Conserved oligomeric Golgi complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COG (conserved oligomeric Golgi) complex component, COG2/Domain of unknown function (DUF3510), putative

Species:

Leishmania mexicana

UniProt:

E9AU39_LEIMU

TriTrypDb:

LmxM.36.6040

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	10
GO:0016020	membrane	2	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0017119	Golgi transport complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

E9AU39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AU39

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006996	organelle organization	4	11
GO:0007030	Golgi organization	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.363
CLV_NRD_NRD_1	123	125	PF00675	0.476
CLV_NRD_NRD_1	672	674	PF00675	0.622
CLV_NRD_NRD_1	799	801	PF00675	0.355
CLV_NRD_NRD_1	873	875	PF00675	0.335
CLV_NRD_NRD_1	957	959	PF00675	0.463
CLV_PCSK_KEX2_1	122	124	PF00082	0.476
CLV_PCSK_KEX2_1	672	674	PF00082	0.696
CLV_PCSK_KEX2_1	872	874	PF00082	0.335
CLV_PCSK_KEX2_1	957	959	PF00082	0.463
CLV_PCSK_SKI1_1	197	201	PF00082	0.469
CLV_PCSK_SKI1_1	460	464	PF00082	0.492
CLV_PCSK_SKI1_1	477	481	PF00082	0.411
CLV_PCSK_SKI1_1	647	651	PF00082	0.483
CLV_PCSK_SKI1_1	927	931	PF00082	0.555
DEG_APCC_DBOX_1	188	196	PF00400	0.447
DEG_APCC_DBOX_1	449	457	PF00400	0.429
DEG_APCC_DBOX_1	926	934	PF00400	0.554
DEG_SCF_FBW7_1	658	664	PF00400	0.498
DEG_SPOP_SBC_1	275	279	PF00917	0.477
DOC_ANK_TNKS_1	465	472	PF00023	0.528
DOC_CDC14_PxL_1	488	496	PF14671	0.484
DOC_CKS1_1	50	55	PF01111	0.517
DOC_CKS1_1	632	637	PF01111	0.417
DOC_CKS1_1	658	663	PF01111	0.414
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	632	638	PF00134	0.538
DOC_MAPK_gen_1	139	148	PF00069	0.480
DOC_MAPK_gen_1	915	922	PF00069	0.335
DOC_MAPK_MEF2A_6	561	568	PF00069	0.509
DOC_MAPK_MEF2A_6	688	697	PF00069	0.401
DOC_MAPK_MEF2A_6	915	924	PF00069	0.335
DOC_MAPK_NFAT4_5	917	925	PF00069	0.361
DOC_PP2B_LxvP_1	449	452	PF13499	0.469
DOC_USP7_MATH_1	147	151	PF00917	0.408
DOC_USP7_MATH_1	22	26	PF00917	0.703
DOC_USP7_MATH_1	275	279	PF00917	0.776
DOC_USP7_MATH_1	292	296	PF00917	0.685
DOC_USP7_MATH_1	34	38	PF00917	0.589
DOC_USP7_MATH_1	364	368	PF00917	0.539
DOC_USP7_MATH_1	394	398	PF00917	0.775
DOC_USP7_MATH_1	455	459	PF00917	0.464
DOC_USP7_MATH_1	465	469	PF00917	0.444
DOC_USP7_MATH_1	589	593	PF00917	0.494
DOC_USP7_MATH_1	661	665	PF00917	0.733
DOC_USP7_MATH_1	687	691	PF00917	0.506
DOC_USP7_MATH_1	720	724	PF00917	0.642
DOC_USP7_MATH_1	758	762	PF00917	0.485
DOC_USP7_MATH_1	825	829	PF00917	0.449
DOC_USP7_MATH_1	888	892	PF00917	0.442
DOC_USP7_MATH_1	93	97	PF00917	0.460
DOC_USP7_UBL2_3	219	223	PF12436	0.480
DOC_USP7_UBL2_3	69	73	PF12436	0.599
DOC_WW_Pin1_4	395	400	PF00397	0.796
DOC_WW_Pin1_4	406	411	PF00397	0.711
DOC_WW_Pin1_4	414	419	PF00397	0.400
DOC_WW_Pin1_4	49	54	PF00397	0.783
DOC_WW_Pin1_4	560	565	PF00397	0.380
DOC_WW_Pin1_4	592	597	PF00397	0.490
DOC_WW_Pin1_4	6	11	PF00397	0.789
DOC_WW_Pin1_4	631	636	PF00397	0.444
DOC_WW_Pin1_4	657	662	PF00397	0.653
DOC_WW_Pin1_4	673	678	PF00397	0.791
DOC_WW_Pin1_4	681	686	PF00397	0.654
DOC_WW_Pin1_4	737	742	PF00397	0.701
DOC_WW_Pin1_4	884	889	PF00397	0.436
LIG_14-3-3_CanoR_1	124	130	PF00244	0.320
LIG_14-3-3_CanoR_1	197	206	PF00244	0.407
LIG_14-3-3_CanoR_1	318	326	PF00244	0.531
LIG_14-3-3_CanoR_1	466	473	PF00244	0.437
LIG_14-3-3_CanoR_1	582	590	PF00244	0.483
LIG_14-3-3_CanoR_1	639	643	PF00244	0.451
LIG_14-3-3_CanoR_1	672	677	PF00244	0.700
LIG_14-3-3_CanoR_1	688	692	PF00244	0.572
LIG_14-3-3_CanoR_1	745	751	PF00244	0.568
LIG_14-3-3_CanoR_1	769	775	PF00244	0.493
LIG_14-3-3_CanoR_1	793	803	PF00244	0.390
LIG_14-3-3_CanoR_1	827	835	PF00244	0.220
LIG_14-3-3_CanoR_1	844	853	PF00244	0.369
LIG_14-3-3_CanoR_1	906	910	PF00244	0.429
LIG_Actin_WH2_2	324	340	PF00022	0.497
LIG_Actin_WH2_2	624	641	PF00022	0.440
LIG_APCC_ABBA_1	331	336	PF00400	0.511
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BIR_III_2	21	25	PF00653	0.520
LIG_BRCT_BRCA1_1	625	629	PF00533	0.545
LIG_CtBP_PxDLS_1	937	941	PF00389	0.342
LIG_EVH1_1	29	33	PF00568	0.503
LIG_FHA_1	174	180	PF00498	0.440
LIG_FHA_1	377	383	PF00498	0.562
LIG_FHA_1	40	46	PF00498	0.736
LIG_FHA_1	483	489	PF00498	0.400
LIG_FHA_1	503	509	PF00498	0.196
LIG_FHA_1	706	712	PF00498	0.524
LIG_FHA_1	745	751	PF00498	0.552
LIG_FHA_1	917	923	PF00498	0.335
LIG_FHA_2	292	298	PF00498	0.431
LIG_FHA_2	909	915	PF00498	0.335
LIG_FHA_2	942	948	PF00498	0.555
LIG_GBD_Chelix_1	839	847	PF00786	0.305
LIG_LIR_Apic_2	808	813	PF02991	0.319
LIG_LIR_Gen_1	109	118	PF02991	0.465
LIG_LIR_Gen_1	176	186	PF02991	0.447
LIG_LIR_Gen_1	204	215	PF02991	0.188
LIG_LIR_Gen_1	233	244	PF02991	0.332
LIG_LIR_Gen_1	626	637	PF02991	0.452
LIG_LIR_Gen_1	848	858	PF02991	0.480
LIG_LIR_Nem_3	109	114	PF02991	0.464
LIG_LIR_Nem_3	176	181	PF02991	0.495
LIG_LIR_Nem_3	204	210	PF02991	0.188
LIG_LIR_Nem_3	485	490	PF02991	0.477
LIG_LIR_Nem_3	507	513	PF02991	0.465
LIG_LIR_Nem_3	626	632	PF02991	0.491
LIG_LIR_Nem_3	81	87	PF02991	0.408
LIG_LIR_Nem_3	848	853	PF02991	0.404
LIG_LIR_Nem_3	865	871	PF02991	0.263
LIG_LIR_Nem_3	950	956	PF02991	0.466
LIG_MYND_1	813	817	PF01753	0.424
LIG_NRBOX	256	262	PF00104	0.507
LIG_PCNA_yPIPBox_3	836	844	PF02747	0.480
LIG_PDZ_Class_2	970	975	PF00595	0.674
LIG_Pex14_2	440	444	PF04695	0.479
LIG_Pex14_2	949	953	PF04695	0.526
LIG_SH2_CRK	132	136	PF00017	0.447
LIG_SH2_CRK	207	211	PF00017	0.188
LIG_SH2_CRK	578	582	PF00017	0.423
LIG_SH2_CRK	646	650	PF00017	0.497
LIG_SH2_NCK_1	207	211	PF00017	0.188
LIG_SH2_NCK_1	247	251	PF00017	0.447
LIG_SH2_NCK_1	3	7	PF00017	0.720
LIG_SH2_NCK_1	431	435	PF00017	0.466
LIG_SH2_PTP2	810	813	PF00017	0.424
LIG_SH2_STAP1	247	251	PF00017	0.447
LIG_SH2_STAP1	3	7	PF00017	0.720
LIG_SH2_STAP1	541	545	PF00017	0.494
LIG_SH2_STAT5	158	161	PF00017	0.407
LIG_SH2_STAT5	240	243	PF00017	0.447
LIG_SH2_STAT5	360	363	PF00017	0.534
LIG_SH2_STAT5	614	617	PF00017	0.447
LIG_SH2_STAT5	810	813	PF00017	0.335
LIG_SH3_3	25	31	PF00018	0.802
LIG_SH3_3	284	290	PF00018	0.642
LIG_SH3_3	380	386	PF00018	0.553
LIG_SH3_3	445	451	PF00018	0.516
LIG_SH3_3	47	53	PF00018	0.712
LIG_SH3_3	486	492	PF00018	0.510
LIG_SH3_3	524	530	PF00018	0.482
LIG_SH3_3	590	596	PF00018	0.543
LIG_SH3_3	655	661	PF00018	0.348
LIG_SH3_3	930	936	PF00018	0.565
LIG_SH3_3	965	971	PF00018	0.561
LIG_SUMO_SIM_anti_2	373	380	PF11976	0.498
LIG_SUMO_SIM_anti_2	542	550	PF11976	0.463
LIG_SUMO_SIM_anti_2	555	561	PF11976	0.472
LIG_SUMO_SIM_par_1	373	380	PF11976	0.552
LIG_SUMO_SIM_par_1	542	550	PF11976	0.502
LIG_SUMO_SIM_par_1	693	699	PF11976	0.507
LIG_SUMO_SIM_par_1	936	942	PF11976	0.608
LIG_TYR_ITIM	245	250	PF00017	0.356
LIG_UBA3_1	333	338	PF00899	0.508
LIG_WRC_WIRS_1	108	113	PF05994	0.188
MOD_CDK_SPK_2	49	54	PF00069	0.521
MOD_CDK_SPxxK_3	592	599	PF00069	0.523
MOD_CDK_SPxxK_3	681	688	PF00069	0.475
MOD_CK1_1	103	109	PF00069	0.449
MOD_CK1_1	110	116	PF00069	0.453
MOD_CK1_1	2	8	PF00069	0.717
MOD_CK1_1	214	220	PF00069	0.414
MOD_CK1_1	274	280	PF00069	0.679
MOD_CK1_1	299	305	PF00069	0.547
MOD_CK1_1	312	318	PF00069	0.493
MOD_CK1_1	346	352	PF00069	0.626
MOD_CK1_1	388	394	PF00069	0.724
MOD_CK1_1	395	401	PF00069	0.759
MOD_CK1_1	592	598	PF00069	0.568
MOD_CK1_1	627	633	PF00069	0.472
MOD_CK1_1	665	671	PF00069	0.693
MOD_CK1_1	729	735	PF00069	0.529
MOD_CK1_1	791	797	PF00069	0.349
MOD_CK1_1	805	811	PF00069	0.335
MOD_CK1_1	828	834	PF00069	0.344
MOD_CK1_1	939	945	PF00069	0.594
MOD_CK1_1	96	102	PF00069	0.446
MOD_CK2_1	190	196	PF00069	0.419
MOD_CK2_1	520	526	PF00069	0.433
MOD_CK2_1	720	726	PF00069	0.577
MOD_CK2_1	941	947	PF00069	0.564
MOD_GlcNHglycan	181	184	PF01048	0.335
MOD_GlcNHglycan	207	210	PF01048	0.268
MOD_GlcNHglycan	266	269	PF01048	0.687
MOD_GlcNHglycan	273	276	PF01048	0.762
MOD_GlcNHglycan	284	287	PF01048	0.533
MOD_GlcNHglycan	300	304	PF01048	0.465
MOD_GlcNHglycan	314	317	PF01048	0.571
MOD_GlcNHglycan	389	393	PF01048	0.729
MOD_GlcNHglycan	399	402	PF01048	0.643
MOD_GlcNHglycan	4	7	PF01048	0.720
MOD_GlcNHglycan	467	470	PF01048	0.509
MOD_GlcNHglycan	499	502	PF01048	0.419
MOD_GlcNHglycan	664	667	PF01048	0.764
MOD_GlcNHglycan	722	725	PF01048	0.589
MOD_GlcNHglycan	758	761	PF01048	0.515
MOD_GlcNHglycan	793	796	PF01048	0.335
MOD_GlcNHglycan	804	807	PF01048	0.357
MOD_GlcNHglycan	827	830	PF01048	0.443
MOD_GlcNHglycan	878	881	PF01048	0.201
MOD_GlcNHglycan	892	897	PF01048	0.385
MOD_GSK3_1	100	107	PF00069	0.374
MOD_GSK3_1	169	176	PF00069	0.447
MOD_GSK3_1	2	9	PF00069	0.675
MOD_GSK3_1	264	271	PF00069	0.625
MOD_GSK3_1	274	281	PF00069	0.720
MOD_GSK3_1	292	299	PF00069	0.449
MOD_GSK3_1	34	41	PF00069	0.750
MOD_GSK3_1	384	391	PF00069	0.678
MOD_GSK3_1	623	630	PF00069	0.515
MOD_GSK3_1	657	664	PF00069	0.651
MOD_GSK3_1	672	679	PF00069	0.691
MOD_GSK3_1	701	708	PF00069	0.529
MOD_GSK3_1	728	735	PF00069	0.658
MOD_GSK3_1	857	864	PF00069	0.335
MOD_GSK3_1	876	883	PF00069	0.335
MOD_GSK3_1	884	891	PF00069	0.388
MOD_GSK3_1	91	98	PF00069	0.409
MOD_LATS_1	341	347	PF00433	0.498
MOD_N-GLC_1	179	184	PF02516	0.421
MOD_N-GLC_1	34	39	PF02516	0.770
MOD_N-GLC_1	48	53	PF02516	0.645
MOD_N-GLC_1	680	685	PF02516	0.794
MOD_N-GLC_2	405	407	PF02516	0.479
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	213	218	PF00069	0.346
MOD_NEK2_1	261	266	PF00069	0.453
MOD_NEK2_1	291	296	PF00069	0.644
MOD_NEK2_1	309	314	PF00069	0.586
MOD_NEK2_1	376	381	PF00069	0.558
MOD_NEK2_1	483	488	PF00069	0.441
MOD_NEK2_1	513	518	PF00069	0.510
MOD_NEK2_1	623	628	PF00069	0.527
MOD_NEK2_1	638	643	PF00069	0.341
MOD_NEK2_1	733	738	PF00069	0.675
MOD_NEK2_1	743	748	PF00069	0.367
MOD_NEK2_1	835	840	PF00069	0.464
MOD_NEK2_1	842	847	PF00069	0.345
MOD_NEK2_2	24	29	PF00069	0.521
MOD_PIKK_1	149	155	PF00454	0.429
MOD_PIKK_1	214	220	PF00454	0.354
MOD_PIKK_1	377	383	PF00454	0.498
MOD_PIKK_1	39	45	PF00454	0.735
MOD_PIKK_1	460	466	PF00454	0.438
MOD_PIKK_1	603	609	PF00454	0.537
MOD_PKA_1	672	678	PF00069	0.595
MOD_PKA_2	317	323	PF00069	0.547
MOD_PKA_2	384	390	PF00069	0.550
MOD_PKA_2	465	471	PF00069	0.440
MOD_PKA_2	581	587	PF00069	0.498
MOD_PKA_2	638	644	PF00069	0.420
MOD_PKA_2	671	677	PF00069	0.811
MOD_PKA_2	687	693	PF00069	0.342
MOD_PKA_2	744	750	PF00069	0.614
MOD_PKA_2	770	776	PF00069	0.512
MOD_PKA_2	799	805	PF00069	0.447
MOD_PKA_2	854	860	PF00069	0.447
MOD_PKA_2	905	911	PF00069	0.364
MOD_PKA_2	96	102	PF00069	0.422
MOD_Plk_1	103	109	PF00069	0.480
MOD_Plk_1	190	196	PF00069	0.447
MOD_Plk_1	364	370	PF00069	0.531
MOD_Plk_1	864	870	PF00069	0.335
MOD_Plk_2-3	190	196	PF00069	0.434
MOD_Plk_2-3	910	916	PF00069	0.335
MOD_Plk_4	190	196	PF00069	0.417
MOD_Plk_4	24	30	PF00069	0.515
MOD_Plk_4	356	362	PF00069	0.536
MOD_Plk_4	364	370	PF00069	0.452
MOD_Plk_4	483	489	PF00069	0.494
MOD_Plk_4	504	510	PF00069	0.424
MOD_Plk_4	513	519	PF00069	0.404
MOD_Plk_4	520	526	PF00069	0.321
MOD_Plk_4	624	630	PF00069	0.466
MOD_Plk_4	638	644	PF00069	0.400
MOD_Plk_4	770	776	PF00069	0.529
MOD_Plk_4	805	811	PF00069	0.335
MOD_Plk_4	854	860	PF00069	0.354
MOD_ProDKin_1	395	401	PF00069	0.792
MOD_ProDKin_1	406	412	PF00069	0.710
MOD_ProDKin_1	414	420	PF00069	0.386
MOD_ProDKin_1	49	55	PF00069	0.781
MOD_ProDKin_1	560	566	PF00069	0.375
MOD_ProDKin_1	592	598	PF00069	0.492
MOD_ProDKin_1	6	12	PF00069	0.790
MOD_ProDKin_1	631	637	PF00069	0.436
MOD_ProDKin_1	657	663	PF00069	0.665
MOD_ProDKin_1	673	679	PF00069	0.789
MOD_ProDKin_1	681	687	PF00069	0.644
MOD_ProDKin_1	737	743	PF00069	0.699
MOD_ProDKin_1	884	890	PF00069	0.436
TRG_DiLeu_BaEn_1	328	333	PF01217	0.509
TRG_DiLeu_BaEn_4	555	561	PF01217	0.544
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.603
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.472
TRG_DiLeu_BaLyEn_6	689	694	PF01217	0.299
TRG_DiLeu_BaLyEn_6	951	956	PF01217	0.278
TRG_ENDOCYTIC_2	132	135	PF00928	0.447
TRG_ENDOCYTIC_2	207	210	PF00928	0.188
TRG_ENDOCYTIC_2	247	250	PF00928	0.378
TRG_ENDOCYTIC_2	541	544	PF00928	0.494
TRG_ENDOCYTIC_2	578	581	PF00928	0.385
TRG_ENDOCYTIC_2	646	649	PF00928	0.476
TRG_ER_diArg_1	122	124	PF00400	0.476
TRG_ER_diArg_1	769	772	PF00400	0.413
TRG_ER_diArg_1	871	874	PF00400	0.335
TRG_ER_diArg_1	956	958	PF00400	0.449
TRG_NES_CRM1_1	204	218	PF08389	0.363
TRG_NES_CRM1_1	841	856	PF08389	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9C0	Leptomonas seymouri	60%	100%
A0A1X0P3C4	Trypanosomatidae	33%	100%
A0A3Q8II01	Leishmania donovani	89%	100%
A0A3R7L6I8	Trypanosoma rangeli	33%	100%
A4HQC3	Leishmania braziliensis	76%	100%
A4IE16	Leishmania infantum	89%	100%
D0A8R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q0F6	Leishmania major	88%	100%
V5DND8	Trypanosoma cruzi	34%	100%