TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU49_LEIMU

TriTrypDb:

LmxM.36.6140

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.742
CLV_C14_Caspase3-7	673	677	PF00656	0.529
CLV_NRD_NRD_1	199	201	PF00675	0.608
CLV_NRD_NRD_1	251	253	PF00675	0.670
CLV_NRD_NRD_1	274	276	PF00675	0.643
CLV_NRD_NRD_1	385	387	PF00675	0.692
CLV_NRD_NRD_1	388	390	PF00675	0.684
CLV_NRD_NRD_1	466	468	PF00675	0.731
CLV_NRD_NRD_1	661	663	PF00675	0.725
CLV_NRD_NRD_1	75	77	PF00675	0.742
CLV_PCSK_FUR_1	657	661	PF00082	0.637
CLV_PCSK_KEX2_1	199	201	PF00082	0.597
CLV_PCSK_KEX2_1	251	253	PF00082	0.670
CLV_PCSK_KEX2_1	298	300	PF00082	0.621
CLV_PCSK_KEX2_1	385	387	PF00082	0.561
CLV_PCSK_KEX2_1	659	661	PF00082	0.715
CLV_PCSK_KEX2_1	75	77	PF00082	0.742
CLV_PCSK_KEX2_1	757	759	PF00082	0.712
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.652
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.676
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.712
CLV_PCSK_PC7_1	657	663	PF00082	0.707
CLV_PCSK_SKI1_1	359	363	PF00082	0.550
CLV_PCSK_SKI1_1	493	497	PF00082	0.570
DEG_MDM2_SWIB_1	208	216	PF02201	0.612
DEG_SCF_FBW7_1	182	188	PF00400	0.671
DEG_SPOP_SBC_1	421	425	PF00917	0.710
DEG_SPOP_SBC_1	484	488	PF00917	0.642
DEG_SPOP_SBC_1	581	585	PF00917	0.696
DOC_CKS1_1	182	187	PF01111	0.673
DOC_PP2B_LxvP_1	443	446	PF13499	0.601
DOC_PP2B_LxvP_1	693	696	PF13499	0.534
DOC_PP4_FxxP_1	648	651	PF00568	0.692
DOC_USP7_MATH_1	108	112	PF00917	0.688
DOC_USP7_MATH_1	11	15	PF00917	0.668
DOC_USP7_MATH_1	121	125	PF00917	0.633
DOC_USP7_MATH_1	126	130	PF00917	0.726
DOC_USP7_MATH_1	132	136	PF00917	0.613
DOC_USP7_MATH_1	158	162	PF00917	0.715
DOC_USP7_MATH_1	185	189	PF00917	0.690
DOC_USP7_MATH_1	27	31	PF00917	0.651
DOC_USP7_MATH_1	415	419	PF00917	0.750
DOC_USP7_MATH_1	421	425	PF00917	0.712
DOC_USP7_MATH_1	450	454	PF00917	0.690
DOC_USP7_MATH_1	477	481	PF00917	0.600
DOC_USP7_MATH_1	484	488	PF00917	0.632
DOC_USP7_MATH_1	558	562	PF00917	0.623
DOC_USP7_MATH_1	569	573	PF00917	0.621
DOC_USP7_MATH_1	581	585	PF00917	0.679
DOC_USP7_MATH_1	61	65	PF00917	0.614
DOC_USP7_MATH_1	655	659	PF00917	0.648
DOC_USP7_MATH_1	700	704	PF00917	0.770
DOC_USP7_MATH_1	71	75	PF00917	0.544
DOC_USP7_MATH_1	742	746	PF00917	0.709
DOC_WW_Pin1_4	122	127	PF00397	0.652
DOC_WW_Pin1_4	128	133	PF00397	0.628
DOC_WW_Pin1_4	142	147	PF00397	0.719
DOC_WW_Pin1_4	178	183	PF00397	0.686
DOC_WW_Pin1_4	284	289	PF00397	0.719
DOC_WW_Pin1_4	291	296	PF00397	0.655
DOC_WW_Pin1_4	360	365	PF00397	0.674
DOC_WW_Pin1_4	401	406	PF00397	0.572
DOC_WW_Pin1_4	487	492	PF00397	0.762
DOC_WW_Pin1_4	512	517	PF00397	0.621
DOC_WW_Pin1_4	553	558	PF00397	0.706
DOC_WW_Pin1_4	577	582	PF00397	0.713
DOC_WW_Pin1_4	603	608	PF00397	0.752
DOC_WW_Pin1_4	631	636	PF00397	0.552
DOC_WW_Pin1_4	647	652	PF00397	0.564
DOC_WW_Pin1_4	722	727	PF00397	0.705
LIG_14-3-3_CanoR_1	138	144	PF00244	0.727
LIG_14-3-3_CanoR_1	191	196	PF00244	0.565
LIG_14-3-3_CanoR_1	275	280	PF00244	0.697
LIG_14-3-3_CanoR_1	283	288	PF00244	0.639
LIG_14-3-3_CanoR_1	306	315	PF00244	0.692
LIG_14-3-3_CanoR_1	34	38	PF00244	0.670
LIG_14-3-3_CanoR_1	359	364	PF00244	0.545
LIG_14-3-3_CanoR_1	371	380	PF00244	0.530
LIG_14-3-3_CanoR_1	392	401	PF00244	0.746
LIG_14-3-3_CanoR_1	428	437	PF00244	0.751
LIG_14-3-3_CanoR_1	493	498	PF00244	0.566
LIG_14-3-3_CanoR_1	564	569	PF00244	0.624
LIG_14-3-3_CanoR_1	576	580	PF00244	0.712
LIG_14-3-3_CanoR_1	601	605	PF00244	0.690
LIG_14-3-3_CanoR_1	625	633	PF00244	0.673
LIG_14-3-3_CanoR_1	75	80	PF00244	0.711
LIG_Actin_WH2_2	99	117	PF00022	0.623
LIG_AP2alpha_2	300	302	PF02296	0.496
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BRCT_BRCA1_1	35	39	PF00533	0.632
LIG_deltaCOP1_diTrp_1	32	39	PF00928	0.641
LIG_FHA_1	107	113	PF00498	0.668
LIG_FHA_1	360	366	PF00498	0.545
LIG_FHA_1	393	399	PF00498	0.720
LIG_FHA_1	401	407	PF00498	0.659
LIG_FHA_1	474	480	PF00498	0.600
LIG_FHA_1	484	490	PF00498	0.574
LIG_FHA_1	563	569	PF00498	0.633
LIG_FHA_2	33	39	PF00498	0.640
LIG_FHA_2	402	408	PF00498	0.573
LIG_FHA_2	60	66	PF00498	0.612
LIG_FHA_2	632	638	PF00498	0.709
LIG_FHA_2	68	74	PF00498	0.544
LIG_IBAR_NPY_1	80	82	PF08397	0.704
LIG_LIR_Apic_2	140	146	PF02991	0.658
LIG_LIR_Gen_1	102	108	PF02991	0.707
LIG_LIR_Nem_3	193	198	PF02991	0.672
LIG_LIR_Nem_3	77	82	PF02991	0.698
LIG_Pex14_2	208	212	PF04695	0.620
LIG_PTAP_UEV_1	710	715	PF05743	0.704
LIG_RPA_C_Fungi	303	315	PF08784	0.501
LIG_SH2_CRK	82	86	PF00017	0.653
LIG_SH2_STAP1	433	437	PF00017	0.539
LIG_SH2_STAT5	113	116	PF00017	0.716
LIG_SH3_1	630	636	PF00018	0.556
LIG_SH3_1	708	714	PF00018	0.706
LIG_SH3_2	81	86	PF14604	0.708
LIG_SH3_3	143	149	PF00018	0.730
LIG_SH3_3	176	182	PF00018	0.657
LIG_SH3_3	212	218	PF00018	0.605
LIG_SH3_3	486	492	PF00018	0.554
LIG_SH3_3	601	607	PF00018	0.692
LIG_SH3_3	630	636	PF00018	0.686
LIG_SH3_3	708	714	PF00018	0.601
LIG_SH3_3	78	84	PF00018	0.704
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.673
LIG_SUMO_SIM_anti_2	333	341	PF11976	0.668
LIG_SUMO_SIM_anti_2	343	350	PF11976	0.597
LIG_SUMO_SIM_anti_2	402	412	PF11976	0.571
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.658
LIG_SUMO_SIM_par_1	594	600	PF11976	0.655
LIG_TRAF2_2	295	300	PF00917	0.679
LIG_WRC_WIRS_1	245	250	PF05994	0.602
LIG_WW_3	356	360	PF00397	0.532
LIG_WW_3	490	494	PF00397	0.681
LIG_WW_3	694	698	PF00397	0.614
MOD_CDC14_SPxK_1	490	493	PF00782	0.723
MOD_CDK_SPK_2	128	133	PF00069	0.604
MOD_CDK_SPxK_1	487	493	PF00069	0.729
MOD_CDK_SPxxK_3	291	298	PF00069	0.684
MOD_CDK_SPxxK_3	360	367	PF00069	0.730
MOD_CDK_SPxxK_3	553	560	PF00069	0.706
MOD_CDK_SPxxK_3	722	729	PF00069	0.624
MOD_CK1_1	137	143	PF00069	0.679
MOD_CK1_1	181	187	PF00069	0.724
MOD_CK1_1	244	250	PF00069	0.695
MOD_CK1_1	25	31	PF00069	0.664
MOD_CK1_1	287	293	PF00069	0.700
MOD_CK1_1	338	344	PF00069	0.725
MOD_CK1_1	350	356	PF00069	0.617
MOD_CK1_1	372	378	PF00069	0.559
MOD_CK1_1	422	428	PF00069	0.708
MOD_CK1_1	431	437	PF00069	0.603
MOD_CK1_1	487	493	PF00069	0.700
MOD_CK1_1	536	542	PF00069	0.773
MOD_CK1_1	580	586	PF00069	0.733
MOD_CK1_1	600	606	PF00069	0.518
MOD_CK1_1	614	620	PF00069	0.589
MOD_CK1_1	703	709	PF00069	0.632
MOD_CK1_1	731	737	PF00069	0.553
MOD_CK1_1	74	80	PF00069	0.615
MOD_CK2_1	59	65	PF00069	0.607
MOD_CK2_1	631	637	PF00069	0.710
MOD_CK2_1	67	73	PF00069	0.533
MOD_DYRK1A_RPxSP_1	512	516	PF00069	0.657
MOD_GlcNHglycan	10	14	PF01048	0.656
MOD_GlcNHglycan	15	18	PF01048	0.623
MOD_GlcNHglycan	228	231	PF01048	0.664
MOD_GlcNHglycan	241	244	PF01048	0.592
MOD_GlcNHglycan	259	263	PF01048	0.572
MOD_GlcNHglycan	309	312	PF01048	0.522
MOD_GlcNHglycan	321	324	PF01048	0.713
MOD_GlcNHglycan	370	374	PF01048	0.713
MOD_GlcNHglycan	430	433	PF01048	0.724
MOD_GlcNHglycan	443	446	PF01048	0.617
MOD_GlcNHglycan	447	450	PF01048	0.584
MOD_GlcNHglycan	479	482	PF01048	0.564
MOD_GlcNHglycan	535	538	PF01048	0.722
MOD_GlcNHglycan	55	58	PF01048	0.605
MOD_GlcNHglycan	560	563	PF01048	0.656
MOD_GlcNHglycan	587	590	PF01048	0.712
MOD_GlcNHglycan	627	630	PF01048	0.761
MOD_GlcNHglycan	702	705	PF01048	0.774
MOD_GlcNHglycan	733	736	PF01048	0.569
MOD_GlcNHglycan	752	755	PF01048	0.686
MOD_GSK3_1	122	129	PF00069	0.710
MOD_GSK3_1	18	25	PF00069	0.643
MOD_GSK3_1	180	187	PF00069	0.732
MOD_GSK3_1	258	265	PF00069	0.733
MOD_GSK3_1	28	35	PF00069	0.660
MOD_GSK3_1	283	290	PF00069	0.697
MOD_GSK3_1	319	326	PF00069	0.617
MOD_GSK3_1	347	354	PF00069	0.722
MOD_GSK3_1	415	422	PF00069	0.756
MOD_GSK3_1	441	448	PF00069	0.714
MOD_GSK3_1	473	480	PF00069	0.658
MOD_GSK3_1	483	490	PF00069	0.720
MOD_GSK3_1	558	565	PF00069	0.725
MOD_GSK3_1	575	582	PF00069	0.616
MOD_GSK3_1	67	74	PF00069	0.642
MOD_GSK3_1	709	716	PF00069	0.762
MOD_GSK3_1	9	16	PF00069	0.711
MOD_N-GLC_1	585	590	PF02516	0.716
MOD_N-GLC_1	720	725	PF02516	0.744
MOD_N-GLC_1	729	734	PF02516	0.684
MOD_NEK2_1	347	352	PF00069	0.544
MOD_NEK2_1	472	477	PF00069	0.741
MOD_NEK2_1	568	573	PF00069	0.620
MOD_NEK2_2	108	113	PF00069	0.675
MOD_NEK2_2	452	457	PF00069	0.538
MOD_PIKK_1	236	242	PF00454	0.716
MOD_PIKK_1	347	353	PF00454	0.544
MOD_PIKK_1	422	428	PF00454	0.753
MOD_PIKK_1	493	499	PF00454	0.559
MOD_PIKK_1	688	694	PF00454	0.685
MOD_PK_1	485	491	PF00069	0.557
MOD_PK_1	729	735	PF00069	0.682
MOD_PKA_1	275	281	PF00069	0.661
MOD_PKA_1	462	468	PF00069	0.531
MOD_PKA_1	75	81	PF00069	0.636
MOD_PKA_1	757	763	PF00069	0.712
MOD_PKA_2	132	138	PF00069	0.691
MOD_PKA_2	190	196	PF00069	0.567
MOD_PKA_2	282	288	PF00069	0.711
MOD_PKA_2	307	313	PF00069	0.707
MOD_PKA_2	33	39	PF00069	0.640
MOD_PKA_2	391	397	PF00069	0.732
MOD_PKA_2	544	550	PF00069	0.768
MOD_PKA_2	569	575	PF00069	0.699
MOD_PKA_2	600	606	PF00069	0.733
MOD_PKA_2	624	630	PF00069	0.727
MOD_PKA_2	709	715	PF00069	0.763
MOD_PKA_2	728	734	PF00069	0.541
MOD_PKA_2	74	80	PF00069	0.681
MOD_PKA_2	743	749	PF00069	0.657
MOD_PKA_2	757	763	PF00069	0.601
MOD_Plk_1	338	344	PF00069	0.725
MOD_Plk_1	574	580	PF00069	0.769
MOD_Plk_1	729	735	PF00069	0.766
MOD_Plk_2-3	335	341	PF00069	0.723
MOD_Plk_4	108	114	PF00069	0.713
MOD_Plk_4	139	145	PF00069	0.716
MOD_Plk_4	191	197	PF00069	0.671
MOD_Plk_4	241	247	PF00069	0.728
MOD_Plk_4	611	617	PF00069	0.562
MOD_ProDKin_1	122	128	PF00069	0.653
MOD_ProDKin_1	142	148	PF00069	0.719
MOD_ProDKin_1	178	184	PF00069	0.685
MOD_ProDKin_1	284	290	PF00069	0.722
MOD_ProDKin_1	291	297	PF00069	0.657
MOD_ProDKin_1	360	366	PF00069	0.673
MOD_ProDKin_1	401	407	PF00069	0.572
MOD_ProDKin_1	487	493	PF00069	0.766
MOD_ProDKin_1	512	518	PF00069	0.621
MOD_ProDKin_1	553	559	PF00069	0.705
MOD_ProDKin_1	577	583	PF00069	0.710
MOD_ProDKin_1	603	609	PF00069	0.752
MOD_ProDKin_1	631	637	PF00069	0.556
MOD_ProDKin_1	647	653	PF00069	0.566
MOD_ProDKin_1	722	728	PF00069	0.707
MOD_SUMO_for_1	45	48	PF00179	0.535
MOD_SUMO_for_1	629	632	PF00179	0.724
MOD_SUMO_for_1	91	94	PF00179	0.671
MOD_SUMO_rev_2	38	47	PF00179	0.558
MOD_SUMO_rev_2	524	529	PF00179	0.543
TRG_ENDOCYTIC_2	220	223	PF00928	0.634
TRG_ENDOCYTIC_2	82	85	PF00928	0.652
TRG_ER_diArg_1	198	200	PF00400	0.604
TRG_ER_diArg_1	250	252	PF00400	0.670
TRG_ER_diArg_1	306	309	PF00400	0.498
TRG_ER_diArg_1	660	662	PF00400	0.710
TRG_ER_diArg_1	708	711	PF00400	0.762
TRG_NLS_MonoCore_2	658	663	PF00514	0.637
TRG_NLS_MonoExtC_3	388	393	PF00514	0.692
TRG_NLS_MonoExtC_3	658	664	PF00514	0.551
TRG_NLS_MonoExtN_4	386	393	PF00514	0.544
TRG_NLS_MonoExtN_4	657	663	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.705

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XC30	Leishmania donovani	84%	100%
A4HQD3	Leishmania braziliensis	59%	100%
A4IE25	Leishmania infantum	82%	100%
Q4Q0E6	Leishmania major	84%	100%