MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 4 gamma 4

Species:

Leishmania mexicana

UniProt:

E9AU41_LEIMU

TriTrypDb:

LmxM.36.6060

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AU41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU41

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003743	translation initiation factor activity	4	8
GO:0005488	binding	1	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	216	218	PF00675	0.367
CLV_NRD_NRD_1	320	322	PF00675	0.359
CLV_NRD_NRD_1	514	516	PF00675	0.599
CLV_NRD_NRD_1	54	56	PF00675	0.690
CLV_NRD_NRD_1	85	87	PF00675	0.406
CLV_PCSK_KEX2_1	192	194	PF00082	0.457
CLV_PCSK_KEX2_1	218	220	PF00082	0.367
CLV_PCSK_KEX2_1	278	280	PF00082	0.457
CLV_PCSK_KEX2_1	320	322	PF00082	0.374
CLV_PCSK_KEX2_1	85	87	PF00082	0.436
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.457
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.367
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.457
CLV_PCSK_SKI1_1	187	191	PF00082	0.392
CLV_PCSK_SKI1_1	239	243	PF00082	0.406
CLV_PCSK_SKI1_1	258	262	PF00082	0.406
CLV_PCSK_SKI1_1	44	48	PF00082	0.634
CLV_PCSK_SKI1_1	577	581	PF00082	0.518
CLV_PCSK_SKI1_1	588	592	PF00082	0.477
CLV_PCSK_SKI1_1	603	607	PF00082	0.473
DEG_MDM2_SWIB_1	28	35	PF02201	0.655
DEG_MDM2_SWIB_1	677	685	PF02201	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.685
DOC_ANK_TNKS_1	445	452	PF00023	0.869
DOC_CKS1_1	520	525	PF01111	0.701
DOC_CYCLIN_RxL_1	41	48	PF00134	0.630
DOC_MAPK_DCC_7	55	64	PF00069	0.663
DOC_MAPK_gen_1	12	22	PF00069	0.709
DOC_MAPK_gen_1	217	226	PF00069	0.567
DOC_MAPK_MEF2A_6	119	126	PF00069	0.606
DOC_MAPK_MEF2A_6	55	64	PF00069	0.664
DOC_MAPK_RevD_3	264	279	PF00069	0.606
DOC_MAPK_RevD_3	60	75	PF00069	0.617
DOC_PP1_RVXF_1	318	325	PF00149	0.569
DOC_PP2B_LxvP_1	481	484	PF13499	0.581
DOC_PP2B_LxvP_1	662	665	PF13499	0.585
DOC_PP4_FxxP_1	381	384	PF00568	0.806
DOC_PP4_MxPP_1	431	434	PF00568	0.583
DOC_PP4_MxPP_1	474	477	PF00568	0.756
DOC_PP4_MxPP_1	493	496	PF00568	0.677
DOC_SPAK_OSR1_1	323	327	PF12202	0.606
DOC_USP7_MATH_1	243	247	PF00917	0.606
DOC_USP7_MATH_1	308	312	PF00917	0.606
DOC_USP7_MATH_1	344	348	PF00917	0.857
DOC_USP7_MATH_1	352	356	PF00917	0.783
DOC_USP7_MATH_1	457	461	PF00917	0.804
DOC_USP7_MATH_1	503	507	PF00917	0.847
DOC_USP7_MATH_1	638	642	PF00917	0.489
DOC_USP7_UBL2_3	93	97	PF12436	0.606
DOC_WW_Pin1_4	105	110	PF00397	0.567
DOC_WW_Pin1_4	253	258	PF00397	0.658
DOC_WW_Pin1_4	339	344	PF00397	0.694
DOC_WW_Pin1_4	519	524	PF00397	0.700
LIG_14-3-3_CanoR_1	233	242	PF00244	0.657
LIG_14-3-3_CanoR_1	307	316	PF00244	0.582
LIG_14-3-3_CanoR_1	607	612	PF00244	0.444
LIG_AP2alpha_1	197	201	PF02296	0.606
LIG_APCC_ABBAyCdc20_2	749	755	PF00400	0.672
LIG_BRCT_BRCA1_1	596	600	PF00533	0.600
LIG_BRCT_BRCA1_1	640	644	PF00533	0.481
LIG_CtBP_PxDLS_1	433	437	PF00389	0.756
LIG_deltaCOP1_diTrp_1	331	337	PF00928	0.606
LIG_deltaCOP1_diTrp_1	672	677	PF00928	0.491
LIG_deltaCOP1_diTrp_1	679	688	PF00928	0.452
LIG_EH1_1	323	331	PF00400	0.606
LIG_EVH1_2	484	488	PF00568	0.811
LIG_FHA_1	160	166	PF00498	0.624
LIG_FHA_1	245	251	PF00498	0.584
LIG_FHA_1	46	52	PF00498	0.682
LIG_FHA_1	612	618	PF00498	0.513
LIG_FHA_1	680	686	PF00498	0.525
LIG_FHA_2	19	25	PF00498	0.634
LIG_FHA_2	260	266	PF00498	0.606
LIG_FHA_2	357	363	PF00498	0.817
LIG_FHA_2	542	548	PF00498	0.685
LIG_FHA_2	580	586	PF00498	0.585
LIG_FHA_2	696	702	PF00498	0.650
LIG_Integrin_isoDGR_2	183	185	PF01839	0.457
LIG_Integrin_RGD_1	439	441	PF01839	0.893
LIG_LIR_Apic_2	472	476	PF02991	0.668
LIG_LIR_Gen_1	136	146	PF02991	0.606
LIG_LIR_Gen_1	30	40	PF02991	0.654
LIG_LIR_Gen_1	459	468	PF02991	0.781
LIG_LIR_Gen_1	641	652	PF02991	0.535
LIG_LIR_Gen_1	674	685	PF02991	0.457
LIG_LIR_Gen_1	96	107	PF02991	0.567
LIG_LIR_Nem_3	132	138	PF02991	0.567
LIG_LIR_Nem_3	30	35	PF02991	0.658
LIG_LIR_Nem_3	303	309	PF02991	0.567
LIG_LIR_Nem_3	459	464	PF02991	0.735
LIG_LIR_Nem_3	623	628	PF02991	0.570
LIG_LIR_Nem_3	660	666	PF02991	0.516
LIG_LIR_Nem_3	674	680	PF02991	0.416
LIG_LIR_Nem_3	748	753	PF02991	0.563
LIG_LIR_Nem_3	96	102	PF02991	0.567
LIG_PCNA_yPIPBox_3	39	53	PF02747	0.639
LIG_PDZ_Class_3	760	765	PF00595	0.727
LIG_Pex14_1	673	677	PF04695	0.494
LIG_Pex14_2	197	201	PF04695	0.606
LIG_Pex14_2	28	32	PF04695	0.649
LIG_Pex14_2	677	681	PF04695	0.476
LIG_PTB_Apo_2	220	227	PF02174	0.567
LIG_SH2_CRK	139	143	PF00017	0.575
LIG_SH2_CRK	473	477	PF00017	0.664
LIG_SH2_PTP2	663	666	PF00017	0.598
LIG_SH2_SRC	573	576	PF00017	0.433
LIG_SH2_SRC	658	661	PF00017	0.525
LIG_SH2_STAP1	149	153	PF00017	0.606
LIG_SH2_STAP1	609	613	PF00017	0.503
LIG_SH2_STAP1	629	633	PF00017	0.264
LIG_SH2_STAT5	573	576	PF00017	0.375
LIG_SH2_STAT5	658	661	PF00017	0.525
LIG_SH2_STAT5	663	666	PF00017	0.598
LIG_SH2_STAT5	731	734	PF00017	0.659
LIG_SH3_1	473	479	PF00018	0.721
LIG_SH3_3	109	115	PF00018	0.577
LIG_SH3_3	199	205	PF00018	0.606
LIG_SH3_3	473	479	PF00018	0.804
LIG_SH3_3	481	487	PF00018	0.797
LIG_SH3_3	494	500	PF00018	0.700
LIG_Sin3_3	99	106	PF02671	0.657
LIG_SUMO_SIM_par_1	240	247	PF11976	0.606
LIG_UBA3_1	272	278	PF00899	0.572
LIG_UBA3_1	517	525	PF00899	0.628
LIG_UBA3_1	599	603	PF00899	0.583
LIG_UBA3_1	702	710	PF00899	0.567
LIG_WW_3	205	209	PF00397	0.601
MOD_CDK_SPK_2	253	258	PF00069	0.657
MOD_CDK_SPxK_1	519	525	PF00069	0.631
MOD_CK1_1	234	240	PF00069	0.601
MOD_CK1_1	348	354	PF00069	0.873
MOD_CK1_1	355	361	PF00069	0.818
MOD_CK1_1	373	379	PF00069	0.847
MOD_CK1_1	399	405	PF00069	0.823
MOD_CK1_1	508	514	PF00069	0.649
MOD_CK1_1	594	600	PF00069	0.557
MOD_CK1_1	646	652	PF00069	0.453
MOD_CK1_1	697	703	PF00069	0.585
MOD_CK2_1	356	362	PF00069	0.797
MOD_CK2_1	579	585	PF00069	0.569
MOD_CK2_1	77	83	PF00069	0.580
MOD_Cter_Amidation	276	279	PF01082	0.406
MOD_GlcNHglycan	135	138	PF01048	0.406
MOD_GlcNHglycan	347	350	PF01048	0.809
MOD_GlcNHglycan	381	384	PF01048	0.884
MOD_GlcNHglycan	398	401	PF01048	0.615
MOD_GlcNHglycan	411	414	PF01048	0.659
MOD_GlcNHglycan	447	450	PF01048	0.691
MOD_GlcNHglycan	503	506	PF01048	0.852
MOD_GlcNHglycan	596	599	PF01048	0.576
MOD_GSK3_1	344	351	PF00069	0.864
MOD_GSK3_1	352	359	PF00069	0.794
MOD_GSK3_1	361	368	PF00069	0.718
MOD_GSK3_1	501	508	PF00069	0.739
MOD_GSK3_1	530	537	PF00069	0.513
MOD_GSK3_1	577	584	PF00069	0.508
MOD_GSK3_1	603	610	PF00069	0.497
MOD_GSK3_1	634	641	PF00069	0.563
MOD_N-GLC_1	309	314	PF02516	0.457
MOD_N-GLC_1	355	360	PF02516	0.830
MOD_N-GLC_1	370	375	PF02516	0.729
MOD_N-GLC_1	38	43	PF02516	0.636
MOD_N-GLC_1	743	748	PF02516	0.586
MOD_NEK2_1	197	202	PF00069	0.657
MOD_NEK2_1	268	273	PF00069	0.645
MOD_NEK2_1	28	33	PF00069	0.655
MOD_NEK2_1	309	314	PF00069	0.608
MOD_NEK2_1	419	424	PF00069	0.715
MOD_NEK2_1	591	596	PF00069	0.505
MOD_NEK2_1	652	657	PF00069	0.517
MOD_NEK2_1	724	729	PF00069	0.642
MOD_NEK2_2	705	710	PF00069	0.549
MOD_PIKK_1	462	468	PF00454	0.718
MOD_PIKK_1	505	511	PF00454	0.791
MOD_PIKK_1	724	730	PF00454	0.651
MOD_PKA_1	577	583	PF00069	0.558
MOD_PKA_2	28	34	PF00069	0.601
MOD_PKA_2	316	322	PF00069	0.559
MOD_PKA_2	366	372	PF00069	0.834
MOD_PKA_2	445	451	PF00069	0.635
MOD_Plk_1	309	315	PF00069	0.657
MOD_Plk_1	38	44	PF00069	0.638
MOD_Plk_1	462	468	PF00069	0.785
MOD_Plk_2-3	541	547	PF00069	0.606
MOD_Plk_2-3	581	587	PF00069	0.596
MOD_Plk_4	197	203	PF00069	0.657
MOD_Plk_4	268	274	PF00069	0.601
MOD_Plk_4	301	307	PF00069	0.606
MOD_Plk_4	643	649	PF00069	0.538
MOD_Plk_4	680	686	PF00069	0.535
MOD_Plk_4	736	742	PF00069	0.542
MOD_ProDKin_1	105	111	PF00069	0.567
MOD_ProDKin_1	253	259	PF00069	0.658
MOD_ProDKin_1	339	345	PF00069	0.700
MOD_ProDKin_1	519	525	PF00069	0.710
MOD_SUMO_rev_2	176	182	PF00179	0.601
MOD_SUMO_rev_2	508	518	PF00179	0.622
MOD_SUMO_rev_2	597	605	PF00179	0.556
TRG_DiLeu_BaEn_1	164	169	PF01217	0.657
TRG_DiLeu_BaEn_1	513	518	PF01217	0.647
TRG_DiLeu_BaEn_1	58	63	PF01217	0.689
TRG_ENDOCYTIC_2	139	142	PF00928	0.567
TRG_ENDOCYTIC_2	461	464	PF00928	0.696
TRG_ENDOCYTIC_2	629	632	PF00928	0.473
TRG_ENDOCYTIC_2	663	666	PF00928	0.598
TRG_ENDOCYTIC_2	750	753	PF00928	0.598
TRG_ER_diArg_1	216	219	PF00400	0.567
TRG_ER_diArg_1	320	323	PF00400	0.574
TRG_ER_diArg_1	69	72	PF00400	0.673
TRG_ER_diArg_1	84	86	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL6	Leptomonas seymouri	69%	100%
A0A3Q8IJA9	Leishmania donovani	95%	100%
A4HQC5	Leishmania braziliensis	83%	98%
A4IE18	Leishmania infantum	95%	100%
D0A8R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q0F4	Leishmania major	95%	100%