Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AU48_LEIMU

TriTrypDb:

LmxM.36.6130

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AU48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.652
CLV_NRD_NRD_1	232	234	PF00675	0.786
CLV_NRD_NRD_1	306	308	PF00675	0.656
CLV_PCSK_KEX2_1	162	164	PF00082	0.652
CLV_PCSK_KEX2_1	27	29	PF00082	0.791
CLV_PCSK_KEX2_1	4	6	PF00082	0.812
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.791
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.557
CLV_PCSK_SKI1_1	127	131	PF00082	0.560
CLV_PCSK_SKI1_1	41	45	PF00082	0.520
DEG_COP1_1	53	63	PF00400	0.818
DEG_SCF_FBW7_1	29	34	PF00400	0.776
DOC_MAPK_gen_1	307	313	PF00069	0.734
DOC_MAPK_RevD_3	218	234	PF00069	0.774
DOC_PP4_FxxP_1	215	218	PF00568	0.549
DOC_USP7_MATH_1	12	16	PF00917	0.800
DOC_USP7_MATH_1	19	23	PF00917	0.693
DOC_USP7_MATH_1	203	207	PF00917	0.569
DOC_USP7_MATH_1	237	241	PF00917	0.631
DOC_USP7_MATH_1	243	247	PF00917	0.672
DOC_USP7_MATH_1	249	253	PF00917	0.611
DOC_USP7_MATH_1	83	87	PF00917	0.785
DOC_WW_Pin1_4	257	262	PF00397	0.581
DOC_WW_Pin1_4	27	32	PF00397	0.782
LIG_14-3-3_CanoR_1	127	136	PF00244	0.643
LIG_14-3-3_CanoR_1	142	150	PF00244	0.411
LIG_BIR_II_1	1	5	PF00653	0.816
LIG_BIR_III_4	69	73	PF00653	0.754
LIG_CaM_IQ_9	101	116	PF13499	0.637
LIG_FHA_1	28	34	PF00498	0.779
LIG_FHA_1	308	314	PF00498	0.752
LIG_LIR_Apic_2	214	218	PF02991	0.548
LIG_LIR_Gen_1	206	216	PF02991	0.632
LIG_LIR_Nem_3	206	212	PF02991	0.636
LIG_NRBOX	114	120	PF00104	0.632
LIG_PCNA_PIPBox_1	169	178	PF02747	0.626
LIG_PCNA_yPIPBox_3	106	119	PF02747	0.635
LIG_PCNA_yPIPBox_3	162	176	PF02747	0.630
LIG_SH2_NCK_1	209	213	PF00017	0.756
LIG_SH2_STAP1	209	213	PF00017	0.756
LIG_SH3_3	179	185	PF00018	0.384
LIG_SH3_3	217	223	PF00018	0.751
LIG_SH3_3	252	258	PF00018	0.632
LIG_SH3_3	267	273	PF00018	0.541
LIG_TRAF2_1	167	170	PF00917	0.628
LIG_WRC_WIRS_1	212	217	PF05994	0.747
LIG_WRC_WIRS_1	33	38	PF05994	0.778
MOD_CK1_1	15	21	PF00069	0.800
MOD_CK1_1	22	28	PF00069	0.686
MOD_CK1_1	265	271	PF00069	0.673
MOD_CK1_1	86	92	PF00069	0.727
MOD_GlcNHglycan	115	118	PF01048	0.624
MOD_GlcNHglycan	14	17	PF01048	0.800
MOD_GlcNHglycan	204	208	PF01048	0.727
MOD_GlcNHglycan	239	242	PF01048	0.677
MOD_GlcNHglycan	245	248	PF01048	0.668
MOD_GlcNHglycan	267	270	PF01048	0.633
MOD_GlcNHglycan	273	276	PF01048	0.523
MOD_GlcNHglycan	315	318	PF01048	0.584
MOD_GlcNHglycan	48	51	PF01048	0.558
MOD_GlcNHglycan	88	91	PF01048	0.712
MOD_GSK3_1	15	22	PF00069	0.723
MOD_GSK3_1	203	210	PF00069	0.747
MOD_GSK3_1	23	30	PF00069	0.587
MOD_GSK3_1	237	244	PF00069	0.597
MOD_GSK3_1	46	53	PF00069	0.571
MOD_GSK3_1	55	62	PF00069	0.655
MOD_GSK3_1	7	14	PF00069	0.754
MOD_GSK3_1	82	89	PF00069	0.685
MOD_GSK3_1	92	99	PF00069	0.506
MOD_N-GLC_1	249	254	PF02516	0.619
MOD_NEK2_1	168	173	PF00069	0.620
MOD_NEK2_1	197	202	PF00069	0.770
MOD_NEK2_1	226	231	PF00069	0.537
MOD_NEK2_1	46	51	PF00069	0.724
MOD_NEK2_1	97	102	PF00069	0.647
MOD_PIKK_1	142	148	PF00454	0.646
MOD_PIKK_1	71	77	PF00454	0.803
MOD_PIKK_1	92	98	PF00454	0.667
MOD_PIKK_1	99	105	PF00454	0.531
MOD_PKA_1	307	313	PF00069	0.744
MOD_PKA_2	293	299	PF00069	0.759
MOD_PKA_2	313	319	PF00069	0.561
MOD_Plk_1	203	209	PF00069	0.746
MOD_Plk_1	7	13	PF00069	0.549
MOD_Plk_4	19	25	PF00069	0.548
MOD_Plk_4	211	217	PF00069	0.749
MOD_Plk_4	221	227	PF00069	0.611
MOD_Plk_4	307	313	PF00069	0.744
MOD_Plk_4	32	38	PF00069	0.483
MOD_ProDKin_1	257	263	PF00069	0.583
MOD_ProDKin_1	27	33	PF00069	0.783
TRG_ENDOCYTIC_2	136	139	PF00928	0.646
TRG_ENDOCYTIC_2	209	212	PF00928	0.757
TRG_ER_diArg_1	161	163	PF00400	0.655
TRG_ER_diArg_1	38	41	PF00400	0.776

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK47	Leishmania donovani	80%	99%
A4IE24	Leishmania infantum	80%	99%
Q4Q0E7	Leishmania major	82%	99%