Putative rab-like GTPase activating protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rab-like GTPase activating protein, putative

Species:

Leishmania mexicana

UniProt:

E9AU43_LEIMU

TriTrypDb:

LmxM.36.6080

Length:

413

Annotations

LeishMANIAdb annotations

Related to animal TBC proteins. Likely cytosolic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AU43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU43

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.495
CLV_NRD_NRD_1	114	116	PF00675	0.464
CLV_NRD_NRD_1	12	14	PF00675	0.608
CLV_NRD_NRD_1	147	149	PF00675	0.385
CLV_NRD_NRD_1	155	157	PF00675	0.279
CLV_NRD_NRD_1	360	362	PF00675	0.368
CLV_NRD_NRD_1	47	49	PF00675	0.657
CLV_NRD_NRD_1	88	90	PF00675	0.570
CLV_PCSK_KEX2_1	114	116	PF00082	0.465
CLV_PCSK_KEX2_1	12	14	PF00082	0.608
CLV_PCSK_KEX2_1	143	145	PF00082	0.358
CLV_PCSK_KEX2_1	147	149	PF00082	0.368
CLV_PCSK_KEX2_1	154	156	PF00082	0.248
CLV_PCSK_KEX2_1	360	362	PF00082	0.245
CLV_PCSK_KEX2_1	382	384	PF00082	0.410
CLV_PCSK_KEX2_1	47	49	PF00082	0.718
CLV_PCSK_KEX2_1	88	90	PF00082	0.583
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.355
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.318
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.466
CLV_PCSK_SKI1_1	271	275	PF00082	0.387
CLV_PCSK_SKI1_1	349	353	PF00082	0.366
CLV_PCSK_SKI1_1	360	364	PF00082	0.139
CLV_PCSK_SKI1_1	389	393	PF00082	0.341
DEG_APCC_DBOX_1	348	356	PF00400	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DEG_SPOP_SBC_1	32	36	PF00917	0.686
DOC_MAPK_MEF2A_6	345	354	PF00069	0.249
DOC_MAPK_MEF2A_6	389	396	PF00069	0.394
DOC_PP1_RVXF_1	391	397	PF00149	0.420
DOC_PP2B_LxvP_1	84	87	PF13499	0.583
DOC_USP7_MATH_1	183	187	PF00917	0.252
DOC_USP7_MATH_1	33	37	PF00917	0.516
DOC_USP7_MATH_1	58	62	PF00917	0.709
DOC_USP7_MATH_1	64	68	PF00917	0.656
DOC_USP7_MATH_1	77	81	PF00917	0.674
DOC_USP7_UBL2_3	267	271	PF12436	0.221
DOC_USP7_UBL2_3	389	393	PF12436	0.384
DOC_WW_Pin1_4	13	18	PF00397	0.770
DOC_WW_Pin1_4	60	65	PF00397	0.601
LIG_14-3-3_CanoR_1	155	159	PF00244	0.186
LIG_14-3-3_CanoR_1	178	183	PF00244	0.465
LIG_14-3-3_CanoR_1	205	210	PF00244	0.221
LIG_14-3-3_CanoR_1	360	366	PF00244	0.471
LIG_14-3-3_CanoR_1	395	404	PF00244	0.434
LIG_14-3-3_CanoR_1	81	87	PF00244	0.567
LIG_AP2alpha_1	94	98	PF02296	0.351
LIG_APCC_ABBA_1	2	7	PF00400	0.681
LIG_Clathr_ClatBox_1	354	358	PF01394	0.340
LIG_deltaCOP1_diTrp_1	125	134	PF00928	0.349
LIG_deltaCOP1_diTrp_1	252	259	PF00928	0.393
LIG_DLG_GKlike_1	205	213	PF00625	0.135
LIG_eIF4E_1	326	332	PF01652	0.367
LIG_FHA_1	201	207	PF00498	0.333
LIG_FHA_1	22	28	PF00498	0.761
LIG_FHA_1	242	248	PF00498	0.322
LIG_FHA_1	367	373	PF00498	0.429
LIG_FHA_2	101	107	PF00498	0.474
LIG_FHA_2	32	38	PF00498	0.539
LIG_FHA_2	365	371	PF00498	0.316
LIG_GBD_Chelix_1	189	197	PF00786	0.318
LIG_LIR_Gen_1	125	135	PF02991	0.376
LIG_LIR_Gen_1	157	163	PF02991	0.345
LIG_LIR_Gen_1	175	184	PF02991	0.212
LIG_LIR_Gen_1	254	263	PF02991	0.313
LIG_LIR_Gen_1	333	340	PF02991	0.390
LIG_LIR_Gen_1	93	102	PF02991	0.380
LIG_LIR_Nem_3	132	137	PF02991	0.363
LIG_LIR_Nem_3	157	162	PF02991	0.335
LIG_LIR_Nem_3	175	179	PF02991	0.232
LIG_LIR_Nem_3	253	259	PF02991	0.275
LIG_LIR_Nem_3	277	281	PF02991	0.347
LIG_LIR_Nem_3	321	326	PF02991	0.321
LIG_LIR_Nem_3	333	339	PF02991	0.364
LIG_LIR_Nem_3	342	347	PF02991	0.286
LIG_LIR_Nem_3	96	101	PF02991	0.367
LIG_PCNA_PIPBox_1	296	305	PF02747	0.390
LIG_Pex14_1	344	348	PF04695	0.279
LIG_Pex14_2	274	278	PF04695	0.360
LIG_Pex14_2	319	323	PF04695	0.289
LIG_Pex14_2	94	98	PF04695	0.332
LIG_PTB_Apo_2	262	269	PF02174	0.427
LIG_PTB_Phospho_1	262	268	PF10480	0.427
LIG_SH2_CRK	176	180	PF00017	0.246
LIG_SH2_GRB2like	225	228	PF00017	0.261
LIG_SH2_GRB2like	326	329	PF00017	0.367
LIG_SH2_GRB2like	400	403	PF00017	0.277
LIG_SH2_NCK_1	119	123	PF00017	0.330
LIG_SH2_STAP1	119	123	PF00017	0.330
LIG_SH2_STAP1	314	318	PF00017	0.229
LIG_SH2_STAT3	400	403	PF00017	0.415
LIG_SH2_STAT3	408	411	PF00017	0.418
LIG_SH2_STAT5	123	126	PF00017	0.398
LIG_SH2_STAT5	145	148	PF00017	0.544
LIG_SH2_STAT5	234	237	PF00017	0.289
LIG_SH2_STAT5	326	329	PF00017	0.330
LIG_SH2_STAT5	400	403	PF00017	0.222
LIG_SH3_3	147	153	PF00018	0.339
LIG_SH3_3	270	276	PF00018	0.274
LIG_SH3_3	305	311	PF00018	0.174
LIG_SH3_3	52	58	PF00018	0.535
LIG_SUMO_SIM_par_1	361	370	PF11976	0.456
LIG_TRAF2_1	35	38	PF00917	0.537
LIG_UBA3_1	206	210	PF00899	0.135
LIG_UBA3_1	371	376	PF00899	0.411
MOD_CK1_1	16	22	PF00069	0.647
MOD_CK1_1	208	214	PF00069	0.451
MOD_CK1_1	364	370	PF00069	0.325
MOD_CK2_1	100	106	PF00069	0.432
MOD_CK2_1	31	37	PF00069	0.538
MOD_CK2_1	364	370	PF00069	0.397
MOD_GlcNHglycan	210	213	PF01048	0.252
MOD_GlcNHglycan	397	400	PF01048	0.294
MOD_GlcNHglycan	60	63	PF01048	0.659
MOD_GlcNHglycan	84	87	PF01048	0.632
MOD_GSK3_1	12	19	PF00069	0.674
MOD_GSK3_1	129	136	PF00069	0.314
MOD_GSK3_1	56	63	PF00069	0.666
MOD_GSK3_1	73	80	PF00069	0.607
MOD_NEK2_1	162	167	PF00069	0.300
MOD_NEK2_1	197	202	PF00069	0.289
MOD_NEK2_1	241	246	PF00069	0.307
MOD_NEK2_1	263	268	PF00069	0.220
MOD_NEK2_1	387	392	PF00069	0.405
MOD_NEK2_1	73	78	PF00069	0.661
MOD_NEK2_2	318	323	PF00069	0.299
MOD_PIKK_1	178	184	PF00454	0.336
MOD_PIKK_1	41	47	PF00454	0.704
MOD_PKA_1	12	18	PF00069	0.609
MOD_PKA_1	154	160	PF00069	0.400
MOD_PKA_2	12	18	PF00069	0.783
MOD_PKA_2	154	160	PF00069	0.207
MOD_Plk_1	197	203	PF00069	0.221
MOD_Plk_4	241	247	PF00069	0.277
MOD_Plk_4	318	324	PF00069	0.300
MOD_ProDKin_1	13	19	PF00069	0.769
MOD_ProDKin_1	60	66	PF00069	0.596
MOD_SUMO_for_1	355	358	PF00179	0.287
TRG_DiLeu_BaEn_1	358	363	PF01217	0.282
TRG_DiLeu_BaEn_4	358	364	PF01217	0.295
TRG_DiLeu_LyEn_5	358	363	PF01217	0.280
TRG_ENDOCYTIC_2	176	179	PF00928	0.287
TRG_ENDOCYTIC_2	300	303	PF00928	0.258
TRG_ENDOCYTIC_2	326	329	PF00928	0.327
TRG_ER_diArg_1	11	13	PF00400	0.547
TRG_ER_diArg_1	360	362	PF00400	0.326
TRG_ER_diArg_1	87	89	PF00400	0.594
TRG_NES_CRM1_1	236	251	PF08389	0.306
TRG_NLS_Bipartite_1	143	158	PF00514	0.214
TRG_NLS_MonoExtN_4	151	158	PF00514	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T4	Leptomonas seymouri	58%	96%
A0A0N1PDX9	Leptomonas seymouri	35%	75%
A0A0S4II34	Bodo saltans	35%	97%
A0A0S4ITU5	Bodo saltans	26%	100%
A0A1X0NLM2	Trypanosomatidae	45%	100%
A0A1X0NLQ9	Trypanosomatidae	43%	97%
A0A1X0P1K5	Trypanosomatidae	26%	100%
A0A3S7XBZ8	Leishmania donovani	89%	100%
A0A3S7XC15	Leishmania donovani	40%	83%
A0A422NJ84	Trypanosoma rangeli	40%	99%
A0A422NJE8	Trypanosoma rangeli	40%	100%
A4HHG8	Leishmania braziliensis	28%	70%
A4HQC6	Leishmania braziliensis	40%	84%
A4HQC7	Leishmania braziliensis	72%	100%
A4IE19	Leishmania infantum	40%	83%
A4IE20	Leishmania infantum	89%	100%
D0A3X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
E9AU42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	74%
P58802	Mus musculus	32%	83%
Q4Q0F2	Leishmania major	89%	100%
Q4Q0F3	Leishmania major	40%	100%
V5BDT8	Trypanosoma cruzi	26%	73%
V5BT66	Trypanosoma cruzi	41%	100%