CCR4-NOT transcription complex subunit 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CCR4-NOT transcription complex subunit 10, putative

Species:

Leishmania mexicana

UniProt:

E9AU45_LEIMU

TriTrypDb:

LmxM.36.6100

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030014	CCR4-NOT complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU45

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006417	regulation of translation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0017148	negative regulation of translation	7	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.568
CLV_NRD_NRD_1	139	141	PF00675	0.729
CLV_NRD_NRD_1	294	296	PF00675	0.600
CLV_NRD_NRD_1	298	300	PF00675	0.644
CLV_NRD_NRD_1	401	403	PF00675	0.516
CLV_NRD_NRD_1	453	455	PF00675	0.517
CLV_NRD_NRD_1	505	507	PF00675	0.615
CLV_PCSK_KEX2_1	111	113	PF00082	0.568
CLV_PCSK_KEX2_1	298	300	PF00082	0.603
CLV_PCSK_KEX2_1	401	403	PF00082	0.592
CLV_PCSK_KEX2_1	453	455	PF00082	0.530
CLV_PCSK_SKI1_1	111	115	PF00082	0.446
CLV_PCSK_SKI1_1	13	17	PF00082	0.522
CLV_PCSK_SKI1_1	348	352	PF00082	0.645
CLV_PCSK_SKI1_1	447	451	PF00082	0.471
DEG_APCC_DBOX_1	453	461	PF00400	0.523
DEG_SPOP_SBC_1	158	162	PF00917	0.442
DOC_ANK_TNKS_1	61	68	PF00023	0.714
DOC_CDC14_PxL_1	166	174	PF14671	0.627
DOC_MAPK_gen_1	474	482	PF00069	0.589
DOC_MAPK_MEF2A_6	476	484	PF00069	0.473
DOC_PP1_RVXF_1	550	556	PF00149	0.548
DOC_PP2B_LxvP_1	365	368	PF13499	0.461
DOC_USP7_MATH_1	181	185	PF00917	0.513
DOC_USP7_MATH_1	285	289	PF00917	0.461
DOC_USP7_MATH_1	338	342	PF00917	0.684
DOC_USP7_MATH_1	422	426	PF00917	0.564
DOC_USP7_MATH_1	472	476	PF00917	0.574
DOC_USP7_UBL2_3	137	141	PF12436	0.728
DOC_WW_Pin1_4	517	522	PF00397	0.682
LIG_14-3-3_CanoR_1	140	146	PF00244	0.728
LIG_14-3-3_CanoR_1	304	310	PF00244	0.681
LIG_14-3-3_CanoR_1	453	458	PF00244	0.530
LIG_Actin_WH2_2	151	169	PF00022	0.633
LIG_APCC_ABBA_1	532	537	PF00400	0.460
LIG_BRCT_BRCA1_1	220	224	PF00533	0.447
LIG_BRCT_BRCA1_1	274	278	PF00533	0.422
LIG_BRCT_BRCA1_2	220	226	PF00533	0.460
LIG_deltaCOP1_diTrp_1	548	555	PF00928	0.634
LIG_DLG_GKlike_1	453	460	PF00625	0.526
LIG_EH1_1	433	441	PF00400	0.449
LIG_eIF4E_1	434	440	PF01652	0.443
LIG_FHA_1	134	140	PF00498	0.603
LIG_FHA_1	428	434	PF00498	0.518
LIG_FHA_2	66	72	PF00498	0.773
LIG_GBD_Chelix_1	44	52	PF00786	0.528
LIG_IRF3_LxIS_1	480	487	PF10401	0.597
LIG_LIR_Gen_1	320	330	PF02991	0.579
LIG_LIR_Gen_1	372	381	PF02991	0.542
LIG_LIR_Gen_1	478	489	PF02991	0.467
LIG_LIR_Gen_1	533	539	PF02991	0.579
LIG_LIR_Nem_3	264	268	PF02991	0.465
LIG_LIR_Nem_3	323	327	PF02991	0.543
LIG_LIR_Nem_3	372	376	PF02991	0.526
LIG_LIR_Nem_3	478	484	PF02991	0.467
LIG_LIR_Nem_3	533	538	PF02991	0.572
LIG_NRBOX	249	255	PF00104	0.476
LIG_PCNA_yPIPBox_3	199	213	PF02747	0.526
LIG_PCNA_yPIPBox_3	242	254	PF02747	0.454
LIG_PCNA_yPIPBox_3	37	48	PF02747	0.569
LIG_PTB_Apo_2	318	325	PF02174	0.587
LIG_PTB_Apo_2	358	365	PF02174	0.522
LIG_SH2_CRK	389	393	PF00017	0.480
LIG_SH2_GRB2like	203	206	PF00017	0.432
LIG_SH2_GRB2like	319	322	PF00017	0.700
LIG_SH2_NCK_1	21	25	PF00017	0.580
LIG_SH2_NCK_1	509	513	PF00017	0.668
LIG_SH2_SRC	21	24	PF00017	0.612
LIG_SH2_STAP1	127	131	PF00017	0.524
LIG_SH2_STAP1	389	393	PF00017	0.457
LIG_SH2_STAT3	302	305	PF00017	0.667
LIG_SH2_STAT5	203	206	PF00017	0.432
LIG_SH2_STAT5	434	437	PF00017	0.513
LIG_SH2_STAT5	47	50	PF00017	0.579
LIG_SH2_STAT5	519	522	PF00017	0.691
LIG_SH2_STAT5	529	532	PF00017	0.544
LIG_SH3_3	330	336	PF00018	0.660
LIG_SH3_4	137	144	PF00018	0.655
LIG_SH3_4	234	241	PF00018	0.678
LIG_SUMO_SIM_par_1	208	215	PF11976	0.462
LIG_TRAF2_1	381	384	PF00917	0.587
LIG_TRAF2_1	410	413	PF00917	0.584
LIG_TRFH_1	324	328	PF08558	0.612
LIG_TRFH_1	364	368	PF08558	0.538
LIG_TYR_ITIM	387	392	PF00017	0.493
LIG_UBA3_1	131	137	PF00899	0.614
LIG_UBA3_1	363	369	PF00899	0.607
LIG_UBA3_1	500	507	PF00899	0.596
MOD_CDK_SPxK_1	517	523	PF00069	0.677
MOD_CK1_1	144	150	PF00069	0.749
MOD_CK1_1	157	163	PF00069	0.565
MOD_CK1_1	456	462	PF00069	0.532
MOD_CK2_1	158	164	PF00069	0.539
MOD_CK2_1	208	214	PF00069	0.533
MOD_CK2_1	317	323	PF00069	0.686
MOD_CK2_1	338	344	PF00069	0.701
MOD_CK2_1	372	378	PF00069	0.505
MOD_CK2_1	472	478	PF00069	0.555
MOD_CK2_1	496	502	PF00069	0.502
MOD_GlcNHglycan	182	186	PF01048	0.592
MOD_GlcNHglycan	314	317	PF01048	0.611
MOD_GlcNHglycan	355	358	PF01048	0.461
MOD_GlcNHglycan	63	66	PF01048	0.724
MOD_GlcNHglycan	99	102	PF01048	0.469
MOD_GSK3_1	121	128	PF00069	0.502
MOD_GSK3_1	140	147	PF00069	0.483
MOD_GSK3_1	154	161	PF00069	0.557
MOD_GSK3_1	268	275	PF00069	0.506
MOD_GSK3_1	339	346	PF00069	0.682
MOD_GSK3_1	455	462	PF00069	0.516
MOD_GSK3_1	484	491	PF00069	0.532
MOD_GSK3_1	496	503	PF00069	0.422
MOD_GSK3_1	513	520	PF00069	0.643
MOD_GSK3_1	61	68	PF00069	0.701
MOD_N-GLC_1	482	487	PF02516	0.530
MOD_NEK2_1	125	130	PF00069	0.454
MOD_NEK2_1	131	136	PF00069	0.511
MOD_NEK2_1	154	159	PF00069	0.623
MOD_NEK2_1	175	180	PF00069	0.502
MOD_NEK2_1	272	277	PF00069	0.514
MOD_NEK2_1	312	317	PF00069	0.658
MOD_NEK2_1	397	402	PF00069	0.559
MOD_NEK2_1	427	432	PF00069	0.553
MOD_NEK2_1	484	489	PF00069	0.465
MOD_NEK2_1	490	495	PF00069	0.520
MOD_NEK2_1	551	556	PF00069	0.621
MOD_OFUCOSY	282	289	PF10250	0.555
MOD_PK_1	273	279	PF00069	0.281
MOD_PKA_1	140	146	PF00069	0.708
MOD_PKA_1	453	459	PF00069	0.532
MOD_PKA_2	139	145	PF00069	0.662
MOD_PKA_2	453	459	PF00069	0.534
MOD_PKA_2	522	528	PF00069	0.624
MOD_PKA_2	61	67	PF00069	0.704
MOD_Plk_1	482	488	PF00069	0.570
MOD_Plk_4	121	127	PF00069	0.525
MOD_Plk_4	154	160	PF00069	0.616
MOD_Plk_4	208	214	PF00069	0.472
MOD_Plk_4	273	279	PF00069	0.370
MOD_Plk_4	372	378	PF00069	0.549
MOD_Plk_4	427	433	PF00069	0.498
MOD_Plk_4	456	462	PF00069	0.545
MOD_Plk_4	496	502	PF00069	0.483
MOD_Plk_4	522	528	PF00069	0.624
MOD_ProDKin_1	517	523	PF00069	0.677
MOD_SUMO_for_1	225	228	PF00179	0.450
MOD_SUMO_rev_2	211	217	PF00179	0.578
MOD_SUMO_rev_2	34	38	PF00179	0.574
TRG_DiLeu_BaEn_1	105	110	PF01217	0.564
TRG_DiLeu_BaEn_1	171	176	PF01217	0.558
TRG_ENDOCYTIC_2	319	322	PF00928	0.668
TRG_ENDOCYTIC_2	389	392	PF00928	0.466
TRG_ENDOCYTIC_2	529	532	PF00928	0.459
TRG_ER_diArg_1	110	112	PF00400	0.570
TRG_ER_diArg_1	452	454	PF00400	0.521
TRG_ER_diArg_1	474	477	PF00400	0.609
TRG_NLS_MonoExtC_3	294	299	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z8	Leptomonas seymouri	80%	100%
A0A0S4ILH8	Bodo saltans	28%	100%
A0A1X0NLF6	Trypanosomatidae	47%	99%
A0A3Q8IJX9	Leishmania donovani	97%	100%
A0A422NJ69	Trypanosoma rangeli	48%	99%
A4HQC9	Leishmania braziliensis	90%	100%
A4IE22	Leishmania infantum	97%	100%
D0A3X0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q0F0	Leishmania major	96%	100%
V5BT61	Trypanosoma cruzi	48%	99%