FHA_1	83	89	PF00498	0.525
LIG_FHA_2	230	236	PF00498	0.743
LIG_FHA_2	266	272	PF00498	0.659
LIG_FHA_2	69	75	PF00498	0.568
LIG_LIR_Apic_2	151	156	PF02991	0.734
LIG_LIR_Apic_2	265	270	PF02991	0.606
LIG_LIR_Apic_2	283	287	PF02991	0.537
LIG_LIR_Gen_1	146	157	PF02991	0.735
LIG_LIR_Gen_1	19	27	PF02991	0.569
LIG_LIR_Gen_1	31	40	PF02991	0.522
LIG_LIR_Nem_3	101	106	PF02991	0.592
LIG_LIR_Nem_3	146	152	PF02991	0.784
LIG_LIR_Nem_3	19	24	PF02991	0.573
LIG_LIR_Nem_3	31	37	PF02991	0.517
LIG_LIR_Nem_3	351	355	PF02991	0.214
LIG_LYPXL_SIV_4	72	80	PF13949	0.526
LIG_NRBOX	333	339	PF00104	0.511
LIG_PDZ_Class_2	357	362	PF00595	0.335
LIG_Pex14_1	149	153	PF04695	0.739
LIG_Pex14_2	348	352	PF04695	0.214
LIG_SH2_CRK	305	309	PF00017	0.521
LIG_SH2_GRB2like	298	301	PF00017	0.546
LIG_SH2_GRB2like	47	50	PF00017	0.603
LIG_SH2_SRC	47	50	PF00017	0.603
LIG_SH2_STAP1	126	130	PF00017	0.649
LIG_SH2_STAP1	291	295	PF00017	0.619
LIG_SH2_STAP1	73	77	PF00017	0.535
LIG_SH2_STAT5	267	270	PF00017	0.609
LIG_SH2_STAT5	305	308	PF00017	0.509
LIG_SH2_STAT5	317	320	PF00017	0.516
LIG_SH2_STAT5	34	37	PF00017	0.551
LIG_SH2_STAT5	343	346	PF00017	0.335
LIG_SH2_STAT5	47	50	PF00017	0.544
LIG_SH2_STAT5	97	100	PF00017	0.548
LIG_SH3_3	167	173	PF00018	0.728
LIG_SH3_3	204	210	PF00018	0.655
LIG_SUMO_SIM_par_1	83	90	PF11976	0.522
LIG_TYR_ITIM	289	294	PF00017	0.458
LIG_TYR_ITIM	303	308	PF00017	0.348
LIG_UBA3_1	94	100	PF00899	0.518
MOD_CK1_1	113	119	PF00069	0.677
MOD_CK1_1	229	235	PF00069	0.694
MOD_CK1_1	236	242	PF00069	0.717
MOD_CK1_1	247	253	PF00069	0.613
MOD_CK1_1	262	268	PF00069	0.744
MOD_CK1_1	325	331	PF00069	0.402
MOD_CK1_1	36	42	PF00069	0.382
MOD_CK2_1	152	158	PF00069	0.690
MOD_CK2_1	16	22	PF00069	0.469
MOD_CK2_1	229	235	PF00069	0.594
MOD_CK2_1	68	74	PF00069	0.448
MOD_GlcNHglycan	115	118	PF01048	0.577
MOD_GlcNHglycan	174	177	PF01048	0.735
MOD_GlcNHglycan	185	188	PF01048	0.613
MOD_GlcNHglycan	189	192	PF01048	0.620
MOD_GlcNHglycan	198	201	PF01048	0.627
MOD_GlcNHglycan	228	231	PF01048	0.684
MOD_GlcNHglycan	235	238	PF01048	0.574
MOD_GlcNHglycan	4	7	PF01048	0.623
MOD_GSK3_1	172	179	PF00069	0.720
MOD_GSK3_1	183	190	PF00069	0.626
MOD_GSK3_1	2	9	PF00069	0.494
MOD_GSK3_1	213	220	PF00069	0.594
MOD_GSK3_1	225	232	PF00069	0.659
MOD_GSK3_1	235	242	PF00069	0.611
MOD_GSK3_1	259	266	PF00069	0.613
MOD_GSK3_1	269	276	PF00069	0.603
MOD_GSK3_1	35	42	PF00069	0.602
MOD_GSK3_1	64	71	PF00069	0.654
MOD_N-GLC_1	162	167	PF02516	0.680
MOD_N-GLC_2	212	214	PF02516	0.497
MOD_NEK2_1	183	188	PF00069	0.496
MOD_NEK2_1	196	201	PF00069	0.613
MOD_NEK2_1	2	7	PF00069	0.655
MOD_NEK2_1	253	258	PF00069	0.608
MOD_NEK2_1	259	264	PF00069	0.674
MOD_NEK2_1	316	321	PF00069	0.427
MOD_NEK2_1	348	353	PF00069	0.380
MOD_NEK2_1	35	40	PF00069	0.548
MOD_PIKK_1	129	135	PF00454	0.756
MOD_PIKK_1	189	195	PF00454	0.615
MOD_PIKK_1	229	235	PF00454	0.568
MOD_PKA_2	113	119	PF00069	0.677
MOD_PKA_2	196	202	PF00069	0.773
MOD_PKB_1	223	231	PF00069	0.682
MOD_Plk_1	68	74	PF00069	0.551
MOD_Plk_2-3	16	22	PF00069	0.462
MOD_Plk_4	16	22	PF00069	0.439
MOD_Plk_4	217	223	PF00069	0.566
MOD_Plk_4	82	88	PF00069	0.509
MOD_ProDKin_1	152	158	PF00069	0.636
MOD_ProDKin_1	322	328	PF00069	0.397
MOD_ProDKin_1	36	42	PF00069	0.375
TRG_DiLeu_BaEn_1	329	334	PF01217	0.324
TRG_DiLeu_BaEn_1	90	95	PF01217	0.495
TRG_DiLeu_BaEn_4	329	335	PF01217	0.501
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.346
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.335
TRG_ENDOCYTIC_2	106	109	PF00928	0.382
TRG_ENDOCYTIC_2	291	294	PF00928	0.464
TRG_ENDOCYTIC_2	298	301	PF00928	0.319
TRG_ENDOCYTIC_2	305	308	PF00928	0.299
TRG_ENDOCYTIC_2	34	37	PF00928	0.415
TRG_ER_diArg_1	111	114	PF00400	0.600
TRG_ER_diArg_1	334	336	PF00400	0.487
TRG_NES_CRM1_1	46	60	PF08389	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I247	Leptomonas seymouri	41%	100%
A0A3S7XC14	Leishmania donovani	85%	100%
A4HQD4	Leishmania braziliensis	63%	99%
A4IE26	Leishmania infantum	85%	100%
Q4Q0E5	Leishmania major	85%	100%