LeishMANIAdb
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Putative rab-like GTPase activating protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative rab-like GTPase activating protein
Gene product:
rab-like GTPase activating protein, putative
Species:
Leishmania mexicana
UniProt:
E9AU42_LEIMU
TriTrypDb:
LmxM.36.6070
Length:
561

Annotations

LeishMANIAdb annotations

Related to animal TBC proteins. Likely cytosolic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0000331 contractile vacuole 6 1
GO:0005773 vacuole 5 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AU42
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU42

Function

Biological processes
Term Name Level Count
GO:0043085 positive regulation of catalytic activity 4 2
GO:0043087 regulation of GTPase activity 5 2
GO:0043547 positive regulation of GTPase activity 6 2
GO:0044093 positive regulation of molecular function 3 2
GO:0050790 regulation of catalytic activity 3 2
GO:0051336 regulation of hydrolase activity 4 2
GO:0051345 positive regulation of hydrolase activity 5 2
GO:0065007 biological regulation 1 2
GO:0065009 regulation of molecular function 2 2
GO:0090630 activation of GTPase activity 7 2
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 2
GO:0008047 enzyme activator activity 3 2
GO:0030234 enzyme regulator activity 2 2
GO:0030695 GTPase regulator activity 4 2
GO:0060589 nucleoside-triphosphatase regulator activity 3 2
GO:0098772 molecular function regulator activity 1 4
GO:0140677 molecular function activator activity 2 2
GO:0003824 catalytic activity 1 2
GO:0003924 GTPase activity 7 2
GO:0003925 G protein activity 2 2
GO:0016462 pyrophosphatase activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 523 527 PF00656 0.406
CLV_NRD_NRD_1 179 181 PF00675 0.590
CLV_NRD_NRD_1 263 265 PF00675 0.352
CLV_NRD_NRD_1 290 292 PF00675 0.380
CLV_NRD_NRD_1 49 51 PF00675 0.490
CLV_NRD_NRD_1 532 534 PF00675 0.410
CLV_PCSK_KEX2_1 179 181 PF00082 0.519
CLV_PCSK_KEX2_1 263 265 PF00082 0.376
CLV_PCSK_KEX2_1 434 436 PF00082 0.236
CLV_PCSK_KEX2_1 446 448 PF00082 0.226
CLV_PCSK_KEX2_1 49 51 PF00082 0.490
CLV_PCSK_KEX2_1 532 534 PF00082 0.439
CLV_PCSK_PC1ET2_1 434 436 PF00082 0.236
CLV_PCSK_PC1ET2_1 446 448 PF00082 0.226
CLV_PCSK_PC7_1 259 265 PF00082 0.349
CLV_PCSK_SKI1_1 203 207 PF00082 0.560
CLV_PCSK_SKI1_1 264 268 PF00082 0.351
CLV_PCSK_SKI1_1 365 369 PF00082 0.282
CLV_PCSK_SKI1_1 39 43 PF00082 0.489
CLV_PCSK_SKI1_1 416 420 PF00082 0.313
CLV_PCSK_SKI1_1 474 478 PF00082 0.235
CLV_PCSK_SKI1_1 489 493 PF00082 0.345
CLV_Separin_Metazoa 529 533 PF03568 0.391
DEG_MDM2_SWIB_1 458 466 PF02201 0.315
DEG_MDM2_SWIB_1 484 491 PF02201 0.304
DOC_CKS1_1 204 209 PF01111 0.608
DOC_CYCLIN_RxL_1 470 481 PF00134 0.232
DOC_MAPK_gen_1 443 453 PF00069 0.286
DOC_MAPK_gen_1 532 539 PF00069 0.374
DOC_PP1_RVXF_1 262 269 PF00149 0.332
DOC_PP1_RVXF_1 297 304 PF00149 0.271
DOC_PP1_RVXF_1 487 493 PF00149 0.259
DOC_PP1_RVXF_1 534 540 PF00149 0.375
DOC_PP2B_LxvP_1 507 510 PF13499 0.296
DOC_PP4_FxxP_1 353 356 PF00568 0.230
DOC_USP7_MATH_1 43 47 PF00917 0.619
DOC_USP7_MATH_1 53 57 PF00917 0.727
DOC_USP7_MATH_1 95 99 PF00917 0.682
DOC_USP7_UBL2_3 281 285 PF12436 0.368
DOC_USP7_UBL2_3 329 333 PF12436 0.315
DOC_USP7_UBL2_3 60 64 PF12436 0.490
DOC_WW_Pin1_4 111 116 PF00397 0.594
DOC_WW_Pin1_4 129 134 PF00397 0.669
DOC_WW_Pin1_4 203 208 PF00397 0.715
LIG_14-3-3_CanoR_1 179 187 PF00244 0.538
LIG_14-3-3_CanoR_1 49 53 PF00244 0.530
LIG_14-3-3_CanoR_1 80 86 PF00244 0.491
LIG_Actin_WH2_2 171 186 PF00022 0.477
LIG_BRCT_BRCA1_1 459 463 PF00533 0.260
LIG_deltaCOP1_diTrp_1 265 275 PF00928 0.372
LIG_deltaCOP1_diTrp_1 486 492 PF00928 0.259
LIG_eIF4E_1 413 419 PF01652 0.312
LIG_eIF4E_1 83 89 PF01652 0.454
LIG_FHA_1 103 109 PF00498 0.517
LIG_FHA_1 145 151 PF00498 0.582
LIG_FHA_1 157 163 PF00498 0.500
LIG_FHA_1 333 339 PF00498 0.307
LIG_FHA_1 347 353 PF00498 0.327
LIG_FHA_1 463 469 PF00498 0.252
LIG_FHA_1 539 545 PF00498 0.316
LIG_FHA_2 193 199 PF00498 0.646
LIG_GBD_Chelix_1 387 395 PF00786 0.260
LIG_LIR_Gen_1 198 209 PF02991 0.565
LIG_LIR_Gen_1 265 273 PF02991 0.378
LIG_LIR_Gen_1 309 317 PF02991 0.300
LIG_LIR_Gen_1 460 471 PF02991 0.283
LIG_LIR_Gen_1 526 534 PF02991 0.291
LIG_LIR_Gen_1 549 558 PF02991 0.397
LIG_LIR_Gen_1 98 106 PF02991 0.518
LIG_LIR_LC3C_4 114 119 PF02991 0.478
LIG_LIR_Nem_3 198 204 PF02991 0.571
LIG_LIR_Nem_3 235 240 PF02991 0.426
LIG_LIR_Nem_3 296 301 PF02991 0.323
LIG_LIR_Nem_3 309 313 PF02991 0.310
LIG_LIR_Nem_3 398 404 PF02991 0.284
LIG_LIR_Nem_3 460 466 PF02991 0.289
LIG_LIR_Nem_3 485 491 PF02991 0.268
LIG_LIR_Nem_3 526 531 PF02991 0.293
LIG_LIR_Nem_3 549 555 PF02991 0.385
LIG_LIR_Nem_3 98 102 PF02991 0.519
LIG_OCRL_FandH_1 400 412 PF00620 0.259
LIG_PALB2_WD40_1 458 466 PF16756 0.232
LIG_PAM2_1 453 465 PF00658 0.279
LIG_Pex14_1 480 484 PF04695 0.328
LIG_Pex14_1 488 492 PF04695 0.318
LIG_Pex14_2 419 423 PF04695 0.315
LIG_Pex14_2 458 462 PF04695 0.285
LIG_Pex14_2 463 467 PF04695 0.280
LIG_Pex14_2 484 488 PF04695 0.321
LIG_PTB_Apo_2 407 414 PF02174 0.382
LIG_PTB_Phospho_1 407 413 PF10480 0.382
LIG_REV1ctd_RIR_1 428 439 PF16727 0.186
LIG_SH2_CRK 201 205 PF00017 0.505
LIG_SH2_PTP2 322 325 PF00017 0.271
LIG_SH2_STAP1 201 205 PF00017 0.496
LIG_SH2_STAP1 30 34 PF00017 0.476
LIG_SH2_STAT3 83 86 PF00017 0.492
LIG_SH2_STAT5 252 255 PF00017 0.438
LIG_SH2_STAT5 322 325 PF00017 0.319
LIG_SH2_STAT5 380 383 PF00017 0.301
LIG_SH3_3 109 115 PF00018 0.602
LIG_SH3_3 418 424 PF00018 0.266
LIG_SH3_3 59 65 PF00018 0.498
LIG_SUMO_SIM_anti_2 113 120 PF11976 0.532
LIG_SUMO_SIM_anti_2 494 500 PF11976 0.315
LIG_TRAF2_1 121 124 PF00917 0.551
LIG_TRAF2_1 195 198 PF00917 0.567
LIG_TRAF2_1 396 399 PF00917 0.254
LIG_UBA3_1 440 446 PF00899 0.311
LIG_UBA3_1 515 519 PF00899 0.374
LIG_WRC_WIRS_1 307 312 PF05994 0.315
MOD_CK1_1 153 159 PF00069 0.739
MOD_CK1_1 84 90 PF00069 0.761
MOD_CK2_1 190 196 PF00069 0.651
MOD_CK2_1 217 223 PF00069 0.534
MOD_CK2_1 95 101 PF00069 0.534
MOD_Cter_Amidation 47 50 PF01082 0.484
MOD_GlcNHglycan 170 173 PF01048 0.549
MOD_GlcNHglycan 219 222 PF01048 0.672
MOD_GlcNHglycan 45 48 PF01048 0.500
MOD_GSK3_1 153 160 PF00069 0.774
MOD_GSK3_1 188 195 PF00069 0.624
MOD_GSK3_1 199 206 PF00069 0.704
MOD_GSK3_1 453 460 PF00069 0.258
MOD_GSK3_1 48 55 PF00069 0.558
MOD_GSK3_1 501 508 PF00069 0.295
MOD_GSK3_1 84 91 PF00069 0.592
MOD_N-GLC_1 217 222 PF02516 0.625
MOD_N-GLC_1 275 280 PF02516 0.428
MOD_NEK2_1 178 183 PF00069 0.631
MOD_NEK2_1 306 311 PF00069 0.297
MOD_NEK2_1 343 348 PF00069 0.308
MOD_NEK2_1 457 462 PF00069 0.269
MOD_NEK2_1 511 516 PF00069 0.297
MOD_NEK2_2 462 467 PF00069 0.301
MOD_PIKK_1 153 159 PF00454 0.718
MOD_PIKK_1 178 184 PF00454 0.636
MOD_PIKK_1 390 396 PF00454 0.232
MOD_PIKK_1 457 463 PF00454 0.232
MOD_PKA_2 128 134 PF00069 0.787
MOD_PKA_2 178 184 PF00069 0.562
MOD_PKA_2 211 217 PF00069 0.628
MOD_PKA_2 442 448 PF00069 0.292
MOD_PKA_2 48 54 PF00069 0.500
MOD_Plk_1 217 223 PF00069 0.589
MOD_Plk_1 3 9 PF00069 0.531
MOD_Plk_1 397 403 PF00069 0.259
MOD_Plk_1 501 507 PF00069 0.320
MOD_Plk_1 511 517 PF00069 0.359
MOD_Plk_2-3 192 198 PF00069 0.625
MOD_Plk_4 157 163 PF00069 0.484
MOD_Plk_4 3 9 PF00069 0.485
MOD_Plk_4 359 365 PF00069 0.240
MOD_Plk_4 397 403 PF00069 0.263
MOD_Plk_4 453 459 PF00069 0.301
MOD_Plk_4 462 468 PF00069 0.349
MOD_Plk_4 511 517 PF00069 0.291
MOD_Plk_4 53 59 PF00069 0.520
MOD_Plk_4 84 90 PF00069 0.557
MOD_ProDKin_1 111 117 PF00069 0.597
MOD_ProDKin_1 129 135 PF00069 0.667
MOD_ProDKin_1 203 209 PF00069 0.714
MOD_SUMO_for_1 499 502 PF00179 0.281
MOD_SUMO_rev_2 243 253 PF00179 0.518
TRG_DiLeu_BaEn_1 502 507 PF01217 0.281
TRG_DiLeu_BaEn_1 553 558 PF01217 0.336
TRG_DiLeu_BaEn_2 3 9 PF01217 0.531
TRG_DiLeu_BaEn_4 502 508 PF01217 0.271
TRG_DiLeu_BaLyEn_6 112 117 PF01217 0.514
TRG_DiLeu_BaLyEn_6 421 426 PF01217 0.315
TRG_DiLeu_BaLyEn_6 432 437 PF01217 0.315
TRG_ENDOCYTIC_2 201 204 PF00928 0.522
TRG_ENDOCYTIC_2 322 325 PF00928 0.323
TRG_ENDOCYTIC_2 528 531 PF00928 0.284
TRG_ENDOCYTIC_2 551 554 PF00928 0.294
TRG_ENDOCYTIC_2 99 102 PF00928 0.522
TRG_ER_diArg_1 178 180 PF00400 0.499
TRG_ER_diArg_1 262 264 PF00400 0.331
TRG_ER_diArg_1 531 533 PF00400 0.396
TRG_Pf-PMV_PEXEL_1 446 450 PF00026 0.315

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDX9 Leptomonas seymouri 64% 100%
A0A0S4II34 Bodo saltans 54% 100%
A0A3Q8IEG1 Leishmania donovani 28% 100%
A0A3S7XBZ8 Leishmania donovani 35% 100%
A0A3S7XC15 Leishmania donovani 89% 100%
A4HQC6 Leishmania braziliensis 79% 100%
A4HQC7 Leishmania braziliensis 40% 100%
A4I4L7 Leishmania infantum 28% 100%
A4IE19 Leishmania infantum 90% 100%
A4IE20 Leishmania infantum 35% 100%
E9AU43 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
M0R7T9 Rattus norvegicus 25% 81%
O60347 Homo sapiens 26% 72%
Q4Q0F2 Leishmania major 42% 100%
Q4Q0F3 Leishmania major 88% 100%
Q6A039 Mus musculus 25% 81%
V5BT66 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS